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where up to 5&#8211;10&#37; of weight loss is associated with improved asthma control and quality of life&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">1&#44;5</span></a> In this way&#44; bariatric surgery is considered as the key option to promote a substantial weight loss&#46;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">6&#8211;8</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Here&#44; we report the case of an obese adult woman who presented with severe allergic-predominant asthma&#44; who really improved her symptoms and frequency of exacerbations following bariatric surgery&#46; However&#44; she developed a psychiatric disorder due to the non-acceptance of her new body image&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">A thirty-eight-year-old woman was referred to a pulmonology department because of severe uncontrolled steroid-dependent asthma&#46; She had frequent cough&#44; shortness of breath&#44; wheezing and recurrent exacerbations&#46; She had other comorbidities&#44; like obesity &#40;BMI 38&#41;&#44; gastroesophageal reflux disease &#40;GERD&#41; and chronic rhinosinusitis&#46; The patient&#39;s comorbidities&#44; exposure to allergens or other harmful agents&#44; as well as adherence and the appropriate use of current treatment were assessed&#46; After the evaluation&#44; weight loss was proposed and proton pump inhibitors and intranasal corticosteroids were prescribed&#46; Asthma treatment was reviewed and optimized &#40;with reduction of systemic corticosteroids &#40;SC&#41;&#44; high-dose inhaled corticosteroids &#40;ICS&#41; and long-acting beta 2-agonists &#40;LABA&#41;&#44; long-acting muscarinic antagonists &#40;LAMA&#41;&#44; leukotriene receptor antagonists &#40;LTRAs&#41;&#41;&#46; However&#44; the patient continued to have uncontrolled asthma&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The patient had reduced lung function &#40;FEV1 63&#37; pred&#44; Tiffeneau index 61&#41;&#44; atopy &#40;skin prick test positive&#41;&#44; IgE 454<span class="elsevierStyleHsp" style=""></span>kU&#47;L and blood eosinophils count of 890 cells&#47;l&#46; Based on this&#44; anti-IgE treatment &#40;omalizumab 525<span class="elsevierStyleHsp" style=""></span>mg&#44; SC each 2 weeks&#41; was started&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Over the next four years &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#44; the patient was asymptomatic&#44; had a total CARAT score of 22 &#40;9<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>13&#41;&#44; decreased blood eosinophil count &#40;260 cells&#47;l&#41;&#44; improved respiratory function tests &#40;FEV1 87&#37; pred&#41;&#44; showed a clear decrease in the number of exacerbations and did not report the need for systemic therapy with corticosteroids&#46; After that&#44; the patient had progressively worse asthma control&#44; despite using specific asthma therapy&#46; Thus&#44; the patient&#39;s comorbidities&#44; exposure to allergens&#44; as well as adherence and the appropriate use of current treatment were re-evaluated&#46; The patient gained weight&#44; reaching BMI of 40<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#46; She was diagnosed with moderate obstructive sleep apnea &#40;OSA&#41; syndrome &#40;apnea-hypopnea index of 20&#46;3 events&#47;h&#41; and automatic positive airway pressure &#40;APAP&#41; therapy was initiated&#46; Meanwhile&#44; after a psychiatric evaluation&#44; she underwent bariatric surgery&#46; Following bariatric surgery&#44; the patient had a rapid reduction in BMI&#44; 65<span class="elsevierStyleHsp" style=""></span>kg in 6 months&#46; Subsequently&#44; the patient presented a clinical &#40;total CARAT score of 28&#41; and functional improvement and did not require systemic corticosteroids or omalizumab therapy&#46; However&#44; the patient started having depressive symptoms and lack of acceptance of her new body image&#44; being referred for psychiatric re-evaluation&#46; She started drug treatment and cognitive-behavioral therapy&#44; but her weight persistently increased and asthma became uncontrolled&#46; Thus&#44; due to a new severe uncontrolled asthma&#44; anti-IgE treatment was repurposed&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">In fact&#44; obesity and asthma are prevalent disorders&#44; and there is an association between the two conditions&#44;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">1&#44;3&#44;4</span></a> where obesity is both a major risk factor and an asthma modifier&#46; Patients with severe asthma usually have limiting symptoms&#44; exacerbations and side effects of medications&#44; especially with the prolonged and recurrent use of SC&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">2&#44;9</span></a> The adverse effects of SC include obesity&#44; diabetes&#44; hypertension and psychological disorders&#44; such as depression and anxiety&#46; Therefore&#44; although asthma in obese patients is more commonly associated with non-type 2 inflammation&#44;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">2</span></a> obese patients with childhood-onset asthma tend to have higher markers of Th2 inflammation and more severe disease among obese asthmatics&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">4&#44;9</span></a> Studies have shown that weight loss interventions are associated with better control of asthma and respiratory function&#44;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">2&#44;10</span></a> and that bariatric surgery promotes a rapid and sustained weight loss&#44; and is generally associated with significant improvement in both asthma control and quality of life scores&#44; reducing the risk of hospitalizations due to asthma exacerbation&#44;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">7&#44;8&#44;10</span></a> and even triggering a significant decrease in treatment step&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">10</span></a> However&#44; although obese asthmatic patients can be treated with specific asthma therapy and weight loss interventions&#44; some patients still remain uncontrolled&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Obesity and asthma are frequently and independently associated with other conditions&#44; which are also associated with worse asthma control&#44; such as GERD&#44; OSA and mood disorders&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">2&#8211;4</span></a> Mood disorders&#44; which consisted mainly of anxiety and depression&#44; have been reported to be strongly correlated with asthma symptoms severity&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">11</span></a> Thus&#44; severe asthma management is difficult and needs a careful and multidimensional assessment&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">12</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Here we report the case of an obese adult woman who presented with predominant severe allergic asthma&#44; who truly improved her symptoms and exacerbations frequency following specific asthma therapy and bariatric surgery&#46; However&#44; despite all comorbidities and risk factors having been systematically assessed&#44; their management was difficult&#44; never allowing a longstanding asthma control&#46; This may be due to a different type of airway inflammation&#44; mechanical factors and other commodities that are associated with obesity&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">2&#8211;4</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Specifically&#44; although the evaluation of all comorbidities is extremely important&#44; it must be emphasized that&#44; in the case of mood disorders evaluation&#44; this can have a negative impact if not appropriately recognized and treated&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">11</span></a> The patient mentioned in this case started unpredictable depressive symptoms and lack of acceptance of her new body image&#44; following a rapid reduction in BMI&#46; Once depression was suspected&#44; the patient was referred for psychiatric evaluation and management&#46; She started drug treatment and cognitive-behavioral therapy&#44; but her weight persistently increased and her asthma became uncontrolled&#46; In conclusion&#44; the management of this patient remains difficult&#44; as the various comorbidities diverge and antagonize each other&#46; Taking this into account&#44; anti-IgE therapy was restarted&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">In short&#44; given that obesity is an important risk factor for asthma and asthma-related morbidity&#44; weight loss interventions should be highly encouraged to ensure proper control of asthma&#44; lung function and quality of life&#46; However&#44; although this aspect is extremely important&#44; it is also essential to ensure holistic management with an appropriate approach to all comorbid conditions in obese asthmatic individuals&#46;</p></span>"
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Letter to the Editor
Severe asthma intervention in adult obese patients
M. Serinoa,
Corresponding author
mariana.serino@gmail.com

Corresponding author.
, M. van Zellera,b, N. Martinsa,b,c, M. Drummonda,b
a Pulmonology Department, Centro Hospitalar Universitário São João, Porto, Portugal
b Faculty of Medicine, University of Porto, Portugal
c Institute for Research and Innovation in Health, University of Porto, Portugal
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Obesity and asthma are prevalent disorders&#44; both with an important impact on public health&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">1</span></a> A meta-analysis of seven prospective studies found a relationship between obesity and asthma&#58; incident asthma OR in overweight and obese groups was 1&#46;5 and 1&#46;9&#44; respectively&#44; when compared to the normal weight group&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">1</span></a> In fact&#44; obese patients have an increased risk of asthma&#44; and obese asthmatics have even more symptoms&#44; frequent and severe exacerbations and worse response to asthma-specific therapies&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">1&#8211;4</span></a> Weight loss has been proposed as essential in these patients&#44; where up to 5&#8211;10&#37; of weight loss is associated with improved asthma control and quality of life&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">1&#44;5</span></a> In this way&#44; bariatric surgery is considered as the key option to promote a substantial weight loss&#46;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">6&#8211;8</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Here&#44; we report the case of an obese adult woman who presented with severe allergic-predominant asthma&#44; who really improved her symptoms and frequency of exacerbations following bariatric surgery&#46; However&#44; she developed a psychiatric disorder due to the non-acceptance of her new body image&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">A thirty-eight-year-old woman was referred to a pulmonology department because of severe uncontrolled steroid-dependent asthma&#46; She had frequent cough&#44; shortness of breath&#44; wheezing and recurrent exacerbations&#46; She had other comorbidities&#44; like obesity &#40;BMI 38&#41;&#44; gastroesophageal reflux disease &#40;GERD&#41; and chronic rhinosinusitis&#46; The patient&#39;s comorbidities&#44; exposure to allergens or other harmful agents&#44; as well as adherence and the appropriate use of current treatment were assessed&#46; After the evaluation&#44; weight loss was proposed and proton pump inhibitors and intranasal corticosteroids were prescribed&#46; Asthma treatment was reviewed and optimized &#40;with reduction of systemic corticosteroids &#40;SC&#41;&#44; high-dose inhaled corticosteroids &#40;ICS&#41; and long-acting beta 2-agonists &#40;LABA&#41;&#44; long-acting muscarinic antagonists &#40;LAMA&#41;&#44; leukotriene receptor antagonists &#40;LTRAs&#41;&#41;&#46; However&#44; the patient continued to have uncontrolled asthma&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The patient had reduced lung function &#40;FEV1 63&#37; pred&#44; Tiffeneau index 61&#41;&#44; atopy &#40;skin prick test positive&#41;&#44; IgE 454<span class="elsevierStyleHsp" style=""></span>kU&#47;L and blood eosinophils count of 890 cells&#47;l&#46; Based on this&#44; anti-IgE treatment &#40;omalizumab 525<span class="elsevierStyleHsp" style=""></span>mg&#44; SC each 2 weeks&#41; was started&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Over the next four years &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#44; the patient was asymptomatic&#44; had a total CARAT score of 22 &#40;9<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>13&#41;&#44; decreased blood eosinophil count &#40;260 cells&#47;l&#41;&#44; improved respiratory function tests &#40;FEV1 87&#37; pred&#41;&#44; showed a clear decrease in the number of exacerbations and did not report the need for systemic therapy with corticosteroids&#46; After that&#44; the patient had progressively worse asthma control&#44; despite using specific asthma therapy&#46; Thus&#44; the patient&#39;s comorbidities&#44; exposure to allergens&#44; as well as adherence and the appropriate use of current treatment were re-evaluated&#46; The patient gained weight&#44; reaching BMI of 40<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#46; She was diagnosed with moderate obstructive sleep apnea &#40;OSA&#41; syndrome &#40;apnea-hypopnea index of 20&#46;3 events&#47;h&#41; and automatic positive airway pressure &#40;APAP&#41; therapy was initiated&#46; Meanwhile&#44; after a psychiatric evaluation&#44; she underwent bariatric surgery&#46; Following bariatric surgery&#44; the patient had a rapid reduction in BMI&#44; 65<span class="elsevierStyleHsp" style=""></span>kg in 6 months&#46; Subsequently&#44; the patient presented a clinical &#40;total CARAT score of 28&#41; and functional improvement and did not require systemic corticosteroids or omalizumab therapy&#46; However&#44; the patient started having depressive symptoms and lack of acceptance of her new body image&#44; being referred for psychiatric re-evaluation&#46; She started drug treatment and cognitive-behavioral therapy&#44; but her weight persistently increased and asthma became uncontrolled&#46; Thus&#44; due to a new severe uncontrolled asthma&#44; anti-IgE treatment was repurposed&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">In fact&#44; obesity and asthma are prevalent disorders&#44; and there is an association between the two conditions&#44;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">1&#44;3&#44;4</span></a> where obesity is both a major risk factor and an asthma modifier&#46; Patients with severe asthma usually have limiting symptoms&#44; exacerbations and side effects of medications&#44; especially with the prolonged and recurrent use of SC&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">2&#44;9</span></a> The adverse effects of SC include obesity&#44; diabetes&#44; hypertension and psychological disorders&#44; such as depression and anxiety&#46; Therefore&#44; although asthma in obese patients is more commonly associated with non-type 2 inflammation&#44;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">2</span></a> obese patients with childhood-onset asthma tend to have higher markers of Th2 inflammation and more severe disease among obese asthmatics&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">4&#44;9</span></a> Studies have shown that weight loss interventions are associated with better control of asthma and respiratory function&#44;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">2&#44;10</span></a> and that bariatric surgery promotes a rapid and sustained weight loss&#44; and is generally associated with significant improvement in both asthma control and quality of life scores&#44; reducing the risk of hospitalizations due to asthma exacerbation&#44;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">7&#44;8&#44;10</span></a> and even triggering a significant decrease in treatment step&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">10</span></a> However&#44; although obese asthmatic patients can be treated with specific asthma therapy and weight loss interventions&#44; some patients still remain uncontrolled&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Obesity and asthma are frequently and independently associated with other conditions&#44; which are also associated with worse asthma control&#44; such as GERD&#44; OSA and mood disorders&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">2&#8211;4</span></a> Mood disorders&#44; which consisted mainly of anxiety and depression&#44; have been reported to be strongly correlated with asthma symptoms severity&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">11</span></a> Thus&#44; severe asthma management is difficult and needs a careful and multidimensional assessment&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">12</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Here we report the case of an obese adult woman who presented with predominant severe allergic asthma&#44; who truly improved her symptoms and exacerbations frequency following specific asthma therapy and bariatric surgery&#46; However&#44; despite all comorbidities and risk factors having been systematically assessed&#44; their management was difficult&#44; never allowing a longstanding asthma control&#46; This may be due to a different type of airway inflammation&#44; mechanical factors and other commodities that are associated with obesity&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">2&#8211;4</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Specifically&#44; although the evaluation of all comorbidities is extremely important&#44; it must be emphasized that&#44; in the case of mood disorders evaluation&#44; this can have a negative impact if not appropriately recognized and treated&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">11</span></a> The patient mentioned in this case started unpredictable depressive symptoms and lack of acceptance of her new body image&#44; following a rapid reduction in BMI&#46; Once depression was suspected&#44; the patient was referred for psychiatric evaluation and management&#46; She started drug treatment and cognitive-behavioral therapy&#44; but her weight persistently increased and her asthma became uncontrolled&#46; In conclusion&#44; the management of this patient remains difficult&#44; as the various comorbidities diverge and antagonize each other&#46; Taking this into account&#44; anti-IgE therapy was restarted&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">In short&#44; given that obesity is an important risk factor for asthma and asthma-related morbidity&#44; weight loss interventions should be highly encouraged to ensure proper control of asthma&#44; lung function and quality of life&#46; However&#44; although this aspect is extremely important&#44; it is also essential to ensure holistic management with an appropriate approach to all comorbid conditions in obese asthmatic individuals&#46;</p></span>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Variation in &#40;A&#41; FEV &#40;&#37;&#41; and weight &#40;kg&#41; and &#40;B&#41; eosinophils count &#40;cells&#47;L&#41; and weight &#40;kg&#41; over time following omalizumab treatment initiation&#46;</p>"
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Article information
ISSN: 25310437
Original language: English
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Pulmonology

Are you a health professional able to prescribe or dispense drugs?