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Tracheal amyloidosis visualized by autofluorescence endoscopy
a Department of Respiratory Medicine, Centre Hospitalier Universitaire Saint-Pierre, Université Libre de Bruxelles, Brussels, Belgium
b Department of Respiratory Medicine, Centre Hospitalier Universitaire Brugmann, Université Libre de Bruxelles, Brussels, Belgium
c Department of Pathology, Centre Hospitalier Universitaire Saint-Pierre, Université Libre de Bruxelles, Brussels, Belgium
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Thoracic (B) CT scan revealing multiple mediastinal and hilar nodes (white arrowheads) with no pulmonary findings. Immunohistochemistry from biopsy of the right supraclavicular mass whose pathology result was compatible with a large cell neuroendocrine carcinoma of the lung: positivity for neuroendocrine markers, including synaptophysin (C) and for thyroid transcription factor-1 (TTF-1) (D).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J.C. Duarte, S. Ferreira, M. Valério, H. Garcia, C. Lousada" "autores" => array:5 [ 0 => array:2 [ "nombre" => "J.C." "apellidos" => "Duarte" ] 1 => array:2 [ "nombre" => "S." "apellidos" => "Ferreira" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Valério" ] 3 => array:2 [ "nombre" => "H." "apellidos" => "Garcia" ] 4 => array:2 [ "nombre" => "C." 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Polastri, E. Pehlivan" "autores" => array:2 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "Polastri" ] 1 => array:2 [ "nombre" => "E." "apellidos" => "Pehlivan" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2531043722001131?idApp=UINPBA00004E" "url" => "/25310437/0000002900000001/v1_202301030817/S2531043722001131/v1_202301030817/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Photo</span>" "titulo" => "Tracheal amyloidosis visualized by autofluorescence endoscopy" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "99" "paginaFinal" => "101" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "V. Inthasot, M. Gabrovska, M. Bruyneel, R. de Wind, V. Ninane" "autores" => array:5 [ 0 => array:3 [ "nombre" => "V." "apellidos" => "Inthasot" "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0001" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0002" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0001" ] ] ] 1 => array:3 [ "nombre" => "M." "apellidos" => "Gabrovska" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0001" ] ] ] 2 => array:3 [ "nombre" => "M." "apellidos" => "Bruyneel" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0001" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0002" ] ] ] 3 => array:3 [ "nombre" => "R." "apellidos" => "de Wind" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0003" ] ] ] 4 => array:3 [ "nombre" => "V." "apellidos" => "Ninane" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0001" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0002" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Department of Respiratory Medicine, Centre Hospitalier Universitaire Saint-Pierre, Université Libre de Bruxelles, Brussels, Belgium" "etiqueta" => "a" "identificador" => "aff0001" ] 1 => array:3 [ "entidad" => "Department of Respiratory Medicine, Centre Hospitalier Universitaire Brugmann, Université Libre de Bruxelles, Brussels, Belgium" "etiqueta" => "b" "identificador" => "aff0002" ] 2 => array:3 [ "entidad" => "Department of Pathology, Centre Hospitalier Universitaire Saint-Pierre, Université Libre de Bruxelles, Brussels, Belgium" "etiqueta" => "c" "identificador" => "aff0003" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0001" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0001" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 3780 "Ancho" => 2519 "Tamanyo" => 1167560 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0001" "detalle" => "Fig " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spara001" class="elsevierStyleSimplePara elsevierViewall">White light bronchoscopy (WLB) showing nodular mucosa irregularities along the anterior tracheal wall up to the carina (A); upon switching to autofluorescence imaging bronchoscopy, green spots interweaved with magenta areas are visible (B). Normal-appearing main carina on WLB (C); using autofluorescence imaging bronchoscopy, a flat pathological magenta lesion is now visible near the posterior tracheal wall (D). Tracheal biopsy showing abundant amorphous amyloid deposits within the submucosal tissue on standard haematoxylin-eosin staining (E, black arrows). Congo red staining demonstrates the characteristic orange-red appearance of amyloid deposits (F, black arrows).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="para0001" class="elsevierStylePara elsevierViewall">A 70-year-old woman with a 3-year history of progressive voice hoarseness was diagnosed with primary localized subglottic amyloidosis. Her medical history consisted of treated osteoporosis, hypothyroidism, and arterial hypertension, and a history of smoking six packs of cigarettes per year. The patient was referred to our department for bronchoscopic evaluation in the setting of worsened hoarseness.</p><p id="para0002" class="elsevierStylePara elsevierViewall">White light bronchoscopy (WLB) revealed nodular mucosa irregularities along the anterior tracheal wall extending from 3 cm below the vocal cords to the main carina (<a class="elsevierStyleCrossRef" href="#fig0001">Fig. 1</a>A). Upon switching to autofluorescence imaging bronchoscopy (BF-F260, Olympus Optical Co., Tokyo, Japan), green spots surrounded by diffuse magenta amyloid plaques were observed (<a class="elsevierStyleCrossRef" href="#fig0001">Fig. 1</a>B). A flat pathological magenta lesion on the posterior tracheal wall near the main carina was made visible by the autofluorescence light but was not visible using WLB (<a class="elsevierStyleCrossRef" href="#fig0001">Fig. 1</a>C and <a class="elsevierStyleCrossRef" href="#fig0001">1</a>D). Abundant deposits of amyloid within the submucosal tissue were present in the five biopsies taken from the proximal anterior tracheal wall to the main carina (<a class="elsevierStyleCrossRef" href="#fig0001">Fig. 1</a>E and <a class="elsevierStyleCrossRef" href="#fig0001">1</a>F).</p><elsevierMultimedia ident="fig0001"></elsevierMultimedia><p id="para0003" class="elsevierStylePara elsevierViewall">Localized tracheobronchial amyloidosis (TBA) is a very uncommon disease, with only a few hundred cases ever reported. TBA is characterized by extracellular amyloid infiltration throughout the proximal, mid, and lower airways.<a class="elsevierStyleCrossRef" href="#bib0001"><span class="elsevierStyleSup">1</span></a> The endoscopic features of TBA are variable and include intraluminal nodules, luminal stenosis, bronchial wall thickening or rigidity, brittle and easily bleeding mucosa, mucosal unevenness, hyperemia, edema, or paleness.<a class="elsevierStyleCrossRef" href="#bib0002"><span class="elsevierStyleSup">2</span></a> The use of autofluorescence imaging to look for amyloid deposition has been described in retinal imaging but has only been investigated for airway imaging in one case report.<a class="elsevierStyleCrossRef" href="#bib0003"><span class="elsevierStyleSup">3</span></a></p><p id="para0004" class="elsevierStylePara elsevierViewall">In our case, switching to autofluorescence endoscopy enabled us to observe the extent of tracheal infiltration by amyloid deposits and guided the choice of biopsy sites when we found that the conventional WLB view was not accurate enough. This technique may, therefore, be of interest for the assessment of suspected cases of TBA.</p><span id="sec0001" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0002">Patient's consent</span><p id="para0005" class="elsevierStylePara elsevierViewall">Informed consent was obtained for publication</p></span><span id="sec0002" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0003">Funding</span><p id="para0006" class="elsevierStylePara elsevierViewall">The present manuscript did not have any source of support.</p></span><span id="sec0003" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0004">Author contribution</span><p id="para0007" class="elsevierStylePara elsevierViewall">Conception and design: VI, MG, MB, VN - Acquisition of the data: MG, RDW, VN -</p><p id="para0008" class="elsevierStylePara elsevierViewall">Drafting of the manuscript: VI - Critical revision of the manuscript: MB, VN, RDW, MG</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0001" "titulo" => "Patient's consent" ] 1 => array:2 [ "identificador" => "sec0002" "titulo" => "Funding" ] 2 => array:2 [ "identificador" => "sec0003" "titulo" => "Author contribution" ] 3 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2022-05-31" "fechaAceptado" => "2022-06-07" "multimedia" => array:1 [ 0 => array:8 [ "identificador" => "fig0001" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 3780 "Ancho" => 2519 "Tamanyo" => 1167560 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "alt0001" "detalle" => "Fig " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spara001" class="elsevierStyleSimplePara elsevierViewall">White light bronchoscopy (WLB) showing nodular mucosa irregularities along the anterior tracheal wall up to the carina (A); upon switching to autofluorescence imaging bronchoscopy, green spots interweaved with magenta areas are visible (B). Normal-appearing main carina on WLB (C); using autofluorescence imaging bronchoscopy, a flat pathological magenta lesion is now visible near the posterior tracheal wall (D). Tracheal biopsy showing abundant amorphous amyloid deposits within the submucosal tissue on standard haematoxylin-eosin staining (E, black arrows). Congo red staining demonstrates the characteristic orange-red appearance of amyloid deposits (F, black arrows).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "cebibsec1" "bibliografiaReferencia" => array:3 [ 0 => array:3 [ "identificador" => "bib0001" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tracheobronchial amyloidosis. The Boston University experience from 1984 to 1999" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A O'Regan" 1 => "H M Fenlon" 2 => "Beamis Jr J F" 3 => "M P Steele" 4 => "M Skinner" 5 => "J.L. Berk" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/00005792-200003000-00001" "Revista" => array:7 [ "tituloSerie" => "Medicine (Baltimore)" "fecha" => "2000" "volumen" => "79" "numero" => "2" "paginaInicial" => "69" "paginaFinal" => "79" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10771705" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0002" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bronchoscopic diagnosis and treatment of primary tracheobronchial amyloidosis: a retrospective analysis from China" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "X Lu" 1 => "B He" 2 => "G Wang" 3 => "B He" 4 => "L Wang" 5 => "Q. Chen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1155/2017/3425812" "Revista" => array:3 [ "tituloSerie" => "Biomed Res Int" "fecha" => "2017" "volumen" => "2017" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0003" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tracheobronchial amyloidosis: a bright sight with autofluorescence light" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "T De Keukeleire" 1 => "S Hanon" 2 => "B Dieriks" 3 => "L Vanmaele" 4 => "M. Noppen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000098883" "Revista" => array:6 [ "tituloSerie" => "Respiration" "fecha" => "2009" "volumen" => "77" "numero" => "4" "paginaInicial" => "454" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17237614" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/25310437/0000002900000001/v1_202301030817/S2531043722001465/v1_202301030817/en/main.assets" "Apartado" => array:4 [ "identificador" => "88777" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Images" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/25310437/0000002900000001/v1_202301030817/S2531043722001465/v1_202301030817/en/main.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2531043722001465?idApp=UINPBA00004E" ]
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