array:24 [
  "pii" => "S2173511515001955"
  "issn" => "21735115"
  "doi" => "10.1016/j.rppnen.2015.10.013"
  "estado" => "S300"
  "fechaPublicacion" => "2016-05-01"
  "aid" => "1115"
  "copyright" => "Sociedade Portuguesa de Pneumologia"
  "copyrightAnyo" => "2015"
  "documento" => "simple-article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "cor"
  "cita" => "Rev Port Pneumol. 2016;22:177-8"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 1448
    "formatos" => array:3 [
      "EPUB" => 224
      "HTML" => 660
      "PDF" => 564
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S2173511515001918"
    "issn" => "21735115"
    "doi" => "10.1016/j.rppnen.2015.10.010"
    "estado" => "S300"
    "fechaPublicacion" => "2016-05-01"
    "aid" => "1111"
    "documento" => "simple-article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "cor"
    "cita" => "Rev Port Pneumol. 2016;22:179-80"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1484
      "formatos" => array:3 [
        "EPUB" => 192
        "HTML" => 706
        "PDF" => 586
      ]
    ]
    "en" => array:9 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Research letter</span>"
      "titulo" => "Interstitial lung disease in the intensive unit care setting"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "179"
          "paginaFinal" => "180"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "A&#46;F&#46; Gon&#231;alves, S&#46; Campainha, C&#46; Nogueira, F&#46; Costa, P&#46; Castel&#245;es, S&#46; Neves"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "A&#46;F&#46;"
              "apellidos" => "Gon&#231;alves"
            ]
            1 => array:2 [
              "nombre" => "S&#46;"
              "apellidos" => "Campainha"
            ]
            2 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Nogueira"
            ]
            3 => array:2 [
              "nombre" => "F&#46;"
              "apellidos" => "Costa"
            ]
            4 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Castel&#245;es"
            ]
            5 => array:2 [
              "nombre" => "S&#46;"
              "apellidos" => "Neves"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511515001918?idApp=UINPBA00004E"
    "url" => "/21735115/0000002200000003/v1_201605310123/S2173511515001918/v1_201605310123/en/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S2173511516000142"
    "issn" => "21735115"
    "doi" => "10.1016/j.rppnen.2016.01.004"
    "estado" => "S300"
    "fechaPublicacion" => "2016-05-01"
    "aid" => "1137"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Rev Port Pneumol. 2016;22:167-76"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1437
      "formatos" => array:3 [
        "EPUB" => 205
        "HTML" => 663
        "PDF" => 569
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Special article</span>"
      "titulo" => "COPD control&#58; Can a consensus be found&#63;"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "167"
          "paginaFinal" => "176"
        ]
      ]
      "contieneResumen" => array:1 [
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "M&#46; Guimar&#227;es, A&#46; Bugalho, A&#46;S&#46; Oliveira, J&#46; Moita, A&#46; Marques"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Guimar&#227;es"
            ]
            1 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Bugalho"
            ]
            2 => array:2 [
              "nombre" => "A&#46;S&#46;"
              "apellidos" => "Oliveira"
            ]
            3 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Moita"
            ]
            4 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Marques"
            ]
            5 => array:1 [
              "colaborador" => "on behalf of the GI DPOC-Grupo de Interesse na Doen&#231;a Pulmonar Obstrutiva Cr&#243;nica"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511516000142?idApp=UINPBA00004E"
    "url" => "/21735115/0000002200000003/v1_201605310123/S2173511516000142/v1_201605310123/en/main.assets"
  ]
  "en" => array:12 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Research Letter</span>"
    "titulo" => "Impact of sleepiness on arterial stiffness and cardio-vascular risk in men with moderate to severe obstructive sleep apnea"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "177"
        "paginaFinal" => "178"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "M&#46;A&#46; Mineiro, P&#46;M&#46; da Silva, M&#46; Alves, D&#46; Virella, M&#46;J&#46;M&#46; Gomes, J&#46; Cardoso"
        "autores" => array:6 [
          0 => array:4 [
            "nombre" => "M&#46;A&#46;"
            "apellidos" => "Mineiro"
            "email" => array:1 [
              0 => "xmineiro&#64;gmail&#46;com"
            ]
            "referencia" => array:3 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "P&#46;M&#46;"
            "apellidos" => "da Silva"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "M&#46;"
            "apellidos" => "Alves"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "D&#46;"
            "apellidos" => "Virella"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "M&#46;J&#46;M&#46;"
            "apellidos" => "Gomes"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "J&#46;"
            "apellidos" => "Cardoso"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:4 [
          0 => array:3 [
            "entidad" => "Pulmonology Department&#44; Centro Hospitalar de Lisboa Central &#40;CHLC&#41;&#44; Lisbon&#44; Portugal"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Internal Medicine Department&#44; Arterial Investigation Unit&#44; CHLC&#44; Lisbon&#44; Portugal"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Research Unit&#44; CHLC&#44; Lisbon&#44; Portugal"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "NOVA Medical School&#47;Faculdade de Ci&#234;ncias M&#233;dicas&#44; Lisbon&#44; Portugal"
            "etiqueta" => "d"
            "identificador" => "aff0020"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Obstructive sleep apnea &#40;OSA&#41;&#44; if left untreated&#44; is associated with high cardio-vascular &#40;CV&#41; morbidity and mortality&#46; Based on large-scale epidemiological studies&#44; it is known that excessive sleepiness is a cardinal symptom but the majority of individuals with high Apnea Hypopnea Index &#40;IAH&#41; do not complain of it&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Arterial stiffness&#44; evaluated by pulse wave velocity &#40;PWV&#41;&#44; has a predictive value for CV events&#44; beyond classical risk factors&#44; and can be considered as an intermediate endpoint for CV events&#46; Carotid-femoral pulse wave velocity &#40;cf-PWV&#41; remains the most commonly used non-invasive method and is considered as the gold standard&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Increased PWV is associated with various conditions&#44; of which age and blood pressure &#40;BP&#41; are the most important&#46; In OSA cf-PWV value is augmented&#44; with improvement after treatment with CPAP&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">In order to explore the association of sleepiness with CV risk in patients with OSA&#44; we conducted a prospective study of consecutive males&#44; younger than 65 years old&#44; referred for snoring or OSA related symptoms&#46; They were included if they had moderate to severe OSA &#40;AHI<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>15&#41; diagnosed by cardiorespiratory polygraphic study&#44; level 3&#44; in our institution&#39;s sleep laboratory&#44; and excluded if they had other sleep disturbances&#44; diabetes or CV disease beyond hypertension&#46; Epworth Sleepiness Scale &#40;ESS&#41; score<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>10 defined excessive sleepiness&#46; Patients with high BP in 24<span class="elsevierStyleHsp" style=""></span>h monitoring &#40;ABPM&#41; or already taking antihypertensive drugs were considered hypertensive&#46; Arterial stiffness was assessed by cf-PWV&#44; and 10<span class="elsevierStyleHsp" style=""></span>m&#47;s was used as threshold value&#46; CV risk was calculated by SCORE &#8211; European Low Risk Chart&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Univariable logistic regression and stratified Mantel&#8211;Haenszel analyses were performed to quantify associations between variables&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">From approximately 700 patients referred to the Clinic during the study&#44; 34 patients were recruited&#44; with median age 53&#46;0 years&#59; 24 &#40;70&#46;6&#37;&#41; were hypertensive &#40;15 with medication&#41;&#44; 18 &#40;52&#46;9&#37;&#41; had metabolic syndrome and 30 &#40;91&#37;&#41; had dyslipidaemia&#46; The cf-PWV was high in 27 &#40;79&#46;4&#37;&#41; and the median SCORE CV risk was 2 &#40;0&#8211;5&#41;&#44; 26 out of 33 patients had moderate CV risk&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">All patients with normal cf-PWV had moderate OSA&#44; and cf-PWV was significantly higher when OSA was severe rather than moderate OSA &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;047&#41;&#46; In fact&#44; weak evidence was found that the odds for high cf-PWV increase with either increasing AHI &#40;OR 1&#46;08&#59; 95&#37;CI 0&#46;99&#8211;1&#46;18&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;078&#41; or ODI &#40;OR 1&#46;14&#59; 95&#37;CI 0&#46;98&#8211;1&#46;32&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;086&#41;&#46; No association was found between cf-PWV and ABPM measurements&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Patients with high cf-PWV also had similar prevalence rates of arterial hypertension &#40;57&#46;1&#37; &#91;95&#37; CI 25&#46;05&#8211;84&#46;18&#93; vs&#46; 74&#46;1&#37; &#91;95&#37; CI 55&#46;32&#8211;86&#46;83&#93;&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;394&#41; but higher SCORE CV risk &#40;median &#40;maximum&#41; 1 &#40;2&#41; vs&#46; 3 &#40;5&#41;&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;029&#41;&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Excessive sleepiness was diagnosed in 10 &#40;29&#46;4&#37;&#41; patients which had significantly higher AHI&#44; ODI and higher SaO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>90&#37; but lower minimum SaO<span class="elsevierStyleInf">2</span> than non-sleepy patients &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0050" class="elsevierStylePara elsevierViewall">Sleepy and non-sleepy patients did not differ in prevalence rates of hypertension &#40;70&#46;0&#37; vs&#46; 70&#46;8&#37;&#41; or average BP values&#46; However&#44; all patients with normal average ABPM values under medication were non-sleepy&#46; Both cf-PWV and SCORE CV risk were similar regarding sleepiness &#40;median &#40;maximum&#41; 2 &#40;4&#41; vs&#46; 2 &#40;5&#41;&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;764&#41;&#46; A weak evidence was found of a better control of BP with medication in non-sleepy patients&#44; based on the ABPM values &#40;Mantel&#8211;Haenszel&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;091&#41;&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Other authors reported similar relationships between sleepiness and cf-PWV in OSA&#46; Drager et al&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">6</span></a> made an observational study of patients with metabolic syndrome&#44; and Kohler et al&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">7</span></a> used a different arterial stiffness index&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">In this sample of male patients without significant comorbidities&#44; who are suspected by their primary care physician of having OSA and needing treatment&#44; a high prevalence of arterial hypertension was found&#44; common in OSA&#59; It should be noted that in 25&#37; of the sample it was previously undiagnosed and in 80&#37; of the patients under drug therapy&#44; it was uncontrolled&#46; High BP was present regardless of sleepiness&#44; but in non-sleepy patients it may be easier to control with medication&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">This analysis had&#44; as limitations&#44; the small number of patients and the exclusion of patients with mild OSA&#44; older patients or those patients with serious comorbidities&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">In conclusion&#44; sleepy patients have more severe OSA&#44; they tend to be more hypertensive and have uncontrolled BP&#44; but arterial stiffness and CV risk are similar in regard of sleepiness&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0075" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:2 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Conflicts of interest"
        ]
        1 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "multimedia" => array:1 [
      0 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Epworth &#8211; Epworth Sleepiness Scale&#59; BMI &#8211; body mass index&#59; SaO<span class="elsevierStyleInf">2</span> &#8211; arterial oxygen saturation&#59; SaO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>90&#37; &#8211; time under 90&#37;&#59; ODI &#8211; oxygen desaturation index&#59; AHI &#8211; Apnoea-Hypopnoea Index&#59; SBP &#8211; systolic blood pressure&#59; DBP &#8211; diastolic blood pressure&#59; cf-PWV &#8211; carotid-femoral pulse wave velocity&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Sleepy &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Non-sleepy &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>24&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>-Value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Epworth&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13 &#40;11&#46;8&#8211;14&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&#46;5 &#40;4&#46;0&#8211;7&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Age &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">54&#46;0 &#40;47&#46;0&#8211;57&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">53&#46;0 &#40;46&#46;3&#8211;59&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ns&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">BMI &#40;kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">31&#46;5 &#40;27&#46;6&#8211;32&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">29&#46;7 &#40;26&#46;8&#8211;34&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ns&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Waist &#40;cm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">104&#46;5 &#40;94&#46;8&#8211;105&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">100&#46;0 &#40;94&#46;8&#8211;115&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ns&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Mean SaO<span class="elsevierStyleInf">2</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">92&#46;3 &#40;90&#46;8&#8211;93&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">93&#46;5 &#40;92&#46;0&#8211;94&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ns&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Minimum SaO<span class="elsevierStyleInf">2</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">70&#46;5 &#40;68&#46;3&#8211;76&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">81&#46;5 &#40;74&#46;8&#8211;84&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;031&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">SaO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>90&#37; &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13&#46;5 &#40;7&#46;4&#8211;28&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&#46;5 &#40;2&#46;1&#8211;16&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;042&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">ODI &#40;events&#47;h&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">32&#46;9 &#40;13&#46;4&#8211;46&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12&#46;2 &#40;6&#46;6&#8211;22&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;034&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">AHI &#40;events&#47;h&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">46&#46;9 &#40;23&#46;7&#8211;52&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">21&#46;9 &#40;16&#46;1&#8211;36&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;018&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">24-h SBP&#44; mmHg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">127&#46;5 &#40;119&#46;8&#8211;138&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">127&#46;0 &#40;121&#46;0&#8211;136&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ns&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">24-h DBP&#44; mmHg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">85&#46;5 &#40;74&#46;3&#8211;88&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">80&#46;5 &#40;74&#46;0&#8211;85&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ns&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Daytime SBP &#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">133&#46;5 &#40;125&#46;3&#8211;142&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">131&#46;0 &#40;124&#46;3&#8211;138&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ns&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Daytime DBP &#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">88&#46;0 &#40;78&#46;3&#8211;90&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">82&#46;0 &#40;75&#46;5&#8211;88&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ns&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Night-time SBP &#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">109&#46;5 &#40;104&#46;0&#8211;126&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">116&#46;5 &#40;109&#46;0&#8211;124&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ns&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Night-time DBP &#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">68&#46;5 &#40;64&#46;5&#8211;78&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">71&#46;0 &#40;61&#46;3&#8211;75&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ns&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">cf-PWV &#40;m&#47;s&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#46;5 &#40;10&#46;9&#8211;12&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#46;1 &#40;10&#46;1&#8211;11&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ns&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1095487.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Clinical characteristics of the participants&#44; classified by sleepiness group&#46; Values are median and interquartile range &#40;IQR&#41;&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:7 [
            0 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sleep disordered breathing and mortality&#58; eighteen-year follow-up of the Wisconsin Sleep Cohort"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46; Young"
                            1 => "L&#46; Finn"
                            2 => "P&#46;E&#46; Peppard"
                            3 => "M&#46; Szklo-Coxe"
                            4 => "D&#46; Austin"
                            5 => "F&#46;J&#46; Nieto"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Sleep"
                        "fecha" => "2008"
                        "volumen" => "31"
                        "paginaInicial" => "1071"
                        "paginaFinal" => "1078"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18714778"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The occurrence of sleep disordered breathing among middle aged adults"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "T&#46; Young"
                            1 => "M&#46; Palta"
                            2 => "J&#46; Dempsey"
                            3 => "J&#46; Skatrud"
                            4 => "S&#46; Weber"
                            5 => "S&#46; Badr"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199304293281704"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1993"
                        "volumen" => "328"
                        "paginaInicial" => "1230"
                        "paginaFinal" => "1235"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8464434"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of vascular biomarkers for primary and secondary prevention&#46; A position paper from the European Society of Cardiology Working Group on peripheral circulation&#58; endorsed by the Association for Research into Arterial Structure and Physiology &#40;ARTERY&#41; Society"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Vlachopoulos"
                            1 => "P&#46; Xaplanteris"
                            2 => "V&#46; Aboyans"
                            3 => "M&#46; Brodmann"
                            4 => "R&#46; C&#237;fkov&#225;"
                            5 => "F&#46; Cosentino"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.atherosclerosis.2015.05.007"
                      "Revista" => array:6 [
                        "tituloSerie" => "Atherosclerosis"
                        "fecha" => "2015"
                        "volumen" => "241"
                        "paginaInicial" => "507"
                        "paginaFinal" => "532"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26117398"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased arterial stiffness in obstructive sleep apnea&#58; a systematic review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;J&#46; Doonan"
                            1 => "P&#46; Scheffler"
                            2 => "M&#46; Lalli"
                            3 => "R&#46;J&#46; Kimoff"
                            4 => "E&#46;T&#46; Petridou"
                            5 => "M&#46;E&#46; Daskalopoulos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/hr.2010.200"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hypertens Res"
                        "fecha" => "2011"
                        "volumen" => "34"
                        "paginaInicial" => "23"
                        "paginaFinal" => "32"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20962788"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of continuous positive airway pressure &#40;CPAP&#41; treatment for obstructive sleep apnea in arterial stiffness&#58; a meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "I&#46;T&#46; Vlachantoni"
                            1 => "E&#46; Dikaiakou"
                            2 => "C&#46; Antonopoulos"
                            3 => "C&#46; Stefanadis"
                            4 => "S&#46; Daskalopoulou"
                            5 => "E&#46;T&#46; Petridou"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.smrv.2012.01.002"
                      "Revista" => array:6 [
                        "tituloSerie" => "Sleep Med Rev"
                        "fecha" => "2013"
                        "volumen" => "17"
                        "paginaInicial" => "19"
                        "paginaFinal" => "28"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22575367"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The incremental role of obstructive sleep apnea on markers of atherosclerosis in patients with metabolic syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46;F&#46; Drager"
                            1 => "L&#46;A&#46; Bortolotto"
                            2 => "C&#46; Maki-Nunes"
                            3 => "I&#46;C&#46; Trombetta"
                            4 => "M&#46;J&#46;N&#46;N&#46; Alves"
                            5 => "R&#46;F&#46; Fraga"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.atherosclerosis.2009.08.016"
                      "Revista" => array:6 [
                        "tituloSerie" => "Atherosclerosis"
                        "fecha" => "2010"
                        "volumen" => "208"
                        "paginaInicial" => "490"
                        "paginaFinal" => "495"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19762024"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Endothelial function and arterial stiffness in minimally symptomatic obstructive sleep apnea"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Kohler"
                            1 => "S&#46; Craig"
                            2 => "D&#46; Nicoll"
                            3 => "P&#46; Leeson"
                            4 => "R&#46;J&#46;O&#46; Davies"
                            5 => "R&#46; Stradling"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.200805-717OC"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2008"
                        "volumen" => "178"
                        "paginaInicial" => "984"
                        "paginaFinal" => "988"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18658111"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735115/0000002200000003/v1_201605310123/S2173511515001955/v1_201605310123/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "47902"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Research Letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735115/0000002200000003/v1_201605310123/S2173511515001955/v1_201605310123/en/main.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511515001955?idApp=UINPBA00004E"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Research Letter
Impact of sleepiness on arterial stiffness and cardio-vascular risk in men with moderate to severe obstructive sleep apnea
M.A. Mineiroa,d,
Corresponding author
xmineiro@gmail.com

Corresponding author.
, P.M. da Silvab, M. Alvesc, D. Virellac, M.J.M. Gomesd, J. Cardosoa,d
a Pulmonology Department, Centro Hospitalar de Lisboa Central (CHLC), Lisbon, Portugal
b Internal Medicine Department, Arterial Investigation Unit, CHLC, Lisbon, Portugal
c Research Unit, CHLC, Lisbon, Portugal
d NOVA Medical School/Faculdade de Ciências Médicas, Lisbon, Portugal
Read
1247
Times
was read the article
614
Total PDF
633
Total HTML
Share statistics
 array:24 [
  "pii" => "S2173511515001955"
  "issn" => "21735115"
  "doi" => "10.1016/j.rppnen.2015.10.013"
  "estado" => "S300"
  "fechaPublicacion" => "2016-05-01"
  "aid" => "1115"
  "copyright" => "Sociedade Portuguesa de Pneumologia"
  "copyrightAnyo" => "2015"
  "documento" => "simple-article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "cor"
  "cita" => "Rev Port Pneumol. 2016;22:177-8"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 1448
    "formatos" => array:3 [
      "EPUB" => 224
      "HTML" => 660
      "PDF" => 564
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S2173511515001918"
    "issn" => "21735115"
    "doi" => "10.1016/j.rppnen.2015.10.010"
    "estado" => "S300"
    "fechaPublicacion" => "2016-05-01"
    "aid" => "1111"
    "documento" => "simple-article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "cor"
    "cita" => "Rev Port Pneumol. 2016;22:179-80"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1484
      "formatos" => array:3 [
        "EPUB" => 192
        "HTML" => 706
        "PDF" => 586
      ]
    ]
    "en" => array:9 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Research letter</span>"
      "titulo" => "Interstitial lung disease in the intensive unit care setting"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "179"
          "paginaFinal" => "180"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "A&#46;F&#46; Gon&#231;alves, S&#46; Campainha, C&#46; Nogueira, F&#46; Costa, P&#46; Castel&#245;es, S&#46; Neves"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "A&#46;F&#46;"
              "apellidos" => "Gon&#231;alves"
            ]
            1 => array:2 [
              "nombre" => "S&#46;"
              "apellidos" => "Campainha"
            ]
            2 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Nogueira"
            ]
            3 => array:2 [
              "nombre" => "F&#46;"
              "apellidos" => "Costa"
            ]
            4 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Castel&#245;es"
            ]
            5 => array:2 [
              "nombre" => "S&#46;"
              "apellidos" => "Neves"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511515001918?idApp=UINPBA00004E"
    "url" => "/21735115/0000002200000003/v1_201605310123/S2173511515001918/v1_201605310123/en/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S2173511516000142"
    "issn" => "21735115"
    "doi" => "10.1016/j.rppnen.2016.01.004"
    "estado" => "S300"
    "fechaPublicacion" => "2016-05-01"
    "aid" => "1137"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Rev Port Pneumol. 2016;22:167-76"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1437
      "formatos" => array:3 [
        "EPUB" => 205
        "HTML" => 663
        "PDF" => 569
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Special article</span>"
      "titulo" => "COPD control&#58; Can a consensus be found&#63;"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "167"
          "paginaFinal" => "176"
        ]
      ]
      "contieneResumen" => array:1 [
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "M&#46; Guimar&#227;es, A&#46; Bugalho, A&#46;S&#46; Oliveira, J&#46; Moita, A&#46; Marques"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Guimar&#227;es"
            ]
            1 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Bugalho"
            ]
            2 => array:2 [
              "nombre" => "A&#46;S&#46;"
              "apellidos" => "Oliveira"
            ]
            3 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Moita"
            ]
            4 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Marques"
            ]
            5 => array:1 [
              "colaborador" => "on behalf of the GI DPOC-Grupo de Interesse na Doen&#231;a Pulmonar Obstrutiva Cr&#243;nica"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511516000142?idApp=UINPBA00004E"
    "url" => "/21735115/0000002200000003/v1_201605310123/S2173511516000142/v1_201605310123/en/main.assets"
  ]
  "en" => array:12 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Research Letter</span>"
    "titulo" => "Impact of sleepiness on arterial stiffness and cardio-vascular risk in men with moderate to severe obstructive sleep apnea"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "177"
        "paginaFinal" => "178"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "M&#46;A&#46; Mineiro, P&#46;M&#46; da Silva, M&#46; Alves, D&#46; Virella, M&#46;J&#46;M&#46; Gomes, J&#46; Cardoso"
        "autores" => array:6 [
          0 => array:4 [
            "nombre" => "M&#46;A&#46;"
            "apellidos" => "Mineiro"
            "email" => array:1 [
              0 => "xmineiro&#64;gmail&#46;com"
            ]
            "referencia" => array:3 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "P&#46;M&#46;"
            "apellidos" => "da Silva"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "M&#46;"
            "apellidos" => "Alves"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "D&#46;"
            "apellidos" => "Virella"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "M&#46;J&#46;M&#46;"
            "apellidos" => "Gomes"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "J&#46;"
            "apellidos" => "Cardoso"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:4 [
          0 => array:3 [
            "entidad" => "Pulmonology Department&#44; Centro Hospitalar de Lisboa Central &#40;CHLC&#41;&#44; Lisbon&#44; Portugal"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Internal Medicine Department&#44; Arterial Investigation Unit&#44; CHLC&#44; Lisbon&#44; Portugal"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Research Unit&#44; CHLC&#44; Lisbon&#44; Portugal"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "NOVA Medical School&#47;Faculdade de Ci&#234;ncias M&#233;dicas&#44; Lisbon&#44; Portugal"
            "etiqueta" => "d"
            "identificador" => "aff0020"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Obstructive sleep apnea &#40;OSA&#41;&#44; if left untreated&#44; is associated with high cardio-vascular &#40;CV&#41; morbidity and mortality&#46; Based on large-scale epidemiological studies&#44; it is known that excessive sleepiness is a cardinal symptom but the majority of individuals with high Apnea Hypopnea Index &#40;IAH&#41; do not complain of it&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Arterial stiffness&#44; evaluated by pulse wave velocity &#40;PWV&#41;&#44; has a predictive value for CV events&#44; beyond classical risk factors&#44; and can be considered as an intermediate endpoint for CV events&#46; Carotid-femoral pulse wave velocity &#40;cf-PWV&#41; remains the most commonly used non-invasive method and is considered as the gold standard&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Increased PWV is associated with various conditions&#44; of which age and blood pressure &#40;BP&#41; are the most important&#46; In OSA cf-PWV value is augmented&#44; with improvement after treatment with CPAP&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">In order to explore the association of sleepiness with CV risk in patients with OSA&#44; we conducted a prospective study of consecutive males&#44; younger than 65 years old&#44; referred for snoring or OSA related symptoms&#46; They were included if they had moderate to severe OSA &#40;AHI<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>15&#41; diagnosed by cardiorespiratory polygraphic study&#44; level 3&#44; in our institution&#39;s sleep laboratory&#44; and excluded if they had other sleep disturbances&#44; diabetes or CV disease beyond hypertension&#46; Epworth Sleepiness Scale &#40;ESS&#41; score<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>10 defined excessive sleepiness&#46; Patients with high BP in 24<span class="elsevierStyleHsp" style=""></span>h monitoring &#40;ABPM&#41; or already taking antihypertensive drugs were considered hypertensive&#46; Arterial stiffness was assessed by cf-PWV&#44; and 10<span class="elsevierStyleHsp" style=""></span>m&#47;s was used as threshold value&#46; CV risk was calculated by SCORE &#8211; European Low Risk Chart&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Univariable logistic regression and stratified Mantel&#8211;Haenszel analyses were performed to quantify associations between variables&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">From approximately 700 patients referred to the Clinic during the study&#44; 34 patients were recruited&#44; with median age 53&#46;0 years&#59; 24 &#40;70&#46;6&#37;&#41; were hypertensive &#40;15 with medication&#41;&#44; 18 &#40;52&#46;9&#37;&#41; had metabolic syndrome and 30 &#40;91&#37;&#41; had dyslipidaemia&#46; The cf-PWV was high in 27 &#40;79&#46;4&#37;&#41; and the median SCORE CV risk was 2 &#40;0&#8211;5&#41;&#44; 26 out of 33 patients had moderate CV risk&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">All patients with normal cf-PWV had moderate OSA&#44; and cf-PWV was significantly higher when OSA was severe rather than moderate OSA &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;047&#41;&#46; In fact&#44; weak evidence was found that the odds for high cf-PWV increase with either increasing AHI &#40;OR 1&#46;08&#59; 95&#37;CI 0&#46;99&#8211;1&#46;18&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;078&#41; or ODI &#40;OR 1&#46;14&#59; 95&#37;CI 0&#46;98&#8211;1&#46;32&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;086&#41;&#46; No association was found between cf-PWV and ABPM measurements&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Patients with high cf-PWV also had similar prevalence rates of arterial hypertension &#40;57&#46;1&#37; &#91;95&#37; CI 25&#46;05&#8211;84&#46;18&#93; vs&#46; 74&#46;1&#37; &#91;95&#37; CI 55&#46;32&#8211;86&#46;83&#93;&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;394&#41; but higher SCORE CV risk &#40;median &#40;maximum&#41; 1 &#40;2&#41; vs&#46; 3 &#40;5&#41;&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;029&#41;&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Excessive sleepiness was diagnosed in 10 &#40;29&#46;4&#37;&#41; patients which had significantly higher AHI&#44; ODI and higher SaO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>90&#37; but lower minimum SaO<span class="elsevierStyleInf">2</span> than non-sleepy patients &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0050" class="elsevierStylePara elsevierViewall">Sleepy and non-sleepy patients did not differ in prevalence rates of hypertension &#40;70&#46;0&#37; vs&#46; 70&#46;8&#37;&#41; or average BP values&#46; However&#44; all patients with normal average ABPM values under medication were non-sleepy&#46; Both cf-PWV and SCORE CV risk were similar regarding sleepiness &#40;median &#40;maximum&#41; 2 &#40;4&#41; vs&#46; 2 &#40;5&#41;&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;764&#41;&#46; A weak evidence was found of a better control of BP with medication in non-sleepy patients&#44; based on the ABPM values &#40;Mantel&#8211;Haenszel&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;091&#41;&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Other authors reported similar relationships between sleepiness and cf-PWV in OSA&#46; Drager et al&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">6</span></a> made an observational study of patients with metabolic syndrome&#44; and Kohler et al&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">7</span></a> used a different arterial stiffness index&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">In this sample of male patients without significant comorbidities&#44; who are suspected by their primary care physician of having OSA and needing treatment&#44; a high prevalence of arterial hypertension was found&#44; common in OSA&#59; It should be noted that in 25&#37; of the sample it was previously undiagnosed and in 80&#37; of the patients under drug therapy&#44; it was uncontrolled&#46; High BP was present regardless of sleepiness&#44; but in non-sleepy patients it may be easier to control with medication&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">This analysis had&#44; as limitations&#44; the small number of patients and the exclusion of patients with mild OSA&#44; older patients or those patients with serious comorbidities&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">In conclusion&#44; sleepy patients have more severe OSA&#44; they tend to be more hypertensive and have uncontrolled BP&#44; but arterial stiffness and CV risk are similar in regard of sleepiness&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0075" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:2 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Conflicts of interest"
        ]
        1 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "multimedia" => array:1 [
      0 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Epworth &#8211; Epworth Sleepiness Scale&#59; BMI &#8211; body mass index&#59; SaO<span class="elsevierStyleInf">2</span> &#8211; arterial oxygen saturation&#59; SaO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>90&#37; &#8211; time under 90&#37;&#59; ODI &#8211; oxygen desaturation index&#59; AHI &#8211; Apnoea-Hypopnoea Index&#59; SBP &#8211; systolic blood pressure&#59; DBP &#8211; diastolic blood pressure&#59; cf-PWV &#8211; carotid-femoral pulse wave velocity&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Sleepy &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Non-sleepy &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>24&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>-Value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Epworth&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13 &#40;11&#46;8&#8211;14&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&#46;5 &#40;4&#46;0&#8211;7&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Age &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">54&#46;0 &#40;47&#46;0&#8211;57&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">53&#46;0 &#40;46&#46;3&#8211;59&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ns&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">BMI &#40;kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">31&#46;5 &#40;27&#46;6&#8211;32&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">29&#46;7 &#40;26&#46;8&#8211;34&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ns&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Waist &#40;cm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">104&#46;5 &#40;94&#46;8&#8211;105&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">100&#46;0 &#40;94&#46;8&#8211;115&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ns&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Mean SaO<span class="elsevierStyleInf">2</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">92&#46;3 &#40;90&#46;8&#8211;93&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">93&#46;5 &#40;92&#46;0&#8211;94&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ns&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Minimum SaO<span class="elsevierStyleInf">2</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">70&#46;5 &#40;68&#46;3&#8211;76&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">81&#46;5 &#40;74&#46;8&#8211;84&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;031&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">SaO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>90&#37; &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13&#46;5 &#40;7&#46;4&#8211;28&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&#46;5 &#40;2&#46;1&#8211;16&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;042&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">ODI &#40;events&#47;h&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">32&#46;9 &#40;13&#46;4&#8211;46&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12&#46;2 &#40;6&#46;6&#8211;22&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;034&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">AHI &#40;events&#47;h&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">46&#46;9 &#40;23&#46;7&#8211;52&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">21&#46;9 &#40;16&#46;1&#8211;36&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;018&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">24-h SBP&#44; mmHg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">127&#46;5 &#40;119&#46;8&#8211;138&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">127&#46;0 &#40;121&#46;0&#8211;136&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ns&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">24-h DBP&#44; mmHg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">85&#46;5 &#40;74&#46;3&#8211;88&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">80&#46;5 &#40;74&#46;0&#8211;85&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ns&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Daytime SBP &#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">133&#46;5 &#40;125&#46;3&#8211;142&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">131&#46;0 &#40;124&#46;3&#8211;138&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ns&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Daytime DBP &#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">88&#46;0 &#40;78&#46;3&#8211;90&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">82&#46;0 &#40;75&#46;5&#8211;88&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ns&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Night-time SBP &#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">109&#46;5 &#40;104&#46;0&#8211;126&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">116&#46;5 &#40;109&#46;0&#8211;124&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ns&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Night-time DBP &#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">68&#46;5 &#40;64&#46;5&#8211;78&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">71&#46;0 &#40;61&#46;3&#8211;75&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ns&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">cf-PWV &#40;m&#47;s&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#46;5 &#40;10&#46;9&#8211;12&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#46;1 &#40;10&#46;1&#8211;11&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ns&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1095487.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Clinical characteristics of the participants&#44; classified by sleepiness group&#46; Values are median and interquartile range &#40;IQR&#41;&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:7 [
            0 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sleep disordered breathing and mortality&#58; eighteen-year follow-up of the Wisconsin Sleep Cohort"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46; Young"
                            1 => "L&#46; Finn"
                            2 => "P&#46;E&#46; Peppard"
                            3 => "M&#46; Szklo-Coxe"
                            4 => "D&#46; Austin"
                            5 => "F&#46;J&#46; Nieto"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Sleep"
                        "fecha" => "2008"
                        "volumen" => "31"
                        "paginaInicial" => "1071"
                        "paginaFinal" => "1078"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18714778"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The occurrence of sleep disordered breathing among middle aged adults"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "T&#46; Young"
                            1 => "M&#46; Palta"
                            2 => "J&#46; Dempsey"
                            3 => "J&#46; Skatrud"
                            4 => "S&#46; Weber"
                            5 => "S&#46; Badr"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199304293281704"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1993"
                        "volumen" => "328"
                        "paginaInicial" => "1230"
                        "paginaFinal" => "1235"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8464434"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of vascular biomarkers for primary and secondary prevention&#46; A position paper from the European Society of Cardiology Working Group on peripheral circulation&#58; endorsed by the Association for Research into Arterial Structure and Physiology &#40;ARTERY&#41; Society"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Vlachopoulos"
                            1 => "P&#46; Xaplanteris"
                            2 => "V&#46; Aboyans"
                            3 => "M&#46; Brodmann"
                            4 => "R&#46; C&#237;fkov&#225;"
                            5 => "F&#46; Cosentino"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.atherosclerosis.2015.05.007"
                      "Revista" => array:6 [
                        "tituloSerie" => "Atherosclerosis"
                        "fecha" => "2015"
                        "volumen" => "241"
                        "paginaInicial" => "507"
                        "paginaFinal" => "532"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26117398"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased arterial stiffness in obstructive sleep apnea&#58; a systematic review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;J&#46; Doonan"
                            1 => "P&#46; Scheffler"
                            2 => "M&#46; Lalli"
                            3 => "R&#46;J&#46; Kimoff"
                            4 => "E&#46;T&#46; Petridou"
                            5 => "M&#46;E&#46; Daskalopoulos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/hr.2010.200"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hypertens Res"
                        "fecha" => "2011"
                        "volumen" => "34"
                        "paginaInicial" => "23"
                        "paginaFinal" => "32"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20962788"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of continuous positive airway pressure &#40;CPAP&#41; treatment for obstructive sleep apnea in arterial stiffness&#58; a meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "I&#46;T&#46; Vlachantoni"
                            1 => "E&#46; Dikaiakou"
                            2 => "C&#46; Antonopoulos"
                            3 => "C&#46; Stefanadis"
                            4 => "S&#46; Daskalopoulou"
                            5 => "E&#46;T&#46; Petridou"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.smrv.2012.01.002"
                      "Revista" => array:6 [
                        "tituloSerie" => "Sleep Med Rev"
                        "fecha" => "2013"
                        "volumen" => "17"
                        "paginaInicial" => "19"
                        "paginaFinal" => "28"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22575367"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The incremental role of obstructive sleep apnea on markers of atherosclerosis in patients with metabolic syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46;F&#46; Drager"
                            1 => "L&#46;A&#46; Bortolotto"
                            2 => "C&#46; Maki-Nunes"
                            3 => "I&#46;C&#46; Trombetta"
                            4 => "M&#46;J&#46;N&#46;N&#46; Alves"
                            5 => "R&#46;F&#46; Fraga"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.atherosclerosis.2009.08.016"
                      "Revista" => array:6 [
                        "tituloSerie" => "Atherosclerosis"
                        "fecha" => "2010"
                        "volumen" => "208"
                        "paginaInicial" => "490"
                        "paginaFinal" => "495"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19762024"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Endothelial function and arterial stiffness in minimally symptomatic obstructive sleep apnea"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Kohler"
                            1 => "S&#46; Craig"
                            2 => "D&#46; Nicoll"
                            3 => "P&#46; Leeson"
                            4 => "R&#46;J&#46;O&#46; Davies"
                            5 => "R&#46; Stradling"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.200805-717OC"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2008"
                        "volumen" => "178"
                        "paginaInicial" => "984"
                        "paginaFinal" => "988"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18658111"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735115/0000002200000003/v1_201605310123/S2173511515001955/v1_201605310123/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "47902"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Research Letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735115/0000002200000003/v1_201605310123/S2173511515001955/v1_201605310123/en/main.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511515001955?idApp=UINPBA00004E"
]
Article information
ISSN: 21735115
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 8 7 15
2024 October 30 28 58
2024 September 37 54 91
2024 August 53 46 99
2024 July 63 28 91
2024 June 49 37 86
2024 May 69 50 119
2024 April 38 41 79
2024 March 50 31 81
2024 February 36 23 59
2024 January 26 34 60
2023 December 22 30 52
2023 November 27 45 72
2023 October 19 32 51
2023 September 25 33 58
2023 August 10 15 25
2023 July 16 25 41
2023 June 22 14 36
2023 May 22 30 52
2023 April 11 11 22
Show all

Follow this link to access the full text of the article

Pulmonology

Are you a health professional able to prescribe or dispense drugs?