Resistance exercise training improves mucociliary clearance in subjects with COPD: A randomized clinical trial

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GET: training with elastic tubing and GCT: training with weight training equipment." ] ] ] "textoCompleto" => "IntroductionPeripheral muscle dysfunction is a prevalent condition in patients with chronic obstructive pulmonary disease (COPD). Common features include reduced muscle strength and endurance, muscle atrophy and poor oxidative capacity.<a class="elsevierStyleCrossRef" href="#bib0210">1</a> This muscle dysfunction is directly related to exercise intolerance, impaired health-related quality of life<a class="elsevierStyleCrossRef" href="#bib0215">2</a> and involves increased use of health care resources.<a class="elsevierStyleCrossRef" href="#bib0220">3</a>In addition to peripheral muscle dysfunction subjects with COPD may present impairment in mucociliary clearance, an essential mechanism of pulmonary defense. Mucociliary clearance removes inhaled particles and microorganisms from the respiratory tract.<a class="elsevierStyleCrossRefs" href="#bib0225">4,5</a> Dysfunction of this mechanism causes hypersecretion leading to lung infections and exacerbations.<a class="elsevierStyleCrossRefs" href="#bib0225">4,5</a>The efficiency of mucociliary clearance can be analyzed by the velocity of nasal mucociliary transport (MCT) and is well correlated with tracheobronchial transport<a class="elsevierStyleCrossRefs" href="#bib0235">6,7</a> which requires more invasive procedures to assess. MCT is measured using substances with a characteristic flavor, for example, the saccharin transit time (STT).<a class="elsevierStyleCrossRefs" href="#bib0235">6–9</a> STT test has been widely reported in previous studies as being simple, valid and reliable with similar results to those obtained with the use of radioisotope particles for MCT analysis.<a class="elsevierStyleCrossRefs" href="#bib0235">6,10</a>Pulmonary rehabilitation (PR) in subjects with COPD is supported by the highest-level of evidence.<a class="elsevierStyleCrossRef" href="#bib0260">11</a> Resistance training (RT) is an important component in improving muscle strength, activities of daily living and functional exercise capacity and reducing fatigue and dyspnea symptoms.<a class="elsevierStyleCrossRefs" href="#bib0210">1,12,13</a>RT protocols routinely include weight machines and free weights in standard proposals, however elastic tubing (ET) was recently investigated as an alternative to the conventional RT for subjects with COPD. Studies with elastic devices have demonstrated similar benefits to conventional training<a class="elsevierStyleCrossRefs" href="#bib0275">14–17</a> with the added advantage of being portable, and inexpensive.<a class="elsevierStyleCrossRefs" href="#bib0275">14,17</a> The linear increase of resistance occurring in ET is less harmful to the joints, and provides a greater recruitment of motor units when compared to the conventional resistance training.<a class="elsevierStyleCrossRef" href="#bib0295">18</a> This is particularly interesting for patients with muscle dysfunction like COPD.There is evidence that aerobic exercise improves the mucociliary system by altering the viscosity of nasal mucus, thus can be recommended as an adjunctive treatment to respiratory physiotherapy techniques.<a class="elsevierStyleCrossRefs" href="#bib0225">4,19,20</a> This type of exercise increases the levels of adrenergic mediators that contribute to changes in mucociliary clearance during or after exercise.<a class="elsevierStyleCrossRef" href="#bib0310">21</a> Although the effects of RT on mucociliary system have not yet been reported, it is reasonable to hypothesize that it has a positive influence on mucociliary clearance as RT modulates changes in the autonomic control in subjects with COPD.<a class="elsevierStyleCrossRef" href="#bib0315">22</a>Knowing the effects of RT on MCT in subjects with COPD is essential for health professionals involved in pulmonary rehabilitation for COPD. MCT is the first line of defense of the respiratory system against aggressor agents and irritants. The maintenance of its integrity, therefore, is necessary to reduce the risk of respiratory infections and hospitalizations in COPD.<a class="elsevierStyleCrossRefs" href="#bib0225">4,19</a> Furthermore, such knowledge could lead to strategies to improve mucociliary clearance in subjects with COPD. Therefore, the aim of this study was to evaluate the effects of two RT programs on mucociliary clearance in subjects with COPD.MethodsDesign of the studyInitially, subjects referred to an outpatient pulmonary rehabilitation program were screened for inclusion in this randomized, parallel group, clinical trial. COPD diagnosis was made according to internationally accepted criteria.<a class="elsevierStyleCrossRef" href="#bib0295">18</a> Patients included should be clinically stable (i.e. absence of exacerbation in the month before inclusion) and have quit smoking for at least one year prior to the inclusion. Subjects were excluded if they presented nasal trauma or deviated septum, unstable severe cardiac disease or musculoskeletal disorders that hindered the implementation of the experimental protocol. Recruitment and follow-up of individuals was conducted between 2014 and 2015 in a specialized rehabilitation center in Presidente Prudente, São Paulo, Brazil. This clinical trial (RBR-7KCR2P) was approved by the local ethics committee (CAAE: 12492113.5.0000.5402) and all included subjects provided written consent form.Twenty-eight subjects were randomly allocated to one of the two a priori defined groups: Conventional RT (GCT) or RT using elastic tubing (GET). The randomization was performed by strata,<a class="elsevierStyleCrossRef" href="#bib0320">23</a> where subjects were classified into quartiles according to individual strength of lower limbs (i.e. isometric maximum voluntary contraction of the knee extensors). Subjects in each quartile were numbered in brown envelopes and randomized into one of the 2 groups, by a researcher unrelated to the study.Although therapists and subjects were not blinded for the interventions, data analysis was performed by a researcher who was not involved with the data collection.This study is part of a major project, with knee extension strength defined as primary outcome (data not shown). Sample size calculation was done based on an equivalence study. Twenty patients (10 per group) were needed to achieve a power of 80%, expecting a difference of 45N between groups with a standard deviation of 36N and taking into account a typical dropout rate of 20%.The evaluations were performed before and after the 12 weeks of RT. The initial evaluation took place in two days. On the first day the identification and measurement of vital signs (blood pressure, heart rate and respiratory rate) and lung function (spirometry) were performed. To confirm abstinence from smoking, the carbon monoxide concentration of the expired air was measured (COex). On the second day of the protocol, the mucociliary transport analysis via the saccharin transit time test (STT) was performed. Details of all the assessments are provided below. To determine initial workload of training groups, the repetition maximum (RM) test was performed on each subject on the first day of training protocols.Pulmonary function testPulmonary function was measured prior to the protocols of training by means of simple spirometry (MIR-Spirobank v3.6, Italy) in accordance with the standards of the American Thoracic Society (ATS) and European Respiratory Society (ERS).<a class="elsevierStyleCrossRef" href="#bib0325">24</a>Measurement of hemodynamic parametersRespiratory rate was measured by observing the number of expansions of the rib cage, watching the respiratory mechanics of the individual for 1min. Heart rate was determined using a heart rate monitor (Polar S810i, Finland). The auscultation method was used to measure the blood pressure in the left arm, using an aneroid sphygmomanometer and stethoscope (BD, Brazil). All vital signs were collected after 20min of initial resting.Measurement of nasal mucociliary transport (saccharin transit time)The evaluation of mucociliary transport was done via the assessment of SST, prior to the start of training and after a minimum of 48h upon completion of the final training session, following the measurements of hemodynamic parameters. Subjects were seated with their heads over-extended at 10°. The SST test was initiated by introducing 250μg of granulated saccharin through a plastic straw, under visual control, approximately 2cm into the right nostril. Subjects were instructed not to walk, talk, cough, sneeze, scratch or blow their nose, and to swallow a few times per minute until they felt a flavor in their mouth; at which point the patient immediately gestured to the examiner and the time was recorded. The subjects were instructed not to use drugs, such as anesthetics, barbiturates, analgesics, anxiolytics and antidepressants and to avoid alcoholic or caffeine-based substances for a minimum of 12h prior to the measurement.<a class="elsevierStyleCrossRef" href="#bib0330">25</a>Training protocolBoth groups followed the training programs for 12 weeks (3 times per week), totaling 36 training sessions of approximately 60min duration. At the beginning and at the end of each session, vital signs were verified and stretching of the trained muscle groups was carried out. For each RT exercise a RM test was performed (using elastic tubing in the GET and using conventional weight machine in the GCT). Familiarization to the exercises took place prior to the start of training on each separate visit.Training was performed in a periodized and progressive form.<a class="elsevierStyleCrossRef" href="#bib0280">15</a> The distribution of the dynamics of the training conducted for the GET and GCT groups were as follows: Training conducted according to the dynamics of the exercise: 1st to 3rd weeks: 2×15 RM; 4th to 6th weeks: 3×15 RM; 7th to 9th weeks: 3×10 RM; 10th to 12th weeks: 4×6 RM.The repetition maximum (RM) testThe RM test was used for both groups to determine initial workload as well as progression over the sessions and it was performed at the beginning of each session. Participants performed the RM test to verify the maximum number of repetitions they could do with a given load. The load would be maintained for that session when the maximum number of repetitions performed was (according to the dynamics of the exercise) ±2, it would be otherwise adjusted to achieve the expected number of repetitions23, thus with the 1st week: 15 RM (15±2 repetitions), 7thweek: 10 RM (10±2 repetitions) until 12th week: 6 RM (6±2 repetitions). The load was adjusted (via increase/decrease of weight in GCT and via change of tube resistance in GET) until resistance permitted 15 repetitions.RT with elastic tubingElastic tubing was used for the training in the GET. Different tubes with progressive resistance were used in such a way that the higher the reference number, the higher the diameter (and hence, the resistance) of the tube (#200, #201, #202, #203 and #204, Lemgruber©, Brazil<a class="elsevierStyleCrossRef" href="#bib0335">26</a>). Exercises were performed using a specific chair that had an elastic tubing support fitting for each trained muscle group.<a class="elsevierStyleCrossRef" href="#bib0280">15</a>Additionally, metal rings, beams (plastic cable ties) to fix the elastic tubing to the rings were used. Based on a pilot study (unpublished data) we defined the initial selection of tube diameter for each movement using subjects’ dynamometry. The initial lengths of the tubing were determined according to the individual's distance from the upper or lower limb to the hook (fixed point) on the chair. Thus, the length of the tubing used for each patient was unique and remained the same for all sessions. Trained muscle groups were the same as those evaluated during dynamometry.Conventional resistance trainingThe weight machine equipment (Ipiranga®, Brazil) was used for the training of both upper and lower limb muscle groups. Simple pulley exercises were performed for elbow flexion, shoulder flexion and abduction (upper limbs), and a single-leg knee extension and flexion (lower limbs) in each session. Determination of load and training progression were a priori defined to be identical to the elastic tubing group. The training protocol followed the same method as the protocol described in the GET.Statistical analysisA statistical package (SPSS v.22, SPSS Inc., USA) was used for data analysis. Normal distribution of the data was evaluated using the Shapiro–Wilk test. The results are presented as mean values±standard deviations or as median [interquartile range 25–75%] according to the data distribution. ANOVA for repeated measures model in two-factor scheme was performed for each group to compare training effects. Data used for the repeated measurements was checked for violation of sphericity using the Mauchly test. The Greenhouse–Geisser correction was used when the sphericity was violated. Between groups comparisons for both baseline and training changes (Δ=baseline−12 weeks) were performed using the Student t test for independent samples (or Mann–Whitney test for nonparametric data). Categorical variables (training frequency) were analyzed using the chi-square test. The significance level was set at p<0.05.ResultsA complete overview of the study can be seen in <a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>. Twenty-eight subjects with COPD were included and allocated to one of the two groups. Nine subjects quit the study after randomization (three withdrew consent and six dropped out during the training). Eventually 19 subjects completed the study and were included in the analysis (convenience sample). All subjects completed more than 75% of training frequency, with no differences between groups (p>0.05).<elsevierMultimedia ident="fig0005"></elsevierMultimedia><a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> presents the sample characterization. No significant differences were found between the groups in any of the investigated outcomes at baseline. Lung function remained unchanged after interventions in both groups (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>) and the analysis of hemodynamic parameters showed a similar magnitude of changes between the two training groups (<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>).<elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia>In relation to the MCT analysis, no differences were observed between the baseline evaluations of the training groups (p>0.05). There was a significant reduction in the SST values after 12 weeks in GET and GCT (p=0.03) (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>), but no interaction between type of training and SST decrease (p=0.97) and no differences between groups were observed on the magnitude of SST changes after interventions (p=0.97).<elsevierMultimedia ident="fig0010"></elsevierMultimedia>DiscussionThe results of this study indicate significant improvements in MCT after RT in subjects with COPD in both conventional method (weight training), and the elastic tubing method. This is the first study up until now to analyze the effects of RT on the mucociliary system of subjects with COPD.It has been shown that physical exercise is essential for improving airway clearance of subjects with COPD. It is particularly important as the dysfunction of this mechanism causes hypersecretion leading to lung infections and exacerbations and hospitalization.<a class="elsevierStyleCrossRefs" href="#bib0225">4,5,8</a>Few studies in the literature investigated the chronic effects of exercise on MCT. Leite et al. were the only ones to investigate the chronic effect of exercise on MCT in patients with COPD.<a class="elsevierStyleCrossRef" href="#bib0340">27</a> They observed that MCT did not change after 12 weeks of aerobic training. Similarly, Salh et al. performed 8 weeks of aerobic training in patients with cystic fibrosis and concluded that aerobic training had no effect on mucociliary clearance, using an indirect measurement of MCT (i.e. amount of mucus expectoration).<a class="elsevierStyleCrossRef" href="#bib0300">19</a>Essentially exercise induces an increase in the autonomic nervous system activity, release of adrenergic mediators, increases ventilation and respiratory rate, which causes an increase in the velocity of MCT. These phenomena occur consistently in different populations (i.e. athletes aged between 18 and 37 years,<a class="elsevierStyleCrossRef" href="#bib0345">28</a> smokers and nonsmokers with an average age of 40 years<a class="elsevierStyleCrossRef" href="#bib0350">29</a>). Furthermore, two cross-sectional studies,<a class="elsevierStyleCrossRefs" href="#bib0355">30,31</a> have pointed out that for individuals with normal lung function, MCT is more efficient in physically active individuals than in those insufficiently active. The chronic effects of regular exercise, however, remain unclear.It is believed that the improvement in MCT observed in the present study may be related to the behavior of the autonomic nervous system after a period of RT. There is evidence that the autonomic function is impaired in COPD and that exercise has positive effects on it.<a class="elsevierStyleCrossRefs" href="#bib0365">32,33</a> RT induces an overall improvement in the parasympathetic and sympathetic components of the autonomic nervous system.<a class="elsevierStyleCrossRefs" href="#bib0375">34,35</a> Underlying mechanisms of autonomic improvement in these subjects after RT are yet to be clarified. Factors such as the reduction in circulating norepinephrine may be attributed to this improvement.Additionally, it is important to mention that there were similar improvements in the peripheral muscle strength between the groups (data not shown). Due to the important relation between muscle strength and autonomic function in subjects with COPD,<a class="elsevierStyleCrossRef" href="#bib0385">36</a> it could be hypothesized that improvements in muscle function are partly responsible for the improvements in the autonomic nervous system. Since the mucociliary system is regulated by the autonomic nervous system,<a class="elsevierStyleCrossRef" href="#bib0390">37</a> it is believed that the possible improvement in autonomic modulation could influence improved MCT values.Another hypothesis for the improvements in MCT is related to low-grade chronic inflammation. Most of the subjects included in the study were ex-smokers. It is known that the toxic substances released by the cigarette promote local inflammation in the respiratory tract,<a class="elsevierStyleCrossRefs" href="#bib0395">38,39</a> causing damage that can affect mucociliary function.<a class="elsevierStyleCrossRef" href="#bib0405">40</a> When smokers give up there can be reversibility of mucociliary function after 15 days of abstinence from smoking.<a class="elsevierStyleCrossRef" href="#bib0410">41</a> However, when COPD is present, the chronic low-grade inflammation could impair this reparative process. As RT is able to decrease the proinflammatory profile of subjects with COPD,<a class="elsevierStyleCrossRef" href="#bib0285">16</a> we speculate that the anti-inflammatory “millie” generated by chronic exercise training may help in some way to repair the mucociliary function of these subjects. Future studies are warranted in this area to clarify the possible associations between the outcomes of chronic exercise and MCT in COPD.The reduced sample size and absence of a control group may be considered limitations of the study. With the limited sample, it was not possible to verify differences in subgroups of subjects according to COPD severity. Further studies investigating this specific issue are warranted. Another limitation would be that we did not include the effects of RT on outcomes such as cough and sputum, since both are related to MTC.<a class="elsevierStyleCrossRefs" href="#bib0225">4,5</a> However, it is important to note that the data presented in this study are secondary analyzes of a larger project which presents other variables demonstrating the effects of training with elastic tubing.In conclusion, the present study demonstrated that both RT with elastic tubing and conventional training promoted similar gains in the mucociliary transportability of subjects with COPD. Future research needs to approach the chronic effects of exercise on mucociliary clearance in subjects with COPD, in order to clarify the physiological mechanisms that influence this process.FundingThis study was supported by the National Council of Scientific Researches (CNPq) [Grant number: 470742/2014-3]. BSAS is funded by CAPES/Brazil.Conflicts of interestThe authors declare that they have no conflict of interest." "textoCompletoSecciones" => array:1 [ "secciones" => array:10 [ 0 => array:3 [ "identificador" => "xres1261482" "titulo" => "Abstract" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Objective" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Methods" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Results" ] 4 => array:2 [ "identificador" => "abst0025" "titulo" => "Conclusion" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1168233" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 3 => array:3 [ "identificador" => "sec0010" "titulo" => "Methods" "secciones" => array:8 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Design of the study" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Pulmonary function test" ] 2 => array:2 [ "identificador" => "sec0025" "titulo" => "Measurement of hemodynamic parameters" ] 3 => array:2 [ "identificador" => "sec0030" "titulo" => "Measurement of nasal mucociliary transport (saccharin transit time)" ] 4 => array:2 [ "identificador" => "sec0035" "titulo" => "Training protocol" ] 5 => array:2 [ "identificador" => "sec0040" "titulo" => "The repetition maximum (RM) test" ] 6 => array:2 [ "identificador" => "sec0045" "titulo" => "RT with elastic tubing" ] 7 => array:2 [ "identificador" => "sec0050" "titulo" => "Conventional resistance training" ] ] ] 4 => array:2 [ "identificador" => "sec0055" "titulo" => "Statistical analysis" ] 5 => array:2 [ "identificador" => "sec0060" "titulo" => "Results" ] 6 => array:2 [ "identificador" => "sec0065" "titulo" => "Discussion" ] 7 => array:2 [ "identificador" => "sec0070" "titulo" => "Funding" ] 8 => array:2 [ "identificador" => "sec0075" "titulo" => "Conflicts of interest" ] 9 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2018-06-18" "fechaAceptado" => "2019-01-07" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1168233" "palabras" => array:5 [ 0 => "Mucociliary clearance" 1 => "Resistance training" 2 => "Exercise therapy" 3 => "Chronic obstructive pulmonary disease" 4 => "Lung diseases" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "IntroductionElastic tubing was recently investigated as an alternative to the conventional resistance training (RT) in chronic obstructive pulmonary disease (COPD). The effects of RT on the mucociliary system have not yet been reported in the literature. ObjectiveThe aim of this study was to evaluate the effects of two RT programs on mucociliary clearance in subjects with COPD. MethodsTwentyeight subjects with COPD were randomly allocated by strata, according to individual strength of lower limbs, to defined groups: conventional resistance training (GCT) or resistance training using elastic tubing (GET). Nineteen subjects (GET: n=9; GCT: n=10) completed the study and were included in the analysis. The measurement of vital signs (blood pressure, heart rate and respiratory rate), lung function (spirometry) and the primary outcome mucociliary clearance analysis (saccharin transit time test (STT)) were performed before and after the 12 weeks of RT. ResultsIn relation to the mucociliary transportability analysis, no differences were observed between the baseline evaluations of the training groups (p=0.05). There was a significant reduction in the STT values in both training groups, GET (10.64±5.06 to 6.01±4.91) and GCT (12.07±5.10 to 7.36±2.54) with p=0.03. However, no differences between groups were observed on the magnitude of SST changes after interventions (GET: −43.51%; GCT: −38.94%; p=0.97). ConclusionThe present study demonstrated that both RT with elastic tubing and conventional training with weights promoted similar gains in the mucociliary transportability of subjects with COPD." "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Objective" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Methods" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Results" ] 4 => array:2 [ "identificador" => "abst0025" "titulo" => "Conclusion" ] ] ] ] "multimedia" => array:5 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2263 "Ancho" => 2500 "Tamanyo" => 301563 ] ] "descripcion" => array:1 [ "en" => "Consort flow diagram. GET: training with elastic tubing and GCT: training with weight training equipment." ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 792 "Ancho" => 1263 "Tamanyo" => 49029 ] ] "descripcion" => array:1 [ "en" => "Comparison of the mucociliary transportability values before and after resistance training of 12 weeks. Data expressed as mean and standard deviation. STT: saccharin transit time; GET: training with elastic tubings; GCT: training with weight training equipment; *: significant difference between initial and final evaluation (p=0.03)." ] ] 2 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "GET, training with elastic tubings and GCT, conventional; BMI: body mass index; FEV1: forced expiratory volume in one second; FVC: forced vital capacity; STT: saccharin transit time." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">GET (n=14) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">GCT (n=14) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p value \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Anthropometry</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Age (years) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">65±8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">63±9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.40 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">BMI (kg/m2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">27.31±6.24 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">27.95±4.91 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.68 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Pulmonary function</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">FEV1 (L) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.12±0.49 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.61±0.51 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.18 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">FEV1 (% pred) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">45.15±16.21 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">57.58±16.25 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.12 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">FVC (L) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.14±0.89 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.94±0.69 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.32 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">FVC (% pred) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">64.65±19.03 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">79.95±11.51 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.10 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">FEV1/FVC \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">54.77±11.20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">55.98±15.16 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.85 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Mucociliary transport</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">STT (min) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10.64±5.06 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12.07±5.10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.55 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2157886.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Anthropometric, pulmonary function and mucociliary transport of the evaluated groups, expressed as mean and standard deviation." ] ] 3 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at2" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:3 [ "leyenda" => "Data expressed as mean and standard deviation or median and median and interquartile range of 25–75%. Δ(12−0 weeks): difference between (final minus initial evaluations)." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Baseline \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">12 weeks \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p<a class="elsevierStyleCrossRef" href="#tblfn0005">†</a> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Δ(12−0 weeks) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p<a class="elsevierStyleCrossRef" href="#tblfn0010">‡</a> \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">FEV1 (L)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">GCT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.76±0.47 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.71±0.51 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Time \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.59 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.05±0.14 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.20 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">GET \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.15±0.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.22±0.48 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Group×time \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.21 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.02±0.09 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">FEV1 (% pred)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">GCT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">64.22±11.76 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">62.02±11.91 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Time \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.45 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−2.2±5.56 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.21 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">GET \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">42.67±13.56 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">43.89±14.19 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Group×time \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.23 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.46±2.61 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">FVC (L)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">GCT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.946±0.77 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.88±0.81 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Time \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.87 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.07±0.23 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.48 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">GET \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.25±0.85 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.4±0.73 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Group×time \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.50 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.04±0.38 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">FVC (% pred)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">GCT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">82.59±11.79 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">79.70±9.97 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Time \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.73 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−2.89±7.51 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.41 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">GET \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">64.67±18.21 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">68.03±17.89 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Group×time \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.43 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.02±12.44 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">FEV1/FVC (%)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">GCT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">61.37±12.66 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">60.75±12.30 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Time \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.95 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.62±2.76 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.60 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">GET \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">52.03±10.45 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">50.84±11.15 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Group×time \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.60 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.44±5.56 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">FEF25–75% (L)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">GCT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.89 (0.71–1.44) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.85 (0.70–0.39) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Time \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.23 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.07±0.14 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.33 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">GET \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.57 (0.43–0.65) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.53 (0.48–0.65) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Group×time \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.38 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.01±0.10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">FEF25–75% (% pred)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">GCT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">43 (30.37–50.25) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">41.50 (28.50–48.75) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Time \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.32 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−2.35±5.29 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.27 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">GET \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">21 (17–26) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">21.25 (17.50–27.75) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Group×time \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.29 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.06±3.66 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">PEF (L)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">GCT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.65 (3.21–6.76) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.18 (3.20–7.78) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Time \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.39 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.58±1.07 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.06 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">GET \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.86 (2.14–3.94) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.03 (2.28–3.85) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Group×time \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.07 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.20±0.45 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">PEF (% pred)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">GCT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">56.53±21.73 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">56.97±18.13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Time \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.55 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.44±10.23 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.44 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">GET \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">42.56±17.71 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">41.30±15.50 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Group×time \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.42 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−2.51±4.40 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2157887.png" ] ] ] "notaPie" => array:2 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "†" "nota" => "Analysis of variance technique for a repeated measures model in two-factor scheme." ] 1 => array:3 [ "identificador" => "tblfn0010" "etiqueta" => "‡" "nota" => "Student t test for parametric distributions." ] ] ] "descripcion" => array:1 [ "en" => "Comparison of spirometric values before and after physical training (GET (n=9), training with elastic tubings and GCT (n=10), training with weight equipment)." ] ] 4 => array:8 [ "identificador" => "tbl0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at3" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:3 [ "leyenda" => "Data expressed as mean and standard deviation or median and median and interquartile range of 25–75%. Δ(12−0 weeks): difference between (final minus initial evaluations); SBP: systolic blood pressure; DBP: diastolic blood pressure; HR: heart rate; RR: Respiratory rate; mmHg: millimeters of mercury; bpm: beats per minute; ipm: incursions per minute." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Baseline \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">12 weeks \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p<a class="elsevierStyleCrossRef" href="#tblfn0015">†</a> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Δ(12−0 weeks) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p<a class="elsevierStyleCrossRef" href="#tblfn0020">‡</a> \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">SBP (mmHg)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">GCT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">120 (117.50–130) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">120 (110–120) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Time \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−4.00±10.74 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.95 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">GET \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">120 (105–135) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">120 (110–120) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Group×time \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.94 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−4.44±16.66 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">DBP (mmHg)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">GCT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">80 (70–90) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">75 (67.50–80) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Time \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.19 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−5.00±12.69 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.60 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">GET \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">70 (70–80) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">70 (70–75) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Group×time \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−2.22±9.71 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">HR (bpm)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">GCT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">71.40±6.43 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">68.90±9.85 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Time \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.97 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−2.50±10.12 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.28 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">GET \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">74.11±8.82 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">76.78±8.90 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Group×time \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.28 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.66±10.19 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">RR (ipm)</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">GCT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">19.60±3.63 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17.60±3.50 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Time \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−2.00±4.21 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.88 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">GET \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">18.78±±4.35 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17.11±2.67 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Group×time \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.88 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−1.66±5.00 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2157888.png" ] ] ] "notaPie" => array:2 [ 0 => array:3 [ "identificador" => "tblfn0015" "etiqueta" => "†" "nota" => "Analysis of variance technique for a repeated measures model in two-factor scheme." ] 1 => array:3 [ "identificador" => "tblfn0020" "etiqueta" => "‡" "nota" => "Student t test for parametric distributions." ] ] ] "descripcion" => array:1 [ "en" => "Comparison of hemodynamic parameters before and after physical training (GET (n=9), training with elastic tubings and GCT (n=10), training with weight equipment)." ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:41 [ 0 => array:3 [ "identificador" => "bib0210" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "An official American Thoracic Society/European Respiratory Society statement: update on limb muscle dysfunction in chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F. Maltais" 1 => "M. Decramer" 2 => "R. Casaburi" 3 => "E. Barreiro" 4 => "Y. Burelle" 5 => "R. Debigare" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.201402-0373ST" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2014" "volumen" => "189" "paginaInicial" => "e15" "paginaFinal" => "e62" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24787074" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0215" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tissue depletion and health related quality of life in patients with chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R. Mostert" 1 => "A. Goris" 2 => "C. Weling-Scheepers" 3 => "E.F. Wouters" 4 => "A.M. Schols" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1053/rmed.2000.0829" "Revista" => array:6 [ "tituloSerie" => "Respir Med" "fecha" => "2000" "volumen" => "94" "paginaInicial" => "859" "paginaFinal" => "867" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11001077" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0220" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Muscle weakness is related to utilization of health care resources in COPD patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Decramer" 1 => "R. Gosselink" 2 => "T. Troosters" 3 => "M. Verschueren" 4 => "G. Evers" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1183/09031936.97.10020417" "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "1997" "volumen" => "10" "paginaInicial" => "417" "paginaFinal" => "423" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9042643" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0225" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Improving mucociliary clearance in chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Bhowmik" 1 => "K. Chahal" 2 => "G. Austin" 3 => "I. Chakravorty" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.rmed.2008.10.014" "Revista" => array:6 [ "tituloSerie" => "Respir Med" "fecha" => "2009" "volumen" => "103" "paginaInicial" => "496" "paginaFinal" => "502" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19091536" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0230" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Regional impairment of mucociliary clearance in chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "G.C. Smaldone" 1 => "W.M. Foster" 2 => "T.G. O’Riordan" 3 => "M.S. Messina" 4 => "R.J. Perry" 5 => "E.G. Langenback" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.103.5.1390" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1993" "volumen" => "103" "paginaInicial" => "1390" "paginaFinal" => "1396" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8486016" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0235" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "[Saccharin test for the study of mucociliary clearance: reference values for a Spanish population]" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "P. Plaza Valia" 1 => "F. Carrion Valero" 2 => "J. Marin Pardo" 3 => "D. Bautista Rentero" 4 => "C. Gonzalez Monte" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2008" "volumen" => "44" "paginaInicial" => "540" "paginaFinal" => "545" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19006634" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0240" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "comparison of nasal and tracheobronchial clearance" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "I. Andersen" 1 => "P. Camner" 2 => "P.L. Jensen" 3 => "K. Philipson" 4 => "D.F.A. Proctor" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1080/00039896.1974.10666589" "Revista" => array:6 [ "tituloSerie" => "Arch Environ Health" "fecha" => "1974" "volumen" => "29" "paginaInicial" => "290" "paginaFinal" => "293" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4472935" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0245" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Métodos de estudo do transporte mucociliar" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S.H.K. Trindade" 1 => "J.L. Mello Júnior" 2 => "M. Macchione" 3 => "E.T. Guimarães" 4 => "P.H.N. Saldiva" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rev Bras Otorrinolaringol" "fecha" => "2007" "volumen" => "73" "paginaInicial" => "704" "paginaFinal" => "712" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0250" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mucociliary clearance – a critical upper airway host defense mechanism and methods of assessment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.B. Antunes" 1 => "N.A. Cohen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/ACI.0b013e3280114eef" "Revista" => array:6 [ "tituloSerie" => "Curr Opin Allergy Clin Immunol" "fecha" => "2007" "volumen" => "7" "paginaInicial" => "5" "paginaFinal" => "10" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17218804" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0255" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Padronização dos critérios de seleção em estudos sobre medicações nasais" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A. Borin" 1 => "E. Abib Junior" 2 => "C.I. Araujo" 3 => "L.L. Martinez" 4 => "H. Rodrigues" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/s1808-8694(15)30552-8" "Revista" => array:6 [ "tituloSerie" => "Braz J Otorhinolaryngol" "fecha" => "2009" "volumen" => "75" "paginaInicial" => "872" "paginaFinal" => "878" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20209290" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0260" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pulmonary rehabilitation and exercise training in chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R. Gloeckl" 1 => "T. Schneeberger" 2 => "I. Jarosch" 3 => "K. Kenn" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Deut Ärztebl Int" "fecha" => "2018" "volumen" => "115" "paginaInicial" => "117" "paginaFinal" => "123" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0265" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of 2 exercise training programs on physical activity in daily life in patients with COPD" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "V.S. Probst" 1 => "D. Kovelis" 2 => "N.A. Hernandes" 3 => "C.A. Camillo" 4 => "V. Cavalheri" 5 => "F. Pitta" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4187/respcare.01110" "Revista" => array:6 [ "tituloSerie" => "Respir Care" "fecha" => "2011" "volumen" => "56" "paginaInicial" => "1799" "paginaFinal" => "1807" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22035826" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0270" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Impact of resistance training in subjects with COPD: a systematic review and meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "W.H. Liao" 1 => "J.W. Chen" 2 => "X. Chen" 3 => "L. Lin" 4 => "H.Y. Yan" 5 => "Y.Q. Zhou" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4187/respcare.03598" "Revista" => array:6 [ "tituloSerie" => "Respir Care" "fecha" => "2015" "volumen" => "60" "paginaInicial" => "1130" "paginaFinal" => "1145" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26015595" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0275" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The effects of elastic tubing-based resistance training compared with conventional resistance training in patients with moderate chronic obstructive pulmonary disease: a randomized clinical trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E.M. Ramos" 1 => "A.C. de Toledo-Arruda" 2 => "L.C. Fosco" 3 => "R. Bonfim" 4 => "G.N. Bertolini" 5 => "F.A. Guarnier" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1177/0269215514527842" "Revista" => array:6 [ "tituloSerie" => "Clin Rehabil" "fecha" => "2014" "volumen" => "28" "paginaInicial" => "1096" "paginaFinal" => "1106" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24647863" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0280" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of a resistance training with elastic tubing in strength, quality of life and dypsnea in patients with chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "B.S.A. Silva" 1 => "L.A. Gobbo" 2 => "A.P.C.F. Freire" 3 => "I.B. Trevisan" 4 => "I.G. Silva" 5 => "E.M.C. Ramos" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "J Phys Educ" "fecha" => "2016" "paginaInicial" => "27" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0285" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inflammatory and metabolic responses to different resistance training on chronic obstructive pulmonary disease: a randomized control trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B.S.A. Silva" 1 => "F.S. Lira" 2 => "F.E. Rossi" 3 => "D. Ramos" 4 => "J.S. Uzeloto" 5 => "A. Freire" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3389/fphys.2018.00262" "Revista" => array:5 [ "tituloSerie" => "Front Physiol" "fecha" => "2018" "volumen" => "9" "paginaInicial" => "262" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29628896" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0290" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Resistance training using low cost elastic tubing is equally effective to conventional weight machines in middle-aged to older healthy adults: a quasi-randomized controlled clinical trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F.F. Lima" 1 => "C.A. Camillo" 2 => "L.A. Gobbo" 3 => "I.B. Trevisan" 4 => "W. Nascimento" 5 => "B.S.A. Silva" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Sports Sci Med" "fecha" => "2018" "volumen" => "17" "paginaInicial" => "153" "paginaFinal" => "160" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29535589" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0295" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Muscle fatigue induced by two different resistances: elastic tubing versus weight machines" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G. Melchiorri" 1 => "A. Rainoldi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jelekin.2011.07.015" "Revista" => array:6 [ "tituloSerie" => "J Electromyogr Kinesiol" "fecha" => "2011" "volumen" => "21" "paginaInicial" => "954" "paginaFinal" => "959" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21920774" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0300" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of exercise and physiotherapy in aiding sputum expectoration in adults with cystic fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "W. Salh" 1 => "D. Bilton" 2 => "M. Dodd" 3 => "A.K. Webb" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/thx.44.12.1006" "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "1989" "volumen" => "44" "paginaInicial" => "1006" "paginaFinal" => "1008" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2617441" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0305" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Guidelines for the physiotherapy management of the adult, medical, spontaneously breathing patient" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Bott" 1 => "S. Blumenthal" 2 => "M. Buxton" 3 => "S. Ellum" 4 => "C. Falconer" 5 => "R. Garrod" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/thx.2008.110726" "Revista" => array:7 [ "tituloSerie" => "Thorax" "fecha" => "2009" "volumen" => "64" "numero" => "Suppl. 1" "paginaInicial" => "i1" "paginaFinal" => "i51" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19406863" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0310" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Impaired nasal mucociliary clearance in long-distance runners" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "G. Muns" 1 => "P. Singer" 2 => "F. Wolf" 3 => "I. Rubinstein" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1055/s-2007-972993" "Revista" => array:6 [ "tituloSerie" => "Int J Sports Med" "fecha" => "1995" "volumen" => "16" "paginaInicial" => "209" "paginaFinal" => "213" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7657412" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0315" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Analysis of autonomic modulation after an acute session of resistance exercise at different intensities in chronic obstructive pulmonary disease patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Nicolino" 1 => "D. Ramos" 2 => "M.R. Leite" 3 => "F.M. Rodrigues" 4 => "B.S. de Alencar Silva" 5 => "G.Y. Tacao" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2147/COPD.S64345" "Revista" => array:6 [ "tituloSerie" => "Int J Chron Obstruct Pulmon Dis" "fecha" => "2015" "volumen" => "10" "paginaInicial" => "223" "paginaFinal" => "229" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25673982" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0320" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Strength training improves fall-related gait kinematics in the elderly: a randomized controlled trial" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "L.N. Persch" 1 => "C. Ugrinowitsch" 2 => "G. Pereira" 3 => "A.L. Rodacki" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Clin Biomech (Bristol, Avon)" "fecha" => "2009" "volumen" => "24" "paginaInicial" => "819" "paginaFinal" => "825" ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0325" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Standardisation of spirometry" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.R. Miller" 1 => "J. Hankinson" 2 => "V. Brusasco" 3 => "F. Burgos" 4 => "R. Casaburi" 5 => "A. Coates" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Eur Respir J" "fecha" => "2005" "volumen" => "26" "paginaInicial" => "319" "paginaFinal" => "338" ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0330" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nasal mucociliary transport in healthy subjects is slower when breathing dry air" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "B. Salah" 1 => "A.T. Dinh Xuan" 2 => "J.L. Fouilladieu" 3 => "A. Lockhart" 4 => "J. Regnard" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "1988" "volumen" => "1" "paginaInicial" => "852" "paginaFinal" => "855" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3229484" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0335" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mechanical properties, safety and resistance values of Lemgruber((R)) elastic tubing." "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F.F. Lima" 1 => "C.A. Camillo" 2 => "E. Reis" 3 => "A.E. Job" 4 => "B.S.A. Silva" 5 => "M. Topalovic" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.bjpt.2018.07.001" "Revista" => array:6 [ "tituloSerie" => "Braz J Phys Ther" "fecha" => "2018" "volumen" => "23" "paginaInicial" => "41" "paginaFinal" => "47" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30077519" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0340" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of 12 weeks of aerobic training on autonomic modulation, mucociliary clearance, and aerobic parameters in patients with COPD" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.R. Leite" 1 => "E.M. Ramos" 2 => "C.A. Kalva-Filho" 3 => "A.P. Freire" 4 => "B.S. de Alencar Silva" 5 => "J. Nicolino" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2147/COPD.S81363" "Revista" => array:6 [ "tituloSerie" => "Int J Chron Obstruct Pulmon Dis" "fecha" => "2015" "volumen" => "10" "paginaInicial" => "2549" "paginaFinal" => "2557" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26648712" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0345" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "[Mucociliary clearance after aerobic exertion in athletes]" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "F.A. Salzano" 1 => "M. Manola" 2 => "D. Tricarico" 3 => "D. Precone" 4 => "G. Motta" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Acta Otorhinolaryngol Ital" "fecha" => "2000" "volumen" => "20" "paginaInicial" => "171" "paginaFinal" => "176" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11139875" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0350" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nasal mucociliary clearance in subjects with COPD after smoking cessation" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.T. Ito" 1 => "D. Ramos" 2 => "F.F. Lima" 3 => "F.M. Rodrigues" 4 => "P.R. Gomes" 5 => "G.L. 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Cavalheri" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00408-008-9105-7" "Revista" => array:6 [ "tituloSerie" => "Lung" "fecha" => "2008" "volumen" => "186" "paginaInicial" => "393" "paginaFinal" => "401" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18815834" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib0390" "etiqueta" => "37" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Autonomic control and mucociliary functions" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A. Wanner" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.91.1.49" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1987" "volumen" => "91" "paginaInicial" => "49" "paginaFinal" => "51" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3792086" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib0395" "etiqueta" => "38" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathophysiology of airflow limitation in chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.C. 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Gerhart" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Inhal Toxicol" "fecha" => "1998" "volumen" => "10" "paginaInicial" => "857" "paginaFinal" => "873" ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib0410" "etiqueta" => "41" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reversibility of impaired nasal mucociliary clearance in smokers following a smoking cessation programme" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E.M. Ramos" 1 => "A.C. De Toledo" 2 => "R.F. Xavier" 3 => "L.C. Fosco" 4 => "R.P. Vieira" 5 => "D. 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Original article

Resistance exercise training improves mucociliary clearance in subjects with COPD: A randomized clinical trial

B.S.A. Silvaa, D. Ramosb, G.N. Bertolinia, A.P.C.F. Freireb, M.R. Leiteb, C.A. Camilloc, L.A. Gobboa, E.M.C. Ramosb,

Corresponding author

ercy@bol.com.br

Corresponding author.

a Skeletal Muscle Assessment Laboratory, Department of Physical Education, São Paulo State University (UNESP), Presidente Prudente, Brazil

b Department of Physical Therapy, São Paulo State University (UNESP), Presidente Prudente, SP, Brazil

c Doctoral Program in Rehabilitation Sciences, State University of Londrina (UEL), Brazil

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          "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Consort flow diagram&#46; GET&#58; training with elastic tubing and GCT&#58; training with weight training equipment&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Peripheral muscle dysfunction is a prevalent condition in patients with chronic obstructive pulmonary disease &#40;COPD&#41;&#46; Common features include reduced muscle strength and endurance&#44; muscle atrophy and poor oxidative capacity&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">1</span></a> This muscle dysfunction is directly related to exercise intolerance&#44; impaired health-related quality of life<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">2</span></a> and involves increased use of health care resources&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">In addition to peripheral muscle dysfunction subjects with COPD may present impairment in mucociliary clearance&#44; an essential mechanism of pulmonary defense&#46; Mucociliary clearance removes inhaled particles and microorganisms from the respiratory tract&#46;<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">4&#44;5</span></a> Dysfunction of this mechanism causes hypersecretion leading to lung infections and exacerbations&#46;<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The efficiency of mucociliary clearance can be analyzed by the velocity of nasal mucociliary transport &#40;MCT&#41; and is well correlated with tracheobronchial transport<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">6&#44;7</span></a> which requires more invasive procedures to assess&#46; MCT is measured using substances with a characteristic flavor&#44; for example&#44; the saccharin transit time &#40;STT&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">6&#8211;9</span></a> STT test has been widely reported in previous studies as being simple&#44; valid and reliable with similar results to those obtained with the use of radioisotope particles for MCT analysis&#46;<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">6&#44;10</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Pulmonary rehabilitation &#40;PR&#41; in subjects with COPD is supported by the highest-level of evidence&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">11</span></a> Resistance training &#40;RT&#41; is an important component in improving muscle strength&#44; activities of daily living and functional exercise capacity and reducing fatigue and dyspnea symptoms&#46;<a class="elsevierStyleCrossRefs" href="#bib0210"><span class="elsevierStyleSup">1&#44;12&#44;13</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">RT protocols routinely include weight machines and free weights in standard proposals&#44; however elastic tubing &#40;ET&#41; was recently investigated as an alternative to the conventional RT for subjects with COPD&#46; Studies with elastic devices have demonstrated similar benefits to conventional training<a class="elsevierStyleCrossRefs" href="#bib0275"><span class="elsevierStyleSup">14&#8211;17</span></a> with the added advantage of being portable&#44; and inexpensive&#46;<a class="elsevierStyleCrossRefs" href="#bib0275"><span class="elsevierStyleSup">14&#44;17</span></a> The linear increase of resistance occurring in ET is less harmful to the joints&#44; and provides a greater recruitment of motor units when compared to the conventional resistance training&#46;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">18</span></a> This is particularly interesting for patients with muscle dysfunction like COPD&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">There is evidence that aerobic exercise improves the mucociliary system by altering the viscosity of nasal mucus&#44; thus can be recommended as an adjunctive treatment to respiratory physiotherapy techniques&#46;<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">4&#44;19&#44;20</span></a> This type of exercise increases the levels of adrenergic mediators that contribute to changes in mucociliary clearance during or after exercise&#46;<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">21</span></a> Although the effects of RT on mucociliary system have not yet been reported&#44; it is reasonable to hypothesize that it has a positive influence on mucociliary clearance as RT modulates changes in the autonomic control in subjects with COPD&#46;<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">22</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Knowing the effects of RT on MCT in subjects with COPD is essential for health professionals involved in pulmonary rehabilitation for COPD&#46; MCT is the first line of defense of the respiratory system against aggressor agents and irritants&#46; The maintenance of its integrity&#44; therefore&#44; is necessary to reduce the risk of respiratory infections and hospitalizations in COPD&#46;<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">4&#44;19</span></a> Furthermore&#44; such knowledge could lead to strategies to improve mucociliary clearance in subjects with COPD&#46; Therefore&#44; the aim of this study was to evaluate the effects of two RT programs on mucociliary clearance in subjects with COPD&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Design of the study</span><p id="par0040" class="elsevierStylePara elsevierViewall">Initially&#44; subjects referred to an outpatient pulmonary rehabilitation program were screened for inclusion in this randomized&#44; parallel group&#44; clinical trial&#46; COPD diagnosis was made according to internationally accepted criteria&#46;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">18</span></a> Patients included should be clinically stable &#40;i&#46;e&#46; absence of exacerbation in the month before inclusion&#41; and have quit smoking for at least one year prior to the inclusion&#46; Subjects were excluded if they presented nasal trauma or deviated septum&#44; unstable severe cardiac disease or musculoskeletal disorders that hindered the implementation of the experimental protocol&#46; Recruitment and follow-up of individuals was conducted between 2014 and 2015 in a specialized rehabilitation center in Presidente Prudente&#44; S&#227;o Paulo&#44; Brazil&#46; This clinical trial &#40;RBR-7KCR2P&#41; was approved by the local ethics committee &#40;CAAE&#58; 12492113&#46;5&#46;0000&#46;5402&#41; and all included subjects provided written consent form&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Twenty-eight subjects were randomly allocated to one of the two a priori defined groups&#58; Conventional RT &#40;GCT&#41; or RT using elastic tubing &#40;GET&#41;&#46; The randomization was performed by strata&#44;<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">23</span></a> where subjects were classified into quartiles according to individual strength of lower limbs &#40;i&#46;e&#46; isometric maximum voluntary contraction of the knee extensors&#41;&#46; Subjects in each quartile were numbered in brown envelopes and randomized into one of the 2 groups&#44; by a researcher unrelated to the study&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Although therapists and subjects were not blinded for the interventions&#44; data analysis was performed by a researcher who was not involved with the data collection&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">This study is part of a major project&#44; with knee extension strength defined as primary outcome &#40;data not shown&#41;&#46; Sample size calculation was done based on an equivalence study&#46; Twenty patients &#40;10 per group&#41; were needed to achieve a power of 80&#37;&#44; expecting a difference of 45<span class="elsevierStyleHsp" style=""></span>N between groups with a standard deviation of 36<span class="elsevierStyleHsp" style=""></span>N and taking into account a typical dropout rate of 20&#37;&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">The evaluations were performed before and after the 12 weeks of RT&#46; The initial evaluation took place in two days&#46; On the first day the identification and measurement of vital signs &#40;blood pressure&#44; heart rate and respiratory rate&#41; and lung function &#40;spirometry&#41; were performed&#46; To confirm abstinence from smoking&#44; the carbon monoxide concentration of the expired air was measured &#40;COex&#41;&#46; On the second day of the protocol&#44; the mucociliary transport analysis via the saccharin transit time test &#40;STT&#41; was performed&#46; Details of all the assessments are provided below&#46; To determine initial workload of training groups&#44; the repetition maximum &#40;RM&#41; test was performed on each subject on the first day of training protocols&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Pulmonary function test</span><p id="par0065" class="elsevierStylePara elsevierViewall">Pulmonary function was measured prior to the protocols of training by means of simple spirometry &#40;MIR-Spirobank v3&#46;6&#44; Italy&#41; in accordance with the standards of the <span class="elsevierStyleItalic">American Thoracic Society</span> &#40;ATS&#41; and <span class="elsevierStyleItalic">European Respiratory Society</span> &#40;ERS&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">24</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Measurement of hemodynamic parameters</span><p id="par0070" class="elsevierStylePara elsevierViewall">Respiratory rate was measured by observing the number of expansions of the rib cage&#44; watching the respiratory mechanics of the individual for 1<span class="elsevierStyleHsp" style=""></span>min&#46; Heart rate was determined using a heart rate monitor &#40;Polar S810i&#44; Finland&#41;&#46; The auscultation method was used to measure the blood pressure in the left arm&#44; using an aneroid sphygmomanometer and stethoscope &#40;BD&#44; Brazil&#41;&#46; All vital signs were collected after 20<span class="elsevierStyleHsp" style=""></span>min of initial resting&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Measurement of nasal mucociliary transport &#40;saccharin transit time&#41;</span><p id="par0075" class="elsevierStylePara elsevierViewall">The evaluation of mucociliary transport was done via the assessment of SST&#44; prior to the start of training and after a minimum of 48<span class="elsevierStyleHsp" style=""></span>h upon completion of the final training session&#44; following the measurements of hemodynamic parameters&#46; Subjects were seated with their heads over-extended at 10&#176;&#46; The SST test was initiated by introducing 250<span class="elsevierStyleHsp" style=""></span>&#956;g of granulated saccharin through a plastic straw&#44; under visual control&#44; approximately 2<span class="elsevierStyleHsp" style=""></span>cm into the right nostril&#46; Subjects were instructed not to walk&#44; talk&#44; cough&#44; sneeze&#44; scratch or blow their nose&#44; and to swallow a few times per minute until they felt a flavor in their mouth&#59; at which point the patient immediately gestured to the examiner and the time was recorded&#46; The subjects were instructed not to use drugs&#44; such as anesthetics&#44; barbiturates&#44; analgesics&#44; anxiolytics and antidepressants and to avoid alcoholic or caffeine-based substances for a minimum of 12<span class="elsevierStyleHsp" style=""></span>h prior to the measurement&#46;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">25</span></a></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Training protocol</span><p id="par0080" class="elsevierStylePara elsevierViewall">Both groups followed the training programs for 12 weeks &#40;3 times per week&#41;&#44; totaling 36 training sessions of approximately 60<span class="elsevierStyleHsp" style=""></span>min duration&#46; At the beginning and at the end of each session&#44; vital signs were verified and stretching of the trained muscle groups was carried out&#46; For each RT exercise a RM test was performed &#40;using elastic tubing in the GET and using conventional weight machine in the GCT&#41;&#46; Familiarization to the exercises took place prior to the start of training on each separate visit&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Training was performed in a periodized and progressive form&#46;<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">15</span></a> The distribution of the dynamics of the training conducted for the GET and GCT groups were as follows&#58; Training conducted according to the dynamics of the exercise&#58; 1st to 3rd weeks&#58; 2<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>15 RM&#59; 4th to 6th weeks&#58; 3<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>15 RM&#59; 7th to 9th weeks&#58; 3<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10 RM&#59; 10th to 12th weeks&#58; 4<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>6 RM&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">The repetition maximum &#40;RM&#41; test</span><p id="par0090" class="elsevierStylePara elsevierViewall">The RM test was used for both groups to determine initial workload as well as progression over the sessions and it was performed at the beginning of each session&#46; Participants performed the RM test to verify the maximum number of repetitions they could do with a given load&#46; The load would be maintained for that session when the maximum number of repetitions performed was &#40;according to the dynamics of the exercise&#41; &#177;2&#44; it would be otherwise adjusted to achieve the expected number of repetitions23&#44; thus with the 1st week&#58; 15 RM &#40;15<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2 repetitions&#41;&#44; 7thweek&#58; 10 RM &#40;10<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2 repetitions&#41; until 12th week&#58; 6 RM &#40;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2 repetitions&#41;&#46; The load was adjusted &#40;via increase&#47;decrease of weight in GCT and via change of tube resistance in GET&#41; until resistance permitted 15 repetitions&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">RT with elastic tubing</span><p id="par0095" class="elsevierStylePara elsevierViewall">Elastic tubing was used for the training in the GET&#46; Different tubes with progressive resistance were used in such a way that the higher the reference number&#44; the higher the diameter &#40;and hence&#44; the resistance&#41; of the tube &#40;&#35;200&#44; &#35;201&#44; &#35;202&#44; &#35;203 and &#35;204&#44; Lemgruber&#169;&#44; Brazil<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">26</span></a>&#41;&#46; Exercises were performed using a specific chair that had an elastic tubing support fitting for each trained muscle group&#46;<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">15</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">Additionally&#44; metal rings&#44; beams &#40;plastic cable ties&#41; to fix the elastic tubing to the rings were used&#46; Based on a pilot study &#40;unpublished data&#41; we defined the initial selection of tube diameter for each movement using subjects&#8217; dynamometry&#46; The initial lengths of the tubing were determined according to the individual&#39;s distance from the upper or lower limb to the hook &#40;fixed point&#41; on the chair&#46; Thus&#44; the length of the tubing used for each patient was unique and remained the same for all sessions&#46; Trained muscle groups were the same as those evaluated during dynamometry&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Conventional resistance training</span><p id="par0105" class="elsevierStylePara elsevierViewall">The weight machine equipment &#40;Ipiranga&#174;&#44; Brazil&#41; was used for the training of both upper and lower limb muscle groups&#46; Simple pulley exercises were performed for elbow flexion&#44; shoulder flexion and abduction &#40;upper limbs&#41;&#44; and a single-leg knee extension and flexion &#40;lower limbs&#41; in each session&#46; Determination of load and training progression were a priori defined to be identical to the elastic tubing group&#46; The training protocol followed the same method as the protocol described in the GET&#46;</p></span></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Statistical analysis</span><p id="par0110" class="elsevierStylePara elsevierViewall">A statistical package &#40;SPSS v&#46;22&#44; SPSS Inc&#46;&#44; USA&#41; was used for data analysis&#46; Normal distribution of the data was evaluated using the Shapiro&#8211;Wilk test&#46; The results are presented as mean values<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>standard deviations or as median &#91;interquartile range 25&#8211;75&#37;&#93; according to the data distribution&#46; ANOVA for repeated measures model in two-factor scheme was performed for each group to compare training effects&#46; Data used for the repeated measurements was checked for violation of sphericity using the <span class="elsevierStyleItalic">Mauchly</span> test&#46; The <span class="elsevierStyleItalic">Greenhouse&#8211;Geisser</span> correction was used when the sphericity was violated&#46; Between groups comparisons for both baseline and training changes &#40;&#916;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>baseline<span class="elsevierStyleHsp" style=""></span>&#8722;<span class="elsevierStyleHsp" style=""></span>12 weeks&#41; were performed using the Student <span class="elsevierStyleItalic">t</span> test for independent samples &#40;or Mann&#8211;Whitney test for nonparametric data&#41;&#46; Categorical variables &#40;training frequency&#41; were analyzed using the chi-square test&#46; The significance level was set at <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Results</span><p id="par0115" class="elsevierStylePara elsevierViewall">A complete overview of the study can be seen in <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#46; Twenty-eight subjects with COPD were included and allocated to one of the two groups&#46; Nine subjects quit the study after randomization &#40;three withdrew consent and six dropped out during the training&#41;&#46; Eventually 19 subjects completed the study and were included in the analysis &#40;convenience sample&#41;&#46; All subjects completed more than 75&#37; of training frequency&#44; with no differences between groups &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0120" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> presents the sample characterization&#46; No significant differences were found between the groups in any of the investigated outcomes at baseline&#46; Lung function remained unchanged after interventions in both groups &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41; and the analysis of hemodynamic parameters showed a similar magnitude of changes between the two training groups &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0125" class="elsevierStylePara elsevierViewall">In relation to the MCT analysis&#44; no differences were observed between the baseline evaluations of the training groups &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46; There was a significant reduction in the SST values after 12 weeks in GET and GCT &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;03&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#44; but no interaction between type of training and SST decrease &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;97&#41; and no differences between groups were observed on the magnitude of SST changes after interventions &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;97&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Discussion</span><p id="par0130" class="elsevierStylePara elsevierViewall">The results of this study indicate significant improvements in MCT after RT in subjects with COPD in both conventional method &#40;weight training&#41;&#44; and the elastic tubing method&#46; This is the first study up until now to analyze the effects of RT on the mucociliary system of subjects with COPD&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">It has been shown that physical exercise is essential for improving airway clearance of subjects with COPD&#46; It is particularly important as the dysfunction of this mechanism causes hypersecretion leading to lung infections and exacerbations and hospitalization&#46;<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">4&#44;5&#44;8</span></a></p><p id="par0140" class="elsevierStylePara elsevierViewall">Few studies in the literature investigated the chronic effects of exercise on MCT&#46; Leite et al&#46; were the only ones to investigate the chronic effect of exercise on MCT in patients with COPD&#46;<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">27</span></a> They observed that MCT did not change after 12 weeks of aerobic training&#46; Similarly&#44; Salh et al&#46; performed 8 weeks of aerobic training in patients with cystic fibrosis and concluded that aerobic training had no effect on mucociliary clearance&#44; using an indirect measurement of MCT &#40;i&#46;e&#46; amount of mucus expectoration&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">19</span></a></p><p id="par0145" class="elsevierStylePara elsevierViewall">Essentially exercise induces an increase in the autonomic nervous system activity&#44; release of adrenergic mediators&#44; increases ventilation and respiratory rate&#44; which causes an increase in the velocity of MCT&#46; These phenomena occur consistently in different populations &#40;i&#46;e&#46; athletes aged between 18 and 37 years&#44;<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">28</span></a> smokers and nonsmokers with an average age of 40 years<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">29</span></a>&#41;&#46; Furthermore&#44; two cross-sectional studies&#44;<a class="elsevierStyleCrossRefs" href="#bib0355"><span class="elsevierStyleSup">30&#44;31</span></a> have pointed out that for individuals with normal lung function&#44; MCT is more efficient in physically active individuals than in those insufficiently active&#46; The chronic effects of regular exercise&#44; however&#44; remain unclear&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">It is believed that the improvement in MCT observed in the present study may be related to the behavior of the autonomic nervous system after a period of RT&#46; There is evidence that the autonomic function is impaired in COPD and that exercise has positive effects on it&#46;<a class="elsevierStyleCrossRefs" href="#bib0365"><span class="elsevierStyleSup">32&#44;33</span></a> RT induces an overall improvement in the parasympathetic and sympathetic components of the autonomic nervous system&#46;<a class="elsevierStyleCrossRefs" href="#bib0375"><span class="elsevierStyleSup">34&#44;35</span></a> Underlying mechanisms of autonomic improvement in these subjects after RT are yet to be clarified&#46; Factors such as the reduction in circulating norepinephrine may be attributed to this improvement&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Additionally&#44; it is important to mention that there were similar improvements in the peripheral muscle strength between the groups &#40;<span class="elsevierStyleItalic">data not shown</span>&#41;&#46; Due to the important relation between muscle strength and autonomic function in subjects with COPD&#44;<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">36</span></a> it could be hypothesized that improvements in muscle function are partly responsible for the improvements in the autonomic nervous system&#46; Since the mucociliary system is regulated by the autonomic nervous system&#44;<a class="elsevierStyleCrossRef" href="#bib0390"><span class="elsevierStyleSup">37</span></a> it is believed that the possible improvement in autonomic modulation could influence improved MCT values&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">Another hypothesis for the improvements in MCT is related to low-grade chronic inflammation&#46; Most of the subjects included in the study were ex-smokers&#46; It is known that the toxic substances released by the cigarette promote local inflammation in the respiratory tract&#44;<a class="elsevierStyleCrossRefs" href="#bib0395"><span class="elsevierStyleSup">38&#44;39</span></a> causing damage that can affect mucociliary function&#46;<a class="elsevierStyleCrossRef" href="#bib0405"><span class="elsevierStyleSup">40</span></a> When smokers give up there can be reversibility of mucociliary function after 15 days of abstinence from smoking&#46;<a class="elsevierStyleCrossRef" href="#bib0410"><span class="elsevierStyleSup">41</span></a> However&#44; when COPD is present&#44; the chronic low-grade inflammation could impair this reparative process&#46; As RT is able to decrease the proinflammatory profile of subjects with COPD&#44;<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">16</span></a> we speculate that the anti-inflammatory &#8220;<span class="elsevierStyleItalic">millie</span>&#8221; generated by chronic exercise training may help in some way to repair the mucociliary function of these subjects&#46; Future studies are warranted in this area to clarify the possible associations between the outcomes of chronic exercise and MCT in COPD&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">The reduced sample size and absence of a control group may be considered limitations of the study&#46; With the limited sample&#44; it was not possible to verify differences in subgroups of subjects according to COPD severity&#46; Further studies investigating this specific issue are warranted&#46; Another limitation would be that we did not include the effects of RT on outcomes such as cough and sputum&#44; since both are related to MTC&#46;<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">4&#44;5</span></a> However&#44; it is important to note that the data presented in this study are secondary analyzes of a larger project which presents other variables demonstrating the effects of training with elastic tubing&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">In conclusion&#44; the present study demonstrated that both RT with elastic tubing and conventional training promoted similar gains in the mucociliary transportability of subjects with COPD&#46; Future research needs to approach the chronic effects of exercise on mucociliary clearance in subjects with COPD&#44; in order to clarify the physiological mechanisms that influence this process&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Funding</span><p id="par0175" class="elsevierStylePara elsevierViewall">This study was supported by the National Council of Scientific Researches &#40;<span class="elsevierStyleGrantSponsor" id="gs1">CNPq&#41;</span> &#91;Grant number&#58; <span class="elsevierStyleGrantNumber" refid="gs1">470742&#47;2014-3</span>&#93;&#46; BSAS is funded by <span class="elsevierStyleGrantSponsor" id="gs2">CAPES</span>&#47;Brazil&#46;</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Conflicts of interest</span><p id="par0180" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflict of interest&#46;</p></span></span>"
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              "titulo" => "Measurement of hemodynamic parameters"
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              "titulo" => "Measurement of nasal mucociliary transport &#40;saccharin transit time&#41;"
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              "titulo" => "RT with elastic tubing"
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    "fechaRecibido" => "2018-06-18"
    "fechaAceptado" => "2019-01-07"
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            1 => "Resistance training"
            2 => "Exercise therapy"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Elastic tubing was recently investigated as an alternative to the conventional resistance training &#40;RT&#41; in chronic obstructive pulmonary disease &#40;COPD&#41;&#46; The effects of RT on the mucociliary system have not yet been reported in the literature&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The aim of this study was to evaluate the effects of two RT programs on mucociliary clearance in subjects with COPD&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Twentyeight subjects with COPD were randomly allocated by strata&#44; according to individual strength of lower limbs&#44; to defined groups&#58; conventional resistance training &#40;GCT&#41; or resistance training using elastic tubing &#40;GET&#41;&#46; Nineteen subjects &#40;GET&#58; <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>9&#59; GCT&#58; <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>10&#41; completed the study and were included in the analysis&#46; The measurement of vital signs &#40;blood pressure&#44; heart rate and respiratory rate&#41;&#44; lung function &#40;spirometry&#41; and the primary outcome mucociliary clearance analysis &#40;saccharin transit time test &#40;STT&#41;&#41; were performed before and after the 12 weeks of RT&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">In relation to the mucociliary transportability analysis&#44; no differences were observed between the baseline evaluations of the training groups &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46; There was a significant reduction in the STT values in both training groups&#44; GET &#40;10&#46;64<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;06 to 6&#46;01<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;91&#41; and GCT &#40;12&#46;07<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;10 to 7&#46;36<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;54&#41; with <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;03&#46; However&#44; no differences between groups were observed on the magnitude of SST changes after interventions &#40;GET&#58; &#8722;43&#46;51&#37;&#59; GCT&#58; &#8722;38&#46;94&#37;&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;97&#41;&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusion</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The present study demonstrated that both RT with elastic tubing and conventional training with weights promoted similar gains in the mucociliary transportability of subjects with COPD&#46;</p></span>"
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                  \t\t\t\t">64&#46;22<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>11&#46;76&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">62&#46;02<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>11&#46;91&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">Time&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#46;45&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#8722;2&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;56&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">GCT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2&#46;946<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;77&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;88<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;81&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Time&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;87&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;07<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">GET&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;25<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;85&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;73&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Group<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>time&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;04<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">FVC &#40;&#37; pred&#41;</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">GCT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">82&#46;59<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>11&#46;79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">79&#46;70<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9&#46;97&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Time&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;73&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;2&#46;89<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#46;51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">GET&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">64&#46;67<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>18&#46;21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">68&#46;03<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>17&#46;89&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Group<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>time&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;43&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;02<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&#46;44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">FEV1&#47;FVC &#40;&#37;&#41;</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">GCT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">61&#46;37<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&#46;66&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">60&#46;75<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&#46;30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Time&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;95&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;62<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;76&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">GET&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">52&#46;03<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>10&#46;45&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&#46;84<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>11&#46;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Group<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>time&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;44<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;56&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">FEF25&#8211;75&#37; &#40;L&#41;</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">GCT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;89 &#40;0&#46;71&#8211;1&#46;44&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;85 &#40;0&#46;70&#8211;0&#46;39&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Time&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;07<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">GET&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;57 &#40;0&#46;43&#8211;0&#46;65&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;53 &#40;0&#46;48&#8211;0&#46;65&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Group<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>time&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;01<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">FEF25&#8211;75&#37; &#40;&#37; pred&#41;</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">GCT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">43 &#40;30&#46;37&#8211;50&#46;25&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">41&#46;50 &#40;28&#46;50&#8211;48&#46;75&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Time&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;2&#46;35<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">GET&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t  " rowspan="2" align="left" valign="\n
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                  \t\t\t\t">DBP &#40;mmHg&#41;</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">GCT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">80 &#40;70&#8211;90&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">75 &#40;67&#46;50&#8211;80&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Time&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#46;19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">&#8722;5&#46;00<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&#46;69&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">GET&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8722;2&#46;22<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9&#46;71&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">68&#46;90<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9&#46;85&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">74&#46;11<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#46;82&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#46;28&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2&#46;66<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>10&#46;19&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                            4 => "G&#46; Evers"
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                        "tituloSerie" => "Eur Respir J"
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                            2 => "T&#46;G&#46; O&#8217;Riordan"
                            3 => "M&#46;S&#46; Messina"
                            4 => "R&#46;J&#46; Perry"
                            5 => "E&#46;G&#46; Langenback"
                          ]
                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.103.5.1390"
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                        "tituloSerie" => "Chest"
                        "fecha" => "1993"
                        "volumen" => "103"
                        "paginaInicial" => "1390"
                        "paginaFinal" => "1396"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8486016"
                            "web" => "Medline"
                          ]
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                ]
              ]
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              "identificador" => "bib0235"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#91;Saccharin test for the study of mucociliary clearance&#58; reference values for a Spanish population&#93;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "P&#46; Plaza Valia"
                            1 => "F&#46; Carrion Valero"
                            2 => "J&#46; Marin Pardo"
                            3 => "D&#46; Bautista Rentero"
                            4 => "C&#46; Gonzalez Monte"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2008"
                        "volumen" => "44"
                        "paginaInicial" => "540"
                        "paginaFinal" => "545"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19006634"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0240"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "comparison of nasal and tracheobronchial clearance"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "I&#46; Andersen"
                            1 => "P&#46; Camner"
                            2 => "P&#46;L&#46; Jensen"
                            3 => "K&#46; Philipson"
                            4 => "D&#46;F&#46;A&#46; Proctor"
                          ]
                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1080/00039896.1974.10666589"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Environ Health"
                        "fecha" => "1974"
                        "volumen" => "29"
                        "paginaInicial" => "290"
                        "paginaFinal" => "293"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4472935"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "8"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "M&#233;todos de estudo do transporte mucociliar"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46;H&#46;K&#46; Trindade"
                            1 => "J&#46;L&#46; Mello J&#250;nior"
                            2 => "M&#46; Macchione"
                            3 => "E&#46;T&#46; Guimar&#227;es"
                            4 => "P&#46;H&#46;N&#46; Saldiva"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rev Bras Otorrinolaringol"
                        "fecha" => "2007"
                        "volumen" => "73"
                        "paginaInicial" => "704"
                        "paginaFinal" => "712"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "9"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mucociliary clearance &#8211; a critical upper airway host defense mechanism and methods of assessment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46;B&#46; Antunes"
                            1 => "N&#46;A&#46; Cohen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/ACI.0b013e3280114eef"
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Opin Allergy Clin Immunol"
                        "fecha" => "2007"
                        "volumen" => "7"
                        "paginaInicial" => "5"
                        "paginaFinal" => "10"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17218804"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0255"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Padroniza&#231;&#227;o dos crit&#233;rios de sele&#231;&#227;o em estudos sobre medica&#231;&#245;es nasais"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46; Borin"
                            1 => "E&#46; Abib Junior"
                            2 => "C&#46;I&#46; Araujo"
                            3 => "L&#46;L&#46; Martinez"
                            4 => "H&#46; Rodrigues"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/s1808-8694(15)30552-8"
                      "Revista" => array:6 [
                        "tituloSerie" => "Braz J Otorhinolaryngol"
                        "fecha" => "2009"
                        "volumen" => "75"
                        "paginaInicial" => "872"
                        "paginaFinal" => "878"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20209290"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0260"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pulmonary rehabilitation and exercise training in chronic obstructive pulmonary disease"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46; Gloeckl"
                            1 => "T&#46; Schneeberger"
                            2 => "I&#46; Jarosch"
                            3 => "K&#46; Kenn"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Deut &#196;rztebl Int"
                        "fecha" => "2018"
                        "volumen" => "115"
                        "paginaInicial" => "117"
                        "paginaFinal" => "123"
                      ]
                    ]
                  ]
                ]
              ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of 2 exercise training programs on physical activity in daily life in patients with COPD"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "V&#46;S&#46; Probst"
                            1 => "D&#46; Kovelis"
                            2 => "N&#46;A&#46; Hernandes"
                            3 => "C&#46;A&#46; Camillo"
                            4 => "V&#46; Cavalheri"
                            5 => "F&#46; Pitta"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4187/respcare.01110"
                      "Revista" => array:6 [
                        "tituloSerie" => "Respir Care"
                        "fecha" => "2011"
                        "volumen" => "56"
                        "paginaInicial" => "1799"
                        "paginaFinal" => "1807"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22035826"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0270"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of resistance training in subjects with COPD&#58; a systematic review and meta-analysis"
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                          "etal" => true
                          "autores" => array:6 [
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                            2 => "X&#46; Chen"
                            3 => "L&#46; Lin"
                            4 => "H&#46;Y&#46; Yan"
                            5 => "Y&#46;Q&#46; Zhou"
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                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4187/respcare.03598"
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                        "tituloSerie" => "Respir Care"
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                        "paginaInicial" => "1130"
                        "paginaFinal" => "1145"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26015595"
                            "web" => "Medline"
                          ]
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                  ]
                ]
              ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "The effects of elastic tubing-based resistance training compared with conventional resistance training in patients with moderate chronic obstructive pulmonary disease&#58; a randomized clinical trial"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            1 => "A&#46;C&#46; de Toledo-Arruda"
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                    0 => array:2 [
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                        "tituloSerie" => "Clin Rehabil"
                        "fecha" => "2014"
                        "volumen" => "28"
                        "paginaInicial" => "1096"
                        "paginaFinal" => "1106"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24647863"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0280"
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                    0 => array:2 [
                      "titulo" => "Effects of a resistance training with elastic tubing in strength&#44; quality of life and dypsnea in patients with chronic obstructive pulmonary disease"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
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                            4 => "I&#46;G&#46; Silva"
                            5 => "E&#46;M&#46;C&#46; Ramos"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
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                      "Revista" => array:3 [
                        "tituloSerie" => "J Phys Educ"
                        "fecha" => "2016"
                        "paginaInicial" => "27"
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0285"
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                    0 => array:2 [
                      "titulo" => "Inflammatory and metabolic responses to different resistance training on chronic obstructive pulmonary disease&#58; a randomized control trial"
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                          "etal" => true
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                            3 => "D&#46; Ramos"
                            4 => "J&#46;S&#46; Uzeloto"
                            5 => "A&#46; Freire"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
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                        "tituloSerie" => "Front Physiol"
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                        "volumen" => "9"
                        "paginaInicial" => "262"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29628896"
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                    0 => array:2 [
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
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                        "paginaInicial" => "153"
                        "paginaFinal" => "160"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29535589"
                            "web" => "Medline"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Muscle fatigue induced by two different resistances&#58; elastic tubing versus weight machines"
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                          "etal" => false
                          "autores" => array:2 [
                            0 => "G&#46; Melchiorri"
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                  "host" => array:1 [
                    0 => array:2 [
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                        "tituloSerie" => "J Electromyogr Kinesiol"
                        "fecha" => "2011"
                        "volumen" => "21"
                        "paginaInicial" => "954"
                        "paginaFinal" => "959"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21920774"
                            "web" => "Medline"
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                ]
              ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of exercise and physiotherapy in aiding sputum expectoration in adults with cystic fibrosis"
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                          "etal" => false
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                            2 => "M&#46; Dodd"
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                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
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                        "tituloSerie" => "Thorax"
                        "fecha" => "1989"
                        "volumen" => "44"
                        "paginaInicial" => "1006"
                        "paginaFinal" => "1008"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2617441"
                            "web" => "Medline"
                          ]
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                  ]
                ]
              ]
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                    0 => array:2 [
                      "titulo" => "Guidelines for the physiotherapy management of the adult&#44; medical&#44; spontaneously breathing patient"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Bott"
                            1 => "S&#46; Blumenthal"
                            2 => "M&#46; Buxton"
                            3 => "S&#46; Ellum"
                            4 => "C&#46; Falconer"
                            5 => "R&#46; Garrod"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/thx.2008.110726"
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                        "tituloSerie" => "Thorax"
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                        "volumen" => "64"
                        "numero" => "Suppl&#46; 1"
                        "paginaInicial" => "i1"
                        "paginaFinal" => "i51"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19406863"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0310"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impaired nasal mucociliary clearance in long-distance runners"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
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                            2 => "F&#46; Wolf"
                            3 => "I&#46; Rubinstein"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1055/s-2007-972993"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Sports Med"
                        "fecha" => "1995"
                        "volumen" => "16"
                        "paginaInicial" => "209"
                        "paginaFinal" => "213"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7657412"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0315"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Analysis of autonomic modulation after an acute session of resistance exercise at different intensities in chronic obstructive pulmonary disease patients"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            1 => "D&#46; Ramos"
                            2 => "M&#46;R&#46; Leite"
                            3 => "F&#46;M&#46; Rodrigues"
                            4 => "B&#46;S&#46; de Alencar Silva"
                            5 => "G&#46;Y&#46; Tacao"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2147/COPD.S64345"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Chron Obstruct Pulmon Dis"
                        "fecha" => "2015"
                        "volumen" => "10"
                        "paginaInicial" => "223"
                        "paginaFinal" => "229"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25673982"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0320"
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              "referencia" => array:1 [
                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Strength training improves fall-related gait kinematics in the elderly&#58; a randomized controlled trial"
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                          "etal" => false
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                            3 => "A&#46;L&#46; Rodacki"
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                        "tituloSerie" => "Clin Biomech &#40;Bristol&#44; Avon&#41;"
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                    0 => array:2 [
                      "titulo" => "Standardisation of spirometry"
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                            3 => "F&#46; Burgos"
                            4 => "R&#46; Casaburi"
                            5 => "A&#46; Coates"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Eur Respir J"
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                        "paginaInicial" => "319"
                        "paginaFinal" => "338"
                      ]
                    ]
                  ]
                ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nasal mucociliary transport in healthy subjects is slower when breathing dry air"
                      "autores" => array:1 [
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                          "etal" => false
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                            0 => "B&#46; Salah"
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                            2 => "J&#46;L&#46; Fouilladieu"
                            3 => "A&#46; Lockhart"
                            4 => "J&#46; Regnard"
                          ]
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                      ]
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                  "host" => array:1 [
                    0 => array:1 [
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                        "tituloSerie" => "Eur Respir J"
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                        "volumen" => "1"
                        "paginaInicial" => "852"
                        "paginaFinal" => "855"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3229484"
                            "web" => "Medline"
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                ]
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                    0 => array:2 [
                      "titulo" => "Mechanical properties&#44; safety and resistance values of Lemgruber&#40;&#40;R&#41;&#41; elastic tubing&#46;"
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                            4 => "B&#46;S&#46;A&#46; Silva"
                            5 => "M&#46; Topalovic"
                          ]
                        ]
                      ]
                    ]
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                    0 => array:2 [
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                        "tituloSerie" => "Braz J Phys Ther"
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                        "volumen" => "23"
                        "paginaInicial" => "41"
                        "paginaFinal" => "47"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30077519"
                            "web" => "Medline"
                          ]
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                      ]
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                ]
              ]
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                    0 => array:2 [
                      "titulo" => "Effects of 12 weeks of aerobic training on autonomic modulation&#44; mucociliary clearance&#44; and aerobic parameters in patients with COPD"
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                            3 => "A&#46;P&#46; Freire"
                            4 => "B&#46;S&#46; de Alencar Silva"
                            5 => "J&#46; Nicolino"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2147/COPD.S81363"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Chron Obstruct Pulmon Dis"
                        "fecha" => "2015"
                        "volumen" => "10"
                        "paginaInicial" => "2549"
                        "paginaFinal" => "2557"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26648712"
                            "web" => "Medline"
                          ]
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              ]
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                            0 => "F&#46;A&#46; Salzano"
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                            4 => "G&#46; Motta"
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                        ]
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Otorhinolaryngol Ital"
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                        "volumen" => "20"
                        "paginaInicial" => "171"
                        "paginaFinal" => "176"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11139875"
                            "web" => "Medline"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Nasal mucociliary clearance in subjects with COPD after smoking cessation"
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                            3 => "F&#46;M&#46; Rodrigues"
                            4 => "P&#46;R&#46; Gomes"
                            5 => "G&#46;L&#46; Moreira"
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                    ]
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                  "host" => array:1 [
                    0 => array:2 [
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                        "tituloSerie" => "Respir Care"
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                        "paginaInicial" => "399"
                        "paginaFinal" => "405"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25389352"
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                    0 => array:2 [
                      "titulo" => "Transporte mucociliar e sua rela&#231;&#227;o com o n&#237;vel de atividade f&#237;sica na vida di&#225;ria em fumadores saud&#225;veis e n&#227;o fumadores"
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                            2 => "L&#46;C&#46; Mantoani"
                            3 => "K&#46;C&#46; Furlanetto"
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                      ]
                    ]
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                    0 => array:2 [
                      "doi" => "10.1016/j.rppneu.2012.03.003"
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                        "tituloSerie" => "Rev Port Pneumol"
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                        "volumen" => "18"
                        "paginaInicial" => "233"
                        "paginaFinal" => "238"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22608005"
                            "web" => "Medline"
                          ]
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                ]
              ]
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                            3 => "D&#46;G&#46;D&#46; Christofaro"
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                    ]
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                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Sci Med"
                        "fecha" => "2017"
                        "volumen" => "27"
                        "paginaInicial" => "ID26920"
                      ]
                    ]
                  ]
                ]
              ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Evidence for autonomic function and its influencing factors in subjects with COPD&#58; a systematic review"
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                          "etal" => false
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                            1 => "M&#46; Meeus"
                            2 => "E&#46; Derom"
                            3 => "H&#46; Da Silva"
                            4 => "P&#46; Calders"
                          ]
                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4187/respcare.04174"
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                        "tituloSerie" => "Respir Care"
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                        "volumen" => "60"
                        "paginaInicial" => "1841"
                        "paginaFinal" => "1851"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26487747"
                            "web" => "Medline"
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              "identificador" => "bib0370"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Chronic obstructive pulmonary disease and heart rate variability&#58; a literature update"
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                            2 => "T&#46; Massetti"
                            3 => "T&#46;D&#46; da Silva"
                            4 => "Monteiro CBdM"
                            5 => "F&#46;R&#46; Oliveira"
                          ]
                        ]
                      ]
                    ]
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                    0 => array:2 [
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                        "tituloSerie" => "Int Arch Med"
                        "fecha" => "2014"
                        "volumen" => "7"
                        "paginaInicial" => "43"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25945125"
                            "web" => "Medline"
                          ]
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                    ]
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                ]
              ]
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                    0 => array:2 [
                      "titulo" => "Influence of the resistance training on heart rate variability&#44; functional capacity and muscle strength in the chronic obstructive pulmonary disease"
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                        0 => array:2 [
                          "etal" => true
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                            2 => "L&#46;C&#46; Fosco"
                            3 => "G&#46;N&#46; Bertolini"
                            4 => "E&#46;M&#46; Ramos"
                            5 => "D&#46; Ramos"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Phys Rehabil Med"
                        "fecha" => "2013"
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                        "paginaInicial" => "793"
                        "paginaFinal" => "801"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23698474"
                            "web" => "Medline"
                          ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Can geometric indices of heart rate variability predict improvement in autonomic modulation after resistance training in chronic obstructive pulmonary disease&#63;"
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                            3 => "A&#46;P&#46; Santos"
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                  "host" => array:1 [
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                      "doi" => "10.1111/cpf.12275"
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                        "tituloSerie" => "Clin Physiol Funct Imaging"
                        "fecha" => "2017"
                        "volumen" => "37"
                        "paginaInicial" => "124"
                        "paginaFinal" => "130"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26148011"
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                    0 => array:2 [
                      "titulo" => "Heart rate variability and disease characteristics in patients with COPD"
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                        "tituloSerie" => "Lung"
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                        "volumen" => "186"
                        "paginaInicial" => "393"
                        "paginaFinal" => "401"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18815834"
                            "web" => "Medline"
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                ]
              ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Autonomic control and mucociliary functions"
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                        "tituloSerie" => "Chest"
                        "fecha" => "1987"
                        "volumen" => "91"
                        "paginaInicial" => "49"
                        "paginaFinal" => "51"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3792086"
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                      "titulo" => "Pathophysiology of airflow limitation in chronic obstructive pulmonary disease"
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                        "tituloSerie" => "Lancet"
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                      "titulo" => "Cigarette smoke vapor-phase effects in the rat upper respiratory tract"
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                        "paginaFinal" => "873"
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                    ]
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                        "paginaFinal" => "855"
                        "link" => array:1 [
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]

Article information

ISSN: 25310437
Original language: English

DOI:10.1016/j.pulmoe.2019.01.001

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Year/Month	Html	Pdf	Total

2024 November	5	7	12
2024 October	36	28	64
2024 September	42	26	68
2024 August	53	34	87
2024 July	39	29	68
2024 June	39	32	71
2024 May	28	34	62
2024 April	36	34	70
2024 March	30	18	48
2024 February	32	30	62
2024 January	29	27	56
2023 December	15	26	41
2023 November	38	53	91
2023 October	35	37	72
2023 September	23	26	49
2023 August	24	25	49
2023 July	26	28	54
2023 June	15	22	37
2023 May	39	24	63
2023 April	33	18	51
2023 March	56	27	83
2023 February	51	23	74
2023 January	21	21	42
2022 December	62	28	90
2022 November	54	33	87
2022 October	71	38	109
2022 September	32	45	77
2022 August	49	31	80
2022 July	45	59	104
2022 June	33	29	62
2022 May	34	42	76
2022 April	33	77	110
2022 March	35	56	91
2022 February	25	45	70
2022 January	37	49	86
2021 December	34	50	84
2021 November	27	39	66
2021 October	60	66	126
2021 September	23	38	61
2021 August	32	36	68
2021 July	36	29	65
2021 June	38	33	71
2021 May	42	41	83
2021 April	81	109	190
2021 March	60	50	110
2021 February	56	29	85
2021 January	46	29	75
2020 December	51	22	73
2020 November	50	25	75
2020 October	56	31	87
2020 September	60	37	97
2020 August	49	31	80
2020 July	67	26	93
2020 June	93	31	124
2020 May	86	33	119
2020 April	110	21	131
2020 March	102	28	130
2020 February	67	37	104
2020 January	111	52	163
2019 December	135	50	185
2019 November	135	61	196
2019 October	51	23	74
2019 September	55	29	84
2019 August	70	27	97
2019 July	67	33	100
2019 June	61	45	106
2019 May	60	52	112
2019 April	68	41	109
2019 March	62	33	95

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