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Gonçalves, M.M. Mendes, F. João, J.M. Lopes, M. Honavar" "autores" => array:5 [ 0 => array:2 [ "nombre" => "M.J." "apellidos" => "Gonçalves" ] 1 => array:2 [ "nombre" => "M.M." "apellidos" => "Mendes" ] 2 => array:2 [ "nombre" => "F." "apellidos" => "João" ] 3 => array:2 [ "nombre" => "J.M." "apellidos" => "Lopes" ] 4 => array:2 [ "nombre" => "M." "apellidos" => "Honavar" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511511700100?idApp=UINPBA00004E" "url" => "/21735115/0000001700000001/v1_201305151540/S2173511511700100/v1_201305151540/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2173511511700082" "issn" => "21735115" "doi" => "10.1016/S2173-5115(11)70008-2" "estado" => "S300" "fechaPublicacion" => "2011-01-01" "aid" => "70008" "copyright" => "Sociedade Portuguesa de Pneumologia" "documento" => "article" "crossmark" => 0 "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "fla" "cita" => "Rev Port Pneumol. 2011;17:32-40" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 4947 "formatos" => array:3 [ "EPUB" => 248 "HTML" => 3575 "PDF" => 1124 ] ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">SPECIAL ARTICLE</span>" "titulo" => "Bronchiectasis: do we need aetiological investigation?" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "pt" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "32" "paginaFinal" => "40" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Bronquiectasias: será necessária a investigação etiológica?" ] ] "contieneResumen" => array:2 [ "en" => true "pt" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. Amorim, J. Gracia Róldan" "autores" => array:2 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Amorim" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Gracia Róldan" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511511700082?idApp=UINPBA00004E" "url" => "/21735115/0000001700000001/v1_201305151540/S2173511511700082/v1_201305151540/en/main.assets" ] "en" => array:19 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">CASE REPORT</span>" "titulo" => "Severe malaria – Clinical case" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "41" "paginaFinal" => "43" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "A. Pires, C. Capela, P. Gouveia, J.A. Mariz, G. Gomes, J.E. Oliveira" "autores" => array:6 [ 0 => array:4 [ "nombre" => "A." "apellidos" => "Pires" "email" => array:1 [ 0 => "arnpires@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "C." "apellidos" => "Capela" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "P." "apellidos" => "Gouveia" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "J.A." "apellidos" => "Mariz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "G." "apellidos" => "Gomes" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 5 => array:3 [ "nombre" => "J.E." "apellidos" => "Oliveira" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Internal Medicine Department, Hospital de Braga, Braga, Portugal" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Internal Medicine, Intensive Care Unit, Hospital de Braga, Braga, Portugal" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Malária grave – Caso clínico" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "f0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 749 "Ancho" => 996 "Tamanyo" => 85897 ] ] "descripcion" => array:1 [ "en" => "<p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">Picture of the patient's peripheral blood smear showing a very high level of parasitemia with images of trophozoites and merozoites, as well as significant schizocytes. There were no gametocytes and therefore cannot be seen here.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="s0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0025">Introduction</span><p id="p0005" class="elsevierStylePara elsevierViewall">Malaria is caused by the protozoa <span class="elsevierStyleItalic">Plasmodium</span>, <a class="elsevierStyleCrossRef" href="#bb0005"><span class="elsevierStyleSup">1</span></a> with an intra and extra erythrocyte life cycle, and man is infected by the bite of the anopheles mosquito. There are four species responsible for human malaria: <span class="elsevierStyleItalic">Plasmodium falciparum, P. vivax, P. ovale</span> and <span class="elsevierStyleItalic">P. malariae.</span></p><p id="p0010" class="elsevierStylePara elsevierViewall">Most cases of imported malaria are caused by <span class="elsevierStyleItalic">P. falciparum.</span> It is characterized by fever, chills, intense sweating and headaches, that arise between the 9<span class="elsevierStyleSup">th</span> and 14<span class="elsevierStyleSup">th</span> days after bite. Incubation can last for months.</p><p id="p0015" class="elsevierStylePara elsevierViewall">With postponed diagnosis erythrocyte parasitemia may reach critical values, massive hemolysis and multiorgan dysfunction resulting in death.</p><p id="p0020" class="elsevierStylePara elsevierViewall">The pulmonary involvement with edema is a major complication. <a class="elsevierStyleCrossRef" href="#bb0010"><span class="elsevierStyleSup">2</span></a> More common in adults, is more severe in pregnant and non-immunized individuals. <a class="elsevierStyleCrossRef" href="#bb0015"><span class="elsevierStyleSup">3</span></a> The alveolar-capillary barrier suffers increased permeability and alveolar flooding, conditioning acute lung injury/acute respiratory distress syndrome (ARDS). <a class="elsevierStyleCrossRef" href="#bb0020"><span class="elsevierStyleSup">4</span></a></p></span><span id="s0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0030">Case report</span><p id="p0025" class="elsevierStylePara elsevierViewall">Man, 44 year old, black, born in Angola and resident in Portugal for 24 years, where he works in building construction.</p><p id="p0030" class="elsevierStylePara elsevierViewall">Medical and surgical history irrelevant. Denies alcohol or smoking habits, illicit drug use or sexual risk contacts. He had returned from Angola two weeks ago from his first trip there, without taking any precaution.</p><p id="p0035" class="elsevierStylePara elsevierViewall">He recurs to the emergency room with fever (40<span class="elsevierStyleHsp" style=""></span>ºC) and general malaise of a week duration, and watery stools since the last three days.</p><p id="p0040" class="elsevierStylePara elsevierViewall">He presented with a reasonable general condition, dry mucous membranes and icteric sclerae. A hypotensive and tachycardic profile was noted, while being apyretic with good peripheral saturations on ambient air.</p><p id="p0045" class="elsevierStylePara elsevierViewall">No obvious focus of infection was detected and the rest of the objective examination was irrelevant.</p><p id="p0050" class="elsevierStylePara elsevierViewall">Initial laboratory parameters was as follow: hemoglobin 11.9<span class="elsevierStyleHsp" style=""></span>g/dL, WBC 7,200/μL, platelets 27,000/μL; normal ionogram and renal function, mild liver cytolysis without hyperbilirubinemia, LDH 693 U/L, C-reactive protein (CRP) 228.9<span class="elsevierStyleHsp" style=""></span>mg/dL. Positive thick smear for <span class="elsevierStyleItalic">Plasmodium</span> with 43 % of parasitemia (<a class="elsevierStyleCrossRef" href="#f0005">Fig. 1</a>).</p><elsevierMultimedia ident="f0005"></elsevierMultimedia><p id="p0055" class="elsevierStylePara elsevierViewall">Therapy was started with quinine sulfate and doxycycline.</p><p id="p0060" class="elsevierStylePara elsevierViewall">Infection with hepatotropic virus, HIV I/II, intestinal parasites, urinary tract infection, bacterial gastroenteritis or bacteraemia was excluded. The chest radiograph shows no abnormality.</p><p id="p0065" class="elsevierStylePara elsevierViewall">On the 3<span class="elsevierStyleSup">rd</span> hospital day (D3), the patient became more obtunded, pale, dehydrated, and more icteric with profuse sweating, fever, tachypnea and hemodynamic instability. On pulmonary auscultation there was new bilateral inspiratory crackles.</p><p id="p0070" class="elsevierStylePara elsevierViewall">Hemoglobin fall to 6.8<span class="elsevierStyleHsp" style=""></span>g/dL accompanied by hyperbilirubinemia, LDH = 801 U/L, haptoglobin < 7<span class="elsevierStyleHsp" style=""></span>mg/dL, thrombocytopenia (37,000/μL), creatinine 1.7<span class="elsevierStyleHsp" style=""></span>mg/dL and mild hyponatremia. The CRP remained high and procalcitonin reached 42.6<span class="elsevierStyleHsp" style=""></span>mg/dL. <span class="elsevierStyleItalic">Plasmodium</span> on direct examination was negative. The characterization of the agent trough the BinaxNOW® test showed a single antigen band for <span class="elsevierStyleItalic">P. falciparum.</span></p><p id="p0075" class="elsevierStylePara elsevierViewall">The patient was admitted to a High-Dependency Unit (HDU), with multiple dysfunctions, including cardiovascular, hematological, renal, hepatic and respiratory systems (PaO<span class="elsevierStyleInf">2</span>/FiO<span class="elsevierStyleInf">2</span> = 129) with criteria for ARDS (<a class="elsevierStyleCrossRef" href="#f0010">Fig. 2</a>). After attempts was made to exclude secondary septic complications, to the general support measures, which included liberal fluids infusion and transfusion of packed red blood cells, an empiric antimicrobial coverage with linezolid plus piperacillin/tazobactam was instituted.</p><elsevierMultimedia ident="f0010"></elsevierMultimedia><p id="p0080" class="elsevierStylePara elsevierViewall">By D7 the clinical situation allowed us to continue treatment in the general ward. On D8, a clear improvement on radiological findings and gas exchange was noted. The microbiological screening remained negative, and so, we proceed therapy with only quinine sulfate.</p><p id="p0085" class="elsevierStylePara elsevierViewall">By D11 hemoglobin was 9.2<span class="elsevierStyleHsp" style=""></span>g/dL, with no leukocytosis or thrombocytopenia, and renal function, bilirubin and CRP normalized or continued to improve. <span class="elsevierStyleItalic">Plasmodium</span> on ticks mear remained negative. Abdominal ultrasound excluded pathologic findings.</p><p id="p0090" class="elsevierStylePara elsevierViewall">The patient lived the hospital with a good general condition, with permanent apyrexia and without need for oxygen supply. On a subsequent ambulatory revision, a completely normal clinical status was verified.</p></span><span id="s0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0035">Discussion and conclusions</span><p id="p0095" class="elsevierStylePara elsevierViewall">Malaria presentation is very unspecific so alternative and more frequent diagnoses should be excluded, such as severe pneumonia, meningitis, hemorrhagic fevers, salmonellosis, viral hepatitis and dengue. Fever is common and should be treated with paracetamol, to minimize bleeding diathesis. It responds poorly to antipyretics and physical measures can be necessary.</p><p id="p0100" class="elsevierStylePara elsevierViewall">Imported malaria, in the beginning rarely follows the classical pattern of tertian or quartan fever, which appears only after a few cycles when synchronization occurs. Additional symptoms include chills, headache, malaise, nausea, vomiting, diarrhea, abdominal pain and myalgia. Splenomegaly is an inconstant finding. In practice, malaria should be suspected in any febrile individual returning from tropics, especially if coexisting anemia, thrombocytopenia or cytolysis.</p><p id="p0105" class="elsevierStylePara elsevierViewall">10 % of all cases have a malignant evolution. These are mostly induced by <span class="elsevierStyleItalic">P. falciparum</span> and may follow a explosive course with 50 % of deaths occurring in the first 24 hours. <a class="elsevierStyleCrossRef" href="#bb0025"><span class="elsevierStyleSup">5</span></a></p><p id="p0110" class="elsevierStylePara elsevierViewall">Diagnosis is made by direct demonstration of parasites in blood. Parasitaemia should be determined initially, at D3, D7 and D28, to assess severity, therapy monitoring and late failures detection. <a class="elsevierStyleCrossRef" href="#bb0030"><span class="elsevierStyleSup">6</span></a></p><p id="p0115" class="elsevierStylePara elsevierViewall">Agent detection can imply repeating tests at 12<span class="elsevierStyleHsp" style=""></span>h intervals, but is generally accepted treating patients empirically if suspicion remains high.</p><p id="p0120" class="elsevierStylePara elsevierViewall">Malaria is a paradigmatic example where the early therapy and intensive monitoring brings benefits.</p><p id="p0125" class="elsevierStylePara elsevierViewall">ARDS is defined by acute onset of bilateral pulmonary infiltrates in the absence of heart failure and a PaO<span class="elsevierStyleInf">2</span>/FiO<span class="elsevierStyleInf">2</span> ≤ 200<span class="elsevierStyleHsp" style=""></span>mmHg.</p><p id="p0130" class="elsevierStylePara elsevierViewall">The absence jugular engorgement, hepatojugular reflux, peripheral edema and the typical “butterfly” infiltrates and cephalic pulmonary blood redistribution on chest x-ray, don't support cardiogenic edema. These parameters helped us to guide the fluids supplementation, without jeopardize gas exchange. However, alveolar-capillary damage really favors pulmonary edema formation.</p><p id="p0135" class="elsevierStylePara elsevierViewall">Non-cardiogenic pulmonary edema rarely occurs with other species then <span class="elsevierStyleItalic">P. falciparum.</span></p><p id="p0140" class="elsevierStylePara elsevierViewall">Quinine sulfate is the drug of choice for severe malária, but caution should be taken in those patients with a family history of sudden death or long QT by its intrinsic arrhythmogenicity. Glocunato form is even more pro-arrhythmic.</p><p id="p0145" class="elsevierStylePara elsevierViewall">Severe and recurrent hypoglycemia can result from hyperinsulinism induced by quinine/quinidine, malarious toxins or massive parasitism.</p><p id="p0150" class="elsevierStylePara elsevierViewall">Renal failure, usually oliguric, rarely requires dialysis support and reverses in days.</p><p id="p0155" class="elsevierStylePara elsevierViewall">Thrombocytopenia is common, but rarely contributes to hemorrhagic diathesis. Anemia is induced by parasitic hemolysis.</p><p id="p0160" class="elsevierStylePara elsevierViewall">The fever increases during the first two days but should disappear after 48 hours of treatment.</p><p id="p0165" class="elsevierStylePara elsevierViewall">The efficacy of treatment must be verified by microscopic examination of the blade. The degree of parasitaemia decreases 90 % in 48 hours and must be zero at D3.</p><p id="p0170" class="elsevierStylePara elsevierViewall">The actual case illustrates the counsequencies of preventive measures failure, such as chemoprophylaxis.</p><p id="p0175" class="elsevierStylePara elsevierViewall">If a parasitaemia score of 5 % reflects severity, the 43 % presented by out promised a complicated evolution, as was the case with the installation of successive failures that culminated in ARDS.</p><p id="p0180" class="elsevierStylePara elsevierViewall">The inability to microscopically characterize the type of <span class="elsevierStyleItalic">Plasmodium,</span> do limited therapy institution. Results of the BinaxNOW® test, showing a single band for <span class="elsevierStyleItalic">P. falciparum</span> antigen, comes later. Genomic identification by polymerase chain reaction (PCR) is another available mean to identify the <span class="elsevierStyleItalic">Plasmodium.</span></p><p id="p0185" class="elsevierStylePara elsevierViewall">Compared with PCR, BinaxNOW® test showed a sensitivity of 94 % for detection of P <span class="elsevierStyleItalic">falciparum</span> and 84 % for other species, with overall specificity of 99 %.(7,8)</p><p id="p0190" class="elsevierStylePara elsevierViewall">Multiorgan dysfunction, led us to admit secondary sepsis superposed on malaria, influencing the strategy.</p><p id="p0195" class="elsevierStylePara elsevierViewall">Despite severity of the condition and the limited clinical experience, admission to a HDU capable of monitoring and early warning to complications, associated with elected conduct, proved critical to reverse the various dysfunctions, allowing the avoidance of mechanical ventilation.</p><p id="p0200" class="elsevierStylePara elsevierViewall">Although relatively rare in Portugal, the clinical picture of malaria tends to change with progressive flow of people between countries with multiple affinities, as is the case of Portugal with African ex-colonies.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:8 [ 0 => array:2 [ "identificador" => "xres173025" "titulo" => "Abstract" ] 1 => array:2 [ "identificador" => "xpalclavsec161292" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "xres173024" "titulo" => "Resumo" ] 3 => array:2 [ "identificador" => "xpalclavsec161291" "titulo" => "Palavras-chave" ] 4 => array:2 [ "identificador" => "s0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "s0010" "titulo" => "Case report" ] 6 => array:2 [ "identificador" => "s0015" "titulo" => "Discussion and conclusions" ] 7 => array:1 [ "titulo" => "<span class="elsevierStyleSectionTitle" id="st0040">References</span>" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2009-12-09" "fechaAceptado" => "2010-08-29" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec161292" "palabras" => array:4 [ 0 => "Severe malaria" 1 => "ARDS" 2 => "<span class="elsevierStyleItalic">Plasmodium falciparum</span>" 3 => "Parasitemia" ] ] ] "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec161291" "palabras" => array:4 [ 0 => "Malária grave" 1 => "SDRA" 2 => "<span class="elsevierStyleItalic">Plasmodium falciparum</span>" 3 => "Parasitemia" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="sp0015" class="elsevierStyleSimplePara elsevierViewall">We report a clinical case of severe malaria, where the rate of initial parasitaemia by <span class="elsevierStyleItalic">Plasmodium falciparum</span> was 43 %.</p><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall">Multiple organ dysfunction, including ARDS, forced admission in a close surveillance unit, with survival of the same.</p><p id="sp0025" class="elsevierStyleSimplePara elsevierViewall">A brief review of the subject is made, focusing on severity and general conduct, alerting and awareness for this entity, whose expression, among us, could take on increasing importance.</p>" ] "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<p id="sp0030" class="elsevierStyleSimplePara elsevierViewall">Apresenta-se o caso clínico de um doente regressado de Angola com malária grave, em que o índice de parasitémia inicial pelo <span class="elsevierStyleItalic">P. falciparum</span> era de 43 %.</p><p id="sp0035" class="elsevierStyleSimplePara elsevierViewall">Disfunção múltipla de orgãos, incluindo ARDS, implicaram o ingresso do doente numa unidade de alta vigilância, com sobrevivência do mesmo.</p><p id="sp0040" class="elsevierStyleSimplePara elsevierViewall">Faz-se uma breve revisão do assunto, com enfoque nos indicadores de gravidade e na conduta geral, alertando e sensibilizando para esta entidade, cuja expressão, entre nós, poderá vir a assumir importância crescente.</p>" ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "f0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 749 "Ancho" => 996 "Tamanyo" => 85897 ] ] "descripcion" => array:1 [ "en" => "<p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">Picture of the patient's peripheral blood smear showing a very high level of parasitemia with images of trophozoites and merozoites, as well as significant schizocytes. There were no gametocytes and therefore cannot be seen here.</p>" ] ] 1 => array:7 [ "identificador" => "f0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 344 "Ancho" => 997 "Tamanyo" => 41991 ] ] "descripcion" => array:1 [ "en" => "<p id="sp0010" class="elsevierStyleSimplePara elsevierViewall">Chest anteroposterior teleradiography of the 5<span class="elsevierStyleSup">th</span> day, on the left, and of the 10<span class="elsevierStyleSup">th</span> day of hospitalization, on the right.</p>" ] ] ] "lecturaRecomendada" => array:1 [ 0 => array:3 [ "vista" => "all" "titulo" => "<span class="elsevierStyleSectionTitle" id="st0040">References</span>" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:8 [ 0 => array:3 [ "identificador" => "bb0005" "etiqueta" => "1." 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"referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Management and prevention of imported <span class="elsevierStyleItalic">Plamodium falciparum</span> malaria (Revision 2007 of the 1999 Consensus conference)" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "Recommendations for clinical practice" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Med Mal Infect" "fecha" => "2008" "volumen" => "38" "paginaInicial" => "54" "paginaFinal" => "67" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18646360" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bb0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evaluation of the BINAX NOW(r) ICT Test versus polymerase chain reaction and microscopy for the detection of malaria in returned travelers" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "G.A. Farcas" 1 => "K.J.Y. Zhong" 2 => "F.E. Lovegrove" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Trop Med Hyg" "fecha" => "2003" "volumen" => "69" "paginaInicial" => "589" "paginaFinal" => "592" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14740873" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bb0040" "etiqueta" => "8." 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Baek" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1080/00365540600818011" "Revista" => array:6 [ "tituloSerie" => "Scand J Infect Dis" "fecha" => "2006" "volumen" => "38" "paginaInicial" => "1063" "paginaFinal" => "1068" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17148078" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21735115/0000001700000001/v1_201305151540/S2173511511700094/v1_201305151540/en/main.assets" "Apartado" => array:4 [ "identificador" => "9692" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Case report" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21735115/0000001700000001/v1_201305151540/S2173511511700094/v1_201305151540/en/main.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511511700094?idApp=UINPBA00004E" ]
Year/Month | Html | Total | |
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2024 November | 4 | 10 | 14 |
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2024 June | 38 | 36 | 74 |
2024 May | 64 | 50 | 114 |
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2024 March | 47 | 47 | 94 |
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