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is milky&#46;</p><p id="para0003" class="elsevierStylePara elsevierViewall">A 41-year-old male herdsman was hospitalized due to repeated cough and expectoration for 5 years&#44; aggravated with shortness of breath for 5 months&#46; Seven months prior&#44; he was diagnosed with brucellosis with the presentation of lung infection at a local hospital&#44; which improved after one month of treatment&#44; leading to his discharge&#46; His vital signs were normal&#46; Physical examination and routine blood tests revealed unremarkable findings except for the clubbing of his digits&#46; The electrocardiogram was negative&#44; but a lung CT result revealed scattered patchy and large fuzzy shadows &#40;crazy-paving appearance&#41; in the bilateral lungs &#40;<a class="elsevierStyleCrossRef" href="#fig0001">Fig&#46; 1</a>A&#41;&#46; Simultaneously&#44; bronchoscopy was performed&#44; and the BALF revealed a characteristic milky appearance&#46; Interestingly&#44; after centrifuging the BALF sample at 1500&#160;rpm for 5&#160;min and using the cell pellet to make a smear&#44; a large number of phospholipid-rich protein aggregates were easily observed for microscopic examination &#40;<a class="elsevierStyleCrossRef" href="#fig0001">Fig&#46; 1</a>B&#41;&#46; Moreover&#44; the Wright&#8211;Giemsa staining for the above cell pellet smear showed bluish-purple staining &#40;<a class="elsevierStyleCrossRef" href="#fig0001">Fig&#46; 1</a>C&#41;&#46; Also&#44; periodic acid-Schiff &#40;PAS&#41; staining revealed PAS-positive proteinaceous material on the smear &#40;<a class="elsevierStyleCrossRef" href="#fig0001">Fig&#46; 1</a>D&#41;&#46; Moreover&#44; after incubating 100&#160;uL oil red O with 1&#160;mL of the BALF sample for 10&#160;min and centrifuging the stained sample at 1500&#160;rpm for 5&#160;min&#44; we used the cell pellet to make a smear&#44; which clearly revealed an orange aggregate &#40;<a class="elsevierStyleCrossRef" href="#fig0001">Fig&#46; 1</a>E&#41;&#46; Consequently&#44; PAP was suspected&#46; However&#44; a test for serum anti-granulocyte macrophage colony-stimulating factor &#40;GM-CSF&#41; antibody yielded negative results&#59; therefore&#44; he was diagnosed with sPAP in brucellosis&#44; and received several courses of whole lung lavage&#44; his condition improved&#44; and he was discharged&#46;</p><elsevierMultimedia ident="fig0001"></elsevierMultimedia><p id="para0004" class="elsevierStylePara elsevierViewall">Recently&#44; abnormalities in GM-CSF signaling are implicated in the pathogenesis of autoimmune PAP&#44; which accounts for the vast majority of cases&#46; However&#44; sPAP is a rarer disorder&#44; is not dependent on GM-CSF&#44; and mainly occurs owing to a hematological disease&#46;<a class="elsevierStyleCrossRef" href="#bib0003"><span class="elsevierStyleSup">3</span></a></p><p id="para0005" class="elsevierStylePara elsevierViewall">To our knowledge&#44; this is the first report of PAP with a recent brucellosis history and GM-CSF antibody negativity&#46; The herdsman was diagnosed with sPAP in brucellosis&#46; Moreover&#44; our study suggests that if the crazy-paving appearance on CT or milky BALF are observed and characteristic globules of PAS-positive proteinaceous material are also observed on the BALF&#44; 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Images: Secondary pulmonary alveolar proteinosis in brucellosis
L. Yana,b,1, Z. Wangc,1, J. Zhaod,
Corresponding author
zjwjack1979@163.com

Corresponding authors.
, J. Liue,
Corresponding author
liujinlinhz@163.com

Corresponding authors.
a Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
b Department of Clinical Laboratory, Inner Mongolia Baogang Hospital, Baotou, Inner Mongolia, China
c Department of Laboratory Medicine, Hainan General Hospital/Hainan Affiliated Hospital of Hainan Medical University, Haikou, China
d Department of Laboratory Medicine, Nanjing Lishui District Hospital of Traditional Chinese Medicine, Nanjing, People's Republic of China
e Department of Clinical Laboratory, South China Hospital, Health Science Center, Shenzhen University, Shenzhen, 518116, PR China
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          "en" => "<p id="spara001" class="elsevierStyleSimplePara elsevierViewall">Secondary pulmonary alveolar proteinosis in brucellosis in a herdsman&#46; &#40;A&#41; CT reveals a crazy-paving appearance on the bilateral lungs&#46; &#40;B&#41; Phospholipid-rich protein aggregates are clearly observed on the BALF smear through a direct smear for microscopic examination &#40;1000&#215;&#41;&#46; &#40;C&#41; Wright&#8211;Giemsa staining reveals bluish-purple staining &#40;1000&#215;&#41;&#46; &#40;D&#41; Periodic acid-Schiff-positive proteinaceous material is observed &#40;1000&#215;&#41;&#46; &#40;E&#41; Oil red O staining reveals an orange aggregate &#40;1000&#215;&#41;&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="para0002" class="elsevierStylePara elsevierViewall">Pulmonary alveolar proteinosis &#40;PAP&#41; is a rare pulmonary disease with specific features caused by the alveolar accumulation of surfactant&#44; composed of proteins and lipids&#44; due to dysfunctional pulmonary macrophages&#46;<a class="elsevierStyleCrossRef" href="#bib0001"><span class="elsevierStyleSup">1</span></a> It is classified into two types primary PAP and PAP secondary to leukemia&#44; lung infections&#44; and inhalation of mineral particles or chemical material&#46;<a class="elsevierStyleCrossRef" href="#bib0002"><span class="elsevierStyleSup">2</span></a> Secondary PAP &#40;sPAP&#41; is mainly caused by hematological disorders&#59; sPAP associated with brucellosis is extremely rare&#46; Here&#44; we report a rare case of sPAP in brucellosis in a herdsman&#46; Clinicians should consider the possibility of sPAP when chest radiography reveals abnormal findings and the bronchoalveolar lavage fluid &#40;BALF&#41; is milky&#46;</p><p id="para0003" class="elsevierStylePara elsevierViewall">A 41-year-old male herdsman was hospitalized due to repeated cough and expectoration for 5 years&#44; aggravated with shortness of breath for 5 months&#46; Seven months prior&#44; he was diagnosed with brucellosis with the presentation of lung infection at a local hospital&#44; which improved after one month of treatment&#44; leading to his discharge&#46; His vital signs were normal&#46; Physical examination and routine blood tests revealed unremarkable findings except for the clubbing of his digits&#46; The electrocardiogram was negative&#44; but a lung CT result revealed scattered patchy and large fuzzy shadows &#40;crazy-paving appearance&#41; in the bilateral lungs &#40;<a class="elsevierStyleCrossRef" href="#fig0001">Fig&#46; 1</a>A&#41;&#46; Simultaneously&#44; bronchoscopy was performed&#44; and the BALF revealed a characteristic milky appearance&#46; Interestingly&#44; after centrifuging the BALF sample at 1500&#160;rpm for 5&#160;min and using the cell pellet to make a smear&#44; a large number of phospholipid-rich protein aggregates were easily observed for microscopic examination &#40;<a class="elsevierStyleCrossRef" href="#fig0001">Fig&#46; 1</a>B&#41;&#46; Moreover&#44; the Wright&#8211;Giemsa staining for the above cell pellet smear showed bluish-purple staining &#40;<a class="elsevierStyleCrossRef" href="#fig0001">Fig&#46; 1</a>C&#41;&#46; Also&#44; periodic acid-Schiff &#40;PAS&#41; staining revealed PAS-positive proteinaceous material on the smear &#40;<a class="elsevierStyleCrossRef" href="#fig0001">Fig&#46; 1</a>D&#41;&#46; Moreover&#44; after incubating 100&#160;uL oil red O with 1&#160;mL of the BALF sample for 10&#160;min and centrifuging the stained sample at 1500&#160;rpm for 5&#160;min&#44; we used the cell pellet to make a smear&#44; which clearly revealed an orange aggregate &#40;<a class="elsevierStyleCrossRef" href="#fig0001">Fig&#46; 1</a>E&#41;&#46; Consequently&#44; PAP was suspected&#46; However&#44; a test for serum anti-granulocyte macrophage colony-stimulating factor &#40;GM-CSF&#41; antibody yielded negative results&#59; therefore&#44; he was diagnosed with sPAP in brucellosis&#44; and received several courses of whole lung lavage&#44; his condition improved&#44; and he was discharged&#46;</p><elsevierMultimedia ident="fig0001"></elsevierMultimedia><p id="para0004" class="elsevierStylePara elsevierViewall">Recently&#44; abnormalities in GM-CSF signaling are implicated in the pathogenesis of autoimmune PAP&#44; which accounts for the vast majority of cases&#46; However&#44; sPAP is a rarer disorder&#44; is not dependent on GM-CSF&#44; and mainly occurs owing to a hematological disease&#46;<a class="elsevierStyleCrossRef" href="#bib0003"><span class="elsevierStyleSup">3</span></a></p><p id="para0005" class="elsevierStylePara elsevierViewall">To our knowledge&#44; this is the first report of PAP with a recent brucellosis history and GM-CSF antibody negativity&#46; The herdsman was diagnosed with sPAP in brucellosis&#46; Moreover&#44; our study suggests that if the crazy-paving appearance on CT or milky BALF are observed and characteristic globules of PAS-positive proteinaceous material are also observed on the BALF&#44; PAP should be considered as a differential diagnosis&#46;</p><span id="sec0001" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0003">Ethical considerations</span><p id="para0006" class="elsevierStylePara elsevierViewall">Written informed consent was obtained from this patient&#46;</p></span><span id="sec0002" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0004">Funding information</span><p id="para0007" class="elsevierStylePara elsevierViewall">None&#46;</p></span><span id="sec0003" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0005">Consent from all authors</span><p id="para0008" class="elsevierStylePara elsevierViewall">All authors reviewed this manuscript and agreed to submit this manuscipt&#46;</p></span><span id="sec0003a" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0005a">CRediT authorship contribution statement</span><p id="para0008a" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">L&#46; Yan&#58;</span> Writing &#8211; original draft&#44; Visualization&#46; <span class="elsevierStyleBold">Z&#46; Wang&#58;</span> Formal analysis&#44; Writing &#8211; review &#38; editing&#46; <span class="elsevierStyleBold">J&#46; Zhao&#58;</span> Formal analysis&#44; Writing &#8211; review &#38; editing&#46; <span class="elsevierStyleBold">J&#46; Liu&#58;</span> Writing &#8211; original draft&#44; Formal analysis&#46;</p></span></span>"
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Pulmonology

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