array:24 [
  "pii" => "S2173511509701228"
  "issn" => "21735115"
  "doi" => "10.1016/S2173-5115(09)70122-8"
  "estado" => "S300"
  "fechaPublicacion" => "2009-05-01"
  "aid" => "70122"
  "copyright" => "Sociedade Portuguesa de Pneumologia"
  "copyrightAnyo" => "2009"
  "documento" => "article"
  "crossmark" => 0
  "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
  "subdocumento" => "fla"
  "cita" => "Rev Port Pneumol. 2009;15:433-42"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 3088
    "formatos" => array:3 [
      "EPUB" => 261
      "HTML" => 1761
      "PDF" => 1066
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S217351150970123X"
    "issn" => "21735115"
    "doi" => "10.1016/S2173-5115(09)70123-X"
    "estado" => "S300"
    "fechaPublicacion" => "2009-05-01"
    "aid" => "70123"
    "copyright" => "Sociedade Portuguesa de Pneumologia"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "rev"
    "cita" => "Rev Port Pneumol. 2009;15:443-60"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3574
      "formatos" => array:3 [
        "EPUB" => 229
        "HTML" => 1950
        "PDF" => 1395
      ]
    ]
    "pt" => array:9 [
      "idiomaDefecto" => true
      "titulo" => "Avaliação da inflamação das vias aéreas. Vias áreas superiores e compartimento broncopulmonar"
      "tienePdf" => "pt"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "pt"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "443"
          "paginaFinal" => "460"
        ]
      ]
      "contieneResumen" => array:2 [
        "pt" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "pt" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Luísa Geraldes, Ana Todo-Bom, Carlos Loureiro, Mota Pinto"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Luísa"
              "apellidos" => "Geraldes"
            ]
            1 => array:2 [
              "nombre" => "Ana"
              "apellidos" => "Todo-Bom"
            ]
            2 => array:2 [
              "nombre" => "Carlos"
              "apellidos" => "Loureiro"
            ]
            3 => array:2 [
              "nombre" => "Mota"
              "apellidos" => "Pinto"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "pt"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S217351150970123X?idApp=UINPBA00004E"
    "url" => "/21735115/0000001500000003/v1_201305151509/S217351150970123X/v1_201305151509/pt/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2173511509701216"
    "issn" => "21735115"
    "doi" => "10.1016/S2173-5115(09)70121-6"
    "estado" => "S300"
    "fechaPublicacion" => "2009-05-01"
    "aid" => "70121"
    "copyright" => "Sociedade Portuguesa de Pneumologia"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Rev Port Pneumol. 2009;15:419-31"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2542
      "formatos" => array:3 [
        "EPUB" => 239
        "HTML" => 1347
        "PDF" => 956
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Obstructive sleep apnoea syndrome as a cause of road traffic accidents"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "pt"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "419"
          "paginaFinal" => "431"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "pt" => array:1 [
          "titulo" => "Síndroma de apneia obstrutiva do sono como causa de acidentes de viação"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "pt" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "M. Aguiar, J. Valença, M. Felizardo, F. Caeiro, S. Moreira, R. Staats, A.A. Bugalho de Almeida"
          "autores" => array:7 [
            0 => array:2 [
              "nombre" => "M."
              "apellidos" => "Aguiar"
            ]
            1 => array:2 [
              "nombre" => "J."
              "apellidos" => "Valença"
            ]
            2 => array:2 [
              "nombre" => "M."
              "apellidos" => "Felizardo"
            ]
            3 => array:2 [
              "nombre" => "F."
              "apellidos" => "Caeiro"
            ]
            4 => array:2 [
              "nombre" => "S."
              "apellidos" => "Moreira"
            ]
            5 => array:2 [
              "nombre" => "R."
              "apellidos" => "Staats"
            ]
            6 => array:2 [
              "nombre" => "A.A."
              "apellidos" => "Bugalho de Almeida"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511509701216?idApp=UINPBA00004E"
    "url" => "/21735115/0000001500000003/v1_201305151509/S2173511509701216/v1_201305151509/en/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "titulo" => "Interstitial lung disease: Diagnostic accuracy and safety of surgical lung biopsy"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "433"
        "paginaFinal" => "442"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Miguel Guerra, José António Miranda, Francisco Leal, Luís Vouga"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "Miguel"
            "apellidos" => "Guerra"
            "email" => array:1 [
              0 => "migueldavidguerra@yahoo.com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">1</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Jos&#233;"
            "apellidos" => "Ant&#243;nio Miranda"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">1</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Francisco"
            "apellidos" => "Leal"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">1</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Lu&#237;s"
            "apellidos" => "Vouga"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">1</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:3 [
            "entidad" => "Servi&#231;o de Cirurgia Cardiotor&#225;cica&#47;<span class="elsevierStyleItalic">Cardiothoracic Surgery Unit</span>&#44; Centro Hospitalar de Vila Nova de Gaia&#47;Espinho&#44; Porto&#44; Portugal"
            "etiqueta" => "<span class="elsevierStyleSup">1</span>"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Correspondence to&#47;Correspond&#234;ncia&#58; Servi&#231;o de Cirurgia Cardiotor&#225;cica&#44; Centro Hospitalar de Vila Nova de Gaia&#47;Espinho&#44; Rua Concei&#231;&#227;o Fernandes&#44; 4434-502 Vila Nova de Gaia&#44; Porto&#44; Portugal&#44; Tel&#46;&#58; &#40;&#43;351&#41; 227865100&#44; Tlm&#58; &#40;&#43;351&#41; 933734217&#44; Fax&#58; &#40;&#43;351&#41; 227865170&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "pt" => array:1 [
        "titulo" => "Doen&#231;as pulmonares intersticiais&#58; Acuidade diagn&#243;stica e riscos da bi&#243;psia pulmonar cir&#250;rgica"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2008-06-20"
    "fechaAceptado" => "2008-12-30"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key-words"
          "identificador" => "xpalclavsec160089"
          "palabras" => array:5 [
            0 => "Interstitial lung disease"
            1 => "surgical lung biopsy"
            2 => "diagnostic accuracy"
            3 => "postoperative complications"
            4 => "morbimortality"
          ]
        ]
      ]
      "pt" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras-clave"
          "identificador" => "xpalclavsec160088"
          "palabras" => array:5 [
            0 => "Doen&#231;a pulmonar intersticial"
            1 => "bi&#243;psia pulmonar cir&#250;rgica"
            2 => "acuidade diagn&#243;stica"
            3 => "complica&#231;&#245;es p&#243;s-operat&#243;rias"
            4 => "morbimortalidade"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">This study reports our experience&#44; diagnostic accuracy and safety of surgical lung biopsy in patients with interstitial lung diseases&#46; From January 1998 &#8211; December 2007 surgical lung biopsy was performed in 53 patients &#40;22 female &#91;41&#46;5&#37;&#93;&#59; age 47&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13 years&#41;&#46; A total of 37 patients &#40;69&#46;8&#37;&#41; underwent videothoracoscopic lung biopsy and minithoracotomy was performed in 16 patients &#40;30&#46;2&#37;&#41;&#46; Right lung was the choice in 47 patients &#40;88&#46;7&#37;&#41;&#46; Postoperative complications were rare &#40;9&#46;4&#37;&#41; and included three prolonged air leaks &#40;5&#46;7&#37;&#41;&#44; one pneumothorax re-quiring a chest drain &#40;1&#46;9&#37;&#41;&#44; and one haemothorax requiring reoperation &#40;1&#46;9&#37;&#41;&#46; One patient died of cardiac arrest of unknown cause&#46; Average chest tube duration was 4&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3 days and average hospital stay 5&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4 days&#46; Lung biopsy contributed to the diagnosis in 50 patients &#40;94&#46;3&#37;&#41;&#46; In conclusion&#44; the potential benefits of diagnostic surgical lung biopsy must be considered against the risks of the procedure especially in patients with severe cardiopulmonary dysfunction&#46;</p>"
      ]
      "pt" => array:2 [
        "titulo" => "Resumo"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Os autores descrevem a sua casu&#237;stica de bi&#243;psias pulmonares cir&#250;rgicas em doentes com doen&#231;a pulmonar intersticial&#44; de forma a determinar a acuidade diagn&#243;stica&#44; os riscos e a morbimortalidade associados ao procedimento&#46; Entre Janeiro de 1998 e Dezembro de 2007&#44; 53 doentes &#40;idade m&#233;dia de 47&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13 anos&#41; foram referenciados para a realiza&#231;&#227;o de bi&#243;psia pulmonar cir&#250;rgica&#44; dos quais 22 eram mulheres &#40;41&#44;5&#37;&#41;&#46; As bi&#243;psias pulmonares foram realizadas quer por videotoracoscopia &#40;37 doentes&#44; 69&#44;8&#37;&#41;&#44; quer por minitoracotomia &#40;16 doentes&#44; 30&#44;2&#37;&#41;&#46; Foi escolhido o pulm&#227;o direito para biopsar em 88&#44;7&#37; dos casos&#46; Registaram-se complica&#231;&#245;es p&#243;s-operat&#243;rias em 5 doentes &#40;9&#44;4&#37;&#41;&#58; fuga a&#233;rea prolongada em 3 doentes &#40;5&#44;7&#37;&#41;&#44; persist&#234;ncia de loca de pneumot&#243;rax num doente &#40;1&#44;9&#37;&#41; e hemorragia com necessidade de revis&#227;o de hemostase noutro doente &#40;1&#44;9&#37;&#41;&#46; Ocorreu um &#243;bito de causa desconhecida num doente sem risco acrescido&#46; A dura&#231;&#227;o m&#233;dia da drenagem foi de 4&#44;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3 dias e o tempo de internamento m&#233;dio de 5&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4 dias&#46; O diagn&#243;stico histol&#243;gico definitivo foi conseguido em 50 doentes&#44; registando-se uma acuidade diagn&#243;stica de 94&#44;3&#37;&#46; Em conclus&#227;o&#44; o potencial benef&#237;cio de um diagn&#243;stico histopatol&#243;gico conclusivo atrav&#233;s de uma bi&#243;psia pulmonar cir&#250;rgica deve ser balanceado com os riscos associados ao procedimento cir&#250;rgico&#44; especialmente para aqueles doentes com disfun&#231;&#227;o cardiopulmonar severa&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliography&#47;Bibliografia"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:24 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "American Thoracic Society&#44; European Respiratory Society&#46; American Thoracic Society&#47;European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias&#58; this joint statement of the American Thoracic Society &#40;ATS&#41;&#44; and the European Respiratory Society &#40;ERS&#41; was adopted by the ATS board of directors&#44; June 2001 and by the ERS Executive Committee&#44; June 2001&#46; Am J Respir Crit Care Med 2002&#59; 165&#58;277-304&#46;"
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Idiopathic pulmonary fibrosis&#58; diagnosis and treatment&#59; international consensus statement&#8212;American Thoracic Society &#40;ATS&#41;&#44; and the European Respiratory Society &#40;ERS&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "American Thoracic Society"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.161.2.ats3-00"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2000"
                        "volumen" => "161"
                        "paginaInicial" => "646"
                        "paginaFinal" => "664"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10673212"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Radiologic findings are strongly associated with a pathologic diagnosis of usual interstitial pneumonia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "G&#46;W&#46; Hunninghake"
                            1 => "D&#46;A&#46; Lynch"
                            2 => "J&#46;R&#46; Galvin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2003"
                        "volumen" => "124"
                        "paginaInicial" => "1215"
                        "paginaFinal" => "1223"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14555549"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The accuracy of the clinical diagnosis of new-onset idiopathic pulmonary fibrosis and other interstitial lung disease&#58; a prospective study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "G&#46; Raghu"
                            1 => "Y&#46;N&#46; Mageto"
                            2 => "D&#46; Lockhart"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1999"
                        "volumen" => "116"
                        "paginaInicial" => "1168"
                        "paginaFinal" => "1174"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10559072"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Open biopsy for chronic diffuse infilterative lung disease&#58; clinical roentgenographic and physiological correlations in 502 patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "E&#46;A&#46; Gaensler"
                            1 => "C&#46;B&#46; Carrington"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Thorac Surg"
                        "fecha" => "1980"
                        "volumen" => "30"
                        "paginaInicial" => "411"
                        "paginaFinal" => "426"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7436611"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prospective evaluation of aspiration needle&#44; cutting needle&#44; transbronchial&#44; and open lung biopsy in patients with pulmonary infiltrates"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;E&#46; Burt"
                            1 => "M&#46;W&#46; Flye"
                            2 => "B&#46;L&#46; Webber"
                            3 => "R&#46;A&#46; Wesley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Thorac Surg"
                        "fecha" => "1981"
                        "volumen" => "32"
                        "paginaInicial" => "146"
                        "paginaFinal" => "153"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7020617"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Videothoracoscopic lung biopsy in the diagnosis of interstitial lung disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:8 [
                            0 => "O&#46; Rena"
                            1 => "C&#46; Casadio"
                            2 => "F&#46; Leo"
                            3 => "R&#46; Giobbe"
                            4 => "R&#46; Cianci"
                            5 => "S&#46; Baldi"
                            6 => "M&#46; Rapellino"
                            7 => "G&#46; Maggi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Eur J Cardiothorac Surg"
                        "fecha" => "1999"
                        "volumen" => "16"
                        "numero" => "6"
                        "paginaInicial" => "624"
                        "paginaFinal" => "627"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10647831"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "VATS increases costs in patients undergoing lung biopsy for interstitial lung disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "L&#46;J&#46; Molin"
                            1 => "J&#46;B&#46; Steinberg"
                            2 => "L&#46;A&#46; Lanza"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Thorac Surg"
                        "fecha" => "1994"
                        "volumen" => "58"
                        "paginaInicial" => "1595"
                        "paginaFinal" => "1598"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7979720"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Natural history and treated course of usual and desquamative interstitial pneumonia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "C&#46;B&#46; Carrington"
                            1 => "E&#46;A&#46; Gaensler"
                            2 => "R&#46;E&#46; Coutu"
                            3 => "M&#46;X&#46; Fitzgerald"
                            4 => "R&#46;G&#46; Gupta"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM197804132981501"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1978"
                        "volumen" => "298"
                        "paginaInicial" => "801"
                        "paginaFinal" => "809"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/634315"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Present role of thoracoscopy in the diagnosis and treatment of diseases of the chest"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46;J&#46; Mack"
                            1 => "R&#46;J&#46; Aronoff"
                            2 => "T&#46;E&#46; Acuff"
                            3 => "M&#46;B&#46; Douthit"
                            4 => "R&#46;T&#46; Bowman"
                            5 => "W&#46;H&#46; Ryan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Thorac Surg"
                        "fecha" => "1992"
                        "volumen" => "54"
                        "paginaInicial" => "403"
                        "paginaFinal" => "409"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1510505"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "One hundred consecutive patients undergoing video-assisted thoracic operations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46;J&#46; Lewis"
                            1 => "R&#46;J&#46; Caccavale"
                            2 => "G&#46;E&#46; Sisler"
                            3 => "J&#46;W&#46; Mackenzie"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Thorac Surg"
                        "fecha" => "1992"
                        "volumen" => "54"
                        "paginaInicial" => "421"
                        "paginaFinal" => "426"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1510508"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Postoperative pain-related morbidity&#58; video-assisted thoracic surgery versus thoracotomy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "R&#46;J&#46; Landreneau"
                            1 => "S&#46;R&#46; Hazelrigg"
                            2 => "M&#46;J&#46; Mack"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Thorac Surg"
                        "fecha" => "1993"
                        "volumen" => "56"
                        "paginaInicial" => "1285"
                        "paginaFinal" => "1289"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8267426"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Early postoperative stress&#46; Video-assisted wedge resection&#47;lobectomy vs conventional axillary thoracotomy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "E&#46;M&#46; Tschernko"
                            1 => "S&#46; Hofer"
                            2 => "C&#46; Bieglmayer"
                            3 => "W&#46; Wisser"
                            4 => "W&#46; Haider"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1996"
                        "volumen" => "109"
                        "paginaInicial" => "1636"
                        "paginaFinal" => "1642"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8769523"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comparison of videothoracoscopic lung biopsy to open lung biopsy in the diagnosis of interstitial lung disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46;D&#46; Bensard"
                            1 => "R&#46;C&#46; McIntyre"
                            2 => "B&#46;J&#46; Waring"
                            3 => "J&#46;S&#46; Simon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1993"
                        "volumen" => "103"
                        "paginaInicial" => "765"
                        "paginaFinal" => "770"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8449066"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comparison of open versus thoracoscopic lung biopsy for diffuse infiltrative pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "P&#46;F&#46; Ferson"
                            1 => "R&#46;J&#46; Landreneau"
                            2 => "R&#46;D&#46; Dowling"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Thorac Cardiovasc Surg"
                        "fecha" => "1993"
                        "volumen" => "106"
                        "paginaInicial" => "194"
                        "paginaFinal" => "199"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8341061"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Efficacy of video-assisted thoracoscopic lung biopsy&#58; an historical comparison with open lung biopsy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "F&#46;M&#46; Carnochan"
                            1 => "W&#46;S&#46; Walker"
                            2 => "E&#46;W&#46;J&#46; Cameron"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "1994"
                        "volumen" => "49"
                        "paginaInicial" => "361"
                        "paginaFinal" => "363"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8202908"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Outcomes and safety of surgical lung biopsy for interstitial lung disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "C&#46;J&#46; Lettieri"
                            1 => "G&#46;R&#46; Veerappan"
                            2 => "D&#46;L&#46; Helman"
                            3 => "C&#46;R&#46; Mulligan"
                            4 => "A&#46;F&#46; Shorr"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.127.5.1600"
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2005"
                        "volumen" => "127"
                        "paginaInicial" => "1600"
                        "paginaFinal" => "1605"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15888834"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Preoperative risk factors associated with mortality in lung biopsy patients with interstitial lung disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "G&#46; Carrillo"
                            1 => "A&#46; Estrada"
                            2 => "J&#46; Pedroza"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1080/08941930590905206"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Invest Surg"
                        "fecha" => "2005"
                        "volumen" => "18"
                        "paginaInicial" => "39"
                        "paginaFinal" => "45"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15804951"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Videothoracoscopic lung biopsy in diffuse infiltrative lung diseases&#58; a 5-year surgical expe rience"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "R&#46; Zegdi"
                            1 => "J&#46; Azorin"
                            2 => "B&#46; Tremblay"
                            3 => "M&#46;D&#46; Destable"
                            4 => "P&#46;S&#46; Lajos"
                            5 => "D&#46; Valeyre"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Ann Thorac Surg"
                        "fecha" => "1998"
                        "volumen" => "66"
                        "numero" => "4"
                        "paginaInicial" => "1170"
                        "paginaFinal" => "1173"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9800801"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Outcomes and safety of surgical lung biopsy for interstitial lung disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "C&#46;J&#46; Lettieri"
                            1 => "G&#46;R&#46; Veerappan"
                            2 => "D&#46;L&#46; Helman"
                            3 => "C&#46;R&#46; Mulligan"
                            4 => "A&#46;F&#46; Shorr"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.127.5.1600"
                      "Revista" => array:7 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2005"
                        "volumen" => "127"
                        "numero" => "5"
                        "paginaInicial" => "1600"
                        "paginaFinal" => "1605"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15888834"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diagnostic value of surgical lung biopsy&#58; comparison with clinical and radiological diagnosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "G&#46;F&#46; Coutinho"
                            1 => "R&#46; Pancas"
                            2 => "E&#46; Magalhaes"
                            3 => "J&#46;E&#46; Bernardo"
                            4 => "L&#46; Eugenio"
                            5 => "M&#46;J&#46; Antunes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ejcts.2008.02.008"
                      "Revista" => array:7 [
                        "tituloSerie" => "Eur J Cardiothorac Surg"
                        "fecha" => "2008"
                        "volumen" => "33"
                        "numero" => "5"
                        "paginaInicial" => "781"
                        "paginaFinal" => "785"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18356069"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Complications of video-assisted thoracoscopic lung biopsy in patients with interstitial lung disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "M&#46;E&#46; Kreider"
                            1 => "J&#46; Hansen-Flaschen"
                            2 => "N&#46;N&#46; Ahmad"
                            3 => "M&#46;D&#46; Rossman"
                            4 => "L&#46;R&#46; Kaiser"
                            5 => "J&#46;C&#46; Kucharczuk"
                            6 => "J&#46;B&#46; Shrager"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.athoracsur.2006.10.002"
                      "Revista" => array:7 [
                        "tituloSerie" => "Ann Thorac Surg"
                        "fecha" => "2007"
                        "volumen" => "83"
                        "numero" => "3"
                        "paginaInicial" => "1140"
                        "paginaFinal" => "1144"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17307476"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Role of thoracic surgeons in the diagnosis of idiopathic interstitial lung disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46;E&#46; Halkos"
                            1 => "A&#46;A&#46; Gal"
                            2 => "F&#46; Kerendi"
                            3 => "D&#46;L&#46; Miller"
                            4 => "J&#46;I&#46; Miller Jr&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.athoracsur.2004.06.103"
                      "Revista" => array:7 [
                        "tituloSerie" => "Ann Thorac Surg"
                        "fecha" => "2005"
                        "volumen" => "79"
                        "numero" => "6"
                        "paginaInicial" => "2172"
                        "paginaFinal" => "2179"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15919344"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A randomized&#44; controlled trial comparing thoracoscopy and limited thoracotomy for lung biopsy in interstitial lung disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46;D&#46; Miller"
                            1 => "J&#46;D&#46; Urschel"
                            2 => "G&#46; Cox"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Thorac Surg"
                        "fecha" => "2000"
                        "volumen" => "70"
                        "paginaInicial" => "1647"
                        "paginaFinal" => "1650"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11093503"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735115/0000001500000003/v1_201305151509/S2173511509701228/v1_201305151509/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "9552"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Original Article&#47;Artigo Original"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735115/0000001500000003/v1_201305151509/S2173511509701228/v1_201305151509/en/main.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511509701228?idApp=UINPBA00004E"
]
Share
Journal Information
Vol. 15. Issue 3.
Pages 433-442 (May - June 2009)
Share
Share
Download PDF
More article options
Vol. 15. Issue 3.
Pages 433-442 (May - June 2009)
Full text access
Interstitial lung disease: Diagnostic accuracy and safety of surgical lung biopsy
Doenças pulmonares intersticiais: Acuidade diagnóstica e riscos da biópsia pulmonar cirúrgica
Visits
892
Miguel Guerra1,
Corresponding author
migueldavidguerra@yahoo.com

Correspondence to/Correspondência: Serviço de Cirurgia Cardiotorácica, Centro Hospitalar de Vila Nova de Gaia/Espinho, Rua Conceição Fernandes, 4434-502 Vila Nova de Gaia, Porto, Portugal, Tel.: (+351) 227865100, Tlm: (+351) 933734217, Fax: (+351) 227865170.
, José António Miranda1, Francisco Leal1, Luís Vouga1
1 Serviço de Cirurgia Cardiotorácica/Cardiothoracic Surgery Unit, Centro Hospitalar de Vila Nova de Gaia/Espinho, Porto, Portugal
This item has received
Article information
Abstract
Bibliography
Download PDF
Statistics
Abstract

This study reports our experience, diagnostic accuracy and safety of surgical lung biopsy in patients with interstitial lung diseases. From January 1998 – December 2007 surgical lung biopsy was performed in 53 patients (22 female [41.5%]; age 47.2±13 years). A total of 37 patients (69.8%) underwent videothoracoscopic lung biopsy and minithoracotomy was performed in 16 patients (30.2%). Right lung was the choice in 47 patients (88.7%). Postoperative complications were rare (9.4%) and included three prolonged air leaks (5.7%), one pneumothorax re-quiring a chest drain (1.9%), and one haemothorax requiring reoperation (1.9%). One patient died of cardiac arrest of unknown cause. Average chest tube duration was 4.4±3 days and average hospital stay 5.4±4 days. Lung biopsy contributed to the diagnosis in 50 patients (94.3%). In conclusion, the potential benefits of diagnostic surgical lung biopsy must be considered against the risks of the procedure especially in patients with severe cardiopulmonary dysfunction.

Key-words:
Interstitial lung disease
surgical lung biopsy
diagnostic accuracy
postoperative complications
morbimortality
Resumo

Os autores descrevem a sua casuística de biópsias pulmonares cirúrgicas em doentes com doença pulmonar intersticial, de forma a determinar a acuidade diagnóstica, os riscos e a morbimortalidade associados ao procedimento. Entre Janeiro de 1998 e Dezembro de 2007, 53 doentes (idade média de 47,2±13 anos) foram referenciados para a realização de biópsia pulmonar cirúrgica, dos quais 22 eram mulheres (41,5%). As biópsias pulmonares foram realizadas quer por videotoracoscopia (37 doentes, 69,8%), quer por minitoracotomia (16 doentes, 30,2%). Foi escolhido o pulmão direito para biopsar em 88,7% dos casos. Registaram-se complicações pós-operatórias em 5 doentes (9,4%): fuga aérea prolongada em 3 doentes (5,7%), persistência de loca de pneumotórax num doente (1,9%) e hemorragia com necessidade de revisão de hemostase noutro doente (1,9%). Ocorreu um óbito de causa desconhecida num doente sem risco acrescido. A duração média da drenagem foi de 4,4±3 dias e o tempo de internamento médio de 5,5±4 dias. O diagnóstico histológico definitivo foi conseguido em 50 doentes, registando-se uma acuidade diagnóstica de 94,3%. Em conclusão, o potencial benefício de um diagnóstico histopatológico conclusivo através de uma biópsia pulmonar cirúrgica deve ser balanceado com os riscos associados ao procedimento cirúrgico, especialmente para aqueles doentes com disfunção cardiopulmonar severa.

Palabras-clave:
Doença pulmonar intersticial
biópsia pulmonar cirúrgica
acuidade diagnóstica
complicações pós-operatórias
morbimortalidade
Full text is only aviable in PDF
Bibliography/Bibliografia
[1.]
American Thoracic Society, European Respiratory Society. American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias: this joint statement of the American Thoracic Society (ATS), and the European Respiratory Society (ERS) was adopted by the ATS board of directors, June 2001 and by the ERS Executive Committee, June 2001. Am J Respir Crit Care Med 2002; 165:277-304.
[2.]
American Thoracic Society.
Idiopathic pulmonary fibrosis: diagnosis and treatment; international consensus statement—American Thoracic Society (ATS), and the European Respiratory Society (ERS).
Am J Respir Crit Care Med, 161 (2000), pp. 646-664
[3.]
G.W. Hunninghake, D.A. Lynch, J.R. Galvin, et al.
Radiologic findings are strongly associated with a pathologic diagnosis of usual interstitial pneumonia.
Chest, 124 (2003), pp. 1215-1223
[4.]
G. Raghu, Y.N. Mageto, D. Lockhart, et al.
The accuracy of the clinical diagnosis of new-onset idiopathic pulmonary fibrosis and other interstitial lung disease: a prospective study.
Chest, 116 (1999), pp. 1168-1174
[5.]
E.A. Gaensler, C.B. Carrington.
Open biopsy for chronic diffuse infilterative lung disease: clinical roentgenographic and physiological correlations in 502 patients.
Ann Thorac Surg, 30 (1980), pp. 411-426
[6.]
M.E. Burt, M.W. Flye, B.L. Webber, R.A. Wesley.
Prospective evaluation of aspiration needle, cutting needle, transbronchial, and open lung biopsy in patients with pulmonary infiltrates.
Ann Thorac Surg, 32 (1981), pp. 146-153
[7.]
O. Rena, C. Casadio, F. Leo, R. Giobbe, R. Cianci, S. Baldi, M. Rapellino, G. Maggi.
Videothoracoscopic lung biopsy in the diagnosis of interstitial lung disease.
Eur J Cardiothorac Surg, 16 (1999), pp. 624-627
[8.]
L.J. Molin, J.B. Steinberg, L.A. Lanza.
VATS increases costs in patients undergoing lung biopsy for interstitial lung disease.
Ann Thorac Surg, 58 (1994), pp. 1595-1598
[9.]
C.B. Carrington, E.A. Gaensler, R.E. Coutu, M.X. Fitzgerald, R.G. Gupta.
Natural history and treated course of usual and desquamative interstitial pneumonia.
N Engl J Med, 298 (1978), pp. 801-809
[10.]
M.J. Mack, R.J. Aronoff, T.E. Acuff, M.B. Douthit, R.T. Bowman, W.H. Ryan.
Present role of thoracoscopy in the diagnosis and treatment of diseases of the chest.
Ann Thorac Surg, 54 (1992), pp. 403-409
[11.]
R.J. Lewis, R.J. Caccavale, G.E. Sisler, J.W. Mackenzie.
One hundred consecutive patients undergoing video-assisted thoracic operations.
Ann Thorac Surg, 54 (1992), pp. 421-426
[12.]
R.J. Landreneau, S.R. Hazelrigg, M.J. Mack, et al.
Postoperative pain-related morbidity: video-assisted thoracic surgery versus thoracotomy.
Ann Thorac Surg, 56 (1993), pp. 1285-1289
[13.]
E.M. Tschernko, S. Hofer, C. Bieglmayer, W. Wisser, W. Haider.
Early postoperative stress. Video-assisted wedge resection/lobectomy vs conventional axillary thoracotomy.
Chest, 109 (1996), pp. 1636-1642
[14.]
D.D. Bensard, R.C. McIntyre, B.J. Waring, J.S. Simon.
Comparison of videothoracoscopic lung biopsy to open lung biopsy in the diagnosis of interstitial lung disease.
Chest, 103 (1993), pp. 765-770
[15.]
P.F. Ferson, R.J. Landreneau, R.D. Dowling, et al.
Comparison of open versus thoracoscopic lung biopsy for diffuse infiltrative pulmonary disease.
J Thorac Cardiovasc Surg, 106 (1993), pp. 194-199
[16.]
F.M. Carnochan, W.S. Walker, E.W.J. Cameron.
Efficacy of video-assisted thoracoscopic lung biopsy: an historical comparison with open lung biopsy.
Thorax, 49 (1994), pp. 361-363
[17.]
C.J. Lettieri, G.R. Veerappan, D.L. Helman, C.R. Mulligan, A.F. Shorr.
Outcomes and safety of surgical lung biopsy for interstitial lung disease.
Chest, 127 (2005), pp. 1600-1605
[18.]
G. Carrillo, A. Estrada, J. Pedroza, et al.
Preoperative risk factors associated with mortality in lung biopsy patients with interstitial lung disease.
J Invest Surg, 18 (2005), pp. 39-45
[19.]
R. Zegdi, J. Azorin, B. Tremblay, M.D. Destable, P.S. Lajos, D. Valeyre.
Videothoracoscopic lung biopsy in diffuse infiltrative lung diseases: a 5-year surgical expe rience.
Ann Thorac Surg, 66 (1998), pp. 1170-1173
[20.]
C.J. Lettieri, G.R. Veerappan, D.L. Helman, C.R. Mulligan, A.F. Shorr.
Outcomes and safety of surgical lung biopsy for interstitial lung disease.
Chest, 127 (2005), pp. 1600-1605
[21.]
G.F. Coutinho, R. Pancas, E. Magalhaes, J.E. Bernardo, L. Eugenio, M.J. Antunes.
Diagnostic value of surgical lung biopsy: comparison with clinical and radiological diagnosis.
Eur J Cardiothorac Surg, 33 (2008), pp. 781-785
[22.]
M.E. Kreider, J. Hansen-Flaschen, N.N. Ahmad, M.D. Rossman, L.R. Kaiser, J.C. Kucharczuk, J.B. Shrager.
Complications of video-assisted thoracoscopic lung biopsy in patients with interstitial lung disease.
Ann Thorac Surg, 83 (2007), pp. 1140-1144
[23.]
M.E. Halkos, A.A. Gal, F. Kerendi, D.L. Miller, J.I. Miller Jr..
Role of thoracic surgeons in the diagnosis of idiopathic interstitial lung disease.
Ann Thorac Surg, 79 (2005), pp. 2172-2179
[24.]
J.D. Miller, J.D. Urschel, G. Cox, et al.
A randomized, controlled trial comparing thoracoscopy and limited thoracotomy for lung biopsy in interstitial lung disease.
Ann Thorac Surg, 70 (2000), pp. 1647-1650
Copyright © 2009. Sociedade Portuguesa de Pneumologia
Download PDF
Pulmonology
Article options
Tools

Are you a health professional able to prescribe or dispense drugs?