was read the article
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For comparative purposes, the images in each column correspond to identical axial planes.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "T. Oliveira, N. Melo, S. Guimarães, A. Morais" "autores" => array:4 [ 0 => array:2 [ "nombre" => "T." "apellidos" => "Oliveira" ] 1 => array:2 [ "nombre" => "N." "apellidos" => "Melo" ] 2 => array:2 [ "nombre" => "S." "apellidos" => "Guimarães" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "Morais" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2531043720300428?idApp=UINPBA00004E" "url" => "/25310437/0000002600000005/v1_202009020805/S2531043720300428/v1_202009020805/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2531043719302211" "issn" => "25310437" "doi" => "10.1016/j.pulmoe.2019.11.010" "estado" => "S300" "fechaPublicacion" => "2020-09-01" "aid" => "1434" "copyright" => "Sociedade Portuguesa de Pneumologia" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "cor" "cita" => "Pulmonol. 2020;26:317-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 130 "formatos" => array:3 [ "EPUB" => 18 "HTML" => 69 "PDF" => 43 ] ] "en" => array:9 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Tuberculosis screening at social solidarity institutions: a new protocol" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "317" "paginaFinal" => "318" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. Coutinho Costa, J. Neiva Machado, J. Nunes Caldeira, P. Ulisses Brito, P. Cravo Roxo" "autores" => array:5 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Coutinho Costa" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Neiva Machado" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Nunes Caldeira" ] 3 => array:2 [ "nombre" => "P." "apellidos" => "Ulisses Brito" ] 4 => array:2 [ "nombre" => "P." "apellidos" => "Cravo Roxo" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2531043719302211?idApp=UINPBA00004E" "url" => "/25310437/0000002600000005/v1_202009020805/S2531043719302211/v1_202009020805/en/main.assets" ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Insights into tuberculosis: A survival analysis of time to recurrence in Portugal, between 2002 and 2009" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "318" "paginaFinal" => "320" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "P. Soares, R. Duarte, M.G.M. Gomes, C. Rocha, J.S. Lopes" "autores" => array:5 [ 0 => array:4 [ "nombre" => "P." "apellidos" => "Soares" "email" => array:1 [ 0 => "patseraos@gmail.com" ] "referencia" => array:4 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 3 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "R." "apellidos" => "Duarte" "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">f</span>" "identificador" => "aff0030" ] ] ] 2 => array:3 [ "nombre" => "M.G.M." "apellidos" => "Gomes" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">g</span>" "identificador" => "aff0035" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">h</span>" "identificador" => "aff0040" ] ] ] 3 => array:3 [ "nombre" => "C." "apellidos" => "Rocha" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 4 => array:3 [ "nombre" => "J.S." "apellidos" => "Lopes" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">i</span>" "identificador" => "aff0045" ] ] ] ] "afiliaciones" => array:9 [ 0 => array:3 [ "entidad" => "Instituto Gulbenkian de Ciência, Oeiras, Portugal" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Departamento de Estatística e Investigação Operacional, Faculdade de Ciências, Universidade de Lisboa, 1749-016 Lisboa, Portugal" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Centro de Estatística e Aplicações, Faculdade de Ciências, Universidade de Lisboa, 1749-016 Lisboa, Portugal" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Serviço de Pneumologia, Centro Hospitalar de Vila Nova de Gaia/Espinho, Portugal" "etiqueta" => "d" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Faculdade de Medicina, Universidade do Porto, Porto, Portugal" "etiqueta" => "e" "identificador" => "aff0025" ] 5 => array:3 [ "entidad" => "EpiUnit, Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal" "etiqueta" => "f" "identificador" => "aff0030" ] 6 => array:3 [ "entidad" => "Liverpool School of Tropical Medicine, Liverpool, United Kingdom" "etiqueta" => "g" "identificador" => "aff0035" ] 7 => array:3 [ "entidad" => "CIBIO-InBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, and CMUP, Centro de Matemática da Universidade do Porto, Porto, Portugal" "etiqueta" => "h" "identificador" => "aff0040" ] 8 => array:3 [ "entidad" => "Instituto Nacional de Estatística, Lisboa, Portugal" "etiqueta" => "i" "identificador" => "aff0045" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Recurrence of TB has been associated with poor adherence to treatment, smoking, alcoholism, unemployment, drug abuse, the severity of pulmonary cavitation, HIV infection and duration of treatment.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a> However, the risk factors can vary considerably across countries and between studies. Since little is known about risk factors for recurrence in Portugal, we aimed to identify predictors of treatment recurrence in the country. Surveillance data on TB for the period of 2002–2009 was provided by SVIG-TB, a database from the Portuguese National Health System. For this analysis, only cases of confirmed TB disease were considered, and patients that had information on the first and second TB episodes. The variables studied were chosen as TB risk factors according to previous reports about TB recurrence. The existence of missing data was assessed and missing data characterised (missingness between 0 and 10%). From this characterisation, we chose to explore multiple imputation using random-forest based on multivariate imputation by chained equations. We used a semi-parametric Cox regression model in which the event of interest was the second episode of TB, with time being measured from the end of treatment for a first TB episode. Patients without the second episode of TB before the end of the study were eliminated. A total of 8364 individuals were analysed, of which 145 (1.73%) had a recurrent TB episode during the time of the study.</p><p id="par0010" class="elsevierStylePara elsevierViewall">Patients who defaulted TB treatment are ten times more likely to suffer a recurrent case of TB (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). As expected,<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a> HIV was positively associated with recurrence of TB disease (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). Alcohol use disorders have been associated with recurrent TB, mostly by linkage to other confounding factors.<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">1,2</span></a> We found that even when considering treatment default, TB patients with an alcohol use disorder still had 86% increase in the risk of TB recurrence (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). Incarceration is a known risk factor for TB mainly due to overcrowding, delayed diagnosis and/or inadequate treatment. Our study shows that in Portugal, the risk of TB recurrence for prison inmates is four times higher (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). The standard 6-month treatment regimen is often insufficient to prevent TB relapse,<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">3</span></a> nevertheless, the study of treatment length as a risk factor has been mostly restricted to TB patients living with HIV.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">4</span></a> Longer treatments are usually prescribed for patients with poor prognosis, potentially confounding a beneficial effect. We found a decrease of 10% in the risk of recurrence per added month of treatment, even accounting for the effect of other risk factors (e.g. HIV), which may suggest a need to reevaluate standard treatment regimens (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). The inclusion of the clinical form in a study about recurrence is unusual. Most studies discard extrapulmonary TB cases since this form is much less infectious, contributing less to overall TB epidemics.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a> Nevertheless, we found that there is a two-fold increase in the risk of recurrence when suffering from an extrapulmonary form of the disease (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). Driver et al.,<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">4</span></a> showed that in TB patients living with HIV, extrapulmonary disease increased the risk of recurrence, and Millet et al.,<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a> suggested that this was true irrespective of HIV status. Interestingly, some TB risk factors have been shown to be associated with the clinical form – i.e. having HIV or being young increases the chance of having an extrapulmonary infection, while smoking and living with diabetes increases the chance of a pulmonary TB. Regardless of the association between youth and extrapulmonary TB, the role of age in TB recurrence is somewhat uncertain, with some studies<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">5</span></a> indicating a decrease of risk for older people while others<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">6</span></a> suggest a reduction for younger individuals. In Portugal, we found that an increase of one year in the age of the patient leads to a decrease of 1% in the risk of a recurrent episode (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). The association between diabetes and TB incidence has been relatively established, but the association with TB recurrence is unclear.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">3</span></a> Although the variable is not significant, we have estimated a decrease of 80% in the risk of a recurrent episode when having diabetes (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). In this study, 55% of recurrence occurred in the first 12 months after treatment completion, suggesting that in Portugal most of TB recurrence cases were due to relapse since relapse occurs not long after the end of treatment.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">7</span></a> Nevertheless, future studies should consider the inclusion of mycobacterial DNA information to distinguish between relapse and exogenous reinfection.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">To the best of our knowledge, this is the only study, to date, covering risk factors for TB recurrence in Portugal. The study concerns the period 2002–2009 and, although the situation may have changed over the last decade, this cannot be assessed unless datasets linking multiple disease episodes at the individual level are made available to researchers. Understanding risk factors for TB recurrence in Portugal can help to define new guidelines to reduce the prevalence of recurrence, decreasing the chance of multi-drug resistant TB development.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0020" class="elsevierStylePara elsevierViewall">Cristina Rocha's research is partially supported by <span class="elsevierStyleGrantSponsor" id="gs1">FCT</span> (Fundação para a Ciência e a Tecnologia), Portugal, through project UID/MAT/00006/2019. MGMG received funding from Fundação para a Ciência e a Tecnologia (IF/01346/2014).</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflict of interest</span><p id="par0025" class="elsevierStylePara elsevierViewall">The authors reported no conflict of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Funding" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Conflict of interest" ] 2 => array:2 [ "identificador" => "xack479727" "titulo" => "Acknowledgements" ] 3 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:1 [ 0 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">se, standard error; HR, hazard ratio; CI, confidence interval.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Variables \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">β</span> (se) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">HR \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">CI (95%) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>-value \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Treatment outcome \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.32 (0.197) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10.18 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">[6.90, 14.93] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Prison \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.31 (0.522) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.63 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">[1.41, 10.81] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.012 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">HIV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.85 (0.202) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.34 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">[1.58, 3.48] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Clinical form \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.77 (0.235) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.14 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">[1.35, 3.40] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Alcohol use \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.62 (0.195) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.86 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">[1.26, 2.74] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.002 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Age \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.01 (0.006) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.99 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">[0.98, 0.99] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.033 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Length of treatment \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.12 (0.021) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.90 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">[0.86, 0.93] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Diabetes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−1.61 (1.007) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">[0.03, 1.44] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.110 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2370179.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Hazard ratios and 95% confidence intervals for TB recurrence.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:7 [ 0 => array:3 [ "identificador" => "bib0040" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "When tuberculosis comes back: who develops recurrent tuberculosis in california?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "L. Pascopella" 1 => "K. Deriemer" 2 => "J.P. Watt" 3 => "J.M. Flood" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1371/journal.pone.0026541" "Revista" => array:4 [ "tituloSerie" => "PLoS One" "fecha" => "2011" "volumen" => "6" "paginaInicial" => "e26541" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0045" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tuberculosis recurrence after completion treatment in a European city: reinfection or relapse?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.-P. Millet" 1 => "E. Shaw" 2 => "A. Orcau" 3 => "M. Casals" 4 => "J.M. Miró" 5 => "J.a. 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Kim" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.rmed.2014.01.010" "Revista" => array:6 [ "tituloSerie" => "Respir Med" "fecha" => "2014" "volumen" => "108" "paginaInicial" => "654" "paginaFinal" => "659" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24518046" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0055" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Relapse in persons treated for drug-susceptible tuberculosis in a population with high coinfection with human immunodeficiency virus in New York City" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "C.R. Driver" 1 => "S.S. Munsiff" 2 => "J. Li" 3 => "N. Kundamal" 4 => "S.S. Osahan" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1086/323784" "Revista" => array:6 [ "tituloSerie" => "Clin Infect Dis" "fecha" => "2001" "volumen" => "33" "paginaInicial" => "1762" "paginaFinal" => "1769" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11595988" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0060" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recurrent tuberculosis and exogenous reinfection, Shanghai, China" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Shen" 1 => "Z. Xue" 2 => "X. Shen" 3 => "B. Sun" 4 => "X. Gui" 5 => "M. Shen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3201/eid1211.051207" "Revista" => array:6 [ "tituloSerie" => "Emerg Infect Dis" "fecha" => "2006" "volumen" => "12" "paginaInicial" => "1776" "paginaFinal" => "1778" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17283636" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0065" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Why pulmonary tuberculosis recurs: a population-based epidemiological study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A.W. Selassie" 1 => "D.R. Ph" 2 => "C. Pozsik" 3 => "D. Wilson" 4 => "P.L. Ferguson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.annepidem.2005.03.002" "Revista" => array:2 [ "tituloSerie" => "Ann Epidemiol" "fecha" => "2005" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0070" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Timing of relapse in short-course chemotherapy trials for tuberculosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Nunn a" 1 => "P.P.J. Phillips" 2 => "D.A. Mitchison" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int J Tuberc Lung Dis" "fecha" => "2010" "volumen" => "14" "paginaInicial" => "241" "paginaFinal" => "242" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20074418" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] "agradecimientos" => array:1 [ 0 => array:4 [ "identificador" => "xack479727" "titulo" => "Acknowledgements" "texto" => "<p id="par0030" class="elsevierStylePara elsevierViewall">We thank the members of the Collective Dynamics Group of Instituto Gulbenkian de Ciência for help and discussion at various points in the project. We also thank our collaborators from the Portuguese public health authorities, namely, Programa Nacional de Luta contra a Tuberculose, and the reference laboratories, Instituto Nacional de Saúde Ricardo Jorge and Administração Regional de Saúde de Lisboa e Vale do Tejo.</p>" "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/25310437/0000002600000005/v1_202009020805/S2531043720300763/v1_202009020805/en/main.assets" "Apartado" => array:4 [ "identificador" => "72880" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/25310437/0000002600000005/v1_202009020805/S2531043720300763/v1_202009020805/en/main.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2531043720300763?idApp=UINPBA00004E" ]
Year/Month | Html | Total | |
---|---|---|---|
2024 November | 11 | 5 | 16 |
2024 October | 43 | 34 | 77 |
2024 September | 52 | 42 | 94 |
2024 August | 67 | 37 | 104 |
2024 July | 48 | 35 | 83 |
2024 June | 57 | 35 | 92 |
2024 May | 47 | 36 | 83 |
2024 April | 33 | 35 | 68 |
2024 March | 48 | 20 | 68 |
2024 February | 31 | 27 | 58 |
2024 January | 26 | 29 | 55 |
2023 December | 21 | 20 | 41 |
2023 November | 32 | 45 | 77 |
2023 October | 27 | 44 | 71 |
2023 September | 30 | 36 | 66 |
2023 August | 20 | 11 | 31 |
2023 July | 23 | 24 | 47 |
2023 June | 20 | 18 | 38 |
2023 May | 42 | 34 | 76 |
2023 April | 26 | 20 | 46 |
2023 March | 56 | 18 | 74 |
2023 February | 49 | 24 | 73 |
2023 January | 24 | 29 | 53 |
2022 December | 46 | 26 | 72 |
2022 November | 37 | 35 | 72 |
2022 October | 75 | 48 | 123 |
2022 September | 25 | 37 | 62 |
2022 August | 39 | 46 | 85 |
2022 July | 35 | 60 | 95 |
2022 June | 29 | 31 | 60 |
2022 May | 40 | 39 | 79 |
2022 April | 31 | 38 | 69 |
2022 March | 31 | 47 | 78 |
2022 February | 34 | 47 | 81 |
2022 January | 38 | 47 | 85 |
2021 December | 28 | 47 | 75 |
2021 November | 31 | 45 | 76 |
2021 October | 42 | 56 | 98 |
2021 September | 40 | 44 | 84 |
2021 August | 40 | 33 | 73 |
2021 July | 60 | 22 | 82 |
2021 June | 50 | 32 | 82 |
2021 May | 55 | 44 | 99 |
2021 April | 167 | 96 | 263 |
2021 March | 68 | 39 | 107 |
2021 February | 49 | 36 | 85 |
2021 January | 48 | 35 | 83 |
2020 December | 47 | 33 | 80 |
2020 November | 46 | 30 | 76 |
2020 October | 90 | 38 | 128 |
2020 September | 137 | 69 | 206 |
2020 August | 61 | 30 | 91 |
2020 July | 64 | 34 | 98 |
2020 June | 57 | 31 | 88 |
2020 May | 32 | 14 | 46 |