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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Pulmonary function tests &#40;PFT&#41; are useful tools for objective quantification of pulmonary compromise&#44; diagnosis confirmation&#44; therapy monitoring and prognosis assessment of various respiratory diseases&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">In preschool children&#44; given the difficulties of coordination and cooperation&#44; as well as the inadequacy of adult criteria&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> PFT have previously been restricted to clinical research&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">In this age group&#44; it is not possible to measure static lung volumes&#44; because children will not tolerate the valve closing&#46; However&#44; specific airway resistance &#40;sRaw&#41; can be obtained by measuring changes in airflow relative to changes in plethysmographic volume without having to breathe against a closed shutter<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> and spirometry can be performed by experienced technicians using animated software in a friendly and comfortable environment&#44; giving increased success rates in older preschool children&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Recommendations for acceptability and reproducibility criteria in preschool children were published in 2007 by the American Thoracic Society &#40;ATS&#41; and European Respiratory Society &#40;ERS&#41;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&#44; enabling the standardization of methods and practices&#44; with reference equations now already available in this age group for spirometry<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> and specific airway resistance &#40;sRaw&#41; evaluation<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a>&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">With&#160;this study&#44; carried out&#160;in a&#160;specialized&#160;clinic&#44; we aim to&#160;determine the&#160;feasibility of&#160;routine PFT with spirometry and plethysmography&#160;without occlusion&#44; both before and after bronchodilation in preschool children&#44;&#160;and the degree&#160;of success achieved&#160;according to age&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Study design and population</span><p id="par0030" class="elsevierStylePara elsevierViewall">Retrospective analysis of PFT performed in CUF Descobertas Hospital between September 2006 and August 2011&#46; The children selected were between 2 to 6 years old&#44; were followed at the allergy outpatient clinic due to asthma&#44; recurrent wheezing or chronic cough&#44; and referred by their doctor to the respiratory function laboratory of the same hospital&#46; Children with respiratory infection or exacerbation of their respiratory symptoms in the preceding three weeks were not tested&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Pulmonary function testing</span><p id="par0035" class="elsevierStylePara elsevierViewall">Performed before and 20<span class="elsevierStyleHsp" style=""></span>minutes after administration of 400<span class="elsevierStyleHsp" style=""></span>&#956;g of inhaled salbutamol through a spacer device&#44; using a MasterScreen Body Jaeger spirometer &#40;v&#46;4&#46;65&#44; CareFusion Ltd&#44; Viasys Healthcare&#44; Ho&#246;chberg&#44; Germany&#41;&#44; calibrated daily according to manufacturer&#39;s instructions&#46; All data was corrected for body temperature&#44; pressure and saturation &#40;BTPS&#41;&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The study took place in a friendly and comfortable environment&#44; and was performed by an experienced technician&#46; Results were obtained with the child sitting&#44; using a mouthpiece and&#44; preferentially&#44; a nose clip&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">First&#44; sRaw measurements were obtained by body plethysmography without occlusion with the child sitting alone in the plethysmograph&#44; their hands supporting their cheeks and encouraged to adopt a regular breathing rhythm with a respiratory rate between 30 and 45 cycles per minute&#46; Respiratory rate was automatically displayed by the integrated software&#46; The automatic computer selected tangent was used and the median trial of 3 technically acceptable sets of 5 to 10 breaths was reported&#46; Curves were considered acceptable if breaths were super-imposable &#40;i&#46;e&#46; parallel slopes&#41;&#44; of similar size and shape&#44; reasonably closed at zero flow and without obvious distortions to the breath &#40;e&#46;g&#46; glottic closure&#44; cough&#44; talking&#41;&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Spirometry was performed using animation software&#44; which kept the child motivated through positive reinforcement and training to progressively master the technique of forced expiratory maneuvers&#46; A minimum of three and up to 15 maneuvers were obtained and recorded&#46; The volume-time and flow-volume curves were visually inspected by at least two independent investigators&#46; Only curves fulfilling the criteria for acceptability and reproducibility for preschool children published by the ATS&#47;ERS<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> were accepted&#46; Curves obtained after bronchodilation were submitted to the same criteria as baseline curves&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Results were reported only if curves were obtained both before and after bronchodilation&#44; for a maximum expiratory volume at time t &#40;FEV<span class="elsevierStyleInf">t</span>&#41; with maneuver duration equal or higher than 0&#46;5<span class="elsevierStyleHsp" style=""></span>seconds&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Statistical analysis</span><p id="par0060" class="elsevierStylePara elsevierViewall">Statistical analysis was performed using the SPSS version 18&#46;0 for Windows &#40;SPSS&#44; Chicago&#44; IL&#44; USA&#41;&#46; The mean was used as a measure of central tendency and standard deviation as a measure of dispersion&#46;</p></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Results</span><p id="par0065" class="elsevierStylePara elsevierViewall">During the period studied&#44; 1&#44;239 PFT were performed&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">It was possible to obtain curves meeting acceptability and reproducibility criteria for spirometry in 1&#44;092 &#40;88&#37;&#41; 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and FEV<span class="elsevierStyleInf">0&#46;75</span> &#40;children with mean age 4&#46;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;84 years old&#41;&#44; were obtained in younger children comparing to FEV<span class="elsevierStyleInf">1</span> &#40;mean age 4&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;89 years old&#41;<span class="elsevierStyleInf">&#46;</span></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">sRaw was reported in 979 &#40;79&#37;&#41; tests &#40;902 children with mean age of 4&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;87 years&#44; of which 549 &#40;60&#44;9&#37;&#41; were male&#41;&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">For both spirometry and sRaw evauation&#44; there was an increased degree of success in older children &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0085" class="elsevierStylePara elsevierViewall">PFT were requested in a large number of preschool children and performed with a high success rate&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Previously published papers have shown the feasibility of respiratory function testing in this age group&#44; but were mostly based on tests performed in the context of clinical investigation and with a small number of patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;8</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">This study evaluated the PFT success rate in preschool children&#44; both before and after bronchodilation&#44; which is the daily practice of the respiratory function laboratory&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">This was only possible because the physicians were aware of the technical specificities&#44; and the importance of PFT in this age group&#44; and by the fact that tests were performed by an experienced and specialized technician&#44; consistently using the same methodology and equipment&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Studies that focus on this issue have reported success rates in spirometry that can reach 85&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;8&#44;9</span></a> With this study&#44; we prove it is possible to achieve an even higher degree of success&#46; As shown by other authors&#44;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;8&#44;9</span></a> reporting forced expiratory volumes of less than one second has considerably increased the number of PFT in which it was possible to obtain lung function parameters&#44; especially in younger children&#44; whereh determining FEV<span class="elsevierStyleInf">0&#46;75</span> proved particularly useful&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Regarding to the sRaw evaluation&#44; there have been reported success rates of around 75 to 80&#37;&#44;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> which coincides with our results&#46; The feasibility of the technique has been considered to be age-dependent&#44; which is confirmed in our study by the important decrease of success in sRaw determination in those aged 3 years or younger&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">The improvement of spirometry and sRaw reporting in older children in our series is probably not due to learning effect of follow-up repeated measurements&#44; since less than 10&#37; of tests correspond to revaluations&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Thus&#44; the high feasibility of lung function tests in children 2 to 6 years of age may increasingly allow their use in assessing preschool children with respiratory disease&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Studies conducted by Borrego <span class="elsevierStyleItalic">et al</span><a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#44;12</span></a> demonstrated the reproducibility of these measurements over time&#44; as well as functional differences depending on the clinical diagnosis in this age group&#44; although more studies are necessary in the future to demonstrate its usefulness&#44; particularly in clinical correlation and prospective follow-up of these children&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Ethical disclosures</span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Protection of human and animal subjects</span><p id="par0130" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Confidentiality of data</span><p id="par0135" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work center on the publication of patient data and that all the patients included in the study received sufficient information and gave their written informed consent to participate in the study&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Right to privacy and informed consent</span><p id="par0140" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflicts of interest</span><p id="par0145" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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          "palabras" => array:5 [
            0 => "Espirometria"
            1 => "Exequibilidade"
            2 => "Pr&#233;-escolar"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">The assessment of respiratory function in preschool children&#44; which has recently been attracting considerable interest&#44; has several methodological particularities&#46; Whether this is feasible in clinical practice with large groups of patients still needs to be investigated&#46;</p> <span class="elsevierStyleSectionTitle">Aim</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">To assess the feasibility of pulmonary function testing in preschool children in clinical practice&#44; and report the degree of success achieved according to age&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Retrospective analysis of lung function tests performed in children from 2 to 6 years old at the respiratory function laboratory of CUF Descobertas Hospital between September 2006 and August 2011&#46; Whole-body pletismography without occlusion for specific airway resistance &#40;sRaw&#41; assessment and animated spirometry were performed using the equipment Jaeger 4&#46;65 &#40;Viasys Healthcare&#41;&#44; before and after 400<span class="elsevierStyleHsp" style=""></span>&#956;g of inhaled salbutamol via a spacer device&#46; The research fulfilled international criteria &#40;ATS&#47;ERS&#41; for acceptability and reproducibility&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Of 1&#44;239 lung function tests performed&#44; 1&#44;092 &#40;88&#37;&#41; had acceptable and reproducible criteria for spirometry &#40;children with a mean age of 4&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;91 years&#59; 60&#46;7&#37; male&#41;&#44; and 979 &#40;79&#37;&#41; for sRaw measurement&#46; We were able to report FEV<span class="elsevierStyleInf">1</span> in 801 &#40;65&#37;&#41; tests &#40;children with a mean age of 4&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;89 years&#41;&#46; In 23 &#40;2&#37;&#41; tests it was only possible to report FEV<span class="elsevierStyleInf">0&#46;5</span> &#40;children with a mean age of 3&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;67 years&#41; and in 268 &#40;22&#37;&#41; only FEV<span class="elsevierStyleInf">0&#46;75</span> &#40;children with a mean age of 4&#46;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;89 years&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Spirometry and sRaw assessment in preschool children can be used in clinical practice&#44; with an increasing success rate as children get older&#46; Reporting maneuvers of 0&#46;5 or 0&#46;75<span class="elsevierStyleHsp" style=""></span>seconds facilitates spirometric evaluation in a larger number of children&#46;</p>"
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      "pt" => array:2 [
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introdu&#231;&#227;o</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A avalia&#231;&#227;o da fun&#231;&#227;o respirat&#243;ria em idade pr&#233;-escolar reveste-se de particularidades metodol&#243;gicas&#44; tendo ganho recentemente um interesse crescente&#46; A sua exequibilidade na pr&#225;tica cl&#237;nica&#44; em grandes grupos de doentes&#44; continua&#44; no entanto&#44; por investigar&#46;</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Avaliar a exequibilidade do estudo funcional respirat&#243;rio em idade pr&#233;-escolar e o grau de sucesso de acordo com a idade&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">An&#225;lise retrospetiva de provas funcionais respirat&#243;rias realizadas em crian&#231;as com 2 a 6 anos no laborat&#243;rio de explora&#231;&#227;o funcional respirat&#243;ria do Hospital CUF Descobertas entre Setembro de 2006 e Agosto de 2011&#46; Foi efetuada pletismografia corporal sem oclus&#227;o para avalia&#231;&#227;o da resist&#234;ncia espec&#237;fica das vias a&#233;reas &#40;sRaw&#41; e espirometria animada&#44; com equipamento Jaeger4&#46;65 &#40;VIASYS Healthcare&#41; antes e ap&#243;s 400&#160;ug de salbutamol inalado em c&#226;mara expansora&#46; Foram cumpridos os crit&#233;rios internacionais &#40;ATS&#47;ERS&#41; para aceitabilidade e reprodutibilidade&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">De 1&#160;239 provas funcionais respirat&#243;rias realizadas&#44; 1&#160;092 &#40;88&#37;&#41; tinham uma espirometria com crit&#233;rios de aceitabilidade e reprodutibilidade &#40;crian&#231;as com idade m&#233;dia de 4&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;91 anos&#59; 60&#44;7&#37; do sexo masculino&#41;&#44; e 979 &#40;79&#37;&#41; sucesso na determina&#231;&#227;o de sRaw&#46; Foi poss&#237;vel reportar FEV<span class="elsevierStyleInf">1</span> em 801 &#40;65&#37;&#41; provas &#40;crian&#231;as com idade m&#233;dia 4&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;89 anos&#41;&#46; Em 23 &#40;2&#37;&#41; das provas apenas foi poss&#237;vel reportar FEV<span class="elsevierStyleInf">0&#44;5</span> &#40;crian&#231;as com idade m&#233;dia de 3&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;67 anos&#41; e em 268 &#40;22&#37;&#41; apenas FEV<span class="elsevierStyleInf">0&#44;75</span> &#40;crian&#231;as com idade m&#233;dia de 4&#44;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;89 anos&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclus&#227;o</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">A espirometria e a avalia&#231;&#227;o de resist&#234;ncias em idade pr&#233;-escolar s&#227;o exequ&#237;veis na pr&#225;tica cl&#237;nica di&#225;ria&#44; com um aumento do sucesso em crian&#231;as mais velhas&#46; O registo de manobras com dura&#231;&#227;o de 0&#44;5 ou 0&#44;75 s permite a avalia&#231;&#227;o funcional respirat&#243;ria de um maior n&#250;mero de crian&#231;as&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara">Please cite this article as&#58; Santos&#44; N&#59; Exequibilidade do estudo funcional respirat&#243;rio em idade pr&#233;-escolar na pr&#225;tica cl&#237;nica&#46; Rev Port Pneumol 2012&#46; <span class="elsevierStyleInterRef" href="doi:10.1016/j.rppneu.2012.09.004">http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1016&#47;j&#46;rppneu&#46;2012&#46;09&#46;004</span></p>"
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          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Cumulative percent of successful spirometry according to reported FEV<span class="elsevierStyleInf">t</span>&#46;</p>"
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          "leyenda" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">sRaw&#58; Specific airway resistance&#59; FEV<span class="elsevierStyleInf">t</span>&#58; Forced expiratory volume in time t&#46;</p>"
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                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">2 yearsN<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>8n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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Brief Communication
Feasibility of routine respiratory function testing in preschool children
Exequibilidade do estudo funcional respiratório em idade pré-escolar na prática clínica
N. Santosa,c,
Corresponding author
natachalsantos@gmail.com

Corresponding author.
, I. Almeidaa, M. Coutoa,c,d, M. Morais-Almeidaa,e, L.M. Borregoa,b
a Centro de Imunoalergologia, Hospital CUF Descobertas, Lisboa, Portugal
b Departamento de Imunologia, Centro de Estudos de Doenças Crónicas, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa, Portugal
c Serviço de Imunoalergologia, Centro Hospitalar São João E.P.E., Porto, Portugal
d Serviço e Laboratório de Imunologia, Faculdade de Medicina, Universidade do Porto, Porto, Portugal
e Clínica Universitária de Pneumologia, Faculdade de Medicina de Lisboa, Lisboa, Portugal
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          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Cumulative percent of successful spirometry according to reported FEV<span class="elsevierStyleInf">t</span>&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Pulmonary function tests &#40;PFT&#41; are useful tools for objective quantification of pulmonary compromise&#44; diagnosis confirmation&#44; therapy monitoring and prognosis assessment of various respiratory diseases&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">In preschool children&#44; given the difficulties of coordination and cooperation&#44; as well as the inadequacy of adult criteria&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> PFT have previously been restricted to clinical research&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">In this age group&#44; it is not possible to measure static lung volumes&#44; because children will not tolerate the valve closing&#46; However&#44; specific airway resistance &#40;sRaw&#41; can be obtained by measuring changes in airflow relative to changes in plethysmographic volume without having to breathe against a closed shutter<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> and spirometry can be performed by experienced technicians using animated software in a friendly and comfortable environment&#44; giving increased success rates in older preschool children&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Recommendations for acceptability and reproducibility criteria in preschool children were published in 2007 by the American Thoracic Society &#40;ATS&#41; and European Respiratory Society &#40;ERS&#41;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&#44; enabling the standardization of methods and practices&#44; with reference equations now already available in this age group for spirometry<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> and specific airway resistance &#40;sRaw&#41; evaluation<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a>&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">With&#160;this study&#44; carried out&#160;in a&#160;specialized&#160;clinic&#44; we aim to&#160;determine the&#160;feasibility of&#160;routine PFT with spirometry and plethysmography&#160;without occlusion&#44; both before and after bronchodilation in preschool children&#44;&#160;and the degree&#160;of success achieved&#160;according to age&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Study design and population</span><p id="par0030" class="elsevierStylePara elsevierViewall">Retrospective analysis of PFT performed in CUF Descobertas Hospital between September 2006 and August 2011&#46; The children selected were between 2 to 6 years old&#44; were followed at the allergy outpatient clinic due to asthma&#44; recurrent wheezing or chronic cough&#44; and referred by their doctor to the respiratory function laboratory of the same hospital&#46; Children with respiratory infection or exacerbation of their respiratory symptoms in the preceding three weeks were not tested&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Pulmonary function testing</span><p id="par0035" class="elsevierStylePara elsevierViewall">Performed before and 20<span class="elsevierStyleHsp" style=""></span>minutes after administration of 400<span class="elsevierStyleHsp" style=""></span>&#956;g of inhaled salbutamol through a spacer device&#44; using a MasterScreen Body Jaeger spirometer &#40;v&#46;4&#46;65&#44; CareFusion Ltd&#44; Viasys Healthcare&#44; Ho&#246;chberg&#44; Germany&#41;&#44; calibrated daily according to manufacturer&#39;s instructions&#46; All data was corrected for body temperature&#44; pressure and saturation &#40;BTPS&#41;&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The study took place in a friendly and comfortable environment&#44; and was performed by an experienced technician&#46; Results were obtained with the child sitting&#44; using a mouthpiece and&#44; preferentially&#44; a nose clip&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">First&#44; sRaw measurements were obtained by body plethysmography without occlusion with the child sitting alone in the plethysmograph&#44; their hands supporting their cheeks and encouraged to adopt a regular breathing rhythm with a respiratory rate between 30 and 45 cycles per minute&#46; Respiratory rate was automatically displayed by the integrated software&#46; The automatic computer selected tangent was used and the median trial of 3 technically acceptable sets of 5 to 10 breaths was reported&#46; Curves were considered acceptable if breaths were super-imposable &#40;i&#46;e&#46; parallel slopes&#41;&#44; of similar size and shape&#44; reasonably closed at zero flow and without obvious distortions to the breath &#40;e&#46;g&#46; glottic closure&#44; cough&#44; talking&#41;&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Spirometry was performed using animation software&#44; which kept the child motivated through positive reinforcement and training to progressively master the technique of forced expiratory maneuvers&#46; A minimum of three and up to 15 maneuvers were obtained and recorded&#46; The volume-time and flow-volume curves were visually inspected by at least two independent investigators&#46; Only curves fulfilling the criteria for acceptability and reproducibility for preschool children published by the ATS&#47;ERS<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> were accepted&#46; Curves obtained after bronchodilation were submitted to the same criteria as baseline curves&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Results were reported only if curves were obtained both before and after bronchodilation&#44; for a maximum expiratory volume at time t &#40;FEV<span class="elsevierStyleInf">t</span>&#41; with maneuver duration equal or higher than 0&#46;5<span class="elsevierStyleHsp" style=""></span>seconds&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Statistical analysis</span><p id="par0060" class="elsevierStylePara elsevierViewall">Statistical analysis was performed using the SPSS version 18&#46;0 for Windows &#40;SPSS&#44; Chicago&#44; IL&#44; USA&#41;&#46; The mean was used as a measure of central tendency and standard deviation as a measure of dispersion&#46;</p></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Results</span><p id="par0065" class="elsevierStylePara elsevierViewall">During the period studied&#44; 1&#44;239 PFT were performed&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">It was possible to obtain curves meeting acceptability and reproducibility criteria for spirometry in 1&#44;092 &#40;88&#37;&#41; tests &#40;1&#44;013 children with mean age of 4&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;91 years&#44; of which 615 &#40;60&#44;7&#37;&#41; were male&#41;&#46; Seventy nine &#40;7&#46;2&#37;&#41; tests were revaluations performed after a mean of 12&#46;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#46;1 months&#46; FEV<span class="elsevierStyleInf">t</span> achieved according to children&#39;s age is shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; In 23 &#40;2&#37;&#41; tests it was only possible to report FEV<span class="elsevierStyleInf">0&#46;5</span> and in 268 &#40;22&#37;&#41; FEV<span class="elsevierStyleInf">0&#46;75</span>&#44; allowing the reporting of spirometric parameters in more 291 &#40;23&#37;&#41; PFT &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Measurements with reported FEV<span class="elsevierStyleInf">0&#46;5</span> &#40;children with mean age 3&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;67 years old&#41; and FEV<span class="elsevierStyleInf">0&#46;75</span> &#40;children with mean age 4&#46;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;84 years old&#41;&#44; were obtained in younger children comparing to FEV<span class="elsevierStyleInf">1</span> &#40;mean age 4&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;89 years old&#41;<span class="elsevierStyleInf">&#46;</span></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">sRaw was reported in 979 &#40;79&#37;&#41; tests &#40;902 children with mean age of 4&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;87 years&#44; of which 549 &#40;60&#44;9&#37;&#41; were male&#41;&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">For both spirometry and sRaw evauation&#44; there was an increased degree of success in older children &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0085" class="elsevierStylePara elsevierViewall">PFT were requested in a large number of preschool children and performed with a high success rate&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Previously published papers have shown the feasibility of respiratory function testing in this age group&#44; but were mostly based on tests performed in the context of clinical investigation and with a small number of patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;8</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">This study evaluated the PFT success rate in preschool children&#44; both before and after bronchodilation&#44; which is the daily practice of the respiratory function laboratory&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">This was only possible because the physicians were aware of the technical specificities&#44; and the importance of PFT in this age group&#44; and by the fact that tests were performed by an experienced and specialized technician&#44; consistently using the same methodology and equipment&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Studies that focus on this issue have reported success rates in spirometry that can reach 85&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;8&#44;9</span></a> With this study&#44; we prove it is possible to achieve an even higher degree of success&#46; As shown by other authors&#44;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;8&#44;9</span></a> reporting forced expiratory volumes of less than one second has considerably increased the number of PFT in which it was possible to obtain lung function parameters&#44; especially in younger children&#44; whereh determining FEV<span class="elsevierStyleInf">0&#46;75</span> proved particularly useful&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Regarding to the sRaw evaluation&#44; there have been reported success rates of around 75 to 80&#37;&#44;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> which coincides with our results&#46; The feasibility of the technique has been considered to be age-dependent&#44; which is confirmed in our study by the important decrease of success in sRaw determination in those aged 3 years or younger&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">The improvement of spirometry and sRaw reporting in older children in our series is probably not due to learning effect of follow-up repeated measurements&#44; since less than 10&#37; of tests correspond to revaluations&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Thus&#44; the high feasibility of lung function tests in children 2 to 6 years of age may increasingly allow their use in assessing preschool children with respiratory disease&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Studies conducted by Borrego <span class="elsevierStyleItalic">et al</span><a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#44;12</span></a> demonstrated the reproducibility of these measurements over time&#44; as well as functional differences depending on the clinical diagnosis in this age group&#44; although more studies are necessary in the future to demonstrate its usefulness&#44; particularly in clinical correlation and prospective follow-up of these children&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Ethical disclosures</span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Protection of human and animal subjects</span><p id="par0130" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Confidentiality of data</span><p id="par0135" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work center on the publication of patient data and that all the patients included in the study received sufficient information and gave their written informed consent to participate in the study&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Right to privacy and informed consent</span><p id="par0140" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflicts of interest</span><p id="par0145" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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            1 => array:2 [
              "identificador" => "sec0020"
              "titulo" => "Pulmonary function testing"
            ]
            2 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Statistical analysis"
            ]
          ]
        ]
        6 => array:2 [
          "identificador" => "sec0030"
          "titulo" => "Results"
        ]
        7 => array:2 [
          "identificador" => "sec0035"
          "titulo" => "Discussion"
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        8 => array:3 [
          "identificador" => "sec0040"
          "titulo" => "Ethical disclosures"
          "secciones" => array:3 [
            0 => array:2 [
              "identificador" => "sec0045"
              "titulo" => "Protection of human and animal subjects"
            ]
            1 => array:2 [
              "identificador" => "sec0050"
              "titulo" => "Confidentiality of data"
            ]
            2 => array:2 [
              "identificador" => "sec0055"
              "titulo" => "Right to privacy and informed consent"
            ]
          ]
        ]
        9 => array:2 [
          "identificador" => "sec0060"
          "titulo" => "Conflicts of interest"
        ]
        10 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2012-02-27"
    "fechaAceptado" => "2012-09-26"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec164103"
          "palabras" => array:5 [
            0 => "Spirometry"
            1 => "Feasibility"
            2 => "Preschool"
            3 => "Respiratory function tests"
            4 => "Specific airway resistance"
          ]
        ]
      ]
      "pt" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palavras-chave"
          "identificador" => "xpalclavsec164104"
          "palabras" => array:5 [
            0 => "Espirometria"
            1 => "Exequibilidade"
            2 => "Pr&#233;-escolar"
            3 => "Provas de fun&#231;&#227;o respirat&#243;ria"
            4 => "Resist&#234;ncia espec&#237;fica das vias a&#233;ras"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">The assessment of respiratory function in preschool children&#44; which has recently been attracting considerable interest&#44; has several methodological particularities&#46; Whether this is feasible in clinical practice with large groups of patients still needs to be investigated&#46;</p> <span class="elsevierStyleSectionTitle">Aim</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">To assess the feasibility of pulmonary function testing in preschool children in clinical practice&#44; and report the degree of success achieved according to age&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Retrospective analysis of lung function tests performed in children from 2 to 6 years old at the respiratory function laboratory of CUF Descobertas Hospital between September 2006 and August 2011&#46; Whole-body pletismography without occlusion for specific airway resistance &#40;sRaw&#41; assessment and animated spirometry were performed using the equipment Jaeger 4&#46;65 &#40;Viasys Healthcare&#41;&#44; before and after 400<span class="elsevierStyleHsp" style=""></span>&#956;g of inhaled salbutamol via a spacer device&#46; The research fulfilled international criteria &#40;ATS&#47;ERS&#41; for acceptability and reproducibility&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Of 1&#44;239 lung function tests performed&#44; 1&#44;092 &#40;88&#37;&#41; had acceptable and reproducible criteria for spirometry &#40;children with a mean age of 4&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;91 years&#59; 60&#46;7&#37; male&#41;&#44; and 979 &#40;79&#37;&#41; for sRaw measurement&#46; We were able to report FEV<span class="elsevierStyleInf">1</span> in 801 &#40;65&#37;&#41; tests &#40;children with a mean age of 4&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;89 years&#41;&#46; In 23 &#40;2&#37;&#41; tests it was only possible to report FEV<span class="elsevierStyleInf">0&#46;5</span> &#40;children with a mean age of 3&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;67 years&#41; and in 268 &#40;22&#37;&#41; only FEV<span class="elsevierStyleInf">0&#46;75</span> &#40;children with a mean age of 4&#46;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;89 years&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Spirometry and sRaw assessment in preschool children can be used in clinical practice&#44; with an increasing success rate as children get older&#46; Reporting maneuvers of 0&#46;5 or 0&#46;75<span class="elsevierStyleHsp" style=""></span>seconds facilitates spirometric evaluation in a larger number of children&#46;</p>"
      ]
      "pt" => array:2 [
        "titulo" => "Resumo"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introdu&#231;&#227;o</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A avalia&#231;&#227;o da fun&#231;&#227;o respirat&#243;ria em idade pr&#233;-escolar reveste-se de particularidades metodol&#243;gicas&#44; tendo ganho recentemente um interesse crescente&#46; A sua exequibilidade na pr&#225;tica cl&#237;nica&#44; em grandes grupos de doentes&#44; continua&#44; no entanto&#44; por investigar&#46;</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Avaliar a exequibilidade do estudo funcional respirat&#243;rio em idade pr&#233;-escolar e o grau de sucesso de acordo com a idade&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">An&#225;lise retrospetiva de provas funcionais respirat&#243;rias realizadas em crian&#231;as com 2 a 6 anos no laborat&#243;rio de explora&#231;&#227;o funcional respirat&#243;ria do Hospital CUF Descobertas entre Setembro de 2006 e Agosto de 2011&#46; Foi efetuada pletismografia corporal sem oclus&#227;o para avalia&#231;&#227;o da resist&#234;ncia espec&#237;fica das vias a&#233;reas &#40;sRaw&#41; e espirometria animada&#44; com equipamento Jaeger4&#46;65 &#40;VIASYS Healthcare&#41; antes e ap&#243;s 400&#160;ug de salbutamol inalado em c&#226;mara expansora&#46; Foram cumpridos os crit&#233;rios internacionais &#40;ATS&#47;ERS&#41; para aceitabilidade e reprodutibilidade&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">De 1&#160;239 provas funcionais respirat&#243;rias realizadas&#44; 1&#160;092 &#40;88&#37;&#41; tinham uma espirometria com crit&#233;rios de aceitabilidade e reprodutibilidade &#40;crian&#231;as com idade m&#233;dia de 4&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;91 anos&#59; 60&#44;7&#37; do sexo masculino&#41;&#44; e 979 &#40;79&#37;&#41; sucesso na determina&#231;&#227;o de sRaw&#46; Foi poss&#237;vel reportar FEV<span class="elsevierStyleInf">1</span> em 801 &#40;65&#37;&#41; provas &#40;crian&#231;as com idade m&#233;dia 4&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;89 anos&#41;&#46; Em 23 &#40;2&#37;&#41; das provas apenas foi poss&#237;vel reportar FEV<span class="elsevierStyleInf">0&#44;5</span> &#40;crian&#231;as com idade m&#233;dia de 3&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;67 anos&#41; e em 268 &#40;22&#37;&#41; apenas FEV<span class="elsevierStyleInf">0&#44;75</span> &#40;crian&#231;as com idade m&#233;dia de 4&#44;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;89 anos&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclus&#227;o</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">A espirometria e a avalia&#231;&#227;o de resist&#234;ncias em idade pr&#233;-escolar s&#227;o exequ&#237;veis na pr&#225;tica cl&#237;nica di&#225;ria&#44; com um aumento do sucesso em crian&#231;as mais velhas&#46; O registo de manobras com dura&#231;&#227;o de 0&#44;5 ou 0&#44;75 s permite a avalia&#231;&#227;o funcional respirat&#243;ria de um maior n&#250;mero de crian&#231;as&#46;</p>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara">Please cite this article as&#58; Santos&#44; N&#59; Exequibilidade do estudo funcional respirat&#243;rio em idade pr&#233;-escolar na pr&#225;tica cl&#237;nica&#46; Rev Port Pneumol 2012&#46; <span class="elsevierStyleInterRef" href="doi:10.1016/j.rppneu.2012.09.004">http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1016&#47;j&#46;rppneu&#46;2012&#46;09&#46;004</span></p>"
      ]
    ]
    "multimedia" => array:2 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
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        "figura" => array:1 [
          0 => array:4 [
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        "descripcion" => array:1 [
          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Cumulative percent of successful spirometry according to reported FEV<span class="elsevierStyleInf">t</span>&#46;</p>"
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        "tabla" => array:2 [
          "leyenda" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">sRaw&#58; Specific airway resistance&#59; FEV<span class="elsevierStyleInf">t</span>&#58; Forced expiratory volume in time t&#46;</p>"
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">4 yearsN<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>411n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">6 yearsN<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>103n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">309 &#40;84&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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    "bibliografia" => array:2 [
      "titulo" => "References"
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Pulmonology

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