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array:23 [ "pii" => "S2173511515001207" "issn" => "21735115" "doi" => "10.1016/j.rppnen.2015.06.004" "estado" => "S300" "fechaPublicacion" => "2015-11-01" "aid" => "1070" "copyright" => "Sociedade Portuguesa de Pneumologia" "copyrightAnyo" => "2015" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "cor" "cita" => "Rev Port Pneumol. 2015;21:350-1" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1610 "formatos" => array:3 [ "EPUB" => 196 "HTML" => 911 "PDF" => 503 ] ] "itemAnterior" => array:19 [ "pii" => "S217351151500130X" "issn" => "21735115" "doi" => "10.1016/j.rppnen.2015.06.009" "estado" => "S300" "fechaPublicacion" => "2015-11-01" "aid" => "1075" "copyright" => "Sociedade Portuguesa de Pneumologia" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "cor" "cita" => "Rev Port Pneumol. 2015;21:348-9" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1558 "formatos" => array:3 [ "EPUB" => 220 "HTML" => 779 "PDF" => 559 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Management of pediatric primary spontaneous pneumothorax in a tertiary hospital" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "348" "paginaFinal" => "349" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2063 "Ancho" => 3087 "Tamanyo" => 223171 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Therapeutic algorithm in the first and recurrent episodes of primary spontaneous pneumothorax.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "R. Lamas-Pinheiro, J. Branco-Salvador, J. Jardim, C. Ferraz, T. Nunes, L.G. Vaz, I. Azevedo, T. Henriques-Coelho" "autores" => array:8 [ 0 => array:2 [ "nombre" => "R." "apellidos" => "Lamas-Pinheiro" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Branco-Salvador" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Jardim" ] 3 => array:2 [ "nombre" => "C." "apellidos" => "Ferraz" ] 4 => array:2 [ "nombre" => "T." "apellidos" => "Nunes" ] 5 => array:2 [ "nombre" => "L.G." "apellidos" => "Vaz" ] 6 => array:2 [ "nombre" => "I." "apellidos" => "Azevedo" ] 7 => array:2 [ "nombre" => "T." "apellidos" => "Henriques-Coelho" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S217351151500130X?idApp=UINPBA00004E" "url" => "/21735115/0000002100000006/v4_201605090016/S217351151500130X/v4_201605090016/en/main.assets" ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Unusual cause of haemoptysis: Inflammatory myofibroblastic tumour of the lung" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "350" "paginaFinal" => "351" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "A. Araújo, W. Xiaogang, D. Tente, M. Figueiredo" "autores" => array:4 [ 0 => array:4 [ "nombre" => "A." "apellidos" => "Araújo" "email" => array:1 [ 0 => "duartearaujodr@sapo.pt" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "W." "apellidos" => "Xiaogang" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "D." "apellidos" => "Tente" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "M." "apellidos" => "Figueiredo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Respiratory Department, CHAA, Guimarães, Portugal" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Anatomy Department, CHVNG/E, Gaia, Portugal" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1296 "Ancho" => 1650 "Tamanyo" => 322555 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Ovoid mass in the first CT of the chest.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Inflammatory myofibroblastic tumour of the lung, or pulmonary inflammatory pseudo tumour, includes a spectrum of pulmonary lesions<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">1</span></a> of unknown aetiology.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">2</span></a> It is an unusual tumour, or tumour-like mass, and accounts for less than 1% of all tumours of the lung, with no significant racial or geographical differences. It should be considered as a possible diagnosis in a patient usually younger than 40 years, male or female, presenting a pulmonary peripheral mass or nodule in the chest X-ray or CT scan. Although controversial, it is usually defined as a nonneoplastic process characterized by a proliferation of spindle cells, associated with a variably dense polymorphic infiltrate of mononuclear inflammatory cells. Because they mimic malignant tumours, both clinically and radiologically, they are also called quasineoplastic lesions.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">3</span></a> In the majority of cases growth of the lesions is slow, and the diagnosis is difficult before surgery.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">4</span></a> Although the aetiology is not well defined, a background history of respiratory infections is sometimes present, and because of that some authors suggest a reactive inflammatory origin. The behaviour of this lesion is variable and usually benign,<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">5</span></a> but occasionally it may have a malignant course, with recurrence or metastasis in a minority of cases. The diagnosis is usually established after complete surgical resection, the treatment of choice, and curative in most cases. Recurrence is seen occasionally, if the resection is not complete, or the lesions are multiple. The great majority of inflammatory myofibroblastic tumours are pulmonary, but lesions have also been reported in other organs,<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">6</span></a> such as digestive tract, larynx, heart or central nervous system.</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 24-year-old man, a non-smoker, presented at the emergency department with complaints of cough, haemoptysis, dyspnoea on exertion, fever (38<span class="elsevierStyleHsp" style=""></span>°C) and excessive sweating at night, with two days of evolution. He had no relevant pathologic background, and physical examination was normal. On the chest X-ray we found a right infrahilar shadow, the bronchoscopy was normal as were the respiratory function and the blood tests. The first computed tomography (CT) of the chest showed a 44<span class="elsevierStyleHsp" style=""></span>mm heterogeneous (well-circumscribed and probably cavitated) ovoid mass (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>), located in the inner right upper lobe, near the middle lobe. The differential diagnosis was lung abscess, round pneumonia, pulmonary tuberculosis, aspergilloma and tumour. After a 3-week course of antibiotics, a second CT, now with intravenous iodinated contrast, showed a homogenous mass of the same size and location, and the patient was transferred for surgical evaluation, and resection of the right upper and middle lobe. Histopathological examination revealed spindle cell proliferation, with storiform or fascicular pattern, with foci of haemorrhage, inflammatory infiltrate of lymphocytes, neutrophils, eosinophils and aggregates of foam cell (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). Rare Touton giant cells were also found. No significant cytological atypia was identified. The neoplastic cells were diffusely and strongly positive for immunostaining for ALK and histiocytic marker CD163, while weakly and focally positive for smooth muscle marker SMA and cytokeratin CAM5.2.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The inflammatory myofibroblastic tumour is an uncommon tumour of the lung and an uncommon cause of haemoptysis, but must be considered in a young person<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">7</span></a> with a mass or a nodular lesion, although its clinical and radiological presentation is nonspecific. Half of the patients are asymptomatic, the lesion being a radiological finding, but the usual patient complaints are cough, dyspnoea, haemoptysis, chest pain, fever and weigh loss. In this case, despite the rarity of this entity, the form of presentation is consistent with that commonly described in the literature, but the chest pain, although a relatively common symptom, was not present. In our case, as is usual, the diagnosis was chirurgical,<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">8</span></a> and the treatment was complete surgical resection.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0020" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflicts of interest" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1296 "Ancho" => 1650 "Tamanyo" => 322555 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Ovoid mass in the first CT of the chest.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1235 "Ancho" => 1650 "Tamanyo" => 703723 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Spindle cells with storiform or fascicular pattern, haemorrhage and inflammatory infiltrate, including foam cells. 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