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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Indications for lung transplantation are clearly defined and surgical technique has been standardized&#46; Risk and incidence of postoperative surgical complications are&#44; however&#44; high and result in a significantly increased mortality&#46; For most serious complications&#44; such as bleeding&#44; vascular stenoses&#44; and bowel perforations&#44; a high level of suspicion and early measures are key steps to reduce mortality <a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Airways complications</span><p id="par0010" class="elsevierStylePara elsevierViewall">Incidence of airways complications is 5-15&#37; depending on the series and appears higher in patients receiving transplantation due to infectious diseases &#40;bronchiectasis and cystic fibrosis&#41;&#44; with cultures positive for aggressive microbes such as <span class="elsevierStyleItalic">Pseudomonas</span> and fungi such as <span class="elsevierStyleItalic">Aspergillus&#44; Scedosporium</span>&#44; or <span class="elsevierStyleItalic">Penicillium&#46;</span> In such patients&#44; incidence doubles&#44; risk of bronchial suture dehiscence is higher and management becomes more challenging due to mucosa membrane inflammation and persisting secretions&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Additional incriminated factors are good preservation of lung graft&#44; ischemia time&#44; occurrence of hemodynamic instability during surgery&#44; and the need of high doses of amines during postoperative period <a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The following complications are observed&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">-</span><p id="par0025" class="elsevierStylePara elsevierViewall">Bronchial suture dehiscence</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">-</span><p id="par0030" class="elsevierStylePara elsevierViewall">Bronchial suture stenosis</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">-</span><p id="par0035" class="elsevierStylePara elsevierViewall">Non-suture-related stenosis</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">-</span><p id="par0040" class="elsevierStylePara elsevierViewall">Bronchomalacia</p></li></ul></p><p id="par0045" class="elsevierStylePara elsevierViewall">Suture dehiscence is usually an early complication and results in air leakage through chest drains or in pneumothorax and subcutaneous emphysema when drains have already been removed&#46; It is due to poor healing &#40;remember bronchial vasculature is sectioned during surgery&#41;&#44; particularly when an associated infection is present&#46; Diagnosis is based on bronchoscopy&#44; although multisection CT is also very useful and provides 2D and 3D reconstructions&#46; For small dehiscences &#40;smaller than 1<span class="elsevierStyleHsp" style=""></span>cm&#41;&#44; therapy can be conservative&#44; with chest drains being left in place and aspiration bronchoscopies being performed&#44; along with appropriate antibiotic and antifungal therapy when needed&#46; Repeated bronchoscopies allow not only clear airways to be maintained but also the healing course to be monitored&#46; For major or very early fistulas after surgery&#44; surgical repair is recommended&#44; using a repeated bronchial suture and a plasty based on adjacent well-vascularized tissue&#46; When a poor condition of donor bronchial tissue is present&#44; and in patients receiving double-lung grafts&#44; right upper lobectomy followed by reanastomosis of donor&#39;s intermediate bronchus to receptor&#39;s main right bronchus is also possible&#46; In left side transplantation&#44; a longer bronchus usually allows bronchial tissue to be sectioned more proximally in a region showing a better condition <a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Bronchial suture stenoses usually have a later appearance and are due to abnormal healing&#46; Most of them occur after 2 to 3 months&#46; Most common presentation is a non-significant stenosis found during follow-up bronchoscopies or CTs&#59; occasionally stenoses are purely secondary to a size discordance between donor&#39;s bronchus and receptor&#39;s bronchus&#46; In such cases&#44; follow-up to monitor stenosis course is used&#46; In symptomatic patients having stenoses that result in a compromised bronchial lumen &#40;&#62;50&#37;&#41;&#44; therapy is based on balloon dilation and removal of any existing abnormal healing tissue&#59; intercurrent infections should be ruled out or treated&#46; When stenoses recur after 3-4 dilations&#44; an endobronchial stent implant should be used&#46; Based on our experienced we favor autoexpansible bare metallic stents &#40;Ultraflex<span class="elsevierStyleSup">&#174;</span>&#41;&#44; which are implanted under general anesthesia and laryngeal mask&#44; using flexible bronchoscopy and under fluoroscopic monitoring <a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Multisection CT with 2D and 3D reconstructions is very useful to diagnose such bronchial complications&#46; Furthermore&#44; it allows measurements to be obtained for stent implant and a later follow-up not requiring bronchoscopies which are more invasive and bothersome for patients&#46; Sixty-four sections are used&#44; with a fast image acquisition and radiation dose modulation&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Non-suture-related stenosis mainly refers to intermediate right bronchus stenoses and lobar bronchial stenoses distal to bronchial suture&#46; Intermediate bronchus stenoses are caused by difficult revascularization in the area due to a thicker bronchial tissue&#44; and are also treated with dilations and stent implants&#46; Distal lobar stenoses are usually secondary to bronchial inflammation or infection&#44; associated to mucosa membrane thickening&#59; thus&#44; besides medical treatment&#44; dilations and bronchoscopic follow-up are also used&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Bronchomalacia in transplanted lung is not uncommon&#44; and results in a dynamic stenosis and cough&#59; diagnosis is achieved bronchoscopically&#46; Symptomatic patients showing an impact on spirometric measurements can be treated with repeated dilations and&#47;or several bronchial stents&#46; Some patients show a progressive and eventually lethal course <a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#44; <a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Vascular complications</span><p id="par0075" class="elsevierStylePara elsevierViewall">Vascular complications are less common&#44; and are found in 1-3&#37; of lung transplants&#46; However&#44; mortality associated to such complications is high&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Venous suture complications include pulmonary vein stenosis and thrombosis&#46; Lower veins&#44; and particular left lower vein&#44; are more commonly involved&#44; due to their anatomical disposition&#46; A higher incidence in women with pulmonary fibrosis has been reported in literature&#59; this is probably related to a smaller chest cage size&#46; Appropriate auricular cuff size in donor&#39;s lung allowing a wide and less thrombogenic suture to be performed&#44; is very important&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Pulmonary vein obstruction is usually an early complication&#44; occurring during the first few hours after transplantation&#44; and causes severe symptoms&#46; Marked hypoxia&#44; pulmonary edema&#44; and pulmonary infiltrates are observed&#46; If the lower lobe is more severely affected&#44; a high suspicion for such a complication is warranted&#44; and an early additional diagnostic test should be ordered&#46; The initial test should be a transthoracic or transesophageal echocardiogram&#44; in spite of this test being only useful for diagnosis when performed by an experienced operator&#44; due to a challenging visualization and interpretation after recent surgery <a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a>&#46; Alternatively&#44; chest CT angiography can be used&#44; which also allows artery suture and distal vascularization to be assessed and reconstructions to be produced&#46; CT angiography establishes the diagnosis in most cases&#46; Anticoagulation using heparin and clinical course monitoring is used to manage partial thromboses and stenoses&#46; In the event of a complete vein obstruction or a poor course&#44; in patients with a very recent surgery&#44; re-transplantation or lobectomy for double-lung transplantations&#44; may be needed&#46; If the patient is in a stable condition&#44; several days have elapsed&#44; and anatomic characteristics are favorable&#44; an angioplasty with dilation and stent implant can be considered&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Arterial suture complications are usually less common and are found later&#46; They result in persistent hypoxia and pulmonary hypertension&#46; Diagnosis is based on CT angiography and&#47;or arteriography&#46; Some degree of arterial suture stenosis with no clinical significance is commonly found in CT angiography&#44; due to donor-receptor size discordance or to the suture itself&#46; Significant stenoses are due to kinking or thrombosis at the suture level&#46; The former are usually treated win angioplasty and dilation&#44; whereas usual therapy for the latter is stent implant if required&#46; Anticoagulation is used for thrombotic cases <a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a>&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Both re-transplantation and intervention techniques on vascular sutures after lung transplantation result in a high mortality rate&#44; even in expert hands&#46; Prognosis depends on early diagnosis and selection of the most appropriate therapy&#44; depending on the complication&#44; time elapsed after transplantation&#44; and clinical condition <a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a>&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#44; <a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a></p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Pleural complications</span><p id="par0105" class="elsevierStylePara elsevierViewall">Hemothorax is the most common complication after lung transplant and the one more commonly requiring additional surgical procedures&#46; Hemothoraces may appear either early&#44; a few days after the transplant procedure&#44; or some weeks later&#46; They are rarely due to bleeding from vascular sutures&#59; the main cause is bleeding from divided pleural adhesions&#46; Factors associated to such complications include firm pleuropulmonary adhesions with&#47;without pachypleuritis &#40;patients with bronchiectasis&#44; silicosis&#44; tuberculosis sequelae&#41;&#44; previous surgery &#40;particularly talc pleurodesis&#41;&#44; use of bypass circulation during transplant procedure&#44; and patients requiring pretransplant anticoagulant or antiplatelet therapy&#46; Therapy includes early re-operation for a surgical review of hemostasis and correction of coagulation abnormalities&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Prolonged air leakage through chest drains is uncommon because transplant surgery is quite careful and aerostatic&#46; It can be due to lung damage during removal&#44; particularly when pleural adhesions are present in donor lung or an inadvertent damage is caused by graft handling during implantation or closure&#46; Bronchial suture dehiscence must be ruled out by means of a bronchoscopy&#46; Therapy is usually conservative&#44; with chest drains being kept in place&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Pneumothorax is uncommon&#46; It can occur after chest drains removal when a size discordance exist between donor&#39;s graft and receptor with the lung not being large enough to fill the pleural cavity&#59; this may occur in patients with emphysema and a significant pretransplant lung hyperinflation&#46; Pneumothorax can also occur in non-transplanted native lung in patients receiving single-lung transplantation&#44; both in emphysema and pulmonary fibrosis&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">In patients receiving single-lung transplantation to treat emphysema&#44; hyperinflation in native lung with mediastinal compression&#44; or even in transplanted lung&#44; may occur&#46; To prevent such events&#44; early extubation is recommended for such patients&#46; We attempt extubation in the operation room after surgery&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Chylothorax is uncommon&#46; It is usually due to thoracic duct injuries&#44; particularly at a subcarinal level&#44; when lymphadenopaties have been removed in the region&#46; An appropriate diet with chest drains being kept in place is usually enough to achieve chylothorax resolution&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Surgical wound complications</span><p id="par0130" class="elsevierStylePara elsevierViewall">Wound complications are uncommon&#46; In patients receiving single-lung transplantation&#44; a partial thoracotomy dehiscence may occur&#44; particularly in obese patients and in patients receiving high-dose steroids before transplantation &#40;pulmonary fibrosis&#41;&#46; Therapy includes compression for small dehiscences and an early re-operation for larger ones and for dehiscences with an impact on cough and respiratory mechanics&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">In patients receiving double-lung transplants&#44; a dehiscence of transverse sternotomy may occur&#44; particularly in patients with emphysema and a significantly distended thorax&#46; A careful sternum closure using 2 wire double stitches can prevent such complications&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Surgical wound hematoma is usually due to bleeding from small muscle vessels having been sectioned&#44; and is more common in patients receiving antiplatelet or anticoagulant therapy before transplant&#46; Therapy includes pressure dressing&#59; only significantly sized hematomas require drainage to prevent later complications&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Surgical wound sepsis is uncommon&#44; in spite of such patients being immunodepressed&#46; Surgical debridement is only required when deep layers are involved&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#fig0025">Fig&#46; 5</a></p><elsevierMultimedia ident="fig0025"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Nerve injuries</span><p id="par0155" class="elsevierStylePara elsevierViewall">Phrenic&#44; recurrent&#44; and vagus nerves can be injured during transplantation procedure&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">Phrenic nerve injury is the most serious and the one having the largest impact on cough capacity and respiratory mechanics&#46; It can challenge and delay extubation&#46; High-risk patients include those having firm pleuropulmonary adhesions to mediastinum &#40;bronchiectasis&#44; silicosis&#41;&#46; It can also occur in patients receiving double-lung transplant&#44; due to mediastinal tissue pulling with most cases being eventually reversible&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">Recurrent nerve injuries usually occur in left side when lymphadenopaties in aortopulmonary window have to be removed to allow lung artery suture &#40;silicosis&#44; sarcoidosis&#41;&#46; It causes vocal cords paralysis with dysphonia and risk for bronchial aspiration due to inadequate glottis closure&#46; Nevertheless&#44; this is usually compensated within a few weeks&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">Vagus nerve injuries can occur when firm pleuropulmonary adhesions or pachypleuritis are present in posterior mediastinum and thorax&#44; which is typical in patients having bronchiectasis and repeated pneumonia episodes before transplantation&#46; Vagus nerve damage impairs gastric and intestinal motility&#44; particularly when a bilateral injury is present&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Abdominal complications</span><p id="par0175" class="elsevierStylePara elsevierViewall">Abdominal complications are common and are the leading cause for extra-thoracic surgical complications&#46; In some series&#44; postoperative emergency abdominal surgery incidence after lung transplantation is as high as 8-10&#37;&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">Paralytic ileus is very common &#40;30-50&#37;&#41; and may show a varying severity&#46; This is due to prolonged operative time&#44; use of postoperative epidural analgesia&#44; immunosupressive drugs&#44; and water-electrolyte balance impairment&#46; Abdominal distension and tympany result in raised diaphragm with respiratory mechanics and cough efficacy being impaired&#46; Therapy includes NPO diet to maintain gastrointestinal rest&#44; adjusting medication and hydration whenever possible&#44; until bowel peristalsis recovers&#46; Most patients show a good clinical course in a few days&#46;</p><p id="par0185" class="elsevierStylePara elsevierViewall">Gastroparesia is usually related to drug therapy and can be worsened by vagus nerve injuries resulting from surgery&#46; Occasionally&#44; gastroparesia can be persistent&#44; with recurrent vomiting due to retained undigested food in stomach&#44; which shows a poor response to medical treatment&#46;</p><p id="par0190" class="elsevierStylePara elsevierViewall">Acute cholecystitis is common&#44; usually appearing lately in postoperative course&#46; Cholelithiasis is a common finding in candidates to lung transplantation&#46; Clinical course can be insidious because patients may be receiving intravenous analgesia or due to a misdiagnosis resulting from other abdominal clinical pictures&#46; Delayed diagnosis is common and a risk for biliary peritonitis and septicemia exists&#46; A diagnosis suspicion should lead to emergency abdominal ultrasonography or CT&#44; and a prompt cholecistectomy&#46;</p><p id="par0195" class="elsevierStylePara elsevierViewall">Nonetheless&#44; bowel perforations are undoubtedly the abdominal complications resulting in highest mortality rates and most commonly requiring postoperative emergency abdominal surgery after lung transplantation&#46; They are more common in right-side colon&#44; particularly in cecum&#44; due to wall ischemia and local perforation resulting from overdistended colon&#46; Fecal peritonitis occurs&#44; resulting in acute abdomen&#44; hemodynamic instability and fast progression to septic shock&#46; An emergency operation is required for perforated region removal and abdominal cavity washing&#46; External ostomies should be used for both bowel ends&#46; Mortality rates due to such complication amount to 50&#37;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a>&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Conclusions</span><p id="par0200" class="elsevierStylePara elsevierViewall">In spite of an appropriate selection of lung transplantation receptors and a careful surgical technique&#44; multiple postoperative complications occur&#44; some of them being serious and resulting in a high mortality rate&#46;</p><p id="par0205" class="elsevierStylePara elsevierViewall">Immunosuppressive therapy development&#44; use of correct antibiotic therapy protocols&#44; and improved care and support to transplanted patients in Postoperative Recovery Units have contributed to an improved clinical course and survival in patients with complications <a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a>&#46;</p><p id="par0210" class="elsevierStylePara elsevierViewall">A multidisciplinary management and health workers experience are essential for a coordinated and early therapy in such patients&#46;</p><p id="par0215" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Note&#58;</span> This is a review and opinion article based on the 15-year experience of the Lung Transplant Program at University Hospital of A Coru&#241;a&#44; covering 450 lung transplantation procedures with an average number of 40 per year in the last 5 years&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conflicts of interest</span><p id="par0220" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">This is a review article on the main postoperative complications after lung transplantation&#58; airways complications&#44; vascular complications&#44; pleural complications&#44; surgical wound complications&#44; and abdominal complications&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Incidence data&#44; severity&#44; and major management regimens are reported&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Postoperative complications after lung transplantation result in a significantly increased morbidity and mortality&#44; with early diagnosis and therapy being extremely important&#46;</p></span>"
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Review
Postoperative surgical complications after lung transplantation
M. de la Torre
Corresponding author
mtorre@canalejo.org

Corresponding author.
, R. Fernández, E. Fieira, D. González, M. Delgado, L. Méndez, J.M. Borro
Department of Thoracic Surgery and Lung Transplantation, University Hospital of A Coruña, A Coruña, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Indications for lung transplantation are clearly defined and surgical technique has been standardized&#46; Risk and incidence of postoperative surgical complications are&#44; however&#44; high and result in a significantly increased mortality&#46; For most serious complications&#44; such as bleeding&#44; vascular stenoses&#44; and bowel perforations&#44; a high level of suspicion and early measures are key steps to reduce mortality <a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Airways complications</span><p id="par0010" class="elsevierStylePara elsevierViewall">Incidence of airways complications is 5-15&#37; depending on the series and appears higher in patients receiving transplantation due to infectious diseases &#40;bronchiectasis and cystic fibrosis&#41;&#44; with cultures positive for aggressive microbes such as <span class="elsevierStyleItalic">Pseudomonas</span> and fungi such as <span class="elsevierStyleItalic">Aspergillus&#44; Scedosporium</span>&#44; or <span class="elsevierStyleItalic">Penicillium&#46;</span> In such patients&#44; incidence doubles&#44; risk of bronchial suture dehiscence is higher and management becomes more challenging due to mucosa membrane inflammation and persisting secretions&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Additional incriminated factors are good preservation of lung graft&#44; ischemia time&#44; occurrence of hemodynamic instability during surgery&#44; and the need of high doses of amines during postoperative period <a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The following complications are observed&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">-</span><p id="par0025" class="elsevierStylePara elsevierViewall">Bronchial suture dehiscence</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">-</span><p id="par0030" class="elsevierStylePara elsevierViewall">Bronchial suture stenosis</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">-</span><p id="par0035" class="elsevierStylePara elsevierViewall">Non-suture-related stenosis</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">-</span><p id="par0040" class="elsevierStylePara elsevierViewall">Bronchomalacia</p></li></ul></p><p id="par0045" class="elsevierStylePara elsevierViewall">Suture dehiscence is usually an early complication and results in air leakage through chest drains or in pneumothorax and subcutaneous emphysema when drains have already been removed&#46; It is due to poor healing &#40;remember bronchial vasculature is sectioned during surgery&#41;&#44; particularly when an associated infection is present&#46; Diagnosis is based on bronchoscopy&#44; although multisection CT is also very useful and provides 2D and 3D reconstructions&#46; For small dehiscences &#40;smaller than 1<span class="elsevierStyleHsp" style=""></span>cm&#41;&#44; therapy can be conservative&#44; with chest drains being left in place and aspiration bronchoscopies being performed&#44; along with appropriate antibiotic and antifungal therapy when needed&#46; Repeated bronchoscopies allow not only clear airways to be maintained but also the healing course to be monitored&#46; For major or very early fistulas after surgery&#44; surgical repair is recommended&#44; using a repeated bronchial suture and a plasty based on adjacent well-vascularized tissue&#46; When a poor condition of donor bronchial tissue is present&#44; and in patients receiving double-lung grafts&#44; right upper lobectomy followed by reanastomosis of donor&#39;s intermediate bronchus to receptor&#39;s main right bronchus is also possible&#46; In left side transplantation&#44; a longer bronchus usually allows bronchial tissue to be sectioned more proximally in a region showing a better condition <a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Bronchial suture stenoses usually have a later appearance and are due to abnormal healing&#46; Most of them occur after 2 to 3 months&#46; Most common presentation is a non-significant stenosis found during follow-up bronchoscopies or CTs&#59; occasionally stenoses are purely secondary to a size discordance between donor&#39;s bronchus and receptor&#39;s bronchus&#46; In such cases&#44; follow-up to monitor stenosis course is used&#46; In symptomatic patients having stenoses that result in a compromised bronchial lumen &#40;&#62;50&#37;&#41;&#44; therapy is based on balloon dilation and removal of any existing abnormal healing tissue&#59; intercurrent infections should be ruled out or treated&#46; When stenoses recur after 3-4 dilations&#44; an endobronchial stent implant should be used&#46; Based on our experienced we favor autoexpansible bare metallic stents &#40;Ultraflex<span class="elsevierStyleSup">&#174;</span>&#41;&#44; which are implanted under general anesthesia and laryngeal mask&#44; using flexible bronchoscopy and under fluoroscopic monitoring <a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Multisection CT with 2D and 3D reconstructions is very useful to diagnose such bronchial complications&#46; Furthermore&#44; it allows measurements to be obtained for stent implant and a later follow-up not requiring bronchoscopies which are more invasive and bothersome for patients&#46; Sixty-four sections are used&#44; with a fast image acquisition and radiation dose modulation&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Non-suture-related stenosis mainly refers to intermediate right bronchus stenoses and lobar bronchial stenoses distal to bronchial suture&#46; Intermediate bronchus stenoses are caused by difficult revascularization in the area due to a thicker bronchial tissue&#44; and are also treated with dilations and stent implants&#46; Distal lobar stenoses are usually secondary to bronchial inflammation or infection&#44; associated to mucosa membrane thickening&#59; thus&#44; besides medical treatment&#44; dilations and bronchoscopic follow-up are also used&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Bronchomalacia in transplanted lung is not uncommon&#44; and results in a dynamic stenosis and cough&#59; diagnosis is achieved bronchoscopically&#46; Symptomatic patients showing an impact on spirometric measurements can be treated with repeated dilations and&#47;or several bronchial stents&#46; Some patients show a progressive and eventually lethal course <a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#44; <a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Vascular complications</span><p id="par0075" class="elsevierStylePara elsevierViewall">Vascular complications are less common&#44; and are found in 1-3&#37; of lung transplants&#46; However&#44; mortality associated to such complications is high&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Venous suture complications include pulmonary vein stenosis and thrombosis&#46; Lower veins&#44; and particular left lower vein&#44; are more commonly involved&#44; due to their anatomical disposition&#46; A higher incidence in women with pulmonary fibrosis has been reported in literature&#59; this is probably related to a smaller chest cage size&#46; Appropriate auricular cuff size in donor&#39;s lung allowing a wide and less thrombogenic suture to be performed&#44; is very important&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Pulmonary vein obstruction is usually an early complication&#44; occurring during the first few hours after transplantation&#44; and causes severe symptoms&#46; Marked hypoxia&#44; pulmonary edema&#44; and pulmonary infiltrates are observed&#46; If the lower lobe is more severely affected&#44; a high suspicion for such a complication is warranted&#44; and an early additional diagnostic test should be ordered&#46; The initial test should be a transthoracic or transesophageal echocardiogram&#44; in spite of this test being only useful for diagnosis when performed by an experienced operator&#44; due to a challenging visualization and interpretation after recent surgery <a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a>&#46; Alternatively&#44; chest CT angiography can be used&#44; which also allows artery suture and distal vascularization to be assessed and reconstructions to be produced&#46; CT angiography establishes the diagnosis in most cases&#46; Anticoagulation using heparin and clinical course monitoring is used to manage partial thromboses and stenoses&#46; In the event of a complete vein obstruction or a poor course&#44; in patients with a very recent surgery&#44; re-transplantation or lobectomy for double-lung transplantations&#44; may be needed&#46; If the patient is in a stable condition&#44; several days have elapsed&#44; and anatomic characteristics are favorable&#44; an angioplasty with dilation and stent implant can be considered&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Arterial suture complications are usually less common and are found later&#46; They result in persistent hypoxia and pulmonary hypertension&#46; Diagnosis is based on CT angiography and&#47;or arteriography&#46; Some degree of arterial suture stenosis with no clinical significance is commonly found in CT angiography&#44; due to donor-receptor size discordance or to the suture itself&#46; Significant stenoses are due to kinking or thrombosis at the suture level&#46; The former are usually treated win angioplasty and dilation&#44; whereas usual therapy for the latter is stent implant if required&#46; Anticoagulation is used for thrombotic cases <a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a>&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Both re-transplantation and intervention techniques on vascular sutures after lung transplantation result in a high mortality rate&#44; even in expert hands&#46; Prognosis depends on early diagnosis and selection of the most appropriate therapy&#44; depending on the complication&#44; time elapsed after transplantation&#44; and clinical condition <a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a>&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#44; <a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a></p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Pleural complications</span><p id="par0105" class="elsevierStylePara elsevierViewall">Hemothorax is the most common complication after lung transplant and the one more commonly requiring additional surgical procedures&#46; Hemothoraces may appear either early&#44; a few days after the transplant procedure&#44; or some weeks later&#46; They are rarely due to bleeding from vascular sutures&#59; the main cause is bleeding from divided pleural adhesions&#46; Factors associated to such complications include firm pleuropulmonary adhesions with&#47;without pachypleuritis &#40;patients with bronchiectasis&#44; silicosis&#44; tuberculosis sequelae&#41;&#44; previous surgery &#40;particularly talc pleurodesis&#41;&#44; use of bypass circulation during transplant procedure&#44; and patients requiring pretransplant anticoagulant or antiplatelet therapy&#46; Therapy includes early re-operation for a surgical review of hemostasis and correction of coagulation abnormalities&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Prolonged air leakage through chest drains is uncommon because transplant surgery is quite careful and aerostatic&#46; It can be due to lung damage during removal&#44; particularly when pleural adhesions are present in donor lung or an inadvertent damage is caused by graft handling during implantation or closure&#46; Bronchial suture dehiscence must be ruled out by means of a bronchoscopy&#46; Therapy is usually conservative&#44; with chest drains being kept in place&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Pneumothorax is uncommon&#46; It can occur after chest drains removal when a size discordance exist between donor&#39;s graft and receptor with the lung not being large enough to fill the pleural cavity&#59; this may occur in patients with emphysema and a significant pretransplant lung hyperinflation&#46; Pneumothorax can also occur in non-transplanted native lung in patients receiving single-lung transplantation&#44; both in emphysema and pulmonary fibrosis&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">In patients receiving single-lung transplantation to treat emphysema&#44; hyperinflation in native lung with mediastinal compression&#44; or even in transplanted lung&#44; may occur&#46; To prevent such events&#44; early extubation is recommended for such patients&#46; We attempt extubation in the operation room after surgery&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Chylothorax is uncommon&#46; It is usually due to thoracic duct injuries&#44; particularly at a subcarinal level&#44; when lymphadenopaties have been removed in the region&#46; An appropriate diet with chest drains being kept in place is usually enough to achieve chylothorax resolution&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Surgical wound complications</span><p id="par0130" class="elsevierStylePara elsevierViewall">Wound complications are uncommon&#46; In patients receiving single-lung transplantation&#44; a partial thoracotomy dehiscence may occur&#44; particularly in obese patients and in patients receiving high-dose steroids before transplantation &#40;pulmonary fibrosis&#41;&#46; Therapy includes compression for small dehiscences and an early re-operation for larger ones and for dehiscences with an impact on cough and respiratory mechanics&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">In patients receiving double-lung transplants&#44; a dehiscence of transverse sternotomy may occur&#44; particularly in patients with emphysema and a significantly distended thorax&#46; A careful sternum closure using 2 wire double stitches can prevent such complications&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Surgical wound hematoma is usually due to bleeding from small muscle vessels having been sectioned&#44; and is more common in patients receiving antiplatelet or anticoagulant therapy before transplant&#46; Therapy includes pressure dressing&#59; only significantly sized hematomas require drainage to prevent later complications&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Surgical wound sepsis is uncommon&#44; in spite of such patients being immunodepressed&#46; Surgical debridement is only required when deep layers are involved&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#fig0025">Fig&#46; 5</a></p><elsevierMultimedia ident="fig0025"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Nerve injuries</span><p id="par0155" class="elsevierStylePara elsevierViewall">Phrenic&#44; recurrent&#44; and vagus nerves can be injured during transplantation procedure&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">Phrenic nerve injury is the most serious and the one having the largest impact on cough capacity and respiratory mechanics&#46; It can challenge and delay extubation&#46; High-risk patients include those having firm pleuropulmonary adhesions to mediastinum &#40;bronchiectasis&#44; silicosis&#41;&#46; It can also occur in patients receiving double-lung transplant&#44; due to mediastinal tissue pulling with most cases being eventually reversible&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">Recurrent nerve injuries usually occur in left side when lymphadenopaties in aortopulmonary window have to be removed to allow lung artery suture &#40;silicosis&#44; sarcoidosis&#41;&#46; It causes vocal cords paralysis with dysphonia and risk for bronchial aspiration due to inadequate glottis closure&#46; Nevertheless&#44; this is usually compensated within a few weeks&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">Vagus nerve injuries can occur when firm pleuropulmonary adhesions or pachypleuritis are present in posterior mediastinum and thorax&#44; which is typical in patients having bronchiectasis and repeated pneumonia episodes before transplantation&#46; Vagus nerve damage impairs gastric and intestinal motility&#44; particularly when a bilateral injury is present&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Abdominal complications</span><p id="par0175" class="elsevierStylePara elsevierViewall">Abdominal complications are common and are the leading cause for extra-thoracic surgical complications&#46; In some series&#44; postoperative emergency abdominal surgery incidence after lung transplantation is as high as 8-10&#37;&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">Paralytic ileus is very common &#40;30-50&#37;&#41; and may show a varying severity&#46; This is due to prolonged operative time&#44; use of postoperative epidural analgesia&#44; immunosupressive drugs&#44; and water-electrolyte balance impairment&#46; Abdominal distension and tympany result in raised diaphragm with respiratory mechanics and cough efficacy being impaired&#46; Therapy includes NPO diet to maintain gastrointestinal rest&#44; adjusting medication and hydration whenever possible&#44; until bowel peristalsis recovers&#46; Most patients show a good clinical course in a few days&#46;</p><p id="par0185" class="elsevierStylePara elsevierViewall">Gastroparesia is usually related to drug therapy and can be worsened by vagus nerve injuries resulting from surgery&#46; Occasionally&#44; gastroparesia can be persistent&#44; with recurrent vomiting due to retained undigested food in stomach&#44; which shows a poor response to medical treatment&#46;</p><p id="par0190" class="elsevierStylePara elsevierViewall">Acute cholecystitis is common&#44; usually appearing lately in postoperative course&#46; Cholelithiasis is a common finding in candidates to lung transplantation&#46; Clinical course can be insidious because patients may be receiving intravenous analgesia or due to a misdiagnosis resulting from other abdominal clinical pictures&#46; Delayed diagnosis is common and a risk for biliary peritonitis and septicemia exists&#46; A diagnosis suspicion should lead to emergency abdominal ultrasonography or CT&#44; and a prompt cholecistectomy&#46;</p><p id="par0195" class="elsevierStylePara elsevierViewall">Nonetheless&#44; bowel perforations are undoubtedly the abdominal complications resulting in highest mortality rates and most commonly requiring postoperative emergency abdominal surgery after lung transplantation&#46; They are more common in right-side colon&#44; particularly in cecum&#44; due to wall ischemia and local perforation resulting from overdistended colon&#46; Fecal peritonitis occurs&#44; resulting in acute abdomen&#44; hemodynamic instability and fast progression to septic shock&#46; An emergency operation is required for perforated region removal and abdominal cavity washing&#46; External ostomies should be used for both bowel ends&#46; Mortality rates due to such complication amount to 50&#37;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a>&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Conclusions</span><p id="par0200" class="elsevierStylePara elsevierViewall">In spite of an appropriate selection of lung transplantation receptors and a careful surgical technique&#44; multiple postoperative complications occur&#44; some of them being serious and resulting in a high mortality rate&#46;</p><p id="par0205" class="elsevierStylePara elsevierViewall">Immunosuppressive therapy development&#44; use of correct antibiotic therapy protocols&#44; and improved care and support to transplanted patients in Postoperative Recovery Units have contributed to an improved clinical course and survival in patients with complications <a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a>&#46;</p><p id="par0210" class="elsevierStylePara elsevierViewall">A multidisciplinary management and health workers experience are essential for a coordinated and early therapy in such patients&#46;</p><p id="par0215" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Note&#58;</span> This is a review and opinion article based on the 15-year experience of the Lung Transplant Program at University Hospital of A Coru&#241;a&#44; covering 450 lung transplantation procedures with an average number of 40 per year in the last 5 years&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conflicts of interest</span><p id="par0220" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">This is a review article on the main postoperative complications after lung transplantation&#58; airways complications&#44; vascular complications&#44; pleural complications&#44; surgical wound complications&#44; and abdominal complications&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Incidence data&#44; severity&#44; and major management regimens are reported&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Postoperative complications after lung transplantation result in a significantly increased morbidity and mortality&#44; with early diagnosis and therapy being extremely important&#46;</p></span>"
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ISSN: 21735115
Original language: English
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