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array:24 [ "pii" => "S2531043722000733" "issn" => "25310437" "doi" => "10.1016/j.pulmoe.2022.03.001" "estado" => "S300" "fechaPublicacion" => "2022-11-01" "aid" => "1726" "copyright" => "Sociedade Portuguesa de Pneumologia" "copyrightAnyo" => "2022" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "cor" "cita" => "Pulmonol. 2022;28:487-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:19 [ "pii" => "S2531043722001234" "issn" => "25310437" "doi" => "10.1016/j.pulmoe.2022.05.002" "estado" => "S300" "fechaPublicacion" => "2022-11-01" "aid" => "1753" "copyright" => "Sociedade Portuguesa de Pneumologia" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "cor" "cita" => "Pulmonol. 2022;28:489" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:9 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "High-flow oxygen therapy in palliative care: A reality in a near future?" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "489" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M. Carqueijó" "autores" => array:1 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "Carqueijó" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2531043722001234?idApp=UINPBA00004E" "url" => "/25310437/0000002800000006/v1_202211020651/S2531043722001234/v1_202211020651/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2531043722001246" "issn" => "25310437" "doi" => "10.1016/j.pulmoe.2022.05.004" "estado" => "S300" "fechaPublicacion" => "2022-11-01" "aid" => "1755" "copyright" => "Sociedade Portuguesa de Pneumologia" "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "cor" "cita" => "Pulmonol. 2022;28:484-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "The unfriendly side of “happy hypoxaemia”: Sudden cardiac death" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "484" "paginaFinal" => "486" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0001" "etiqueta" => "Fig. 1 (A)" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 3978 "Ancho" => 1667 "Tamanyo" => 450864 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0001" "detalle" => "Fig. 1 (A)" "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spara001" class="elsevierStyleSimplePara elsevierViewall">Chest X-ray taken in a patient with severe COVID-19. showing extensive bilateral opacities, with a slight predominance for the peripheral and basal lung fields. (B) Arterial blood sample, drawn from a patient with COVID-19 receiving non-invasive ventilation (EPAP 12; Pressure Support 4; FiO<span class="elsevierStyleInf">2</span> 100%). Blood gas analysis revealed a P<span class="elsevierStyleInf">a</span>O<span class="elsevierStyleInf">2</span> of 28mmHg (P/F ratio 28mmHg). Despite oxygen saturations below 40%, the patient denied dyspnoea and did not have elevated work of breathing.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "C.M.C. Serbanescu-Kele Apor de Zalán, R.P. Banwarie, K.D. Banwari, B.A. Panka" "autores" => array:4 [ 0 => array:3 [ "preGrado" => "MD" "nombre" => "C.M.C." "apellidos" => "Serbanescu-Kele Apor de Zalán" ] 1 => array:3 [ "preGrado" => "MD" "nombre" => "R.P." "apellidos" => "Banwarie" ] 2 => array:3 [ "preGrado" => "MD" "nombre" => "K.D." "apellidos" => "Banwari" ] 3 => array:3 [ "preGrado" => "MD" "nombre" => "B.A." "apellidos" => "Panka" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2531043722001246?idApp=UINPBA00004E" "url" => "/25310437/0000002800000006/v1_202211020651/S2531043722001246/v1_202211020651/en/main.assets" ] "en" => array:18 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Multiple system atrophy: Inspiratory sighs as a key polysomnographic sign to early diagnosis?" "tieneTextoCompleto" => true "saludo" => "Dear editor," "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "487" "paginaFinal" => "488" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "J.N. Caldeira, J. Moita, A.C. Brás" "autores" => array:3 [ 0 => array:4 [ "nombre" => "J.N." "apellidos" => "Caldeira" "email" => array:1 [ 0 => "joaoncaldeira@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0001" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0001" ] ] ] 1 => array:3 [ "nombre" => "J." "apellidos" => "Moita" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0002" ] ] ] 2 => array:3 [ "nombre" => "A.C." "apellidos" => "Brás" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0002" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0003" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Pulmonology Department, Centro Hospitalar e Universitário de Coimbra, Coimbra 3004-561, Portugal" "etiqueta" => "a" "identificador" => "aff0001" ] 1 => array:3 [ "entidad" => "Sleep Medicine Center, Centro Hospitalar e Universitário de Coimbra, R. do Museu 2, Coimbra 3045-081, Portugal" "etiqueta" => "b" "identificador" => "aff0002" ] 2 => array:3 [ "entidad" => "Neurology Department, Centro Hospitalar e Universitário de Coimbra, Coimbra 3004-561, Portugal" "etiqueta" => "c" "identificador" => "aff0003" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0001" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0001" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2390 "Ancho" => 2126 "Tamanyo" => 1257434 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0001" "detalle" => "Fig " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spara001" class="elsevierStyleSimplePara elsevierViewall">Examples of inspiratory sighs (black arrows), during N2 (A) and N3 (B) sleep. None of the sighs are associated to respiratory events.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="para0002" class="elsevierStylePara elsevierViewall">Multiple system atrophy (MSA) is a rapidly progressive adult neurodegenerative disease associated with sleep disorders, such as rapid eye movement (REM) sleep behavior disorder (RBD), obstructive sleep apnea syndrome (OSAS), or stridor.<a class="elsevierStyleCrossRef" href="#bib0001"><span class="elsevierStyleSup">1</span></a><span class="elsevierStyleSup">,</span><a class="elsevierStyleCrossRef" href="#bib0002"><span class="elsevierStyleSup">2</span></a></p><p id="para0003" class="elsevierStylePara elsevierViewall">A 63-year-old hypertensive woman with sleep onset insomnia complained of harmful motor activity and vivid dreams. The patient had no history of snoring, or other night symptoms, or complaints related to excessive daytime sleepiness. Epworth sleepiness scale score was of 6. She underwent polysomnography which revealed micro-arousal index of 42.4%, respiratory disturbance index of 18.9/h, periodic limb movements (PLM) of 67.5/h, frequent gesticulation and somniloquism and REM sleep without atonia. OSAS plus PLM syndrome and RBD were diagnosed, and she started continuous positive airway pressure treatment and clonazepam 0.5 mg/id. A year later she complained of multiple falls and orthostatic hypotension. Neurological examination revealed scanning dysarthria, distal polyminimyoclonus, limb dysmetria and ataxia A cerebellar-type probable MSA was diagnosed and the patient started levodopa/carbidopa 25/100 mg 3id partially improving symptoms. The polysomnography was reassessed and concluded the existence of multiple inspiratory sighs in different phases of NREM sleep (<a class="elsevierStyleCrossRef" href="#fig0001">Fig. 1</a>), a year prior the onset of neurological symptoms.</p><elsevierMultimedia ident="fig0001"></elsevierMultimedia><p id="para0004" class="elsevierStylePara elsevierViewall">This typical but barely known polysomnographic respiratory finding in MSA – inspiratory sighs – can be present in short disease duration and could help the differential diagnosis. Specially in the presence of stridor, sighs may increase the likelihood of MSA.<a class="elsevierStyleCrossRef" href="#bib0003"><span class="elsevierStyleSup">3</span></a> Besides inspiratory sighs, our patient's polysomnography helps the diagnosis of OSAS, PLM syndrome, and RBD. These are common both in MSA and in Parkinson's disease, and usually start before neurological complaints.<a class="elsevierStyleCrossRef" href="#bib0002"><span class="elsevierStyleSup">2</span></a></p><p id="para0005" class="elsevierStylePara elsevierViewall">In conclusion, pulmonologists in sleep medicine should be aware of this polysomnographic picture (inspiratory sighs, OSAS, PLM syndrome, and RBD) since it could point towards the presence of an extrapyramidal disease, including MSA. Careful evaluation of polysomnography may help to identify early signs of these neurodegenerative diseases and lead to early referral for a neurological consultation.</p><span id="sec0001" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0004">Declaration of Competing Interest</span><p id="para0006" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare.</p></span><span id="sec0002" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0005">Source of funding</span><p id="para0007" class="elsevierStylePara elsevierViewall">This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:4 [ 0 => array:2 [ "identificador" => "xpalclavsec1571425" "titulo" => "Abbreviations" ] 1 => array:2 [ "identificador" => "sec0001" "titulo" => "Declaration of Competing Interest" ] 2 => array:2 [ "identificador" => "sec0002" "titulo" => "Source of funding" ] 3 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2022-02-02" "fechaAceptado" => "2022-03-02" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "abr" "titulo" => "Abbreviations" "identificador" => "xpalclavsec1571425" "palabras" => array:5 [ 0 => "MSA" 1 => "OSAS" 2 => "PLM" 3 => "REM" 4 => "RBD" ] ] ] ] "apendice" => array:1 [ 0 => array:1 [ "seccion" => array:1 [ 0 => array:4 [ "apendice" => "<p id="para0008a" class="elsevierStylePara elsevierViewall"><elsevierMultimedia ident="ecom0001"></elsevierMultimedia></p>" "etiqueta" => "Appendix" "titulo" => "Supplementary materials" "identificador" => "sec0004" ] ] ] ] "multimedia" => array:2 [ 0 => array:8 [ "identificador" => "fig0001" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2390 "Ancho" => 2126 "Tamanyo" => 1257434 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0001" "detalle" => "Fig " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spara001" class="elsevierStyleSimplePara elsevierViewall">Examples of inspiratory sighs (black arrows), during N2 (A) and N3 (B) sleep. None of the sighs are associated to respiratory events.</p>" ] ] 1 => array:6 [ "identificador" => "ecom0001" "tipo" => "MULTIMEDIAECOMPONENTE" "mostrarFloat" => false "mostrarDisplay" => true "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0002" "detalle" => "Image, application " "rol" => "short" ] ] "Ecomponente" => array:2 [ "fichero" => "mmc1.docx" "ficheroTamanyo" => 22669 ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "cebibsec1" "bibliografiaReferencia" => array:3 [ 0 => array:3 [ "identificador" => "bib0001" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sleep abnormalities in multiple system atrophy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "V. Cochen De Cock" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s11940-018-0503-8" "Revista" => array:4 [ "tituloSerie" => "Curr Treat Options Neurol" "fecha" => "2018" "volumen" => "20" "numero" => "16" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0002" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multiple-system atrophy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. Fanciulli" 1 => "G.K. Wenning" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMra1311488" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2015" "volumen" => "372" "numero" => "3" "paginaInicial" => "249" "paginaFinal" => "263" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0003" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sighs during sleep in multiple system atrophy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. Parreira" 1 => "F. Antunes" 2 => "M. Coelho" 3 => "C. Bentes" 4 => "R. Peralta" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.sleep.2020.12.013" "Revista" => array:5 [ "tituloSerie" => "Sleep Med" "fecha" => "2021" "volumen" => "78" "paginaInicial" => "75" "paginaFinal" => "80" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/25310437/0000002800000006/v1_202211020651/S2531043722000733/v1_202211020651/en/main.assets" "Apartado" => array:4 [ "identificador" => "72880" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/25310437/0000002800000006/v1_202211020651/S2531043722000733/v1_202211020651/en/main.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2531043722000733?idApp=UINPBA00004E" ]
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