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        "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0005" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Introdu&#231;&#227;o&#58;</span> As preval&#234;ncias da asma e rinite t&#234;m aumentado nas &#250;ltimas d&#233;cadas&#44; mas nos &#250;ltimos anos tem sido referida a sua estabiliza&#231;&#227;o ou mesmo diminui&#231;&#227;o&#46;</p><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Objectivo&#58;</span> O objectivo foi o de descrever a preval&#234;ncia de rinite&#44; asma ou sintomas do tipo da asma em adolescentes urbanos de 13 anos&#46;</p><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">M&#233;todos&#58;</span> Os participantes eleg&#237;veis foram todos os alunos das escolas p&#250;blicas e privadas do Porto&#44; nascidos em 1990&#59; 2161 &#40;77&#44;5&#37;&#41; concordaram em participar&#46; Atrav&#233;s de question&#225;rios autoaplicados&#44; a informa&#231;&#227;o recolhida contemplou aspectos sociais&#44; demogr&#225;ficos&#44; comportamentais&#44; hist&#243;ria cl&#237;nica de asma e doen&#231;as al&#233;rgicas do adolescente e fam&#237;lia&#46; Foi usada a vers&#227;o portuguesa do <span class="elsevierStyleItalic">International Study of Asthma and Allergies in Childhood&#8217;s</span> &#40;ISAAC&#41; e foram efectuadas espirometrias&#46;</p><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Resultados&#58;</span> Nesta amostra de adolescentes urbanos de 13 anos&#44; a preval&#234;ncia da asma durante a vida foi de 12&#44;9&#37;&#44; 84&#44;4&#37; com diagn&#243;stico m&#233;dico&#46; A pieira durante a vida foi 18&#44;3&#37; e no &#250;ltimo ano de 9&#44;3&#37;&#46; A rinite foi relatada por 10&#44;1&#37;&#44; mas a preval&#234;ncia durante a vida de adolescentes com espirros&#44; rinorreia serosa ou obstru&#231;&#227;o nasal&#44; foi de 32&#44;0&#37;&#44; e no &#250;ltimo ano de 27&#44;4&#37;&#46;</p><p id="sp0025" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Conclus&#227;o&#58;</span> Verificou-se uma estabiliza&#231;&#227;o ou mesmo diminui&#231;&#227;o da preval&#234;ncia dos sintomas e diagn&#243;stico de asma e rinite nos adolescentes do Porto&#44; quando comparada com os resultados do ISAAC em 2002&#44; tal como noutras investiga&#231;&#245;es na Europa&#46; A asma e a rinite est&#227;o frequentemente presentes no mesmo doente e a tosse nocturna &#233; um importante sintoma que surge associado aos sintomas nasais&#46; A fun&#231;&#227;o pulmonar permitiu discriminar os adolescentes com queixas respirat&#243;rias&#46;</p><p id="sp0030" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2008&#59; XIV &#40;6&#41;&#58; 747-768</span></p></span>"
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        "titulo" => "Abstract"
        "resumen" => "<span id="as0010" class="elsevierStyleSection elsevierViewall"><p id="sp0035" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Background&#58;</span> The prevalence of asthma and rhinitis has been increasing over the past few decades&#44; but the last few years have seen these rates stabilise or even decrease&#46;</p><p id="sp0040" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Aim&#58;</span> The aim of our study was to describe the prevalence of rhinitis&#44; asthma or asthma-like symptoms in 13 year-old urban adolescents&#46;</p><p id="sp0045" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Methods&#58;</span> Eligible participants were all students at state and private schools in Porto born in 1990&#46; 2161 &#40;77&#46;5&#37;&#41; agreed to participate&#46; Information was obtained using self-administered questionnaires inquiring into social&#44; demographic&#44; behavioural and clinical history including asthma and allergic diseases in the adolescent and the family&#46; We used the Portuguese version of the International Study of Asthma and Allergies in Childhood &#40;ISAAC&#41; questionnaire and we also performed spirometry tests&#46;</p><p id="sp0050" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Results&#58;</span> In this sample of 13 year old urban adolescents the prevalence of asthma ever was 12&#46;9&#37;&#44; 84&#46;4&#37; with physician diagnosis&#46; Lifetime wheezing was reported by 18&#46;3&#37; and current wheezing by 9&#46;3&#37; of the adolescents&#46; Rhinitis was referred to by 10&#46;1&#37;&#44; but the prevalence of adolescents with sneezing ever&#44; or a runny&#47;blocked nose&#44; was 32&#46;0&#37; and the prevalence in the last 12 months was 27&#46;4&#37;&#46;</p><p id="sp0055" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Conclusion&#58;</span> We concluded that there was stabilisation or even decrease in the prevalence of asthma and rhinitis symptoms and diagnosis in adolescents reported in Porto&#44; compared with the 2002 ISAAC study&#44; as observed in other surveys in Europe&#46; Asthma and rhinitis is frequently present in the same patient and nocturnal cough is an important symptom concomitant with nasal symptoms&#46; Measures of lung function permitted the discrimination of adolescents with respiratory complaints&#46;</p><p id="sp0060" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2008&#59; XIV &#40;6&#41;&#58; 747-768</span></p></span>"
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                "etiqueta" => "39&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
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                        "titulo" => "Childhood antecedents of allergic sensitization in young British adults"
                        "autores" => array:1 [
                          0 => array:2 [
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                            "autores" => array:4 [
                              0 => "D&#46; Strachan"
                              1 => "L&#46; Harkins"
                              2 => "I&#46; Johnston"
                              3 => "H&#46; Anderson"
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                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
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                          "tituloSerie" => "J Allergy Clin Immunol"
                          "fecha" => "1997"
                          "volumen" => "99"
                          "numero" => "1<span class="elsevierStyleHsp" style=""></span>Pt<span class="elsevierStyleHsp" style=""></span>1"
                          "paginaInicial" => "6"
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                          "link" => array:1 [
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                        "titulo" => "Breast-feeding and the risk of bronchial asthma in childhood&#58; a systematic review with meta-analysis of prospective studies"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:3 [
                              0 => "M&#46; Gdalevich"
                              1 => "D&#46; Mimouni"
                              2 => "M&#46; Mimouni"
                            ]
                          ]
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                      ]
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                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1067/mpd.2001.117006"
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                          "tituloSerie" => "J Pediatr"
                          "fecha" => "2001"
                          "volumen" => "139"
                          "numero" => "2"
                          "paginaInicial" => "261"
                          "paginaFinal" => "266"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11487754"
                              "web" => "Medline"
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                        "titulo" => "Environmental factors influencing the development and progression of pediatric asthma"
                        "autores" => array:1 [
                          0 => array:2 [
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                            "autores" => array:1 [
                              0 => "E&#46; von Mutius"
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                          "tituloSerie" => "J Allergy Clin Immunol"
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                          "paginaInicial" => "S525"
                          "paginaFinal" => "S532"
                          "link" => array:1 [
                            0 => array:2 [
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                            "autores" => array:4 [
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                          "link" => array:1 [
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                          0 => array:2 [
                            "etal" => false
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                              2 => "P&#46; Aaby"
                              3 => "T&#46; Westergaard"
                              4 => "E&#46; Benfeldt"
                              5 => "K&#46; Michaelsen"
                              6 => "B&#46; Bj&#246;rkst&#233;n"
                              7 => "M&#46; Melbye"
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                    "host" => array:1 [
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                        "doi" => "10.1093/aje/kwh208"
                        "Revista" => array:6 [
                          "tituloSerie" => "Am J Epidemiol"
                          "fecha" => "2004"
                          "volumen" => "160"
                          "paginaInicial" => "217"
                          "paginaFinal" => "223"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15257994"
                              "web" => "Medline"
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                        "autores" => array:1 [
                          0 => array:2 [
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                            "autores" => array:1 [
                              0 => "E&#46; Sarafino"
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                          "link" => array:1 [
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                            "etal" => false
                            "autores" => array:3 [
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                          "paginaInicial" => "537"
                          "paginaFinal" => "542"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1412098"
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                            "etal" => false
                            "autores" => array:5 [
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                              2 => "S&#46; Illi"
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                              4 => "E&#46; von Mutius"
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                    "host" => array:1 [
                      0 => array:1 [
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                          "tituloSerie" => "Pediatr Allergy Immunol"
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                          "paginaInicial" => "280"
                          "paginaFinal" => "283"
                          "link" => array:1 [
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                              3 => "J&#46; Rosado-Pinto"
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                          "fecha" => "2005"
                          "volumen" => "33"
                          "numero" => "2"
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                          "paginaFinal" => "99"
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                            "autores" => array:4 [
                              0 => "B&#46; Leynaert"
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                              2 => "P&#46; Demoly"
                              3 => "J&#46; Bousquet"
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                          ]
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                      0 => array:2 [
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                          "tituloSerie" => "J Allergy Clin Immunol"
                          "fecha" => "2000"
                          "volumen" => "106"
                          "numero" => "Suppl&#46;5"
                          "paginaInicial" => "201"
                          "paginaFinal" => "205"
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                          0 => array:2 [
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                              0 => "A&#46; Vignola"
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                          "paginaInicial" => "674"
                          "paginaFinal" => "677"
                          "link" => array:1 [
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                              "web" => "Medline"
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                            "autores" => array:1 [
                              0 => "J&#46; Grossman"
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                          "fecha" => "1997"
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Vol. 14. Issue 6.
Pages 747-768 (November - December 2008)
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Vol. 14. Issue 6.
Pages 747-768 (November - December 2008)
Artigo Original/Original Article
Open Access
Prevalência da asma e da rinite em adolescentes de 13 anos do Porto, Portugal
Prevalence of asthma and rhinitis in 13 year old adolescents in Porto, Portugal
Visits
5795
Helena Falcão1,
Corresponding author
hfalcao@med.up.pt

Correspondência / Correspondence to: Helena Falcão, Serviço de Higiene e Epidemiologia da Faculdade de Medicina, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal, Phone: +351-225507597 / Fax: +351-225095618
, Elisabete Ramos2, Agostinho Marques3, Henrique Barros4
1 Investigadora, Serviço de Higiene e Epidemiologia, Faculdade de Medicina da Universidade do Porto / Researcher, Hygiene and Epidemiology Unit, School of Medicine, University of Porto.
2 Professora, Serviço de Higiene e Epidemiologia, Faculdade de Medicina da Universidade do Porto / Professor, Hygiene and Epidemiology Unit, School of Medicine, University of Porto.
3 Professor Catedrático, Serviço de Pneumologia, Faculdade de Medicina da Universidade do Porto / Cathedratic Professor, Pulmonology Unit, School of Medicine, University of Porto.
4 Professor Catedrático e Director do Serviço de Higiene e Epidemiologia, Faculdade de Medicina da Universidade do Porto / Cathedratic Professor and Head, Hygiene and Epidemiology Unit, School of Medicine, University of Porto.
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Resumo

Introdução: As prevalências da asma e rinite têm aumentado nas últimas décadas, mas nos últimos anos tem sido referida a sua estabilização ou mesmo diminuição.

Objectivo: O objectivo foi o de descrever a prevalência de rinite, asma ou sintomas do tipo da asma em adolescentes urbanos de 13 anos.

Métodos: Os participantes elegíveis foram todos os alunos das escolas públicas e privadas do Porto, nascidos em 1990; 2161 (77,5%) concordaram em participar. Através de questionários autoaplicados, a informação recolhida contemplou aspectos sociais, demográficos, comportamentais, história clínica de asma e doenças alérgicas do adolescente e família. Foi usada a versão portuguesa do International Study of Asthma and Allergies in Childhood’s (ISAAC) e foram efectuadas espirometrias.

Resultados: Nesta amostra de adolescentes urbanos de 13 anos, a prevalência da asma durante a vida foi de 12,9%, 84,4% com diagnóstico médico. A pieira durante a vida foi 18,3% e no último ano de 9,3%. A rinite foi relatada por 10,1%, mas a prevalência durante a vida de adolescentes com espirros, rinorreia serosa ou obstrução nasal, foi de 32,0%, e no último ano de 27,4%.

Conclusão: Verificou-se uma estabilização ou mesmo diminuição da prevalência dos sintomas e diagnóstico de asma e rinite nos adolescentes do Porto, quando comparada com os resultados do ISAAC em 2002, tal como noutras investigações na Europa. A asma e a rinite estão frequentemente presentes no mesmo doente e a tosse nocturna é um importante sintoma que surge associado aos sintomas nasais. A função pulmonar permitiu discriminar os adolescentes com queixas respiratórias.

Rev Port Pneumol 2008; XIV (6): 747-768

Palavras-chave:
Adolescentes
asma
rinite
estudos transversais
prevalência
tendência
Abstract

Background: The prevalence of asthma and rhinitis has been increasing over the past few decades, but the last few years have seen these rates stabilise or even decrease.

Aim: The aim of our study was to describe the prevalence of rhinitis, asthma or asthma-like symptoms in 13 year-old urban adolescents.

Methods: Eligible participants were all students at state and private schools in Porto born in 1990. 2161 (77.5%) agreed to participate. Information was obtained using self-administered questionnaires inquiring into social, demographic, behavioural and clinical history including asthma and allergic diseases in the adolescent and the family. We used the Portuguese version of the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire and we also performed spirometry tests.

Results: In this sample of 13 year old urban adolescents the prevalence of asthma ever was 12.9%, 84.4% with physician diagnosis. Lifetime wheezing was reported by 18.3% and current wheezing by 9.3% of the adolescents. Rhinitis was referred to by 10.1%, but the prevalence of adolescents with sneezing ever, or a runny/blocked nose, was 32.0% and the prevalence in the last 12 months was 27.4%.

Conclusion: We concluded that there was stabilisation or even decrease in the prevalence of asthma and rhinitis symptoms and diagnosis in adolescents reported in Porto, compared with the 2002 ISAAC study, as observed in other surveys in Europe. Asthma and rhinitis is frequently present in the same patient and nocturnal cough is an important symptom concomitant with nasal symptoms. Measures of lung function permitted the discrimination of adolescents with respiratory complaints.

Rev Port Pneumol 2008; XIV (6): 747-768

Key-words:
Adolescents
asthma
rhinitis
cross-sectional studies
prevalence
trends
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Bibliografia / Bibliography
[1.]
J. Heinrich, B. Hoelscher, C. Frye, I. Meyer, M. Wjst, H.E. Wichmann.
Trends in prevalence of atopic diseases and allergic sensitization in children in Eastern Germany.
Eur Respir J, 19 (2002), pp. 1040-1046
[2.]
W. Maziak, T. Behrens, T. Brasky, H. Duhme, P. Rzehak, S. Weiland, U. Keil.
Are asthma and allergies in children and adolescents increasing? Results from ISAAC phase I and phase III surveys in Münster, Germany.
Allergy, 58 (2003), pp. 572-579
[3.]
J. Latvala, L. von Hertzen, H. Lindholm, T. Haahtela.
Trends in prevalence of asthma and allergy in Finnish young men: nationwide study.
[4.]
S.G. Campanella, M.I. Asher.
Current controversies: sinus disease and the lower airways.
Pediatr Pulmonol, 31 (2001), pp. 165-172
[5.]
M. Bugiani, A. Carosso, E. Migliore, P. Piccioni, A. Corsico, M. Olivieri, M. Ferrari, Pirina P., de Marco R., ISAYA (ECRHS Italy) Study Group.
Allergic rhinitis and asthma comorbidity in a survey of young adults in Italy.
[6.]
J. Bousquet, P. van Cauwenberge, N. Khaltaev.
World Health Organization. Allergic rhinitis and its impact on asthma.
In collaboration with the World Health Organization. Executive summary of the workshop report. Allergy, 57 (2002), pp. 841-855
[7.]
F. Rusconi, C. Galassi, G. Corbo, F. Forastiere, A. Biggeri, G. Ciccone, E. Renzoni, SIDRIA Collaborative Group.
Risk factors for early, persistent, and late-onset wheezing in young children.
Am J Respir Crit Care Med, 160 (1999), pp. 1617-1622
[8.]
S. Spector.
Overview of comorbid associations of allergic rhinitis.
J Allergy Clin Immunol, 99 (1997), pp. S773-S780
[9.]
J. Corren.
Allergic rhinitis and asthma: how important is the link?.
J Allergy Clin Immunol, 99 (1997), pp. S781-S786
[10.]
A. Hublet, A. Andersen, E. Godeau, C. Vereecken, R. Valimaa, J. Tynjala, W. Boyce, L. Maes.
Asthma and wheezing symptoms in young people in six Western countries.
Rev Epidemiol Sante Publique, 54 (2006), pp. 305-312
[11.]
L. Caussade, C. Valdivia, M. Navarro, B. Perez, S. Aquevedo, D. Sanchez.
Risk factors and prevalence of allergic rhinitis among Chilean children.
Rev Med Chil, 134 (2006), pp. 456-464
[12.]
C. Johnson, D. Ownby, E. Zoratti, S. Alford, K. Williams, C. Joseph.
Environmental epidemiology of pediatric asthma and allergy.
Epidemiol Rev, 24 (2002), pp. 154-175
[13.]
D. Wiesch, D. Meyers, E. Bleeker.
Genetics of asthma.
J Allergy Clin Immunol, 104 (1999), pp. 895-901
[14.]
S. Foliaki, I. Annesi-Maesano, R. Daniel, T. Fakakovikaetau, M. Magatongia, N. Tuuau-Potoi, L. Waqatakirewa, S. Cheng, N. Pearce.
Prevalence of symptoms of childhood asthma, allergic rhinoconjunctivitis and eczema in the Pacific: The International Study of Asthma and Allergies in Childhood (ISAAC).
[15.]
M. Mercer, G. Joubert, R. Ehrlich, H. Nelson, M. Poyser, A. Puterman, E. Weinberg.
Socioeconomic status and prevalence of allergic rhinitis and atopic eczema symptoms in young adolescents.
Pediatr Allergy Immunol, 15 (2004), pp. 234-241
[16.]
M. Asher, U. Keil, H. Anderson, R. Beasley, J. Crane, F. Martinez, E. Mitchell, N. Pearce, B. Sibbald, A. Stewart, D. Strachan, S. Weiland, H. Williams.
International study of asthma and allergies in childhood (ISAAC): rationale and methods.
Eur Respir J, 8 (1995), pp. 483-491
[17.]
American Thoracic Society.
Standardization of spirometry: 1994 update.
Am J Respir Crit Care Med, 152 (1995), pp. 1107-1136
[18.]
M. Masoli, D. Fabian, S. Holt, Beasley R., Global Initiative for asthma (GINA).
Program The global burden of asthma: executive summary of the GINA Dissemination Committee Report.
[19.]
G. Verlato, A. Corsico, S. Villani, I. Cerveri, E. Migliore, S. Accordini, A. Carolei, P. Piccioni, M. Bugiani, V. Lo Cascio, A. Marinoni, A. Poli, R. de Marco.
Is the prevalence of adult asthma and allergic rhinitis still increasing? Results of an Italian study.
J Allergy Clin Immunol, 111 (2003), pp. 1232-1238
[20.]
R. Woods, E. Walters, C. Wharton, N. Watson, M. Abramson.
The rising prevalence of asthma in young Melbourne adults is associated with improvement in treatment.
Ann Allergy Asthma Immunol, 87 (2001), pp. 117-123
[21.]
X. Wang, T. Tan, L. Shek, S. Chng, N. Hia, S. Ma, B. Lee, D. Goh.
The prevalence of asthma and allergies in Singapore; data from two ISAAC surveys seven years apart.
Arch Dis Child, 89 (2004), pp. 423-426
[22.]
H. Anderson, R. Ruggles, D. Strachan, J. Austin, M. Burr, D. Jeffs, P. Stranding, A. Steriu, R. Goulding.
Trends in prevalence of symptoms of asthma, hay fever, and eczema in 12-14 year olds in the British Isles, 1995-2002: questionnaire survey.
[23.]
R. Ronchetti, M. Villa, M. Barreto, R. Rota, J. Pagani, S. Martella, C. Falasca, B. Paggi, F. Guglielmi, G. Ciofetta.
Is the increase in childhood asthma coming to an end? Findings from three surveys of schoolchildren in Rome, Italy.
Eur Respir J, 17 (2001), pp. 881-886
[24.]
B. Toelle, K. Ng, E. Belusova, M. Salome, K. Peat, B. Marks.
Prevalence of asthma and allergy in schoolchildren in Belmont, Australia: three cross-sectional surveys over 20 years.
[25.]
C. Braun-Fahrlander, M. Gassner, L. Grize, K. Takken-Sahli, U. Neu, T. Stricker, H. Varonier, B. Wuthrich, Sennhauser F..
Swiss Study on Childhood Allergy and Respiratory symptoms; Air Pollution (SCARPOL) team. No further increase in asthma, hay fever and atopic sensitisation in adolescents living in Switzerland.
Eur Respir J, 23 (2004), pp. 407-413
[26.]
L. Lee, W. Wong, L. Lau.
Increasing prevalence of allergic rhinitis but not asthma among children in Hong Kong from 1995 to 2001 (Phase 3 International Study of Asthma and Allergies in Childhood).
Pediatr Allergy Immunol, 15 (2004), pp. 72-78
[27.]
L. García-Marcos, A. Blanco Quirós, G. Garcia Hernández, F. Guillan-Grima, C. Gonzalez Díaz, I. Ureňa, A. Pena, R. Monge, M. Suárez-Varela, A. Varela, P. Cabanillas, J. Garrido.
Stabilization of asthma prevalence among adolescents and increase among schoolchildren (ISAAC phases I and III) in Spain.
[28.]
M. Flemming, R. Sunderland, W. Cross, M. Ross.
Declining incidence of episodes of asthma: a study of trends in new episodes presenting to general practitioners in the period 1989-98.
Thorax, 55 (2000), pp. 657-661
[29.]
A. Senthilselvan, J. Lawson, C. Rennie, A. Dosman.
Stabilization of an increasing trend in physician–diagnosed asthma prevalence in Saskatchewan, 1991 to 1998.
Chest, 124 (2003), pp. 438-448
[30.]
L. Hedman, B. Lindgren, M. Perzanowski, E. Ronmark.
Agreement between parental and self-completed questionnaires about asthma in teenagers.
Pediatr Allergy Immunol, 16 (2005), pp. 176-181
[31.]
L. von Hertzen, T. Haahtela.
Signs of reversing trends in prevalence of asthma.
[32.]
W. Nystad, P. Magnus, A. Gulsvik, I. Skarpaas, K. Carlsen.
Changing prevalence of asthma in school children: evidence for diagnostic changes in asthma in two surveys 13yrs apart.
Eur Respir J, 10 (1997), pp. 1046-1051
[33.]
R. Barraclough, G. Devereux, D. Hendrick, S. Stenton.
Apparent but not real increase in asthma prevalence during the 1990s.
Eur Respir J, 20 (2002), pp. 826-833
[34.]
P. Magnus, J. Jaakkola.
Secular trend in the occurrence of asthma among children and young adults: critical appraisal of repeated cross sectional surveys.
BMJ, 314 (1997), pp. 1795-1799
[35.]
G. Kwong, A. Proctor, C. Billings, R. Duggan, C. Das, K. Whyte, V. Powell, R. Primhak.
Increasing prevalence of asthma diagnosis and symptoms in children is confined to mild symptoms.
Thorax, 56 (2001), pp. 312-314
[36.]
T. Haahtela, T. Klaukka, K. Koskela, M. Erhola, L. Laitinen.
Asthma programme in Finland: a community problem needs community solutions.
Thorax, 56 (2001), pp. 806-814
[37.]
M. Upton, A. McConnachie, C. Mc Sharry, C. Hart, G. Smith, C. Gillis, G. Watt.
Intergenerational 20 year trend in the prevalence of asthma and hay fever in adults: the Midspan family study surveys of parents and offspring.
BMJ, 321 (2000), pp. 88-92
[38.]
K. Reijula, T. Haahtela, T. Klaukka, J. Rantanen.
Incidence of occupational asthma and persistent asthma in young adults has increased in Finland.
Chest, 110 (1996), pp. 58-61
[39.]
D. Strachan, L. Harkins, I. Johnston, H. Anderson.
Childhood antecedents of allergic sensitization in young British adults.
J Allergy Clin Immunol, 99 (1997), pp. 6-12
[40.]
M. Gdalevich, D. Mimouni, M. Mimouni.
Breast-feeding and the risk of bronchial asthma in childhood: a systematic review with meta-analysis of prospective studies.
J Pediatr, 139 (2001), pp. 261-266
[41.]
E. von Mutius.
Environmental factors influencing the development and progression of pediatric asthma.
J Allergy Clin Immunol, 109 (2002), pp. S525-S532
[42.]
E. Lanner, M. Wickman, G. Pershagen, L. Nordvall.
Maternal smoking during pregnancy increases the risk of recurrent wheezing during the first years of life (BAMSE).
Respir Res, 7 (2006), pp. 3
[43.]
C. Benn, J. Wohlfahrt, P. Aaby, T. Westergaard, E. Benfeldt, K. Michaelsen, B. Björkstén, M. Melbye.
Breastfeeding and Risk of Atopic Dermatitis, by Parental History of Allergy, during the First 18 Months of Life.
Am J Epidemiol, 160 (2004), pp. 217-223
[44.]
E. Sarafino.
Connections among parent and child atopic illnesses.
Pediatr Allergy Immunol, 11 (2000), pp. 80-86
[45.]
D. Strachan, B. Butland, H. Anderson.
Incidence and prognosis of asthma and wheezing illness from early childhood to age 33 in a national British cohort.
BMJ, 312 (1996), pp. 1195-1199
[46.]
H. Anderson, A. Pottier, D. Strachan.
Asthma from birth to age 23: incidence and relation to prior and concurrent atopic disease.
Thorax, 47 (1992), pp. 537-542
[47.]
T. Nicolai, L. Pereszlenyiova-Bliznakova, S. Illi, D. Reinhardt, E. von Mutius.
Longitudinal follow up of the changing gender ratio in asthma from childhood to adulthood: role of delayed manifestation in girls.
Pediatr Allergy Immunol, 14 (2003), pp. 280-283
[48.]
L. Borrego, M. César, P. Leiria-Pinto, J. Rosado-Pinto.
Prevalence of asthma in a Portuguese countryside town: repercussions in absenteeism and self-concept.
Allergol et Immunopathol, 33 (2005), pp. 92-99
[49.]
C. Nunes, S. Ladeira, Rosado-Pinto J. Definição.
Epidemiologia e Classificação da asma na criança.
A criança asmática no mundo da alergia, pp. 35-55
[50.]
B. Leynaert, F. Neukirch, P. Demoly, J. Bousquet.
Epidemiologic evidence for asthma and rhinitis comorbidity.
J Allergy Clin Immunol, 106 (2000), pp. 201-205
[51.]
A. Vignola, J. Bousquet.
Rhinitis and asthma: a continuum of disease?.
Clin Exp Allergy, 31 (2001), pp. 674-677
[52.]
J. Grossman.
One airway, one disease.
Chest, 111 (1997), pp. 11S-16S
[53.]
F. Simons.
Allergic rhinobronchitis: the asthma-allergic rhinitis link.
J Allergy Clin Immunol, 104 (1999), pp. 534-540
[54.]
S. Mortimer, A. Fallot, J. Balmes, I. Tager.
Evaluating the use of a Portable Spirometer in a Study of Pediatric Asthma.
CHEST, 123 (2003), pp. 1899-1907
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