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array:24 [ "pii" => "S2531043721001859" "issn" => "25310437" "doi" => "10.1016/j.pulmoe.2021.08.008" "estado" => "S300" "fechaPublicacion" => "2022-09-01" "aid" => "1661" "copyright" => "Sociedade Portuguesa de Pneumologia" "copyrightAnyo" => "2021" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "cor" "cita" => "Pulmonol. 2022;28:399-402" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:19 [ "pii" => "S2531043722001106" "issn" => "25310437" "doi" => "10.1016/j.pulmoe.2022.04.005" "estado" => "S300" "fechaPublicacion" => "2022-09-01" "aid" => "1744" "copyright" => "Sociedade Portuguesa de Pneumologia" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by/4.0/" "subdocumento" => "cor" "cita" => "Pulmonol. 2022;28:403-5" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Osimertinib-induced lymphocytopenia and pneumocystis jirovecii pneumonia" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "403" "paginaFinal" => "405" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0001" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2510 "Ancho" => 2917 "Tamanyo" => 658810 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0001" "detalle" => "Fig " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spara001" class="elsevierStyleSimplePara elsevierViewall">Chest X-ray (CXR) and computed tomography (CT) findings of an 86-year-old man on referral (A-C in March), relapse (D-F in August), and admission (G-I, in December). Both CXR and CT show bilateral ground-glass opacities on admission (G and I).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "H. Takechi, H. Endoh, Y. Hata, S. Wasamoto, S. Yanagisawa" "autores" => array:5 [ 0 => array:2 [ "nombre" => "H." "apellidos" => "Takechi" ] 1 => array:2 [ "nombre" => "H." "apellidos" => "Endoh" ] 2 => array:2 [ "nombre" => "Y." "apellidos" => "Hata" ] 3 => array:2 [ "nombre" => "S." "apellidos" => "Wasamoto" ] 4 => array:2 [ "nombre" => "S." "apellidos" => "Yanagisawa" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2531043722001106?idApp=UINPBA00004E" "url" => "/25310437/0000002800000005/v1_202209020713/S2531043722001106/v1_202209020713/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S2531043722001064" "issn" => "25310437" "doi" => "10.1016/j.pulmoe.2022.03.011" "estado" => "S300" "fechaPublicacion" => "2022-09-01" "aid" => "1738" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "cor" "cita" => "Pulmonol. 2022;28:396-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Correlations between radiological and histological findings in patients with pulmonary vein stenosis after radiofrequency ablation: A case series" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "396" "paginaFinal" => "398" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0001" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1398 "Ancho" => 2667 "Tamanyo" => 308922 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0001" "detalle" => "Fig " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spara001" class="elsevierStyleSimplePara elsevierViewall">Ill-defined, rounded and partially confluent consolidations with halo sign are present in the right upper lobe. Mild alveolar ground glass attenuation is present in the surrounding parenchyma (a-c). Tiny cavitation is visible in one of the consolidated lesions (b). Axial images with mediastinal window and MIP reconstructions show right upper pulmonary vein stenosis (d, e - yellow arrows) associated with hypertrophy of bronchial arteries (f - red arrow).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "E. Poletti, M. Galvani, A. Dubini, V. Poletti, S. Piciucchi" "autores" => array:5 [ 0 => array:3 [ "preGrado" => "MD" "nombre" => "E." "apellidos" => "Poletti" ] 1 => array:3 [ "preGrado" => "MD" "nombre" => "M." "apellidos" => "Galvani" ] 2 => array:3 [ "preGrado" => "MD" "nombre" => "A." "apellidos" => "Dubini" ] 3 => array:3 [ "preGrado" => "MD" "nombre" => "V." "apellidos" => "Poletti" ] 4 => array:3 [ "preGrado" => "MD" "nombre" => "S." "apellidos" => "Piciucchi" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2531043722001064?idApp=UINPBA00004E" "url" => "/25310437/0000002800000005/v1_202209020713/S2531043722001064/v1_202209020713/en/main.assets" ] "en" => array:17 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Images. Thoracic NUT carcinoma: an exceptionally rare entity with a challenging approach" "tieneTextoCompleto" => true "saludo" => "Dear Editor," "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "399" "paginaFinal" => "402" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "A. Alfaiate, C. Padrão, V. Clérigo, I. Fernandes" "autores" => array:4 [ 0 => array:4 [ "nombre" => "A." "apellidos" => "Alfaiate" "email" => array:1 [ 0 => "ana.alfaiate92@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0001" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0001" ] ] ] 1 => array:3 [ "nombre" => "C." "apellidos" => "Padrão" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0002" ] ] ] 2 => array:3 [ "nombre" => "V." "apellidos" => "Clérigo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0001" ] ] ] 3 => array:3 [ "nombre" => "I." "apellidos" => "Fernandes" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0001" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Centro Hospitalar de Setúbal EPE, Rua Camilo Castelo Branco 175, 2910-549 Setubal, Portugal" "etiqueta" => "a" "identificador" => "aff0001" ] 1 => array:3 [ "entidad" => "Hospital Professor Doutor Fernando Fonseca EPE, Portugal" "etiqueta" => "b" "identificador" => "aff0002" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0001" "etiqueta" => "⁎" "correspondencia" => "Correspondence author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0001" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2969 "Ancho" => 1342 "Tamanyo" => 246282 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0001" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spara001" class="elsevierStyleSimplePara elsevierViewall">(Original images) (A) Chest x-ray with right mediastinal enlargement. (B-C) Chest computed tomography, depicting an infracarinal mediastinal mass and a right middle lobe consolidation. (Original images).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="para0002" class="elsevierStylePara elsevierViewall">Nuclear protein in testis (NUT) carcinomas are exceptionally rare and aggressive, with unknown incidence. Although these carcinomas were initially recognized as occurring almost exclusively in young patients, recent literature suggests that NUT carcinomas (NCs) may affect both sexes equally, with an extensive age range.<a class="elsevierStyleCrossRefs" href="#bib0001"><span class="elsevierStyleSup">1–3</span></a></p><p id="para0003" class="elsevierStylePara elsevierViewall">NC is a rare and poorly differentiated carcinoma. In nearly 70% of cases, the <span class="elsevierStyleItalic">NUT</span> gene (15q14) is fused to the <span class="elsevierStyleItalic">BRD4</span> gene (19p13.1), resulting in a <span class="elsevierStyleItalic">BRD4-NUT</span> fusion gene that leads to global hypoacetylation and transcriptional repression of differentiation genes.<a class="elsevierStyleCrossRef" href="#bib0001"><span class="elsevierStyleSup">1</span></a><span class="elsevierStyleSup">,</span><a class="elsevierStyleCrossRef" href="#bib0003"><span class="elsevierStyleSup">3</span></a><span class="elsevierStyleSup">,</span><a class="elsevierStyleCrossRef" href="#bib0004"><span class="elsevierStyleSup">4</span></a> Hereditary or environmental factors are not related.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">5</span></a> Almost 51% of NCs originate from thorax, 41% from head and neck, 6% from bone or soft tissue, and 2% from other organs.<a class="elsevierStyleCrossRef" href="#bib0001"><span class="elsevierStyleSup">1</span></a> The “midline” term is no longer included in the “WHO classification of tumours”.<a class="elsevierStyleCrossRef" href="#bib0006"><span class="elsevierStyleSup">6</span></a> Regardless of NC predisposition to involve midline structures, were described cases of carcinomas arising from the bladder, pancreas, salivary glands, and bones.<a class="elsevierStyleCrossRef" href="#bib0004"><span class="elsevierStyleSup">4</span></a><span class="elsevierStyleSup">,</span><a class="elsevierStyleCrossRef" href="#bib0007"><span class="elsevierStyleSup">7</span></a></p><p id="para0004" class="elsevierStylePara elsevierViewall">We report a case of a 25-year-old male with no relevant medical history or smoking habits who sought medical care for a subacute cough lasting four weeks. Clinical examination was unremarkable. Chest X-ray showed right mediastinal enlargement, and chest CT evidenced a 64 × 50 mm infracarinal mediastinal mass and a right middle lobe consolidation (<a class="elsevierStyleCrossRef" href="#fig0001">Fig. 1</a>A–C). Videobronchofibroscopy revealed small nodular lesions on the left main bronchus entrance and middle lobe bronchus narrowing due to a “cauliflower” lesion (<a class="elsevierStyleCrossRef" href="#fig0002">Fig. 2</a>A-B). Bronchial biopsies, endobronchial ultrasound, and transbronchial needle aspiration of station 7 lymph nodes were performed. Bronchial and lymph node samples showed solid to trabecular pattern neoplasia with keratin pearls and abrupt keratinization. Immunohistochemistry was positive for NUT protein (C52B1; 1:40; Cell Signaling Technology, Inc., USA), p40, p63, CK5, CK34B12 and CD56 (<a class="elsevierStyleCrossRef" href="#fig0002">Fig. 2</a>C–E), and negative for TTF-1, Napsin-A, synaptophysin, chromogranin and CD34. FISH and RT-PCR were not performed.</p><elsevierMultimedia ident="fig0001"></elsevierMultimedia><elsevierMultimedia ident="fig0002"></elsevierMultimedia><p id="para0005" class="elsevierStylePara elsevierViewall">Subsequent evaluation, including PET/CT, revealed an extensive middle lobe infiltrative lesion (94 × 69 mm); right broncho-hilar, infracarinal (with left main bronchus projection), oesophageal, and diaphragmatic adenopathies; a hepatic lesion; a right supra-renal nodule; and osteomedullary lesions. An IV-B stage thoracic NC (TNC) was assumed, and the patient is presently enrolled in a clinical trial of a bromodomain and extraterminal (BET) inhibitor.</p><p id="para0006" class="elsevierStylePara elsevierViewall">The clinical signs of TNCs are nonspecific, including dyspnoea, haemoptysis, chronic cough, nausea, and pain from bone metastasis.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">5</span></a> In a review of seven TNCs, all patients complained of cough lasting for more than a month.<a class="elsevierStyleCrossRef" href="#bib0002"><span class="elsevierStyleSup">2</span></a> Usually, symptoms relate to tumour location and mass effect. Because of the tumour's rapid development, constitutional symptoms are not frequent.<a class="elsevierStyleCrossRef" href="#bib0007"><span class="elsevierStyleSup">7</span></a> Usually, TNCs are accompanied by distant metastases at the time of diagnosis.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">5</span></a> Bones are the most common site of extrathoracic involvement, and it is thought that the majority of these patients do not live long enough to develop brain metastases.<a class="elsevierStyleCrossRef" href="#bib0002"><span class="elsevierStyleSup">2</span></a><span class="elsevierStyleSup">,</span><a class="elsevierStyleCrossRef" href="#bib0007"><span class="elsevierStyleSup">7</span></a> A recurrent question has been whether NCs arise primarily in the lung, or secondarily involve the lungs due to aggressive growth within the mediastinum<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">5</span></a>. In WHO 5<span class="elsevierStyleSup">th</span> edition, were reclassified as thoracic NUT carcinomas.<a class="elsevierStyleCrossRef" href="#bib0006"><span class="elsevierStyleSup">6</span></a></p><p id="para0007" class="elsevierStylePara elsevierViewall">The histologic features are unspecific; it is poorly differentiated, with or without squamous differentiation with a monomorphic appearance. Abrupt keratinization is suggestive but not pathognomonic of this entity.<a class="elsevierStyleCrossRef" href="#bib0008"><span class="elsevierStyleSup">8</span></a> NCs can mimic other undifferentiated neoplasms, such as germ cell tumours, Ewing's sarcoma or lymphoma.<a class="elsevierStyleCrossRef" href="#bib0007"><span class="elsevierStyleSup">7</span></a> In the reported case, one of the evaluated neuroendocrine (NE) markers (CD56) was positive, highlighting an unusual finding and the nonspecific character of NE marker expression, underlining the need to maintain a broad differential diagnosis when approaching high-grade carcinomas.<a class="elsevierStyleCrossRef" href="#bib0009"><span class="elsevierStyleSup">9</span></a> Thoracic tumours with aggressive expression and pleomorphic/undifferentiated carcinomas should warrant prompt evaluation for NUT translocation.<a class="elsevierStyleCrossRef" href="#bib0001"><span class="elsevierStyleSup">1</span></a> Diagnosis is based on the demonstration of the <span class="elsevierStyleItalic">NUT</span> genetic rearrangement, either by NUT immunohistochemical analysis, FISH or RT-PCR.<a class="elsevierStyleCrossRef" href="#bib0001"><span class="elsevierStyleSup">1</span></a><span class="elsevierStyleSup">,</span><a class="elsevierStyleCrossRef" href="#bib0007"><span class="elsevierStyleSup">7</span></a><span class="elsevierStyleSup">,</span><a class="elsevierStyleCrossRef" href="#bib0008"><span class="elsevierStyleSup">8</span></a> In imaging descriptions of TNCs, they usually present as large masses with lymphadenopathy and pleural involvement, with no side/lobar predilection<a class="elsevierStyleCrossRef" href="#bib0001"><span class="elsevierStyleSup">1</span></a> — relatively nonspecific but consistent features. In seven assumed pulmonary NCs, the most constant imaging finding was a large unilateral lesion involving the lung, pleura and mediastinal lymph nodes.<a class="elsevierStyleCrossRef" href="#bib0002"><span class="elsevierStyleSup">2</span></a></p><p id="para0008" class="elsevierStylePara elsevierViewall">The diagnosis is frequently overlooked. Several factors contribute to underdiagnosis, namely insufficient reporting, age bias and nonspecific morphology.<a class="elsevierStyleCrossRef" href="#bib0007"><span class="elsevierStyleSup">7</span></a></p><p id="para0009" class="elsevierStylePara elsevierViewall">Currently, there are no standardized guidelines aimed at treating NC.<a class="elsevierStyleCrossRef" href="#bib0001"><span class="elsevierStyleSup">1</span></a><span class="elsevierStyleSup">,</span><a class="elsevierStyleCrossRef" href="#bib0002"><span class="elsevierStyleSup">2</span></a> Surgical options are limited by its fast growth. Radiotherapy frequently has a palliative role, and NC usually does not respond to chemotherapy or immunotherapy regimens.<a class="elsevierStyleCrossRef" href="#bib0007"><span class="elsevierStyleSup">7</span></a></p><p id="para0010" class="elsevierStylePara elsevierViewall">Further possible therapeutic options include histone deacetylase inhibitors and BET inhibitors.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">5</span></a> BET inhibitors bind to the BRD4-NUT chromatin binding site, inhibiting gene activation, and at least three studies have reported improved survival in NC patients.<a class="elsevierStyleCrossRef" href="#bib0001"><span class="elsevierStyleSup">1</span></a> However, the outcome has been invariably fatal, and the average survival rate is six to seven months after diagnosis.<a class="elsevierStyleCrossRef" href="#bib0007"><span class="elsevierStyleSup">7</span></a></p><p id="para0011" class="elsevierStylePara elsevierViewall">Regardless of the patients’ age and the absence of risk factors, NC should be included in the differential diagnosis of thoracic masses with a rapidly progressive clinical course.<a class="elsevierStyleCrossRef" href="#bib0002"><span class="elsevierStyleSup">2</span></a> The outcome is poor, as NCs are refractory to conventional therapy, and promising targeted therapies are currently under testing. Both clinicians and pathologists should be aware of this rare entity to make the proper diagnosis and establish effective treatment algorithms.</p><span id="sec0001" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0002">Author contributions</span><p id="para0012" class="elsevierStylePara elsevierViewall">Study conception and design: Ana Alfaiate, Vera Clérigo.</p><p id="para0013" class="elsevierStylePara elsevierViewall">Data acquisition: Ana Alfaiate, Carolina Padrão, Vera Clérigo, Ivone Fernandes.</p><p id="para0014" class="elsevierStylePara elsevierViewall">Data analysis and interpretation: Ana Alfaiate, Carolina Padrão, Vera Clérigo, Ivone Fernandes.</p><p id="para0015" class="elsevierStylePara elsevierViewall">Drafting of the manuscript: Ana Alfaiate, Vera Clérigo.</p><p id="para0016" class="elsevierStylePara elsevierViewall">Critical revision of the manuscript for important intellectual content: Carolina Padrão, Ivone Fernandes.</p><p id="para0017" class="elsevierStylePara elsevierViewall">All authors had access to the data and played a role in writing this manuscript.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0001" "titulo" => "Author contributions" ] 1 => array:2 [ "identificador" => "xack623813" "titulo" => "Acknowledgements" ] 2 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2021-03-18" "fechaAceptado" => "2021-08-05" "multimedia" => array:2 [ 0 => array:8 [ "identificador" => "fig0001" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2969 "Ancho" => 1342 "Tamanyo" => 246282 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0001" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spara001" class="elsevierStyleSimplePara elsevierViewall">(Original images) (A) Chest x-ray with right mediastinal enlargement. (B-C) Chest computed tomography, depicting an infracarinal mediastinal mass and a right middle lobe consolidation. (Original images).</p>" ] ] 1 => array:8 [ "identificador" => "fig0002" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 3239 "Ancho" => 2809 "Tamanyo" => 1142354 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0002" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spara002" class="elsevierStyleSimplePara elsevierViewall">(Original images) (A-B) Videobronchofibroscopy images: (A) Small nodular lesions on the left main bronchus entrance (B) Middle lobe bronchus narrowing due to a “cauliflower” lesion. (C) Respiratory mucosa fragments, documenting infiltration by solid to trabecular pattern neoplasia of small, cuboidal cells with granular chromatin and generally absent nucleoli, with scant eosinophilic cytoplasm. Foci of necrosis and abrupt keratinization and keratin pearls formation are identified (C-HE 10x, D-HE 20x). (E) Immunohistochemical study positive, strong and diffuse for NUT (HE 10x). (Original images).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "cebibsec1" "bibliografiaReferencia" => array:9 [ 0 => array:3 [ "identificador" => "bib0001" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Imaging spectrum of NUT carcinomas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M Virarkar" 1 => "M Saleh" 2 => "NS Ramani" 3 => "AC Morani" 4 => "P. 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