Article information
Resumo
A asma brônquica é uma doença inflamatória crónica das vias aéreas, de prevalência crescente, particularmente na infância, sendo considerado um importante problema de saúde pública.
É reconhecidamente uma doença de transmissão familiar, sendo um desafio a descrição e potencial identificação dos genes envolvidos na sua génese.
Pretende-se com o presente artigo de revisão explicitar exaustivamente os genes associados a esta patologia, bem como esclarecer os métodos laboratoriais que permitem a sua identificação.
Palavras-chave:
Asma
susceptibilidade genética
genome wide screen
estudos de associação
farmacogenética
Abstract
Asthma is a chronic inflammatory airways disease, with a rising prevalence, particularly in childhood, and is considered an important Public Health problem.
It's familial transmission is recognised, while the description and identification of the genes implicated in this disease are a challenge.
In this revision paper the authors give a comprehensive explanation of the associated genes as well as the laboratorial methods that allow their identification.
Key-words:
Asthma
genetic susceptibility
genome wide screen
association studies
pharmacogenetics
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