Letter to the Editor
Long-life relationships always bring trouble
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"apellidos" => "Bandeira" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2531043719301400?idApp=UINPBA00004E" "url" => "/25310437/0000002600000001/v1_202002062105/S2531043719301400/v1_202002062105/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2531043719300959" "issn" => "25310437" "doi" => "10.1016/j.pulmoe.2019.05.003" "estado" => "S300" "fechaPublicacion" => "2020-01-01" "aid" => "1372" "copyright" => "Sociedade Portuguesa de Pneumologia" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "cor" "cita" => "Pulmonol. 2020;26:50-3" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1116 "formatos" => array:3 [ "EPUB" => 101 "HTML" => 697 "PDF" => 318 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Mutational profile of non-small cell lung cancer patients: Use of next-generation sequencing" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "50" "paginaFinal" => "53" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1880 "Ancho" => 2338 "Tamanyo" => 151668 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) Prevalence of mutations in all NGS patients; (B) prevalence of mutations in NGS positive patients; (C) prevalence of druggable mutations in NGS positive patients (off-label regimen in case of MET, RET and ERBB2 mutations); (D) prevalence of treated mutations in NGS positive patients. KRAS (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>48); EGFR (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>47); ERBB2 (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>11); MET (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>9); BRAF (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>9); ALK (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>9); PI3KCA (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>8); ROS (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>3); RET (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>2); PTEN (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>2); ERBB4 (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "D. Reis, C. Marques, M. Dias, S. Campainha, L. Cirnes, A. Barroso" "autores" => array:6 [ 0 => array:2 [ "nombre" => "D." "apellidos" => "Reis" ] 1 => array:2 [ "nombre" => "C." "apellidos" => "Marques" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Dias" ] 3 => array:2 [ "nombre" => "S." "apellidos" => "Campainha" ] 4 => array:2 [ "nombre" => "L." "apellidos" => "Cirnes" ] 5 => array:2 [ "nombre" => "A." "apellidos" => "Barroso" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2531043719300959?idApp=UINPBA00004E" "url" => "/25310437/0000002600000001/v1_202002062105/S2531043719300959/v1_202002062105/en/main.assets" ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Long-life relationships always bring trouble" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "53" "paginaFinal" => "54" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "A.M. Mutiozabal, M.D. Santiañez, J.I. De Granda Orive" "autores" => array:3 [ 0 => array:4 [ "nombre" => "A.M." "apellidos" => "Mutiozabal" "email" => array:1 [ 0 => "adriana.manrique.mutiozabal@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "M.D." "apellidos" => "Santiañez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "J.I." "apellidos" => "De Granda Orive" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Respiratory Medicine, Hospital Universitario 12 de Octubre, Avda. De Cordoba s/n, 28041 Madrid, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Internal Medicine, Hospital Universitario 12 de Octubre, Avda. De Cordoba s/n, 28041 Madrid, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 668 "Ancho" => 1255 "Tamanyo" => 115626 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Description. Angiography preprocedure (A) shows hypertrophy of right bronchial artery and the presence of a fistula between bronchial artery and pulmonary artery. Angiography postprocedure (B) shows the absence of flood to pulmonary artery.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 58-year-old woman, a butcher from her youth and a history of hemoptysis related to respiratory infection at the age of 30, was admitted into Intensive Care Unit for life-threatening hemoptysis and respiratory hypoxemic insufficiency. The bronchoscopy identified bleeding coming from the lower right lobe with an incipient clot. Computerized thoracic tomography revealed ground glass opacities in the middle and lower right lobes, probably indicative of blood filling alveoli. She was extubated 24<span class="elsevierStyleHsp" style=""></span>h later and continued on antittussive treatment and amoxicillin/clavulanic acid until hemoptysis diminished in the following days. It was assumed that the risk of life-threatening rebleeding was high, so bronchial arterial embolization was performed. The arteriography detected the presence of a fistula connecting right bronchial (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A) and pulmonary arteries and it was occluded with bead-block particles of 500–600<span class="elsevierStyleHsp" style=""></span>μm. The subsequent control demonstrated flow extinction, the fistula was completely blocked (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>B). A week later, in the absence of hemoptysis, the patient was discharged.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Arterial malformations are commonly found in angiography conducted in hemoptysis.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">1</span></a> Cases of systemic-pulmonary circulation shunts have been reported within parenchymal lung involvement, mostly due to bronchiectasis<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">2</span></a> or tuberculosis sequelaes,<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">3</span></a> and rarely due to hereditary haemorragic telangiectasia.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">4</span></a> We present an elderly woman with a congenital brochial-pulmonary artery fistula and life-threatening hemoptysis, who was embolized with inmediate successful angiographic result. Embolization is seen as a safe and effective treatment for life-threatening hemoptysis, recurrence rates depend on different ethiologies.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">1</span></a> Our patient has a considerable risk of rebleeding, that may lead to repeat embolization or elective surgery in the future.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0015" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Funding</span><p id="par0020" class="elsevierStylePara elsevierViewall">There is no funding for this manuscript.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflicts of interest" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Funding" ] 2 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 668 "Ancho" => 1255 "Tamanyo" => 115626 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Description. Angiography preprocedure (A) shows hypertrophy of right bronchial artery and the presence of a fistula between bronchial artery and pulmonary artery. Angiography postprocedure (B) shows the absence of flood to pulmonary artery.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:4 [ 0 => array:3 [ "identificador" => "bib0025" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immediate and long-term outcomes of endovascular treatment for massive hemoptysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "H. Liu" 1 => "D. Zhang" 2 => "F. Zhang" 3 => "J. Ying" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Int Angiol" "fecha" => "2016" "volumen" => "35" "paginaInicial" => "469" "paginaFinal" => "476" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0030" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Massive hemoptysis due to right inferior phrenic artery-to-right pulmonary artery fistula in the right middle lobe of the lung" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "E. Yakushiji" 1 => "S. Ota" 2 => "T. Komatsu" 3 => "M. Ayaori" 4 => "K. Ikewaki" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2169/internalmedicine.56.6783" "Revista" => array:6 [ "tituloSerie" => "Intern Med" "fecha" => "2017" "volumen" => "56" "paginaInicial" => "687" "paginaFinal" => "689" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28321071" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0035" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Embolization of acquired bronchial artery-pulmonary artery fistula in a patient with HIV infection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L. Gorospe Sarasúa" 1 => "F.E. Farfán-Leal" 2 => "R. García-Latorre" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2016" "volumen" => "52" "numero" => "10." "itemHostRev" => array:3 [ "pii" => "S0211139X18300015" "estado" => "S300" "issn" => "0211139X" ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0040" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Idiopathic pulmonary arteriovenous malformations: clinical and imaging characteristics" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "H.H. Wong" 1 => "R.P. Chan" 2 => "R. Klatt" 3 => "M.E. Faughnan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Eur Respir J" "fecha" => "2011" "volumen" => "38" "paginaInicial" => "368" "paginaFinal" => "375" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/25310437/0000002600000001/v1_202002062105/S2531043719301291/v1_202002062105/en/main.assets" "Apartado" => array:4 [ "identificador" => "82163" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to Editor" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/25310437/0000002600000001/v1_202002062105/S2531043719301291/v1_202002062105/en/main.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2531043719301291?idApp=UINPBA00004E" ]
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