Article information
Resumo
A interacção entre os sistemas respiratório e gastrintestinal é reconhecida há várias décadas, sendo motivada por mecanismos anatómicos, fisiológicos e patológicos diversos.
Se é certo que a relação de algumas entidades nosológicas acorre, intuitivamente, ao pneumologista, como é o caso da asma e o refluxo gastroesofágico, outras interacções patológicas tendem a ser subdiagnosticadas, não só pela sua complexidade fisiológica, mas também pela sua menor frequência (doenças da via aérea motivadas pela colite ulcerosa e doença de Crohn, por exemplo).
É objectivo do presente artigo rever os mecanismos anatomofisiológicos, patológicos, clínicos e terapêuticos responsáveis pela complexa interacção entre o pulmão e o sistema gastrintestinal.
Rev Port Pneumol 2010; XVI (1): 133-148
Palavras-chave:
Pulmão
aparelho digestivo
Abstract
The relation between the respiratory and gastrointestinal systems has been long recognized and depends on various anatomical, physiological and pathological mechanisms.
The certain recognition of some interactions, such as the relation between asthma and gastroesophageal reflux, is more or less intuitive to the pulmonogist, whereas other areas of confluence are more easily missed, such as the relation between airway disorders and inflammatory bowel disease.
The purpose of this article is to review the interaction between the lung and the gastrointestinal systems, as far as anatomy, physiology, pathology, clinical manifestations and therapeutical options go.
Rev Port Pneumol 2010; XVI (1): 133-148
Key-words:
Lung
gastrointestinal system
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Bibliografia
[1.]
Fishman’s Pulmonary Diseases and Disorders, 4th, pp. 446-448
[2.]
W.B. Osler.
Bronchial asthma.
The principles and practice of medicine, pp. 497-501
[3.]
E. Mays.
Intrinsic asthma in adults: association with gastroesophageal reflux.
JAMA, 236 (1976), pp. 2626-2628
[4.]
C.A. Schan, et al.
Gastroesophageal reflux-induced bronchoconstriction. An intraesophageal acid infusion study using state-of-the-art technology.
Chest, 106 (1994), pp. 731-737
[5.]
S.M. Harding.
Gastroesophageal reflux, asthma, and mechanisms of interaction.
Am J Med, 111 (2001), pp. 8S-12S
[6.]
A.J. Ing.
Interstitial lung disease and gastroesophageal reflux.
Am J Med, 111 (2001), pp. 41S-44S
[7.]
L. Young, et al.
Lung transplantation exacerbates gastroesophageal reflux disease.
Chest, 124 (2003), pp. 1689-1693
[8.]
R. Robert, et al.
High prevalence of proximal and distal gastroesophageal reflux disease in advanced COPD.
Chest, 131 (2007), pp. 1666-1671
[9.]
T. Peroš-Golubičić.
Clinical atlas of interstitial lung disease.
Springer London., 193–197 (2006),
[10.]
Pulmonary vascular disease, pp. 50-65
[11.]
G.M. Verleden.
Pulmonary manifestations of systemic diseases.
Eur Respir Monograph, 34 (2005), pp. 184-185
[12.]
L.E. Mansfield.
Embryonic origins of the relation of gastroesophageal reflux disease and airway disease.
Am J Med, 111 (2001), pp. 3S-7S
[13.]
S.M. Harding.
Gastroesophageal reflux, asthma, and mechanisms of interaction.
Am J Med, 111 (2001), pp. 8S-12S
[14.]
B. Chernow, et al.
Pulmonary aspiration as a consequence of gastroesophageal reflux, a diagnostic approach.
Dig Dis Sci, 24 (1979), pp. 839-844
[15.]
F.M. Crausaz, et al.
Aspiration of solid food particles into lungs of patients with gastroesophageal reflux and chronic bronchial disease.
Chest, 93 (1988), pp. 376-378
[16.]
M.G. Patti, et al.
Esophageal manometry and 24-hour pH monitoring in the diagnosis of pulmonary aspiration secondary to gastroesophageal reflux.
Am J Surg, 163 (1992), pp. 401-406
[17.]
H. Kawahara, et al.
Role of gastroesophageal reflux in older children with persistent asthma.
Am J Gastroenterol, 96 (2001), pp. 2019-2025
[18.]
M. Ferrari, et al.
Tussive effect of capsaicin in patients with gastroesophageal reflux without cough.
Am J Resp Crit Care Med, 151 (1995), pp. 557-561
[19.]
L. Benini, et al.
Cough threshold in reflux oesophagitis; influence of acid and of laryngeal and oesophageal damage.
Gut, 46 (2000), pp. 762-767
[20.]
D.S. Theodoropolous, et al.
Prevalence of upper respiratory symptoms in patients with gastroesophageal reflux disease.
Am J Resp Crit Care Med, 164 (2001), pp. 72-76
[21.]
M. Martins.
Asthma and gastroesophageal reflux.
J Bras Pneumol, 33 (2007),
[22.]
GINA.
Report WR, (2005),
[23.]
J.L. Leggett, et al.
Prevalence of gastroesophageal reflux in difficult asthma – relationship to asthma outcome.
Chest, 127 (2005), pp. 1227-1231
[24.]
S.J. Sontag, et al.
Asthmatics with gastroesophageal reflux: long term results of a randomized trial of medical and surgical antireflux therapies.
Am J Gastroenterol, 98 (2003), pp. 987-999
[25.]
J. Subin.
Proton-pump inhibitor therapy for gastroesophageal reflux disease.
Chest, 127 (2005), pp. 1097-1098
[26.]
R. Tutuian, et al.
Nonacid reflux in patients with chronic cough on acid-suppressive therapy.
Chest, 130 (2006), pp. 386-391
[27.]
P. Demeter, et al.
The relationship between gastroesophageal reflux disease and obstructive sleep apnea.
J Gastroenterol, 9 (2004), pp. 815-820
[28.]
R.W. Tobin, et al.
Increased prevalence of gastroesophageal reflux in patients with idiopathic pulmonary fibrosis.
Am J Resp Crit Care Med, 158 (1998), pp. 1804-1808
[29.]
Y. Pashinsky, et al.
Gastroesophageal reflux disease and idiopathic pulmonary fibrosis.
The Mount Sinai J Med, 76 (2009), pp. 24-29
[30.]
G. Raghu, et al.
High prevalence of abnormal acid gastro-oesophageal reflux in idiopathic pulmonary fibrosis.
Eur Resp J, 27 (2006), pp. 136-142
[31.]
G. Raghu, et al.
Sole treatment of acid gastroesophageal reflux in idiopathic pulmonary fibrosis: case series.
Eur Resp J, 129 (2006), pp. 794-800
[32.]
I. Marie, et al.
Esophageal involvement and pulmonary manifestations in systemic sclerosis.
Arthritis Rheum, 45 (2001), pp. 346-354
[33.]
C. Casanova, et al.
Increased gastro-oesophageal reflux disease in patients with severe COPD.
Eur Resp J, 23 (2004), pp. 841-845
[34.]
P. Demeter, et al.
The relationship between gastroesophageal reflux disease and obstructive sleep apnoea.
J Gastroenterol, 39 (2004), pp. 815-820
[35.]
A.J. Ing, et al.
Obstructive sleep apnea and gastroesophageal reflux.
Am J Med, 108 (2000), pp. 120S-125S
[36.]
M. Bortolotti, et al.
Obstructive sleep apnoea is improved by a prolonged treatment of gastrooesophageal reflux with omeprazole.
Dig Liver Dis, (2005),
[37.]
L.R. Young, et al.
Lung transplantation exacerbates gastroesophageal reflux disease.
Chest, 124 (2003), pp. 1689-1693
[38.]
D. Hadjiliadis, et al.
Gastroesophageal reflux disease in lung transplant recipients.
Clin Transpl, 17 (2003), pp. 363-368
[39.]
M.G. Hartwig, et al.
Antireflux surgery in the setting of lung transplantation: strategies for treating gastroesophageal reflux in a high risk population.
Thoracic Surg Clin, 15 (2005), pp. 417-427
[40.]
B.H. Rogers, et al.
The epidemiologic and demo-graphic characteristics of infamatory bowel disease: an analysis of computerised file of 1400 patients.
J Chronic Dis, 24 (1971), pp. 743-773
[41.]
G. Hotermans, et al.
Nongranulomatous interstitial lung disease in Crohn’s disease.
Eur Resp J, 9 (1996), pp. 380-382
[42.]
A. Sanjeevi, et al.
Necrobiotic nodules: A rare pulmonary manifestation of Crohn’s disease.
Am J Gastroenterol, 98 (2003), pp. 941-943
[43.]
Al Alrashid, et al.
Crohn’s disease involving the lung: resolution with infliximab.
Dig Dis Sci, 46 (2001), pp. 1736-1739
[44.]
M. Faller, et al.
Pulmonary migratory infiltrates and pachypleuritis in a patient with Crohn’s disease.
Respiration, 67 (2000), pp. 459-463
[45.]
W. Domej, et al.
Colobronchial fistula: a rare complication of Crohn’s colitis.
Am Rev Resp Dis, 142 (1990), pp. 1225-1227
[46.]
G. Ghahremani, et al.
Esophageal manifestations of Crohn’s disease.
Gastroenterol Radiol, 7 (1982), pp. 199-203
[47.]
T. Gumbo, et al.
Recurrent pneumonia from ileo-bronchial fistula complicating Crohn’s disease.
J Clin Gastr, 32 (2001), pp. 365-367
[48.]
S. Weinberger, et al.
Pulmonary complications of inflammatory bowel disease, (2007),
[49.]
R. Mahadeva, et al.
Clinical and radiological characteristics of lung disease in inflammatory bowel disease.
Eur Resp J, 15 (2000), pp. 41-48
[50.]
E. Blanchet, et al.
Pneumomediastianum without colonic perforation during a severe attack of ulcerative colitis.
Gastr Clin Biol, 25 (2001), pp. 1121-1123
[51.]
G. Simonneau, et al.
Clinical classification of pulmonary hypertension.
J Am Col Cardiol, 43 (2004), pp. 5S-12S
[52.]
R. Rodriguez-Roisin, et al.
Pulmonary-Hepatic Vascular Disorders Scientif Committee ERS Task Force.
Eur Resp J, 24 (2004), pp. 861-880
[53.]
G. Rolla, et al.
Exhaled nitric oxide and oxygenation abnormalities in hepatic cirrosis.
Hepatology, 26 (1997), pp. 842-847
[54.]
M.B. Fallon, et al.
The role of endothelial nitric oxide synthase in the pathogenesis of a rat model of hepatopulmonary syndrome.
Gastroenterol, 113 (1997), pp. 606-614
Copyright © 2010. Sociedade Portuguesa de Pneumologia/SPP
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