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Vol. 9. Issue 3.
Pages 225-247 (May - June 2003)
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Vol. 9. Issue 3.
Pages 225-247 (May - June 2003)
MESA-REDONDA/ROUND TABLE
Open Access
A mulher e o cancro do pulmão*
Lung cancer and women
Visits
4994
E. Teixeira, S. Conde, P. Alves, L. Ferreira, A. Figueiredo, B. Parente
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RESUMO

A epidemiologia do cancro do pulmão mudou em vários países nos últimos anos.

No século XIX o cancro do pulmão era raro, mas a sua incidência aumentou drasticamente durante o século XX e é previsível que continue a aumentar no início do século XXI.

Actualmente, as taxas de incidência e mortalidade do cancro do pulmão são maiores nos países desenvolvidos, especialmente EUA e Europa, tendo-se verificado aumento de incidência na mulher. Estas diferenças geográficas e entre os sexos estão largamente relacionadas com os hábitos tabágicos.

As mulheres começam a fumar mais precocemente e têm mais dificuldade na desabituação tabágica, por problemas relacionados com o controlo de peso; apresentam uma susceptibilidade maior aos carcinogéneos, tendo um risco de cancro do pulmão 1,5 vezes superior ao homem com os mesmos hábitos tabágicos. O adenocarcinoma é o tipo histológico mais frequente nos jovens, nas mulheres em todas as idades e nos não fumadores.

Vários factores desde tabaco, poluição doméstica e profissional, nutricional doenças associadas, até factores genéticos e hormonais, têm sido investigados no sentido de definir a sua influência no desenvolvimento de cancro do pulmão na mulher.

Quem trata este tipo de patologia vê-se ainda confrontado com inúmeras questões que se relacionam com a sua especificidade do sexo feminino. A literatura sobre este tema é no entanto vaga.

REV PORT PNEUMOL 2003; IX (3): 225-247

Palavras-chave:
Cancro do pulmão
mulher
epidemiologia
tratamento
ABSTRACT

The epidemiology of lung cancer has changed in the last years in several countries all over the world. In the 19th century, the lung cancer was rare but it incidence increase drastically during the 20th century, and the tendency is to continue in the 20th century. Actually the lung cancer’s incidence and mortality are higher in the developed countries, especially in Europe and Unites States of America, with a increasing in the women incidence. These geographic differences and gender differences are related with smoking habits.

Women begin to smoke earlier and have more difficulty to stop, because of problems related with obesity; they have more sensibility to the carcinogens and the risk of lung cancer is 1,5 times higher than the men with the same habits.

Adenocarcinoma is the more frequent histological type in young people, in the total of the women and in non-smokers.

Many factors since tobacco, home and professional pollution, nutritional, associated diseases even genetic and hormonal factors have been investigated to define its influence in development in women lung cancer.

It specificity in women with lung cancer is the comum problem for the medical people to treat this disease (pathology).The literature about this problem is not clear, and is necessary to advance with many studies in this arca with the objective to clarify this important question.

REV PORT PNEUMOL 2003; IX (3): 225-247

Key-words:
Lung Cancer
women
epidemiology
treatment
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BIBLIOGRAFIA
[1.]
L. Simonato, A. Agudo, W. Ahrens, E. Benhamou, S. Benhamou, P. Boffetta, P. Brennan, S.C. Darby, F. Forastiere, C. Fortes, V. Gaborieau, M. Gerken, C.A. Gonzales, K. Jockel, M. Kreuzer, F. Merletti, F. Nyberg, G. Pershagen, H. Pohlabeln, F. Rosch, E. Whitley, H. Wichmann, P. Zambon.
Lung cancer and cigarrete smoking in Europe: an update of risk estimates and an assessement of inter-contry heterogeneity.
Int. J. Cancer, 91 (2001), pp. 876-887
[2.]
U.S. Dept Of Health And Human Service.
Reducing the health consequences of smoking: 25 years of progress: a report of the Surgeon general, pp. 89-8411
[3.]
S. Benhamou, E. Benhamou.
The effect of age at smoking initiation on lung cancer risk.
Epidemiology, 5 (1994), pp. 560
[4.]
K.T. Hegmann, A.M. Fraser, R.P. Keaney, et al.
The effect of age of smoking initiation on lung cancer risk.
Epidemiology, 4 (1993), pp. 444-448
[5.]
Centers For Disease Control And Prevention.
Tobacco use among high school students- United States, 1997.
MMWR Morb Mortal Wkly Rep, 47 (1998), pp. 229-233
[6.]
Centers For Disease Control And Prevention.
Incidence of initiation of cigarete smoking: United States, 1965-1996.
MMWR Morb Mortal Wkly Rep, 47 (1998), pp. 837-840
[7.]
D.E. Stover.
Women, smoking and lung cancer.
Chest, 113 (1998, January),
[8.]
Health Canadá.
Survey on smoking in Canadá.
Cycle: 1.5, Profile on Youth Aged 15-19,
[9.]
Youth Smoking Survey, 1994: Techical Report,
[10.]
Manso JRP. Factores explicativos do consumo de tabaco num distrito do interior de Portugal. Fonte: Instituto Nacional de Estatística, Portugal.
[11.]
B.M. Pope, M.J. Ashley, R. Ferrence.
The carcinogenic and toxic effects of tobacco smoke: are women particularly susceptible?.
The Journal of Gender-Specific Medicine, 6 (1999), pp. 45-51
[12.]
H.A. Risch, G.R. Howe, M. Jain, et al.
Are female smokers at higher risk for lung cancer than male smokers? A case control analysis by histologic type.
Am J Epidemiol, 38 (1993), pp. 281-293
[13.]
K.E. Osann, H. Anton-Culver, T. Kurosaki, T. Taylor.
Sex differences in lung-cancer risk associated with cigarette smoking.
Int J Cancer, 22 (1993), pp. 592-599
[14.]
B. Cohn, D.L. Wingard, P.M. Cirillo, et al.
Differences in lung cancer risk between men and women: examination of the evidence.
J Natl Cancer Inst, 88 (1996), pp. 1867-1868
[15.]
S.A. Khuder.
Effect of cigarrete smoking on major histo logical types of lung cancer: a meta-analysis.
Lung cancer, 31 (2001), pp. 139-148
[16.]
L.A. Zang, E.L. Winder.
Differences in lung can-cer risk between men and women: examination of the evidence.
Journal of National Institute;, 88 (1996), pp. 183-192
[17.]
R.C. Brownson, J.C. Chang, J.R. Davis.
Gender and histologic type variations in smoking-related risk of lung cancer.
Epidemiology, 3 (1992), pp. 61-64
[18.]
E.A. Zang, E.L. Wynder.
Cumulative tar exposure: a new index for estimating lung cancer risk among cigarette smoking.
Cancer, 70 (1992), pp. 69-76
[19.]
E. Prescott, M. Osler, H.O. Hein, K. Borch Johnson, P. Lange, P. Schnohr, Vestbo J., The Copenhagen Center For Prospective Population Studies.
Gender and smoking-related risk of lung cancer.
Epidemiology, 9 (1998), pp. 79-83
[20.]
M. Kreuzer, P. Boffetta, E. Whitley, W. Ahrens, V. Gaborieau, J. Heinrich, K.H. Jockel, L. Kreienbrock, S. Mallone, F. Merletti, F. Roesch, P. Zambon, L. Simonato.
Gender differences in lung cancer risk by smoking: a multicentre casecontrol study in Germany and Italy.
Br. J. Cancer, 82 (2000), pp. 227-233
[21.]
R. Doll, R. Peto.
The causes of cancer: quantitative estimates of avoidable risks in the United States today.
J Natl Cancer Inst, 66 (1981), pp. 1191-1308
[22.]
C.G. Humble, J.M. Samet, D.R. Pathak, B.J. Skipper.
Cigarette smoking in lung cancer in «Hispanic» whites and other whites in New Mexico.
Am J Public Health, 75 (1985), pp. 145-148
[23.]
J.B. Schoenberg, H.B. Wilcox, J. Masont, J. Bill, A. Stemhagen.
Variation in smoking-related lung cancer risk among New Jersey Women.
Am J Epidemiology, 130 (1989), pp. 688-695
[24.]
S. Payne.
«Smoke like a man, die like a man?»: A review of the relationship between gender, sex and lung cancer.
Social Science and Medicine, 53 (2001), pp. 1067-1080
[25.]
E.L. Wynder, D. Hoffman.
Smoking and lung cancer: scientific challenges and opportunities.
Cancer Res, 54 (1994), pp. 5284-5295
[26.]
D. Hoffman, M.V. Djordjevic, I. Hoffman.
The changing cigarette.
Prev Med, 26 (1997), pp. 427-434
[27.]
S.A. Grover, K. Gray-Donald, L. Joseph, et al.
Life expectancy folloing dietary modification or smoking cessation.
Arch Intern Med, 154 (1994), pp. 1697-1704
[28.]
K.C. Johnson, J. Hu, Mao Y., The Canadian Cancer Registries Epidemiology Group.
Lifetime residential and workplace exposure to environmental tobacco smoke and lung cancer in never smoking women, Canada 1994-97.
Int J Cancer, 93 (2001), pp. 902-906
[29.]
A.K. Hackshaw, M.R. Law, N.J. Wald.
The accumu lated evidence on lung cancer and environmental tobacco smoke.
Br Med J, 315 (1997), pp. 980-988
[30.]
P. Boffeta, A. Agudo, W. Ahrens, et al.
Multicenter case-control study of exposure to environmental tobacco smoke and lung cancer in Europe.
J Natl Cancer Inst, 90 (1998), pp. 1440-1450
[31.]
L. Zhong, M.S. Goldberg, M. Parent, J.A. Hanley.
Exposure to environmental tobacco smoke and the risk of lung cancer: a meta analysis.
Lung cancer, 27 (2000), pp. 3-18
[32.]
Us Environmental Protection Agency (EPA).
Respiratory health effects of passive smoking: Lung cancer and other disorders, pp. 689
[33.]
F. Curtin, A. Morabia, M. Bernstein.
Lifetime exposure to environmental tobacco smoke among urban women: differences by socioeconomic class.
Am J Epidemiol, 148 (1998), pp. 1040-1047
[34.]
S.K. Hammond, G. Sorenson, R. Youngstrom, et al.
Occupational exposure to environmental tobacco smoke.
J Am Med Assoc, 274 (1995), pp. 956-960
[35.]
J.P. Muscat, S.D. Stellman, J.O. Richie, E.L. Wynder.
Lung cancer risk and workplace exposures in black men and women, Environmental Research, (1998),
[36.]
K.E. Anderson, S.G. Carmella, Y.E. Ming, R.L. Bliss, L.E. Chap, L. Murphy, S.S. Hecht.
Metabolites of a tobacco-specific lung carcinogen in nonsmoking women exposed to environmental tobacco smoke.
J Nat Cancer Inst, 7 (2001, March), pp. 93(5)
[37.]
Office Of Health And Environmental As Sessment.
Respiratory health effects of passive smoking: lung cancer and other disorders, Environmental Protection Agency (EPA)-EPA, (1992),
[38.]
P.N. Lee.
Uses and abuses of cotinina as a marker of tobacco smoke exposure.
Analytical determination of nicotine and related compounds and their metabolites, pp. 669-719
[39.]
US Dep. Of Health And Human Services, Environmental Protection Agency.
Respiratory Health Effects of Passive Smoking: Lung Cancer and Other Disorders (Smoking and Tobacco Control Monogrph 4),
[40.]
Office Of Environmental Health Hazard Assessment, California Environmental Protection Agency.
Health effects of exposure to environmental tobacco smoke, California Environmental Protection Agency, (1997),
[41.]
W.J. Blot, J.K. McLaughlin, W.J. Blot, J.K. McLaughlin, W.J. Blot, J.K. McLaughlin.
Passive smoking and lung cancer risk: what is the story now? (editorial).
J Natl Can cer Inst, 90 (1998), pp. 1416-1417
[42.]
International Agency For Research On Cancer.
Cancer Incidence in Five Continents. Lyon, (1992),
[43.]
F. Jin, S.S. Devesa, W. Zheng, W.J. Blot, J.F. Fraumeni, Y.T. Gao.
Cancer incidence in urban Shanghai, 1972-89.
Int J Cancer, 53 (1993), pp. 764-770
[44.]
Y.T. Gao, W.J. Blot, W. Zhang, A.G. Ershow, C.W. Hsu, I. Levin, J.F. Fraumeni Jr.
Lung cancer among Chinese Women.
Int J Cancer, 40 (1987), pp. 604-609
[45.]
A.H. Wu-Williams, X.D. Dai, W.J. Blot, et al.
Lung cancer among women in North-east China.
Br J Cancer, 62 (1990), pp. 982-987
[46.]
X.B. Shen, G.X. Wang, Y.Z. Huang, L.S. Xiang, X.H. Wang.
Analysis and estimates of attributable risk factors for lung cancer in Nanjing, China.
Lung Cancer, 14 (1996), pp. 107-112
[47.]
L. Koo, J.H.C. Ho.
Worldwide epidemiological patterns of lung cancer in non smokers.
International Journal of Epidemiology, 19 (1990), pp. 14-23
[48.]
Z.Z. Feng, X.F. Wu, J.M. Wu.
An epidemiological study of risk factors for lung cancer in Guangzhou. China.
Lung cancer, 14 (1996), pp. 9-37
[49.]
Z.Y. Liu, X.Z. He, R.S. Chapman.
Smoking and other risk factors for lung cancer in Xuanwei. China.
International Journal of Epidemiology, 20 (1991), pp. 26-31
[50.]
C. Metayer, Z. Wang, R.A. Kleinerman, L. Wang, A.V. Brenner, H. Cui, J. Cao, J.H. Lubin.
Cooking oil fumes and risk of lung cancer in women in rural Gansu, China.
Lung cancer, 35 (2002), pp. 111-117
[51.]
G.X. Wang.
Multivariate analyses of casual factors included cooking oil fumes and others in matched case-control study of lung cancer.
Chin J Prev Med, 26 (1992), pp. 89-91
[52.]
T.J. Wang, B.S. Zhou, J.P. Shi.
Lung cancer in nonsmoking Chinese Women: a case-control study.
Lung cancer, 14 (1996), pp. 93-98
[53.]
X.D. Dai, C.Y. Lin, X.W. Sun, Y.B. Shi, Y.J. Lin.
The etiology of lung cancer in nonsmoking females in Harbin, China.
Lung cancer, 14 (1996), pp. 85-90
[54.]
Y.C. Ko, L.S.C. Cheng, C.H. Lee, et al.
Chinese food cooking and lung cancer in women nonsmokers.
Am J Epidemiolo, 151 (2000), pp. 140-147
[55.]
P.G. Shields, G.X. Xu, W.J. Blot, et al.
Mutagens from heated Chinese and US cooking oils.
J Natl Cancer Inst, 87 (1995), pp. 836-841
[56.]
E.D. Pellizari, L.C. Michael, K.W. Thomas, P.G. Shields, C. Harris.
Identification of 1,3 butadiene, benzene and other volatile organics from wok oil emission.
J Exp Anal Envioron Epidemio, 5 (1995), pp. 77-87
[57.]
J. Maçanita.
Epidemiologia e etiologia do cancro do pulmão. Carcinogénese brônquica.
Oncologia Pneumológica, pp. 13-29
[58.]
Pershagen, et al.
Residential radon exposure and lung cancer in Sueden.
N Eng J Med, 330 (1994), pp. 159-164
[59.]
R.C. Brownson, M.C.R. Alavanja, J.C. Chang.
Occupational risk factors for lung cancer among nonsmoking women: a case control study in Missouri (United States).
Cancer Causes Control, 4 (1993), pp. 449-454
[60.]
A.H. Wu-Williams, Z.Y. Xu, W.J. Blot, X.D. Dai, R. Louie, H.P. Xiao, et al.
Occupation and lung cancer risk among women in Northern China.
Am J Ind Med, 24 (1993), pp. 67-79
[61.]
K.J. Aronson, G.R. Howe.
Utility of a surveillance system to detect associations between work and cancer among women in Canada, 1965-1991.
J Occup Med, 36 (1994), pp. 1174-1179
[62.]
C.F. Robinson, C.A. Burnett.
Mortality patterns of US female constrution workers by race, 1979-1990.
J Occup Med, 36 (1994), pp. 1228-1233
[63.]
C.F. Robinson, F. Stern, W. Halperin, H. Venable, M. Petersen, T. Frazier, et al.
Assessment of mortality in the construction industry in the United States, 1984–1986.
Am J Ind Med, 28 (1995), pp. 49-70
[64.]
E.L. Winder, J.R. Herbert, G.C. Kabat.
Association of dietary fat and lung cancer.
J Natl Cancer Inst, 79 (1987), pp. 631-637
[65.]
M.C.R. Alavanja, C.C. Brown, C. Swanson, R.C. Brownson.
Satured fat intake and lung cancer risk among nonsmoking women in Missouri.
J Natl Cancer INST, 85 (1993), pp. 1906-1916
[66.]
M. Jain, E.T.H. Fontham, V. Chen, P. Correra, H. Deneo Pellegrini, A. Ronco.
Dietary factors and the risk of lung cancer:results from a case-control study. Toronto, 1981-1985.
Int J Cancer, 45 (1990), pp. 287-293
[67.]
R.A. Breslow, B.I. Graubard, R. Sinha, A.F. Subar.
Diet and lung cancer mortality: a 1987 National Health Interview Survey cohort study.
Cancer Causes Control, 11 (2000), pp. 419-431
[68.]
R. Sinha, M. Kulldorff, J. Curtain, C.C. Brown, M.C.R. Alavanja, C.A. Swanson.
Fried, well- done red meat and risk of lung cancer in women (United States).
Cancer Causes Control, 9 (1998), pp. 621-630
[69.]
D.W. Layton, K.T. Bogen, M.G. Knize, P.T. Hatch, V.M. Johnson, J.S. Felton.
Cancer risk of hetercyclic amines in cooked foods: an analysis and implications for research.
Carcinogenesis, 16 (1995), pp. 39-52
[70.]
R. Sinha, N. Rothman, C.P. Salmon, M.G. Knize, E.D. Brown.
Heterocyclic amine content in beef cooked by different methods to varying degrees of doneness and gravy made from meat drippings.
Food Chem Toxicol, 36 (1998), pp. 279-287
[71.]
R. Sinha, M.G. Knize, C.P. Salmon, et al.
Heterocyclic amine content of pork products cooked by different methods and to varying degrees of doneness.
Food Chem Toxicol, 36 (1998), pp. 289-297
[72.]
R. Sinha, M. Kuldorff, C.A. Swanson, J. Curtain, R.C. Brownson, M.C.R. Alavanja.
Dietary heterocyclic amines and the risk of lung cancer among Missouri women.
Cancer Research, 60 (2000, July 15), pp. 3753-3756
[73.]
World Cancer Research Fond.
Food, Nutrition and the Prevention of Cancer: a Global Perspective, American Institute for Cancer Research, (1997),
[74.]
M.P. Longnecker, M. Tseng.
Alcohol and cancer.
Nutritional oncology, pp. 277-298
[75.]
J. Rachtan.
Alcoholic beverages consumption and lung cancer cell types among women in Poland.
Lung Cancer, 35 (2002), pp. 119-127
[76.]
R.G. Ziegler, S.T. Mayes, C.A. Swanson.
Nutrition and lung cancer.
Cancer Causes Control, 7 (1996), pp. 157-177
[77.]
L.E. Voorrips, R.A. Goldbohm, D.T.H. Verhoeven, et al.
Vegetable and fruit consumption and lung cancer risk in the Netherlands Cohort Study of Diet and Cancer.
Cancer Causes Control, 11 (2000), pp. 101-115
[78.]
D. Feskanich, R.G. Ziegler, D.S. Michaud, E.L. Giovannucci, F.E. Speizer, W.C. Willett, G.A. Colditz.
Prospective study of fruit and vegetable consumption and risk of lung cancer among men and women.
Journal of the National Cancer Institute, l92 (2000),
[79.]
The Alfa-Tocopherol, Beta Carotene Cancer Prevention Study Group.
The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers.
N Engl J Med, 330 (1994), pp. 1029-1035
[80.]
C.H. Hennekens, J.E. Buring, J.E. Manson, M. Stampfer, B. Rosner, M.R. Cook, et al.
Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease.
N Engl J Med, 334 (1996), pp. 1145-1149
[81.]
J.F. Dorgan, R.G. Ziegler, J.B. Schoenberg, P. Hartge, M.J. Mcadams, R.T. Falk, et al.
Race and sex differences in associations of vegetables, fruits and carotenoids with lung cancer risk in New Jersey (United States).
Cancer Causes Control, 4 (1993), pp. 273-281
[82.]
I. Thune, E. Lund.
The influence of physical activity on lung cancer risk: a prospective study of 81516 men and women.
Int J Cancer, 70 (1997), pp. 57-62
[83.]
M.C.R. Alavanja, R.C. Brownson, J.D. Boice, E. Hock.
Preexisting lung disease and lung cancer among nonsmoking women.
Am J Epidemiol, 136 (1992), pp. 623-632
[84.]
M.C.R. Alavanja, R.C. Brownson, J. Benichou, et al.
Attributable risk of lung cancer in lifetime nonsmokers and long-term ex-smokers (Missouri, United States).
Cancer Causes Control, 6 (1995), pp. 209-216
[85.]
S.T. Mayne, J. Buenconsejo, Dt. Janerich.
Previous lung disease and risk of lung cancer among men and women.
Am J Epidemiol, 149 (1999), pp. 13-20
[86.]
R.E. Harris, E.A. Zang, J.I. Anderson, E.L. Wynder.
Race and sex differences in lung cancer risk associated with cigarette smoking.
Int J Epidemiology, 22 (1993), pp. 592-599
[87.]
C.M. Dresler, C. Fratelli, J. Babb, L. Everly, A.A. Evans, M.L. Clapper.
Gender differences in genetic susceptibility for lung cancer.
Lung Cancer, 30 (2000), pp. 153-160
[88.]
D. Ryberg, A. Hewer, D.H. Phillips, A. Haugen.
Different susceptibility to smoking-induced DNA damage among male and female lung cancer patients.
Cancer Res, 54 (1994), pp. 5801-5803
[89.]
F. Crofts, E. Taioli, J. Trachman, G.N. Cosma, D. Currie, P. Toniolo, S.J. Garte.
Functional significance of different human CYP1A1 genotypes.
Carcinogenesis, 15 (1994), pp. 2961-2963
[90.]
G.S. Hamada, H. Sugimura, I. Susuki, et al.
The hemebinding region of CYP1A1, rather than the Rsa poly morphism of CYP1A1, is associated with lung cancer in Rio de Janeiro.
Cancer Epidemiol Biomark Prev, 4 (1995), pp. 63-67
[91.]
J. Seidgard, R.W. Pero, D.J. Miller, E.J. Beattie.
A glutathione transferase in human leukocytes as a marker for the susceptibility to lung cancer.
Carcinogenesis, 7 (1986), pp. 751-753
[92.]
J. Seidgard, R.W. Pero, M.M. Markowitz, G. Roush, D.G. Miller, E.J. Beattie.
ISOENZYME(S) OF GLUTATHIONe transferase (class Mu) as a marker for the susceptibility to lung cancer.
Carcinogenesis, 11 (1990), pp. 33-36
[93.]
Y. Wang, M.R. Spitz, A.M. Tsou, K. Zhang, N. Makan, X. Wu.
Sulfotransferase (SULT) 1A1 polymorphism as a predisposition factor for lung cancer: a case-control analysis.
Lung Cancer, 35 (2002), pp. 137-142
[94.]
A. Engeland.
Trends in the incidence of smoking associated cancers in Norway, 1954-93.
Int J Cancer, 61 (1996), pp. 39-46
[95.]
K.E. Osann, J.T. Lowery, M.J. Schell.
Small cell lung cancer in women: risk associated with smoking, prior respiratory disease and occupation.
Lung cancer, 28 (2000), pp. 1-10
[96.]
D.L. Tang, A. Rundle, D. Warburton, R.M. Santella, W.Y. Tsai, S. Chiamprasert, Y.Z. Hsu, F.P. Perera.
Associations between both genetic and environmental biomarkers and lung cancer in women smokers.
Carcinogenesis, 19 (1998), pp. 1949-1953
[97.]
A.K. Alexandrie, M.I. Sundberg, J. Seidgard, Tornlingg, A. Rannus.
Genetic susceptibility to lung cancer with special emphasis on CYP1A1 and GSTM1: a study on host factors in relation toage of onset, gender and hitological cancer types.
Carcinogenesis, 15 (1994), pp. 1785-1790
[98.]
E.H. Kure, D. Ryberg, A. Hewer, D.H. Phillips, V. Skaug, R. Baera, A. Haugen.
P53 mutations in lung tumours: relationship to gender and lung DNA adduct levels.
Carcinogenesis, 17 (1996), pp. 2201-2205
[99.]
H.H. Nelson, D.C. Christiani, E.J. Mark, et al.
Implications and prognostic value of K-ras mutation for earlystage lung cancer in women.
J Natl Cancer Inst, 91 (1999), pp. 2032-2038
[100.]
S.P. Shriver, H.A. Bourdeau, C.T. Gubish, D.L. Tirpak, A.L. Davis, J.D. Luketich, J.M. Siegfried.
Sexspecific expression of gastrin-releasing peptide receptor: relationship to smoking history and risk of lung cancer.
J Natl Cancer Inst, 92 (2000), pp. 24-33
[101.]
J.M. Siegfried.
Women and lung cancer: does oestrogen play a role?.
The Lancet Oncology, 2 (2001), pp. 506-513
[102.]
Q. Wei, L. Cheng, C.L. Amos, et al.
Repair of tobacco carcinogen-induced DNA adducts and lung cancer risk: a molecular epidemiologic study.
J Natl Cancer Inst, 92 (2000), pp. 1764-1772
[103.]
E. Taioli, E.L. Wynder.
Endocrine factors and adenocarcinoma of the lung in women.
J Natl Cancer Inst, 84 (1994), pp. 869-870
[104.]
T.A. Sellers, J.D. Potter, A.R. Folsom.
Association of incident lung cancer with family history of female reproductive cancers: the Iowa Women’s Health Study.
Genet Epidemiol, 8 (1991), pp. 199-208
[105.]
R. Kato.
Sex-related differences in drug metabolism.
Drug Metab Rev, 3 (1974), pp. 1-32
[106.]
L.P. Stabile, A.L. Davis, C.T. Gubish, T.M. Hopkins, J.D. Luketich, N. Christie, S. Finkelstein, J.M. Siegfried.
Human non-small cell lung tumors and cells derived from normal lung express both estrogen receptor alpha and beta and show biological responses to estrogen.
Cancer Res, 62 (2002), pp. 2141-2150
[107.]
M.J. Fasco, G.J. Hurteau, S.D. Spivack.
Gender-dependent expression of alpha and beta estrogen receptors in human nontumor and tumor lung tissue.
Mol Cell Endocrinol, 188 (2002), pp. 125-140
[108.]
J.M. Siegfried, A.L. Gaither Davis, C. Gupta.
Role of estrogens in non-small cell lung cancer.
Proc Am Assoc Cancer Res, 41 (2000), pp. 136
BIBLIOGRAFIA
[1.]
Bilello Kathryn Smith, Murin Susan, et al.
Epidemiology, Etiology and Prevention of Lung Cancer.
Clin Chest Med, (March 2002), pp. 1-25
[2.]
Khuder Sadik, Mutgi Anand.
Effect of smoking cessation on major histologic types of Lung Cancer.
Chest, 120 (2001), pp. 1577-1583
[3.]
Baldini Elizabeth, Strauss Gary.
Women and Lung Cancer.
Chest, 112 (1997), pp. 229s-234s
[4.]
Marc de Perrot, Licker Marc, Bouchardy Christine, et al.
Sex differences in presentation, management, and prognosis of patients with Non-Small-Cell Lung Carcinoma.
J Thorac Cardiovasc Surg, 119 (2000), pp. 21-26
[5.]
Minani Hiroya, Yoshimura Masahiro, et al.
Lung Cancer in Women – Sex-Associated differences in survival patients undergoing resection for lung Cancer.
Chest, 118 (2000), pp. 1603-1609
[6.]
C.Y. Castro, D.M. Coffey, et al.
Prognostic significance of percentage of bronchioloalveolar pattern in adenocarcinomas of Lung.
Ann. Diagn. Pathol, 5 (2001), pp. 274-284
[7.]
Barkley John, Green Mark.
Bronchioloalveolar Carcinoma.
J. Clin Oncol, 14 (1996), pp. 2376-2386
[8.]
A.N.G. Peter, et al.
Primary Intrathoracic Malignant Effusion.
Chest, 120 (2001), pp. 50-54
[9.]
Morais António, et al.
Cancro do Pulmão na Mulher.
Rev Port Pneumol, VI (2000),
[10.]
K.S. Sridhar, C.F. Lobo, R.D. Altman.
Digital clubbing and lung cancer.
Chest, 114 (1998), pp. 1535-1537
[11.]
Ferguson Mark, et al.
Sex – Associated Differences in Presentation and Survival in Patients With Lung Cancer.
J. Clin Oncol, 8 (1990), pp. 1402-1407
BIBLIOGRAFIA
[1.]
Payne Sarah.
«Smoke like a man, die like a man»?: A review of the relationship between gender, sex and lung cancer.
Social Science & Medicine, 53 (2001), pp. 1067-1080
[2.]
D. Ouellette, G. Desbiens, C. Emond, G. Beau Champ.
Lung cancer in women compared with men: stage, treatment and survival.
Ann Thorac Surg, 66 (1998), pp. 1140-1144
[3.]
Baldini Elizabeth Healey, Gary M. Strauss.
Women and lung cancer. Waiting to exhale.
Chest, 112 (Oct 1997), pp. 229S-234S
[4.]
E. Quoix.
Les particularités féminines du cancer bronchique.
Rev Pneumol Clin, 55 (1999), pp. 290-295
[5.]
J.R. Bignall, M. Martin.
Survival experience of women with bronchial carcinoma.
The Lancet, (1972), pp. 60-62
[6.]
D.L. Tang, A. Rundle, et al.
Associations between both genetic and environmental biomarkers and lung cancer: evidence of a greater risk of lung cancer in women smokers.
Carcinogenesis, 19 (1998 Nov), pp. 1949-1953
[7.]
C. Alexiou, C.V. Onyeaka, et al.
Do women live longer following lung resection for carcinoma? Eur J Cardiothoracic Surg.
Fev;, 21 (2002), pp. 319-325
[8.]
D.A. Lawlor, S. Ebrahim, G. Davey Smith.
Sex matters: secular and geographical trends in sex differences in coronary heart disease mortality.
BMJ, 323 (2001 Sep), pp. 541-545
[9.]
S.O. Vargas, K.O. Leslie, et al.
Estrogen-receptor-related protein p29 in primary NSCLC: pathologic and prognostic correlations.
Cancer, 82 (1998 Apr 15), pp. 1495-1500
[10.]
M.J. Fasco, G.J. Hurteau, S.D. Spivack.
Gender-dependent expression of alpha and beta estrogen receptors in human nontumor and tumor lung tissue.
Mol Cell Endocrinol, 188 (2002 Feb 25), pp. 125-140
[11.]
D.J. Dabbs, R.J. Landreneau, et al.
Detection of estrogen receptor by immunohistochemistry in pulmonary adenocarcinoma.
Ann Thorac Surg, 73 (2002 Feb), pp. 403-405
[12.]
M.R. Palomares, J.W. Sayre, et al.
Gender influence on weight-loss pattern and survival of nonsmall cell lung carcinoma patients.
Cancer, 78 (1996 Nov 15), pp. 2119-2126
[13.]
M. Sawyer, M.J. Ratain.
Body surface area as a determinant of pharmacokinetics and drug dosing.
Invest New Drugs, 19 (2001 May), pp. 171-177
[14.]
P. Canal, E. Chatelut, S. Guichard.
Practical treatment guide for dose individualisation in cancer chemotherapy.
Drugs, 56 (1998 Dec), pp. 1019-1038
[15.]
D. Desoize, J. Robert.
Individual dose adaptation of anticancer drugs.
Eur J Cancer, 30A (1994), pp. 844-851
[16.]
J.O. Winter, M.A. Wilkowske, E.G. Shaw, P.L. Ogburn, D.J. Pritchard.
Lung cancer complicating pregnancy: case report and review of literature.
Mayo Clin Proc, 70 (1995 Apr), pp. 384-387
[17.]
K. Mujaibel, A. Benjamín, M.F. Delisle, K. Williams.
Lung cancer in pregnancy: case reports and review of the literature.
J Matern Fetal Med, 10 (2001 Dec), pp. 426-432
[18.]
K.Y. Chen, H.C. Wang, J.Y. Shih, P.C. Yang.
Lung cancer in pregnancy: report of two cases.
J Formos Med Assoc, 97 (1998 Aug), pp. 573-576
[19.]
T.L. Harpold, M.Y. Wang, et al.
Maternal lung adenocarcinoma metastatic to the scalp of a fetus.
Case report. Pediatr Neurosurg, 35 (2001 Jul), pp. 39-42
[20.]
A.T. Kochman, J.K. Rab Czynski, et al.
Metastases to the products of conception from a maternal bronchial carcinoma. A case report and review of literature.
Pol J Pathol, 52 (2001), pp. 137-140
[21.]
J. Blatt, J.J. Mulvihill, et al.
Pregnancy outcome following cancer chemotherapy.
Am J Med, 69 (1980 Dec), pp. 828-832
[22.]
P.A. Janne, D. Rodriguez-Thompson, et al.
Chemotherapy for a patient with advanced non-small-cell lung cancer during pregnancy: a case report and a review of chemotherapy treatment during pregnancy.
Oncology, 61 (2001), pp. 175-183
[23.]
J.R. Redman, D.R. Bajorunas, M.J. Lacher.
Hodgkin’s disease: pregnancy and progeny.
Hodgkin’s disease: the consequences of survival. Philadelphia: Lea & Febiger, pp. 244-266
[24.]
E. Friedman, G.W. Jones.
Fetal outcome after maternal radiation treatment of supradiaphragmatic Hodgkin’s disease.
Can Med Assoc J, 149 (1993), pp. 1281-1283
[25.]
J.A. Antolak, E.A. Strom.
Fetal dose estimates for electron-beam treatment to the chest wall of a pregnant patient.
Med Phys, 25 (1998 Dec), pp. 2388-2391
[26.]
M. Magné, S. Marcié, J.P. Pignol, F. Casagrande, J.L. Lagrange.
Radiotherapy for a solitary brain metastasis during pregnancy: a method for reducing fetal dose.
The British Journal of Radiology, 74 (2001 Jul), pp. 638-641

Textos referentes à mesa-redonda com o mesmo título organizada pela Comissão de Trabalho de «Pneumologia Oncológica». Coimbra, 13 de Abril de 2002

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