Journal Information
Vol. 14. Issue 5.
Pages 687-692 (September - October 2008)
Share
Share
Download PDF
More article options
Vol. 14. Issue 5.
Pages 687-692 (September - October 2008)
Caso Clínico/Clinical Case
Open Access
Infecção por Bordetella pertussis com hipertensão pulmonar grave num recém-nascido com boa evolução clínica – Caso clínico
Pertussis with severe pulmonary hypertension in a newborn with good outcome – case report
Visits
6364
Sérgia Soares1, Gustavo Rocha1,
,**
Corresponding author
gusrocha@oninet.pt

Correspondence: Gustavo Rocha, Serviço de Neonatologia / Departamento de Pediatria, Hospital de São João – Piso 2, Alameda Prof. Hernâni Monteiro, 4202 – 451, Porto, Portugal, Tel: +351 225095816, Fax: +351225512273.
, Susana Pissarra1,*, Ana Carriço2, Inês Azevedo3,*, Joana Sobrinho Simões4, Hercília Guimarães1,*
1 Division of Neonatology, Department of Pediatrics
2 Division of Pediatric Cardiology, Department of Pediatrics
3 Unit of Pediatric Pulmonology, Department of Pediatrics
4 Molecular Biopathology Laboratory, Department of Clinical Pathology
This item has received

Under a Creative Commons license
Article information
Resumo

Apesar da ampla cobertura vacinal, a infecção por Bordetella pertussis está longe de estar controlada. Os recém-nascidos e lactentes ainda sem imunização completa e filhos de mães com baixos títulos de anticorpos para a Bordetella pertussis são altamente susceptíveis à infecção e têm maior risco de doença grave e morte. A infecção por Bordetella pertussis associada a hipertensão pulmonar no recém-nascido é frequentemente fatal. Os autores descrevem um caso clínico de doença grave num recém-nascido com insuficiência respiratória aguda e hipertensão pulmonar grave, tratado com sucesso com sildenafil e óxido nítrico inalado.

Rev Port Pneumol 2008; XIV (5): 687-692

Palavras-chave:
Recém-nascido
oxido nítrico
pertussis
hipertensão pulmonar
sildenafil
Abstract

In spite of the availability and widespread use of vaccines, pertussis is far from controlled. Newborns and infants too young to be fully vaccinated, born from mothers with low antibody titers to Bordetella pertussis, are highly susceptible to infection and at risk of severe disease and death. Pertussis associated with pulmonary hypertension in the newborn is often fatal. The authors report a clinical case of severe pertussis-induced respiratory failure associated to severe pulmonary hypertension in a neonate successfully treated with sildenafil and inhaled nitric oxide.

Rev Port Pneumol 2008; XIV (5): 687-692

Key-words:
Neonate
nitric oxide
pertussis
pulmonary hypertension
sildenafil
Full text is only aviable in PDF
Bibliography
[1.]
E.D. Barnett, J.O. Klein.
Bacterial infections of the respiratory tract.
Infectious Diseases of the Fetus and Newborn Infant, 6th Edition, pp. 297-317
[2.]
C.D. Sreenan, H. Osiovich.
Neonatal pertussis requiring extracorporeal membrane oxygenation.
Pediatr Surg Int, 17 (2001), pp. 201-203
[3.]
T. Tan, E. Trindade, D. Skowronski.
Epidemiology of pertussis.
Pediatr Infect Dis J, 24 (2005), pp. 10-18
[4.]
B.B. De Berry, J.E. Lynch, D.H. Chung, J.B. Zwischeenberger.
Pertussis with severe pulmonary hypertension and leukocytosis treated with extracorporeal membrane oxygenation.
Pediatr Surg Int, 21 (2005), pp. 692-694
[5.]
K. Bisgard.
Guidelines for the control of pertussis outbreaks.
National Immunization Program – Centers for Disease Control and Prevention U.S. Department of Health and Human Services, (2000),
[6.]
J.M. Tuyen, K. Bisgard.
Guidelines for the control of pertussis outbreaks.
National Immunization Program – Centers for Disease Control and Prevention U.S. De-partment of Health and Human Services, (2000),
[7.]
P. Casano, M.P. Odena, F.J. Cambra, J.M. Martin, A. Palomeque.
Bordetella pertussis infection causing pulmonary hypertension.
Arch Dis Child, 86 (2002), pp. 453-454
[8.]
A. Donoso, J. León, M. Ramírez, G. Rojas, B. Oberpaur.
Pertussis and fatal pulmonary hypertension: A discouraged entity.
Scand J Infect Dis, 37 (2005), pp. 145-148
[9.]
J.D. Cherry.
The epidemiology of pertussis: a comparison of the epidemiology of the disease pertussis with the epidemiology of Bordetella pertussis infection.
Pediatrics, 115 (2005), pp. 1422-1426
[10.]
Red Book 2000, 25th edition, pp. 556-569
[11.]
J. Raymond, J.B. Armengaud, C. Cosnes-Lambe, M. Chalumeau, E. Bosdure, H. Reglier-Poupet, M.J. El Hajje, J.L. Iniguez, F. Moulin, C. Poyart, D. Grendel.
Pertussis in young infants: apnoea and intra-familial infection.
Clin Microbiol Infect, 13 (2007), pp. 172-175
[12.]
A.M. Wendelboe, E. Njamkepo, A. Bourillon, D.D. Floret, J. Gaudelus, M. Gerber, E. Grimprel, D. Greenberg, S. Halperin, J. Liese, F. Muños-Rivas, R. Teyssou, N. Guiso.
Van Rie A; Infant Pertussis Study Group. Transmission of Bordetella pertussis to young infants.
Pediatr Infect Dis J, 26 (2007), pp. 293-299
[13.]
E. Bamberger, N. Lahat, V. Gershtein, R. Gershtein, D. Benilevi, S. Shapiro, I. Kassis, L. Rubin, I. Srugo.
Diagnosing pertussis: the role of polymerase chain reaction.
Isr Med Assoc J, 7 (2005), pp. 351-354
[14.]
A.M. Wendelboe, A. Van Rie.
Diagnosis of pertussis: a historical review and recent developments.
Expert Rev Mol Diagn, 6 (2006), pp. 857-864
[15.]
C. Koidl, M. Bozic, A. Burmeiter, M. Hess, E. Marth, H. Kessler.
Detection and differentiation of Bordetella spp by real-time PCR.
J Clin Microbiol, 45 (2007), pp. 347-350
[16.]
B. Vincart, R. De Mendonça, S. Rottiers, F. Vermeulen, M.J. Struelens, O. Denis.
A specific real-time PCR assay for the detection of Bordetella pertussis.
J Med Microbiol, 56 (2007), pp. 918-920
[17.]
N.K. Fry, O. Tzivra, Y.T. Li, A. McNiff, N. Doshi, P.A. Maple, N.S. Crowcroft, E. Miller, R.C. George, T.G. Harrison.
Laboratory diagnosis of pertussis infections: the role of PCR and serology.
J Med Microbiol, 53 (2004), pp. 519-525
[18.]
A. Ménard, P. Lehours, J. Sarlanngue, C. Bébéar, F. Mégraud, B. de Barbeyrac.
Development of a real-time PCR for the identification of Bordetella pertussis and Bordetella parapertussis.
Clin Microbiol Infect, 13 (2007), pp. 419-423
[19.]
C.M. Palmer, B. McCall, K. Jarvinen, M.D. Nissen.
Bordetella pertussis PCR positivity, following onset of illness in children under 5 years of age.
Commun Dis Intell, 31 (2007), pp. 202-205
[20.]
P.R. Margotto.
Uso do sildenafil (Viagra®) na hipertensão pulmonar persistente do recém-nascido.
Comum Ciênc Saúde, 17 (2006), pp. 141-154

Faculty of Medicine of Porto University, Porto, Portugal

Copyright © 2008. Sociedade Portuguesa de Pneumologia/SPP
Download PDF
Pulmonology
Article options
Tools

Are you a health professional able to prescribe or dispense drugs?