was read the article
array:24 [ "pii" => "S2173511512000255" "issn" => "21735115" "doi" => "10.1016/j.rppnen.2012.03.001" "estado" => "S300" "fechaPublicacion" => "2012-09-01" "aid" => "79" "copyrightAnyo" => "2012" "documento" => "article" "crossmark" => 0 "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "sco" "cita" => "Rev Port Pneumol. 2012;18:247-50" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 8388 "formatos" => array:3 [ "EPUB" => 255 "HTML" => 6609 "PDF" => 1524 ] ] "Traduccion" => array:1 [ "pt" => array:20 [ "pii" => "S0873215912000190" "issn" => "08732159" "doi" => "10.1016/j.rppneu.2012.02.002" "estado" => "S300" "fechaPublicacion" => "2012-09-01" "aid" => "79" "copyright" => "Sociedade Portuguesa de Pneumologia" "documento" => "article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "sco" "cita" => "Rev Port Pneumol. 2012;18:247-50" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 10036 "formatos" => array:3 [ "EPUB" => 258 "HTML" => 8044 "PDF" => 1734 ] ] "pt" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Caso clínico</span>" "titulo" => "Tuberculose multirresistente diagnosticada através de análise de líquido sinovial" "tienePdf" => "pt" "tieneTextoCompleto" => "pt" "tieneResumen" => array:2 [ 0 => "pt" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "247" "paginaFinal" => "250" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Multidrug resistant tuberculosis diagnosed by synovial fluid analysis" ] ] "contieneResumen" => array:2 [ "pt" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "pt" => true ] "contienePdf" => array:1 [ "pt" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 772 "Ancho" => 950 "Tamanyo" => 59956 ] ] "descripcion" => array:1 [ "pt" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Radiografia torácica com opacidade na base esquerda sugestiva de derrame pleural.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M. van Zeller, R. Monteiro, J. Ramalho, I. Almeida, R. Duarte" "autores" => array:5 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "van Zeller" ] 1 => array:2 [ "nombre" => "R." "apellidos" => "Monteiro" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Ramalho" ] 3 => array:2 [ "nombre" => "I." "apellidos" => "Almeida" ] 4 => array:2 [ "nombre" => "R." "apellidos" => "Duarte" ] ] ] ] ] "idiomaDefecto" => "pt" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2173511512000255" "doi" => "10.1016/j.rppnen.2012.03.001" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511512000255?idApp=UINPBA00004E" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215912000190?idApp=UINPBA00004E" "url" => "/08732159/0000001800000005/v2_201509041422/S0873215912000190/v2_201509041422/pt/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S2173511512000760" "issn" => "21735115" "doi" => "10.1016/j.rppnen.2011.12.009" "estado" => "S300" "fechaPublicacion" => "2012-09-01" "aid" => "80" "copyright" => "Sociedade Portuguesa de Pneumologia" "documento" => "article" "crossmark" => 0 "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "sco" "cita" => "Rev Port Pneumol. 2012;18:251-4" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 4364 "formatos" => array:3 [ "EPUB" => 216 "HTML" => 3273 "PDF" => 875 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>" "titulo" => "Bronchoscopic management of a rare benign endobronchial tumor" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "pt" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "251" "paginaFinal" => "254" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Abordagem broncoscópica de um tumor endobrônquico benigno raro" ] ] "contieneResumen" => array:2 [ "en" => true "pt" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 809 "Ancho" => 952 "Tamanyo" => 77182 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Chest radiograph showing elevation of the right hemidiaphragm with silhouetting of the right cardiac border.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "K. Madan, R. Agarwal, A. Bal, D. Gupta" "autores" => array:4 [ 0 => array:2 [ "nombre" => "K." "apellidos" => "Madan" ] 1 => array:2 [ "nombre" => "R." "apellidos" => "Agarwal" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Bal" ] 3 => array:2 [ "nombre" => "D." "apellidos" => "Gupta" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511512000760?idApp=UINPBA00004E" "url" => "/21735115/0000001800000005/v1_201305151607/S2173511512000760/v1_201305151607/en/main.assets" ] "itemAnterior" => array:20 [ "pii" => "S2173511512000553" "issn" => "21735115" "doi" => "10.1016/j.rppnen.2012.06.004" "estado" => "S300" "fechaPublicacion" => "2012-09-01" "aid" => "106" "copyright" => "Sociedade Portuguesa de Pneumologia" "documento" => "simple-article" "crossmark" => 0 "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "dis" "cita" => "Rev Port Pneumol. 2012;18:244-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 4277 "formatos" => array:3 [ "EPUB" => 240 "HTML" => 2816 "PDF" => 1221 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Comment</span>" "titulo" => "Personalizing medicine – strategies for implementing the evaluation of ALK rearrangement in non-small-cell lung cancer in Portugal" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "244" "paginaFinal" => "246" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Personalizando a medicina – estratégias para implementar a avaliação do rearranjo do <span class="elsevierStyleItalic">ALK</span> no carcinoma do pulmão de não pequenas células em Portugal" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. Araújo, A. Coelho, R. de Mello, I. Azevedo, M. Soares, H. Queiroga, E. Teixeira, B. Parente, F. Barata" "autores" => array:9 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Araújo" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Coelho" ] 2 => array:2 [ "nombre" => "R." "apellidos" => "de Mello" ] 3 => array:2 [ "nombre" => "I." "apellidos" => "Azevedo" ] 4 => array:2 [ "nombre" => "M." "apellidos" => "Soares" ] 5 => array:2 [ "nombre" => "H." "apellidos" => "Queiroga" ] 6 => array:2 [ "nombre" => "E." "apellidos" => "Teixeira" ] 7 => array:2 [ "nombre" => "B." "apellidos" => "Parente" ] 8 => array:2 [ "nombre" => "F." "apellidos" => "Barata" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S0873215912000840" "doi" => "10.1016/j.rppneu.2012.04.011" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215912000840?idApp=UINPBA00004E" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511512000553?idApp=UINPBA00004E" "url" => "/21735115/0000001800000005/v1_201305151607/S2173511512000553/v1_201305151607/en/main.assets" ] "en" => array:20 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>" "titulo" => "Multidrug resistant tuberculosis diagnosed by synovial fluid analysis" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "247" "paginaFinal" => "250" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "M. van Zeller, R. Monteiro, J. Ramalho, I. Almeida, R. Duarte" "autores" => array:5 [ 0 => array:4 [ "nombre" => "M." "apellidos" => "van Zeller" "email" => array:1 [ 0 => "mafalda_vanzeller@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "R." "apellidos" => "Monteiro" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "J." "apellidos" => "Ramalho" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "I." "apellidos" => "Almeida" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 4 => array:3 [ "nombre" => "R." "apellidos" => "Duarte" "referencia" => array:4 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] 3 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">f</span>" "identificador" => "aff0030" ] ] ] ] "afiliaciones" => array:6 [ 0 => array:3 [ "entidad" => "Serviço de Pneumologia, Hospital São João, Porto, Portugal" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Serviço de Pneumologia, Centro Hospitalar de Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Unidade de Imunologia Clínica Hospital Santo António, Centro Hospitalar do Porto, Porto, Portugal" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Centro de Diagnóstico Pneumológico de Vila Nova de Gaia, Vila Nova de Gaia, Portugal" "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Departamento de Higiene e Epidemiologia da Faculdade de Medicina, Universidade do Porto, Porto, Portugal" "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] 5 => array:3 [ "entidad" => "Centro de Referência para a TBMR da Região Norte, Vila Nova de Gaia, Portugal" "etiqueta" => "<span class="elsevierStyleSup">f</span>" "identificador" => "aff0030" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Tuberculose multirresistente diagnosticada através de análise de líquido sinovial" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1035 "Ancho" => 2337 "Tamanyo" => 235460 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Cerebral magnetic resonance imaging showed intrasellar lesion very suggestive of a tuberculous granulomas (A – coronal view, B – sagittal view).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Tuberculosis (TB) remains a major public health problem worldwide. It has been estimated that 14 million people were living with TB in 2009, and that 1.7 million have died from this disease, among whom 0.38 million were seropositive for the human immunodeficiency virus (HIV).<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> HIV infection is not only associated with an increased incidence of TB but also an increased incidence of disease caused by multidrug-resistant (MDR) strains of <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> (MT).<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> As immunocompetence decreases in HIV-infected patients, the incidence of atypical presentations increases, including high proportions of patients with extrapulmonary disease and disseminated TB.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,4</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Although, osteoarticular TB is reported in 1–3% of patients with TB,<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5,6</span></a> knee-joint involvement of TB is extremely rare, present in only about 0.1% of patients.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Unlike all other forms of extrapulmonary manifestations that are more common in HIV-1, extraspinal tuberculous arthritis appears to occur even less frequently.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Non-HIV patients previously treated for TB are also at increased risk of developing drug resistance. MDR is the most critical form of drug-resistant bacteria because it makes therapeutic regimens containing first-line drugs much less effective.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> Furthermore, if MDR is not promptly recognized, resistance can be further amplified.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> Thus, microbiological diagnosis and identification of MDR using drug susceptibility test (DST) have been recommended.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11,12</span></a> Identification of MDR can allow initiation of treatment with second-line drugs, providing a better chance of cure and preventing the development and spread of further resistance.</p><p id="par0020" class="elsevierStylePara elsevierViewall">To reduce MDR-TB incidence in Portugal, by early recognition of resistance and by adequate treatment, reference centers were established. Whenever a MDR strain of <span class="elsevierStyleItalic">M. tuberculosis</span> is detected the center within that geographic area is notified. If necessary, current medication is optimized or a new treatment regimen is started.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Case report</span><p id="par0025" class="elsevierStylePara elsevierViewall">In May 2009, a 40-year-old male patient presented having had a persistent fever for 5 days and a 2-month history of anorexia and weight loss (12<span class="elsevierStyleHsp" style=""></span>kg). He had no dyspnea, cough or sputum. Examination of his medical records showed that he had a history of alcoholism and drug abuse and HIV-infection since 1993 (taking antiretroviral therapy (ART) since 2009). In 2001, he was diagnosed with pulmonary and lymph node tuberculosis. At that time, he had an isoniazid (H) and streptomycin (S) resistant strain and completed 16 months of treatment with H, rifampicin (R), pyrazinamide (Z) and ethambutol (E)/HR.</p><p id="par0030" class="elsevierStylePara elsevierViewall">General examination at the hospital (May 2009) revealed a poorly built, malnourished man weighing 45<span class="elsevierStyleHsp" style=""></span>kg. He was febrile (auricular temperature 39.5<span class="elsevierStyleHsp" style=""></span>°C), tachycardic and normotensive. Pulse oximetry (FiO<span class="elsevierStyleInf">2</span> 21%) was 99% and chest auscultation revealed decreased breath sound in the lower-left lung field.</p><p id="par0035" class="elsevierStylePara elsevierViewall">Laboratory findings on admission revealed a normal WBC count (CD4<span class="elsevierStyleSup">+</span>-269<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">3</span>), a low hemoglobin concentration (11.9<span class="elsevierStyleHsp" style=""></span>g/dL) and an increased C-reactive protein concentration (24<span class="elsevierStyleHsp" style=""></span>mg/dL). Chest X-rays showed the presence of left pleural effusion (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). A thoracic-abdominal computed tomographic scan revealed no lung parenchymal abnormalities but a mesenteric mass with 5.5<span class="elsevierStyleHsp" style=""></span>cm in diameter.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">A diagnostic thoracentesis was performed revealing an exudate with a preponderance of lymphocytes and an elevated adenosine deaminase (ADA) concentration (63<span class="elsevierStyleHsp" style=""></span>U/L). A biopsy of the mesenteric mass showed epithelioid granulomas, smear and culture of this specimen were negative. Sputum and pleural fluid smears and cultures were persistently negative.</p><p id="par0045" class="elsevierStylePara elsevierViewall">These findings suggested pleural and lymph node TB. Despite the past DST (2001) the patient began antituberculosis therapy with HRE. After 2 weeks, however, the fever persisted and he developed pain and swelling of his right knee, with limited joint mobility. An arthrocentesis was performed for both diagnosis and symptom relief, and synovial fluid was collected. Smears of the fluid were negative for acid-fast bacilli, but cultures were positive. Molecular DST showed a MDR strain of MT with resistance to H and R. Second-line DST showed that the MDR strain was susceptible to ethambutol, capreomycin, moxifloxacin, ethionamide and cycloserine.</p><p id="par0050" class="elsevierStylePara elsevierViewall">Following the diagnosis of MDR-TB in July 2009, our reference center was alerted. The patient was started on a new therapeutic regimen, consisting of ethambutol, capreomycin, moxifloxacin, ethionamide and cycloserine.</p><p id="par0055" class="elsevierStylePara elsevierViewall">After 3 months of therapy, the patient had a convulsion. Cycloserine toxicity was suspected and treatment with this drug was suspended. Cerebral magnetic resonance imaging showed probable cerebral tuberculous granulomas (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). Steroids were therefore added to his treatment regimen.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">After 6 months of treatment, capreomycin treatment was halted and the maintenance phase of treatment began. It was concluded after a total of 18 months, by which time there was clear evidence of recovery, regression of the cerebral lesions, complete resolution of knee symptoms and persistent improvement of the pleural effusion.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0065" class="elsevierStylePara elsevierViewall">We describe a patient with MDR-TB who was diagnosed by mycobacteriological analysis of synovial fluid of the knee. Although previous reports of tuberculous synovitis (particularly in HIV patients) have been described in literature,<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">13–15</span></a> to our knowledge this is the first time that the diagnosis of a MDR-TB strain in synovial fluid of the knee has been described.</p><p id="par0070" class="elsevierStylePara elsevierViewall">Knee-joint involvement is a relatively rare manifestation of extrapulmonary TB, but the number of patients is increasing.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> This presentation is particularly associated with HIV infection,<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> usually as a result of hematogenous spread from the primary focus.</p><p id="par0075" class="elsevierStylePara elsevierViewall">This HIV-patient presented with persisting fever, pain and swelling of his right knee, with limited joint mobility after 2 weeks of a probable diagnosis of pleural and lymph node TB, making infection the most likely diagnosis, specifically a manifestation of extra-pulmonary TB. Although it was this previous diagnosis that prevented the diagnostic delay often associated with osteoarticular TB,<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> careful investigation should be performed as other infection agents might be responsible and, as shown in this case, the isolation of infectious agent might have enormous impact on the treatment and final outcome. A bursitis due to <span class="elsevierStyleItalic">Mycobacterium avium complex</span> in an immunocompetent patient<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> has already been described and it also led to a granulomatous response. Although nontuberculous mycobacteria infections could explain the epithelioid granulomas, the osteoarticular, pleural and lymph node involvement found in this patient are not common manifestations of those infections.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">Although 40–60% of patients with disseminated TB also have pulmonary TB,<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> the thorax CT scan in this patient showed no lung parenchyma involvement, and sputum smears were persistently negative. Also interesting were the pleural fluid smear and culture negative results. According to the literature not only is pleural effusion more common in HIV-patients<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> but also, the profitability of direct examination and culture of pleural fluid in those patients is higher.<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">19,20</span></a> One could argue that the presented patient had been under ART since 2009 and had a CD4 counts >200<span class="elsevierStyleHsp" style=""></span>cells/mm<span class="elsevierStyleSup">3</span>, nevertheless this should have been noticed. Although pleural histological examination and microbiologic analysis is known to be profitable it was not performed.</p><p id="par0085" class="elsevierStylePara elsevierViewall">This patient had pulmonary and lymph node tuberculosis in 2001. Whether recurrent tuberculosis is a reactivation or a re-infection is still a controversial question.<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> Recently Reniero et al. found that there was substantial evidence – both experimental and epidemiological – to support the role of exogenous re-infection in tuberculosis.<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> Regarding the presented case, one could only know for sure if <span class="elsevierStyleItalic">M. tuberculosis</span> genotyping had been performed, but we should note the fact the he was not properly treated in 2001 for a isoniazid resistant strain. The patient underwent maintenance therapy period with rifampicin and isoniazid (to which he was known to be resistant) and eight years later was diagnosed with a <span class="elsevierStyleItalic">M. tuberculosis</span> strain resistant to both of those drugs.</p><p id="par0090" class="elsevierStylePara elsevierViewall">Drug resistance may be due to the administration of improper treatment regimens by healthcare workers and failure to ensure that patients complete the whole course of treatment.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> Prior treatment for TB is the most critical patient-specific risk factor for MRD-TB<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">23,24</span></a> as well as HIV infection that has been associated with raised MDR levels.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> Our patient had both of these risk factors for MDR.</p><p id="par0095" class="elsevierStylePara elsevierViewall">To determine the optimal treatment regimen, specimens should be obtained for culture and DST analysis. In our patient, however, sputum and pleural fluid cultures were negative, whereas synovial fluid was positive, allowing only the latter to be analyzed. Our findings highlight the importance of identifying a MDR strain, especially in a patient with disseminated TB and cerebral tuberculomas and also stress the importance of a MDR-TB treatment component integrating the national programme of TB management.</p><p id="par0100" class="elsevierStylePara elsevierViewall">The CRRMR ensures that the most appropriate treatment is selected by experts in programmatic management of drug-resistant TB. It also ensures that drugs to treat drug-resistant TB are available and that domiciliary DOT is strictly performed. In the present case, the CRRMR was notified by the microbiology laboratory only when the results from the fluid analysis were known. Although this reference approach enables the center physicians to suggest a treatment approach in cases of suspected resistant strains (making it difficult to justify the HRE regiment chosen) until diagnosis confirmation, it also ensures that action is taken after the results are known (which did not occur in 2001 when the patient had a HS-resistant tuberculosis).</p><p id="par0105" class="elsevierStylePara elsevierViewall">Monthly evaluations at the reference center allow for rapid intervention in case of clinical deterioration and strict monitoring of adverse effects caused by second-line drugs. Cerebral tuberculomas were diagnosed following the investigation of a convulsion episode that occurred despite 3 months of a correct treatment regimen and was confirmed not only by drug susceptibility tests but also by the patient's final outcome. It is the authors’ belief that the cerebral involvement was probably already present at the time of diagnosis although asymptomatic and that cycloserine, known to increase the brain's general reactivity led it to become symptomatic.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflicts of interest</span><p id="par0110" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:9 [ 0 => array:2 [ "identificador" => "xres173816" "titulo" => "Abstract" ] 1 => array:2 [ "identificador" => "xpalclavsec162113" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "xres173815" "titulo" => "Resumo" ] 3 => array:2 [ "identificador" => "xpalclavsec162114" "titulo" => "Palavras-chave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Case report" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Discussion" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Conflicts of interest" ] 8 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2011-08-02" "fechaAceptado" => "2011-11-28" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec162113" "palabras" => array:3 [ 0 => "Multidrug resistant tuberculosis" 1 => "Drug susceptibility test" 2 => "HIV" ] ] ] "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec162114" "palabras" => array:3 [ 0 => "Tuberculose multirresistente" 1 => "Teste de sensibilidade aos antimicrobiana" 2 => "Infecção VIH" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Tuberculosis remains a major public health problem worldwide. HIV co-infection is contributing to an increased incidence of the disease, particularly that caused by multidrug resistant strains of <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> (MT). We describe an HIV-infected patient with pleural and lymph node tuberculosis diagnosed by pleural effusion characteristics and biopsy specimens, without MT identification, that further presented with knee-joint involvement. Arthrocentesis allowed MT isolation and drug susceptibility testing, resulting in a diagnosis of multidrug-resistant tuberculosis and an appropriate treatment regimen.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">MT identification and drug susceptibility tests are very important, especially for HIV co-infected patients.</p>" ] "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A tuberculose constitui um importante problema de saúde pública mundial. A co-infecção pelo HIV contribui para o aumento da incidência da doença e em particular a causada por estirpes de <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> (MT) multirresistentes. Os autores descrevem um doente HIV-positivo com tuberculose pleural e ganglionar diagnosticada pelas características bioquímicas do líquido pleural e resultados anatomo-patológicos de biopsias mas sem identificação do agente, que posteriormente apresentou envolvimento do joelho. A artrocentese do joelho permitiu o isolamento do MT e a realização de teste de sensibilidade possibilitando o diagnóstico de tuberculose multirresistente e a instituição de um esquema terapêutico adequado.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">A identificação do MT e a realização de testes de sensibilidade são muito importantes, especialmente em doentes com co-infecção por HIV.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Please cite this article as: van Zeller, M, et al. Tuberculose multirresistente diagnosticada através de análise de líquido sinovial. Rev Port Pneumol. 2012. <span class="elsevierStyleInterRef" href="doi:10.1016/j.rppneu.2012.02.002">doi:10.1016/j.rppneu.2012.02.002</span>.</p>" ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1287 "Ancho" => 1587 "Tamanyo" => 97371 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Patient chest X-rays at hospital admission showed the presence of left pleural effusion.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1035 "Ancho" => 2337 "Tamanyo" => 235460 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Cerebral magnetic resonance imaging showed intrasellar lesion very suggestive of a tuberculous granulomas (A – coronal view, B – sagittal view).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:24 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Global tuberculosis control" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "World Health Organization" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:1 [ "fecha" => "2010" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tuberculosis and HIV-infection: a global perspective" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.F. Murray" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Respiration" "fecha" => "1998" "volumen" => "655" "paginaInicial" => "335" "paginaFinal" => "342" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical management of tuberculosis and HIV-1 co-infection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "C. Schutz" 1 => "G. Meintjes" 2 => "F. Almajid" 3 => "R.J. Wilkinson" 4 => "A. Pozniak" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1183/09031936.00110210" "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2010" "volumen" => "36" "paginaInicial" => "1460" "paginaFinal" => "1482" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20947678" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Approaches to tuberculosis screening and diagnosis with people with HIV in resource limited settings" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.J. Reid" 1 => "N.S. Shah" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S1473-3099(09)70043-X" "Revista" => array:6 [ "tituloSerie" => "Lancet Infect Dis" "fecha" => "2009" "volumen" => "9" "paginaInicial" => "173" "paginaFinal" => "184" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19246021" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "General principles of osteoarticular tuberculosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "S.M. Tuli" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Clin Orthop Relat Res" "fecha" => "2002" "volumen" => "398" "paginaInicial" => "11" "paginaFinal" => "19" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11964626" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673603149641" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A review of patients with skeletal tuberculosis treated at the University Hospital" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.F. Silva" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Kuala Lumpur Int Orthop" "fecha" => "1980" "volumen" => "4" "paginaInicial" => "79" "paginaFinal" => "81" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Delayed diagnosis of tuberculosis arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "H. Erdem" 1 => "O. Baylan" 2 => "I. Simsek" 3 => "A. Dinc" 4 => "S. Pay" 5 => "M. Kocaoglu" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Jpn J Infect Dis" "fecha" => "2005" "volumen" => "58" "paginaInicial" => "373" "paginaFinal" => "375" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16377871" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Extraspinal tuberculous arthritis in HIV era" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P. Lertsrisatit" 1 => "K. Nantiruj" 2 => "K. Totemchokchyakarn" 3 => "S. Janwityanujit" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s10067-006-0296-0" "Revista" => array:6 [ "tituloSerie" => "Clin Rheumatol" "fecha" => "2007" "volumen" => "26" "paginaInicial" => "319" "paginaFinal" => "321" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16642407" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Standard short-course chemotherapy for drug-resistant tuberculosis: treatment outcomes in 6 countries" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.A. Espinal" 1 => "S.J. Kim" 2 => "P.G. Suarez" 3 => "K.M. Kam" 4 => "A.G. Khomenko" 5 => "G.B. Migliori" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Am Med Assoc" "fecha" => "2000" "volumen" => "283" "paginaInicial" => "2537" "paginaFinal" => "2545" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Drug resistance among failure and relapse cases of tuberculosis: is the standard re-treatment regimen adequate?" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H.T. Quy" 1 => "N.T. Lan" 2 => "M.W. Borgdorff" 3 => "J. Grosset" 4 => "P.D. Linh" 5 => "L.B. Tung" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Int J Tuberculosis Lung Dis" "fecha" => "2003" "volumen" => "7" "paginaInicial" => "631" "paginaFinal" => "636" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of tuberculosis: update 2010" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "W.W. Yew" 1 => "C. Lange" 2 => "C.C. Leung" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1183/09031936.00033010" "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2011" "volumen" => "37" "paginaInicial" => "441" "paginaFinal" => "462" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20847074" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "World Health Organization. Guidelines for the programmatic management of drug-resistant tuberculosis WHO/HTM/TB/2011." ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tuberculosis diagnosed by PCR analysis of synovial fluid" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N. Fujimoto" 1 => "K. Gemba" 2 => "A. Yao" 3 => "S. Ozaki" 4 => "K. Ono" 5 => "S. Wada" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s10156-009-0010-7" "Revista" => array:6 [ "tituloSerie" => "J Infect Chemother" "fecha" => "2010" "volumen" => "16" "paginaInicial" => "53" "paginaFinal" => "55" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20052514" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tuberculosis of the knee joint: a case report" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "U. Akgun" 1 => "B. Erol" 2 => "C. Cimsit" 3 => "M. Karahan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Acta Orthop Traumatol Turc" "fecha" => "2007" "volumen" => "41" "paginaInicial" => "214" "paginaFinal" => "218" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "<span class="elsevierStyleItalic">Tuberculous synovitis</span> in a HIV positive patient" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "K. Wanjari" 1 => "V.P. Baradkar" 2 => "M. Mathur" 3 => "S. Kumar" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Indian J Med Microbiol" "fecha" => "2009" "volumen" => "27" "paginaInicial" => "72" "paginaFinal" => "75" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19172069" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bursitis due to <span class="elsevierStyleItalic">Mycobacterium intracellulare</span> in an immunocompetent patient" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "H. Wastiaux" 1 => "H. Maillard" 2 => "C. Bara" 3 => "S. Catala" 4 => "M. Steff" 5 => "P. Célérier" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.annder.2007.11.034" "Revista" => array:6 [ "tituloSerie" => "Ann Dermatol Venereol" "fecha" => "2008" "volumen" => "135" "paginaInicial" => "492" "paginaFinal" => "495" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18598800" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "An official ATS/IDSA statement: diagnosis treatment, and prevention of nontuberculous mycobacterial diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D.E. Griffith" 1 => "T. Aksamit" 2 => "B.A. Brown-Elliott" 3 => "A. Catanzaro" 4 => "C. Daley" 5 => "F. Gordin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.200604-571ST" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2007" "volumen" => "175" "paginaInicial" => "367" "paginaFinal" => "416" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17277290" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "HIV-associated tuberculosis indeveloping countries: clinical features, diagnosis and treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.C. Raviglione" 1 => "J.P. Narain" 2 => "A. Kochi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Bull World Health Organ" "fecha" => "1992" "volumen" => "70" "paginaInicial" => "515" "paginaFinal" => "526" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1394786" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tuberculous pleurisy is more common in AIDS than in non-AIDS patients with tuberculosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.D. Frye" 1 => "C.J. Pozsik" 2 => "S.A. Sahn" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1997" "volumen" => "112" "paginaInicial" => "393" "paginaFinal" => "397" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9266874" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pleural tuberculosis and HIV infection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "F. Relkin" 1 => "C.P. Aranda" 2 => "S.M. Garay" 3 => "R. Smith" 4 => "K.A. Berkowitz" 5 => "W.N. Rom" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1994" "volumen" => "105" "paginaInicial" => "1338" "paginaFinal" => "1341" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8181315" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Exogenous reinfection in tuberculosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C.Y. Chiang" 1 => "L.W. Riley" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S1473-3099(05)70240-1" "Revista" => array:6 [ "tituloSerie" => "Lancet Infect Dis" "fecha" => "2005" "volumen" => "5" "paginaInicial" => "629" "paginaFinal" => "636" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16183517" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "AIDS patient's long-term battle with multiply recurrent tuberculosis: reinfection or reactivation?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Reniero" 1 => "M. Beltrán" 2 => "I.N. de Kantor" 3 => "V. Ritacco" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1590/S0325-75412010000400006" "Revista" => array:6 [ "tituloSerie" => "Rev Argent Microbiol" "fecha" => "2010" "volumen" => "42" "paginaInicial" => "271" "paginaFinal" => "273" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21229196" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0115" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Retreatment management strategies when first-line tuberculosis therapy fails" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.C. Saravia" 1 => "S.C. Appleton" 2 => "M.L. Rich" 3 => "M. Sarria" 4 => "J. Bayona" 5 => "M.C. Becerra" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Int J Tuberculosis Lung Dis" "fecha" => "2005" "volumen" => "9" "paginaInicial" => "421" "paginaFinal" => "429" ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0120" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Development of acquired drug resistance in recurrent tuberculosis patients with various previous treatment outcomes" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "T. Yoshiyama" 1 => "H. Yanai" 2 => "D. Rhiengtong" 3 => "P. Palittapongarnpim" 4 => "O. Nampaisan" 5 => "S. Supawitkul" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Int J Tuberculosis Lung Dis" "fecha" => "2004" "volumen" => "8" "paginaInicial" => "31" "paginaFinal" => "38" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21735115/0000001800000005/v1_201305151607/S2173511512000255/v1_201305151607/en/main.assets" "Apartado" => array:4 [ "identificador" => "9711" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Case reports" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21735115/0000001800000005/v1_201305151607/S2173511512000255/v1_201305151607/en/main.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511512000255?idApp=UINPBA00004E" ]
Year/Month | Html | Total | |
---|---|---|---|
2024 November | 6 | 6 | 12 |
2024 October | 19 | 37 | 56 |
2024 September | 34 | 33 | 67 |
2024 August | 35 | 44 | 79 |
2024 July | 29 | 33 | 62 |
2024 June | 35 | 25 | 60 |
2024 May | 37 | 42 | 79 |
2024 April | 31 | 27 | 58 |
2024 March | 22 | 28 | 50 |
2024 February | 23 | 36 | 59 |
2024 January | 21 | 35 | 56 |
2023 December | 21 | 22 | 43 |
2023 November | 25 | 35 | 60 |
2023 October | 23 | 40 | 63 |
2023 September | 14 | 36 | 50 |
2023 August | 16 | 27 | 43 |
2023 July | 20 | 30 | 50 |
2023 June | 14 | 16 | 30 |
2023 May | 32 | 22 | 54 |
2023 April | 12 | 11 | 23 |