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RESUMO
A doença pulmonar obstrutiva crónica é uma das principais causas de mortalidade e morbilidade a nível mundial. O tabaco e as características genéticas de cada indivíduo participam seguramente na sua patogenia. Recentemente o processo inflamatório tem sido considerado um dos principais responsáveis pela progressão continua e irreversível da doença, existindo inúmeras células e mediadores implicados.
Neste trabalho efectua-se uma revisão dos diversos protagonistas do processo inflamatório na DPOC, a sua dinâmica, contributo para o desenrolar da doença e procura-se explicar de forma sucinta os porquês da ineficácia terapêutica dos corticosteróides.
REV PORT PNEUMOL 2001; VII (1):
Palavras-chave:
Doença pulmonar obstrutiva crónica
Inflamação
ABSTRACT
Chronic obstructive pulmonary disease is one of the main causes of morbidity and mortality worldwide. Cigarette smoke and genetics are implicated in its pathogenesis. In the last few years, inflammation as been considered one of the most important causes of progression and irreversibility of the disease, with numerous cells and mediators implicated.
In this paper, the role of different protagonists, their relations and contribute to worsening the disease are reviewed. In a brief way we try to explain why corticosteroids are ineffective in COPD.
REV PORT PNEUMOL 2001; VII (1):
Key-words:
Chronic obstructive pulmonary disease
Inflammation
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