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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Chest computed tomography images at the time of diagnosis of gastric cancer &#40;A&#41;&#59; at 6 months &#40;B&#41; and 19 months &#40;C&#41; after gastrectomy&#59; and at 2 months after the initiation of HFNC&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">High-flow nasal cannula &#40;HFNC&#41; therapy is a novel technique of oxygen therapy that delivers heated and humidified oxygen via a special device at a rate of up to 60<span class="elsevierStyleHsp" style=""></span>L&#47;min&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> HFNC has some physiological effects&#44; including a low level of positive airway pressure&#44; reduction of nasopharyngeal resistance&#44; pharyngeal dead space washout&#44; humidification&#44; and better control of mucociliary clearance&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> HFNC has been used as a mode of noninvasive respiratory support for acute hypoxemic respiratory failure without hypercapnea with adults&#44; children&#44; and neonates&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> Recently&#44; the clinical indications of HFNC have been expanded to post-extubated patients under intensive care or following surgery&#44; those undergoing bronchoscopy&#44; and those with the status of &#8220;do not intubate&#8221;&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> Here&#44; we describe a post-gastrectomy case with chronic lower respiratory tract infection&#44; which was well controlled by domiciliary nocturnal HFNC&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The patient is a 62-year-old&#44; non-smoking&#44; woman who was diagnosed with gastric cancer and was treated by total gastrectomy when she was 60&#46; At the time of diagnosis of gastric cancer&#44; chest computed tomography &#40;CT&#41; revealed mild bronchial wall thickening in both lower lobes &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#46; Six months after gastrectomy&#44; follow-up chest CT showed consolidation in the right middle lobe and left lingular segment and consolidation&#44; mucus plug&#44; and centrilobular nodules in both lower lobes &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46; Therefore&#44; she was referred to the Department of Respiratory Medicine in Hikone Municipal Hospital&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">She complained of productive cough without postnasal discharge&#46; She was not on any medication&#44; including proton pomp inhibitors&#46; Laboratory test results revealed white blood cell counts of 5880&#47;&#956;L&#44; C-reactive protein of 0&#46;29<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; and antinuclear antibody titer of 1&#58;40&#46; The &#37; predicted forced vital capacity and &#37; predicted forced expiratory volume in 1<span class="elsevierStyleHsp" style=""></span>s were 2&#46;07<span class="elsevierStyleHsp" style=""></span>L &#40;81&#46;4&#37;&#41; and 1&#46;56<span class="elsevierStyleHsp" style=""></span>L &#40;75&#46;3&#37;&#41;&#44; respectively&#46; Sinus CT revealed mild mucosal thickening and opacification of the right ethmoid and sphenoid sinuses and the bilateral maxillary sinuses&#59; Lund&#8211;Mackay staging system score was 4&#46; Fiber-optic bronchoscopy revealed purulent bronchial secretions from both inferior lobar bronchi&#44; but there were no detected organisms&#44; including bacteria and acid-fast bacilli&#46; We administered low-dose macrolide therapy with clarithromycin 200<span class="elsevierStyleHsp" style=""></span>mg once daily&#46; However&#44; 1 month later&#44; we discontinued the low-dose macrolide therapy because of hepatotoxicity&#46; Instead&#44; we administered mucolytic agents such as carbocysteine 500<span class="elsevierStyleHsp" style=""></span>mg three times daily&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Nineteen months after gastrectomy&#44; follow-up chest CT showed improvement of the consolidation in the right middle lobe and left lingular segment&#44; but there were no changes in the mucus plug and the centrilobular nodules in both lower lobes &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>C&#41;&#46; There was also a persistent productive cough&#46; Twenty-three months after gastrectomy&#44; we initiated domiciliary nocturnal HFNC &#40;myAIRVO&#8482;2&#44; Fisher and Paykel Healthcare&#44; Auckland&#44; New Zealand&#41; for humidification without oxygen at a flow rate of 30<span class="elsevierStyleHsp" style=""></span>L&#47;min and temperature of 34<span class="elsevierStyleHsp" style=""></span>&#176;C&#46; Two months after the initiation of domiciliary nocturnal HFNC&#44; the patient reported that the productive cough had reduced by half&#46; Furthermore&#44; repeat chest CT revealed decrease of mucus plug and centrilobular nodules &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>D&#41;&#46; This patient did not have any of the adverse reactions induced by HFNC&#44; such as pneumothorax&#44; aerophagia&#44; skin irritation&#44; or epistaxis&#46; During this clinical course&#44; the patient had not undergone pulmonary rehabilitation&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">This chronic lower respiratory tract infection appeared after total gastrectomy&#46; Recurrent aspiration pneumonia is frequently observed in patients who have undergone total gastrectomy because of the esophageal reflux of the intestinal contents and swallowing dysfunction&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a> Therefore&#44; the chronic lower respiratory tract infection in this patient could have been caused by chronic aspiration&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">In this patient&#44; domiciliary humidification through HFNC was able to decrease the chest CT abnormalities &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#8211;D&#41; and the symptoms of productive cough&#46; Rea et al&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a> reported that domiciliary humidification through HFNC improved the lung function and quality of life of patients with chronic lower airway disorders&#44; including chronic obstructive pulmonary disease and bronchiectasis&#46; These effects of HFNC are considered to be caused by improvement in mucociliary clearance&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> Chronic aspiration after total gastrectomy is mainly induced by nocturnal esophageal reflux&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a> This patient used HFNC only at night&#46; Therefore&#44; HFNC was considered to protect the patient from nocturnal aspiration&#44; in addition to improving mucociliary clearance in this patient&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Rea et al&#46; used HFNC at 20&#8211;25<span class="elsevierStyleHsp" style=""></span>L&#47;min of flow rate and temperature of 37<span class="elsevierStyleHsp" style=""></span>&#176;C at an average of 1&#8211;2<span class="elsevierStyleHsp" style=""></span>h per day&#44; which was short&#44; because mucociliary clearance of 3<span class="elsevierStyleHsp" style=""></span>h of daily use had been demonstrated by Hasani et al&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> This patient used HFNC for more than 6<span class="elsevierStyleHsp" style=""></span>h per day&#44; every night&#46; Future studies are required to evaluate the effect of HFNC in patients with different diseases and different settings&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Patients with chronic lower respiratory tract infection are usually treated with antibiotics&#44; including macrolides&#44; mucolytic agents&#44; and bronchodilators&#46; We conclude that HFNC can be an additional treatment option for airway management in such patients&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0045" class="elsevierStylePara elsevierViewall">None of the authors have any disclosure or financial support regarding this report&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflicts of interest</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors have no conflict of interest regarding this report&#46;</p></span></span>"
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Letter to the Editor
The clinical utility of domiciliary nocturnal high-flow nasal cannula in a post-gastrectomy patient with chronic lower respiratory tract infection
Satoshi Hamada
Corresponding author
sh1124@kuhp.kyoto-u.ac.jp

Corresponding author.
, Mitsuhiro Tsukino
Department of Respiratory Medicine, Hikone Municipal Hospital, 1882 Hassakacho, Hikone 522-8539, Japan
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">High-flow nasal cannula &#40;HFNC&#41; therapy is a novel technique of oxygen therapy that delivers heated and humidified oxygen via a special device at a rate of up to 60<span class="elsevierStyleHsp" style=""></span>L&#47;min&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> HFNC has some physiological effects&#44; including a low level of positive airway pressure&#44; reduction of nasopharyngeal resistance&#44; pharyngeal dead space washout&#44; humidification&#44; and better control of mucociliary clearance&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> HFNC has been used as a mode of noninvasive respiratory support for acute hypoxemic respiratory failure without hypercapnea with adults&#44; children&#44; and neonates&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> Recently&#44; the clinical indications of HFNC have been expanded to post-extubated patients under intensive care or following surgery&#44; those undergoing bronchoscopy&#44; and those with the status of &#8220;do not intubate&#8221;&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> Here&#44; we describe a post-gastrectomy case with chronic lower respiratory tract infection&#44; which was well controlled by domiciliary nocturnal HFNC&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The patient is a 62-year-old&#44; non-smoking&#44; woman who was diagnosed with gastric cancer and was treated by total gastrectomy when she was 60&#46; At the time of diagnosis of gastric cancer&#44; chest computed tomography &#40;CT&#41; revealed mild bronchial wall thickening in both lower lobes &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#46; Six months after gastrectomy&#44; follow-up chest CT showed consolidation in the right middle lobe and left lingular segment and consolidation&#44; mucus plug&#44; and centrilobular nodules in both lower lobes &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46; Therefore&#44; she was referred to the Department of Respiratory Medicine in Hikone Municipal Hospital&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">She complained of productive cough without postnasal discharge&#46; She was not on any medication&#44; including proton pomp inhibitors&#46; Laboratory test results revealed white blood cell counts of 5880&#47;&#956;L&#44; C-reactive protein of 0&#46;29<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; and antinuclear antibody titer of 1&#58;40&#46; The &#37; predicted forced vital capacity and &#37; predicted forced expiratory volume in 1<span class="elsevierStyleHsp" style=""></span>s were 2&#46;07<span class="elsevierStyleHsp" style=""></span>L &#40;81&#46;4&#37;&#41; and 1&#46;56<span class="elsevierStyleHsp" style=""></span>L &#40;75&#46;3&#37;&#41;&#44; respectively&#46; Sinus CT revealed mild mucosal thickening and opacification of the right ethmoid and sphenoid sinuses and the bilateral maxillary sinuses&#59; Lund&#8211;Mackay staging system score was 4&#46; Fiber-optic bronchoscopy revealed purulent bronchial secretions from both inferior lobar bronchi&#44; but there were no detected organisms&#44; including bacteria and acid-fast bacilli&#46; We administered low-dose macrolide therapy with clarithromycin 200<span class="elsevierStyleHsp" style=""></span>mg once daily&#46; However&#44; 1 month later&#44; we discontinued the low-dose macrolide therapy because of hepatotoxicity&#46; Instead&#44; we administered mucolytic agents such as carbocysteine 500<span class="elsevierStyleHsp" style=""></span>mg three times daily&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Nineteen months after gastrectomy&#44; follow-up chest CT showed improvement of the consolidation in the right middle lobe and left lingular segment&#44; but there were no changes in the mucus plug and the centrilobular nodules in both lower lobes &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>C&#41;&#46; There was also a persistent productive cough&#46; Twenty-three months after gastrectomy&#44; we initiated domiciliary nocturnal HFNC &#40;myAIRVO&#8482;2&#44; Fisher and Paykel Healthcare&#44; Auckland&#44; New Zealand&#41; for humidification without oxygen at a flow rate of 30<span class="elsevierStyleHsp" style=""></span>L&#47;min and temperature of 34<span class="elsevierStyleHsp" style=""></span>&#176;C&#46; Two months after the initiation of domiciliary nocturnal HFNC&#44; the patient reported that the productive cough had reduced by half&#46; Furthermore&#44; repeat chest CT revealed decrease of mucus plug and centrilobular nodules &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>D&#41;&#46; This patient did not have any of the adverse reactions induced by HFNC&#44; such as pneumothorax&#44; aerophagia&#44; skin irritation&#44; or epistaxis&#46; During this clinical course&#44; the patient had not undergone pulmonary rehabilitation&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">This chronic lower respiratory tract infection appeared after total gastrectomy&#46; Recurrent aspiration pneumonia is frequently observed in patients who have undergone total gastrectomy because of the esophageal reflux of the intestinal contents and swallowing dysfunction&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a> Therefore&#44; the chronic lower respiratory tract infection in this patient could have been caused by chronic aspiration&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">In this patient&#44; domiciliary humidification through HFNC was able to decrease the chest CT abnormalities &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#8211;D&#41; and the symptoms of productive cough&#46; Rea et al&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a> reported that domiciliary humidification through HFNC improved the lung function and quality of life of patients with chronic lower airway disorders&#44; including chronic obstructive pulmonary disease and bronchiectasis&#46; These effects of HFNC are considered to be caused by improvement in mucociliary clearance&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> Chronic aspiration after total gastrectomy is mainly induced by nocturnal esophageal reflux&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a> This patient used HFNC only at night&#46; Therefore&#44; HFNC was considered to protect the patient from nocturnal aspiration&#44; in addition to improving mucociliary clearance in this patient&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Rea et al&#46; used HFNC at 20&#8211;25<span class="elsevierStyleHsp" style=""></span>L&#47;min of flow rate and temperature of 37<span class="elsevierStyleHsp" style=""></span>&#176;C at an average of 1&#8211;2<span class="elsevierStyleHsp" style=""></span>h per day&#44; which was short&#44; because mucociliary clearance of 3<span class="elsevierStyleHsp" style=""></span>h of daily use had been demonstrated by Hasani et al&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> This patient used HFNC for more than 6<span class="elsevierStyleHsp" style=""></span>h per day&#44; every night&#46; Future studies are required to evaluate the effect of HFNC in patients with different diseases and different settings&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Patients with chronic lower respiratory tract infection are usually treated with antibiotics&#44; including macrolides&#44; mucolytic agents&#44; and bronchodilators&#46; We conclude that HFNC can be an additional treatment option for airway management in such patients&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0045" class="elsevierStylePara elsevierViewall">None of the authors have any disclosure or financial support regarding this report&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflicts of interest</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors have no conflict of interest regarding this report&#46;</p></span></span>"
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                      "titulo" => "Can high-flow nasal cannula reduce the rate of endotracheal intubation in adult patients with acute respiratory failure compared with conventional oxygen therapy and noninvasive positive pressure ventilation&#63;&#58; A systematic review and meta-analysis"
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Article information
ISSN: 25310437
Original language: English
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