array:24 [
  "pii" => "S0873215915300532"
  "issn" => "08732159"
  "doi" => "10.1016/S0873-2159(15)30053-2"
  "estado" => "S350"
  "fechaPublicacion" => "2010-07-01"
  "aid" => "5"
  "copyright" => "Sociedade Portuguesa de Pneumologia/SPP"
  "copyrightAnyo" => "2010"
  "documento" => "simple-article"
  "crossmark" => 0
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "rev"
  "cita" => "Rev Port Pneumol. 2010;16:573-88"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 2992
    "formatos" => array:3 [
      "EPUB" => 238
      "HTML" => 2075
      "PDF" => 679
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S0873215915300544"
    "issn" => "08732159"
    "doi" => "10.1016/S0873-2159(15)30054-4"
    "estado" => "S350"
    "fechaPublicacion" => "2010-07-01"
    "aid" => "6"
    "copyright" => "Sociedade Portuguesa de Pneumologia/SPP"
    "documento" => "simple-article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "rev"
    "cita" => "Rev Port Pneumol. 2010;16:589-606"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2742
      "formatos" => array:3 [
        "EPUB" => 239
        "HTML" => 1646
        "PDF" => 857
      ]
    ]
    "pt" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Artigo de Revis&#227;o&#47;Review Article</span>"
      "titulo" => "Ecografia na patologia tor&#225;cica"
      "tienePdf" => "pt"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "pt"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "589"
          "paginaFinal" => "606"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Ultrasound in chest disease"
        ]
      ]
      "contieneResumen" => array:2 [
        "pt" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "pt" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Ant&#243;nio Bugalho, J&#250;lio Semedo, Jo&#227;o Alpendre, Jos&#233; Cepeda Ribeiro, Lu&#237;s Carreiro"
          "autores" => array:5 [
            0 => array:2 [
              "nombre" => "Ant&#243;nio"
              "apellidos" => "Bugalho"
            ]
            1 => array:2 [
              "nombre" => "J&#250;lio"
              "apellidos" => "Semedo"
            ]
            2 => array:2 [
              "nombre" => "Jo&#227;o"
              "apellidos" => "Alpendre"
            ]
            3 => array:2 [
              "nombre" => "Jos&#233; Cepeda"
              "apellidos" => "Ribeiro"
            ]
            4 => array:2 [
              "nombre" => "Lu&#237;s"
              "apellidos" => "Carreiro"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "pt"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215915300544?idApp=UINPBA00004E"
    "url" => "/08732159/0000001600000004/v1_201509151519/S0873215915300544/v1_201509151519/pt/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S0873215915300520"
    "issn" => "08732159"
    "doi" => "10.1016/S0873-2159(15)30052-0"
    "estado" => "S350"
    "fechaPublicacion" => "2010-07-01"
    "aid" => "4"
    "copyright" => "Sociedade Portuguesa de Pneumologia&#47;SPP"
    "documento" => "simple-article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "rev"
    "cita" => "Rev Port Pneumol. 2010;16:559-72"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3633
      "formatos" => array:3 [
        "EPUB" => 223
        "HTML" => 2484
        "PDF" => 926
      ]
    ]
    "pt" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Artigo de Revis&#227;o&#47;Review Article</span>"
      "titulo" => "Abordagem terap&#234;utica da tuberculose e resolu&#231;&#227;o de alguns problemas associados &#224; medica&#231;&#227;o"
      "tienePdf" => "pt"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "pt"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "559"
          "paginaFinal" => "572"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Tuberculosis treatment and management of some problems related to the medication"
        ]
      ]
      "contieneResumen" => array:2 [
        "pt" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "pt" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "R&#46; Duarte, A&#46; Carvalho, D&#46; Ferreira, S&#46; Saleiro, R&#46; Lima, M&#46; Mota, E&#46; Raymundo, M&#46; Villar, A&#46; Correia"
          "autores" => array:9 [
            0 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Duarte"
            ]
            1 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Carvalho"
            ]
            2 => array:2 [
              "nombre" => "D&#46;"
              "apellidos" => "Ferreira"
            ]
            3 => array:2 [
              "nombre" => "S&#46;"
              "apellidos" => "Saleiro"
            ]
            4 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Lima"
            ]
            5 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Mota"
            ]
            6 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Raymundo"
            ]
            7 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Villar"
            ]
            8 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Correia"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "pt"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215915300520?idApp=UINPBA00004E"
    "url" => "/08732159/0000001600000004/v1_201509151519/S0873215915300520/v1_201509151519/pt/main.assets"
  ]
  "pt" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Artigo de Revis&#227;o&#47;Review Article</span>"
    "titulo" => "Pertussis em Portugal &#8211; A import&#226;ncia de uma nova estrat&#233;gia vacinal"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "573"
        "paginaFinal" => "588"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Susana Gama de Sousa, Henrique Barros"
        "autores" => array:2 [
          0 => array:4 [
            "nombre" => "Susana Gama"
            "apellidos" => "de Sousa"
            "email" => array:2 [
              0 => "susana&#46;gama&#64;chma&#46;min&#95;saude&#46;pt"
              1 => "susanagamasousa&#64;gmail&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">1</span>"
                "identificador" => "af0005"
              ]
              1 => array:2 [
                "etiqueta" => "&#42;"
                "identificador" => "cr0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Henrique"
            "apellidos" => "Barros"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">2</span>"
                "identificador" => "af0010"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Pediatra&#44; Servi&#231;o de Higiene e Epidemiologia&#44; Instituto Superior de Sa&#250;de P&#250;blica &#8211; Faculdade de Medicina da Universidade do Porto&#44; Porto e Servi&#231;o de Pediatria&#44; Centro Hospitalar M&#233;dio Ave&#44; Famalic&#227;o&#44; Portugal&#47;Pediatrician&#44; Department of Hygiene and Epidemiology&#44; Institute of Public Health and University of Porto Medical School&#44; Porto and Pediatric Department of Centro Hospitalar M&#233;dio Ave&#44; Famalic&#227;o&#44; Portugal"
            "etiqueta" => "1"
            "identificador" => "af0005"
          ]
          1 => array:3 [
            "entidad" => "Prof&#46; Catedr&#225;tico e Director do Servi&#231;o de Higiene e Epidemiologia&#44; Instituto de Sa&#250;de P&#250;blica &#8211; Faculdade de Medicina da Universidade do Porto&#44; Porto&#44; Portugal&#47;Department of Hygiene and Epidemiology&#44; Institute of Public Health &#8211; University of Porto Medical School&#44; Porto&#44; Portugal"
            "etiqueta" => "2"
            "identificador" => "af0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cr0005"
            "etiqueta" => "&#42;"
            "correspondencia" => "<span class="elsevierStyleBold">Correspond&#234;ncia&#47;<span class="elsevierStyleItalic">Correspondence to&#58;</span></span> Servi&#231;o de Pediatria&#44; Centro Hospitalar M&#233;dio Ave &#8211; Unidade de Famalic&#227;o&#44; Rua Cupertino de Miranda&#44; s&#47;n Apartado 31&#44; 4764-958 Vila Nova de Famalic&#227;o&#44; Telef&#58; &#40;&#43;<span class="elsevierStyleHsp" style=""></span>351&#41; 252300800"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "en" => array:1 [
        "titulo" => "Pertussis in Portugal &#8211; Time for a new strategy"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2009-06-29"
    "fechaAceptado" => "2010-01-07"
    "PalabrasClave" => array:2 [
      "pt" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palavras-chave"
          "identificador" => "xpalclavsec570378"
          "palabras" => array:5 [
            0 => "Tosse convulsa"
            1 => "coqueluche"
            2 => "<span class="elsevierStyleItalic">Bordetella pertussis</span>"
            3 => "vacina&#231;&#227;o"
            4 => "modelos matem&#225;ticos"
          ]
        ]
      ]
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key-words"
          "identificador" => "xpalclavsec570377"
          "palabras" => array:5 [
            0 => "<span class="elsevierStyleItalic">Bordetella pertussis</span>"
            1 => "pertussis"
            2 => "vaccination"
            3 => "Portugal"
            4 => "mathematical models"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "pt" => array:2 [
        "titulo" => "Resumo"
        "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">A introdu&#231;&#227;o da vacina antipertussis nos programas de vacina&#231;&#227;o originou uma diminui&#231;&#227;o dr&#225;stica da incid&#234;ncia de tosse convulsa no mundo&#46; No entanto&#44; nos &#250;ltimos anos tem-se observado um aumento gradual do n&#250;mero de notifica&#231;&#245;es&#44; facto que j&#225; levou v&#225;rios pa&#237;ses a reformularem estrat&#233;gias vacinais para esta doen&#231;a&#46; Foi efectuada uma revis&#227;o epidemiol&#243;gica da tosse convulsa&#44; real&#231;ando estudos baseados em modelos matem&#225;ticos que tentam prever o impacto de novas estrat&#233;gias vacinais e novas recomenda&#231;&#245;es internacionais&#46; Tendo em conta a realidade portuguesa&#44; alerta-se para a necessidade de um refor&#231;o vacinal na idade da adolesc&#234;ncia e sugerem-se outras recomenda&#231;&#245;es para um melhor controlo da tosse convulsa no nosso pa&#237;s&#46;</p><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2010&#59; XVI &#40;4&#41;&#58; 573-588</span></p></span>"
      ]
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span id="as0010" class="elsevierStyleSection elsevierViewall"><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall">The introduction of routine vaccination against <span class="elsevierStyleItalic">Bordetella pertussis</span> led to a drastic decline in the number of reported cases of pertussis&#46; Nevertheless&#44; a gradual increase in pertussis notifications has been observed in the last years&#44; and political vaccination changes have been conducted in some countries&#46; Pertussis epidemiology is reviewed&#44; taking into account mathematical models studies concerning new vaccinal strategies for pertussis prevention and new international recommendations&#46; Regarding Portugal&#44; the need for a &#8220;booster&#8221; in adolescence is emphasized&#44; and other recommendations for pertussis control are suggested&#46;</p><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2010&#59; XVI &#40;4&#41;&#58; 573-588</span></p></span>"
      ]
    ]
    "lecturaRecomendada" => array:1 [
      0 => array:3 [
        "vista" => "all"
        "titulo" => "<span class="elsevierStyleSectionTitle" id="st0025">Bibliografia&#47;Bibliography</span>"
        "seccion" => array:1 [
          0 => array:2 [
            "vista" => "all"
            "bibliografiaReferencia" => array:40 [
              0 => array:3 [
                "identificador" => "bb0005"
                "etiqueta" => "1&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Pertussis &#8211; United States&#44; January 1992&#8211;June 1995"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:1 [
                              0 => "Centers for Disease Control&#44; Prevention"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "MMWR"
                          "fecha" => "1995"
                          "volumen" => "44"
                          "paginaInicial" => "525"
                          "paginaFinal" => "529"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7603428"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              1 => array:3 [
                "identificador" => "bb0010"
                "etiqueta" => "2&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Increase in deaths from pertussis among young infants in the United States in the 1990s"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:4 [
                              0 => "C&#46;R&#46; Vitek"
                              1 => "F&#46;B&#46; Pascual"
                              2 => "A&#46;L&#46; Baughman"
                              3 => "T&#46;V&#46; Murphy"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1097/01.inf.0000073266.30728.0e"
                        "Revista" => array:7 [
                          "tituloSerie" => "Pediatr Infect Dis J"
                          "fecha" => "2003"
                          "volumen" => "22"
                          "numero" => "7"
                          "paginaInicial" => "628"
                          "paginaFinal" => "634"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12867839"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              2 => array:3 [
                "identificador" => "bb0015"
                "etiqueta" => "3&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "WHO position paper on pertussis"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:1 [
                              0 => "World Health Organization"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "WWW" => array:2 [
                          "link" => "www&#46;who&#46;int&#47;"
                          "fecha" => "January 2005"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              3 => array:3 [
                "identificador" => "bb0020"
                "etiqueta" => "4&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Outcomes of <span class="elsevierStyleItalic">Bordetella pertussis</span> infection in different age groups of an immunized population"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:5 [
                              0 => "Q&#46; He"
                              1 => "M&#46;K&#46; Viljanen"
                              2 => "S&#46; Nikkari"
                              3 => "R&#46; Lyytikainen"
                              4 => "J&#46; Mertsola"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:7 [
                          "tituloSerie" => "J Infect Dis"
                          "fecha" => "1994"
                          "volumen" => "170"
                          "numero" => "4"
                          "paginaInicial" => "873"
                          "paginaFinal" => "877"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7930729"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              4 => array:3 [
                "identificador" => "bb0025"
                "etiqueta" => "5&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Duration of effectiveness of pertussis vaccine&#58; evidence from a 10 year community study"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:1 [
                              0 => "D&#46; Jenkinson"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:7 [
                          "tituloSerie" => "Br Med J &#40;Clin Res Ed&#41;"
                          "fecha" => "1988"
                          "volumen" => "296"
                          "numero" => "6622"
                          "paginaInicial" => "612"
                          "paginaFinal" => "614"
                          "itemHostRev" => array:3 [
                            "pii" => "S0140673602093327"
                            "estado" => "S300"
                            "issn" => "01406736"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              5 => array:3 [
                "identificador" => "bb0030"
                "etiqueta" => "6&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Pertussis outbreak in an elementary school with high vaccination coverage"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => true
                            "autores" => array:6 [
                              0 => "N&#46; Khetsuriani"
                              1 => "K&#46; Bisgard"
                              2 => "D&#46;R&#46; Prevots"
                              3 => "M&#46; Brennan"
                              4 => "M&#46; Wharton"
                              5 => "S&#46; Pandya"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:7 [
                          "tituloSerie" => "Pediatr Infect Dis J"
                          "fecha" => "2001"
                          "volumen" => "20"
                          "numero" => "12"
                          "paginaInicial" => "1108"
                          "paginaFinal" => "1112"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11740314"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              6 => array:3 [
                "identificador" => "bb0035"
                "etiqueta" => "7&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "High prevalence of antibody titers against Bordetella pertussis in an adult population with prolonged cough"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:6 [
                              0 => "A&#46;M&#46; Kapaskelis"
                              1 => "E&#46;K&#46; Vouloumanou"
                              2 => "E&#46;K&#46; Rafailidis"
                              3 => "P&#46; Hatzoupoulou"
                              4 => "D&#46; Nikita"
                              5 => "M&#46;E&#46; Falagas"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:5 [
                          "tituloSerie" => "Resp Med"
                          "fecha" => "2008"
                          "volumen" => "102"
                          "paginaInicial" => "1586"
                          "paginaFinal" => "1591"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              7 => array:3 [
                "identificador" => "bb0040"
                "etiqueta" => "8&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Population based incidence of pertussis among adolescents and adults&#44; Minnesota 1995-1996"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:3 [
                              0 => "P&#46; Strebel"
                              1 => "J&#46; Nordin"
                              2 => "K&#46; Edwards"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1086/319853"
                        "Revista" => array:6 [
                          "tituloSerie" => "J Infect Dis"
                          "fecha" => "2001"
                          "volumen" => "183"
                          "paginaInicial" => "1353"
                          "paginaFinal" => "1359"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11294666"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              8 => array:3 [
                "identificador" => "bb0045"
                "etiqueta" => "9&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Neonatal vaccination with acellular pertussis vaccine accelerates the acquisition of pertussis antibodies in infants"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:8 [
                              0 => "M&#46; Knuf"
                              1 => "H&#46;J&#46; Schmitt"
                              2 => "J&#46; Wolter"
                              3 => "L&#46; Schuerman"
                              4 => "J&#46;M&#46; Jacquet"
                              5 => "D&#46; Kieninger"
                              6 => "C&#46;A&#46; Siegrist"
                              7 => "F&#46; Zepp"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1016/j.jpeds.2007.09.034"
                        "Revista" => array:7 [
                          "tituloSerie" => "J Pediatr"
                          "fecha" => "2008"
                          "volumen" => "152"
                          "numero" => "5"
                          "paginaInicial" => "655"
                          "paginaFinal" => "660"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18410769"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              9 => array:3 [
                "identificador" => "bb0050"
                "etiqueta" => "10&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Infectious diseases of humans&#58; dynamics and control"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:1 [
                              0 => "R&#46;M&#46;M&#46;R&#46; Anderson"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Libro" => array:2 [
                          "fecha" => "1991"
                          "editorial" => "Oxford Science Publications"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              10 => array:3 [
                "identificador" => "bb0055"
                "etiqueta" => "11&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "The science and fiction of the &#8220;resurgence&#8221; of pertussis"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:1 [
                              0 => "J&#46;D&#46; Cherry"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:7 [
                          "tituloSerie" => "Pediatrics"
                          "fecha" => "2003"
                          "volumen" => "112"
                          "numero" => "2"
                          "paginaInicial" => "405"
                          "paginaFinal" => "406"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12897292"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              11 => array:3 [
                "identificador" => "bb0060"
                "etiqueta" => "12&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:1 [
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:2 [
                              0 => "K&#46;M&#46; Edwards MD&#46;"
                              1 => "Mortimer EA Jr&#46;"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Libro" => array:5 [
                          "edicion" => "3rd ed"
                          "titulo" => "Pertussis vaccine"
                          "fecha" => "1999"
                          "editorial" => "W&#46;B&#46; Saunders"
                          "editorialLocalizacion" => "Philadelphia"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              12 => array:3 [
                "identificador" => "bb0065"
                "etiqueta" => "13&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Whooping cough makes global comeback"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:1 [
                              0 => "P&#46; Das"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Lancet Infect Dis"
                          "fecha" => "2002"
                          "volumen" => "2"
                          "numero" => "6"
                          "paginaInicial" => "322"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12144890"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              13 => array:3 [
                "identificador" => "bb0070"
                "etiqueta" => "14&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Pertussis resurgence in Canada largely caused by a cohort effect"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:3 [
                              0 => "B&#46; Ntezayabo"
                              1 => "G&#46; De Serres"
                              2 => "B&#46; Duval"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1097/01.inf.0000045220.82991.5a"
                        "Revista" => array:7 [
                          "tituloSerie" => "Pediatr Infect Dis J"
                          "fecha" => "2003"
                          "volumen" => "22"
                          "numero" => "1"
                          "paginaInicial" => "22"
                          "paginaFinal" => "27"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12544404"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              14 => array:3 [
                "identificador" => "bb0075"
                "etiqueta" => "15&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Adaptation of <span class="elsevierStyleItalic">Bordetella pertussis</span> to vaccination&#58; a cause for its reemergence&#63;"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:3 [
                              0 => "F&#46;R&#46; Mooi"
                              1 => "I&#46;H&#46; van Loo"
                              2 => "A&#46;J&#46; King"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.3201/eid0707.010708"
                        "Revista" => array:8 [
                          "tituloSerie" => "Emerg Infect Dis"
                          "fecha" => "2001"
                          "volumen" => "7"
                          "numero" => "3 Suppl"
                          "paginaInicial" => "526"
                          "paginaFinal" => "528"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11485646"
                              "web" => "Medline"
                            ]
                          ]
                          "itemHostRev" => array:3 [
                            "pii" => "S0016508508004599"
                            "estado" => "S300"
                            "issn" => "00165085"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              15 => array:3 [
                "identificador" => "bb0080"
                "etiqueta" => "16&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Thirty-five years&#8217; experience with the whole-cell pertussis vaccine in France&#58; vaccine strains analysis and immunogenicity"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:4 [
                              0 => "E&#46; Njamkepo"
                              1 => "F&#46; Rimlinger"
                              2 => "S&#46; Thiberge"
                              3 => "N&#46; Guiso"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:5 [
                          "tituloSerie" => "Vaccine"
                          "fecha" => "2002"
                          "volumen" => "31"
                          "paginaInicial" => "1290"
                          "paginaFinal" => "1294"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              16 => array:3 [
                "identificador" => "bb0085"
                "etiqueta" => "17&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Shifts of <span class="elsevierStyleItalic">Bordetella pertussis</span> variants in Sweden from 1970 to 2003&#44; during three periods marked by different vaccination programs"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:5 [
                              0 => "H&#46;O&#46; Hallander"
                              1 => "A&#46; Advani"
                              2 => "D&#46; Donnelly"
                              3 => "L&#46; Gustafsson"
                              4 => "R&#46;M&#46; Carlsson"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1128/JCM.43.6.2856-2865.2005"
                        "Revista" => array:7 [
                          "tituloSerie" => "J Clin Microbiol"
                          "fecha" => "2005"
                          "volumen" => "43"
                          "numero" => "6"
                          "paginaInicial" => "2856"
                          "paginaFinal" => "2865"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15956409"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              17 => array:3 [
                "identificador" => "bb0090"
                "etiqueta" => "18&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Large-scale comparative analysis of pertussis population dynamics&#58; periodicity&#44; synchrony&#44; and impact of vaccination"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:5 [
                              0 => "H&#46; Broutin"
                              1 => "J&#46;F&#46; Guegan"
                              2 => "E&#46; Elguero"
                              3 => "F&#46; Simondon"
                              4 => "B&#46; Cazelles"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1093/aje/kwi141"
                        "Revista" => array:7 [
                          "tituloSerie" => "Am J Epidemiol"
                          "fecha" => "2005"
                          "volumen" => "161"
                          "numero" => "12"
                          "paginaInicial" => "1159"
                          "paginaFinal" => "1167"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15937025"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              18 => array:3 [
                "identificador" => "bb0095"
                "etiqueta" => "19&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Trends in pertussis among infants in the United States&#44; 1980-1999"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:6 [
                              0 => "M&#46; Tanaka"
                              1 => "C&#46;R&#46; Vitek"
                              2 => "F&#46;B&#46; Pascual"
                              3 => "K&#46;M&#46; Bisgard"
                              4 => "J&#46;E&#46; Tate"
                              5 => "T&#46;V&#46; Murphy"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1001/jama.290.22.2968"
                        "Revista" => array:7 [
                          "tituloSerie" => "Jama"
                          "fecha" => "2003"
                          "volumen" => "290"
                          "numero" => "22"
                          "paginaInicial" => "2968"
                          "paginaFinal" => "2975"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14665658"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              19 => array:3 [
                "identificador" => "bb0100"
                "etiqueta" => "20&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Pertussis in adults&#58; frequency of transmission after household exposure"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:4 [
                              0 => "Konig C&#46;H&#46; Wirsing von"
                              1 => "S&#46; Postels-Multani"
                              2 => "H&#46;L&#46; Bock"
                              3 => "H&#46;J&#46; Schmitt"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:8 [
                          "tituloSerie" => "Lancet"
                          "fecha" => "1995"
                          "volumen" => "346"
                          "numero" => "8986"
                          "paginaInicial" => "1326"
                          "paginaFinal" => "1329"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7475771"
                              "web" => "Medline"
                            ]
                          ]
                          "itemHostRev" => array:3 [
                            "pii" => "S0016508502547430"
                            "estado" => "S300"
                            "issn" => "00165085"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              20 => array:3 [
                "identificador" => "bb0105"
                "etiqueta" => "21&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Return of epidemic pertussis in the United States"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:2 [
                              0 => "J&#46;W&#46; Bass"
                              1 => "R&#46;R&#46; Wittler"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:8 [
                          "tituloSerie" => "Pediatr Infect Dis J"
                          "fecha" => "1994"
                          "volumen" => "13"
                          "numero" => "5"
                          "paginaInicial" => "343"
                          "paginaFinal" => "345"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8072813"
                              "web" => "Medline"
                            ]
                          ]
                          "itemHostRev" => array:3 [
                            "pii" => "S0091674914010100"
                            "estado" => "S300"
                            "issn" => "00916749"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              21 => array:3 [
                "identificador" => "bb0110"
                "etiqueta" => "22&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "An adult formulation of a five-component acellular pertussis vaccine combined with diphtheria and tetanus toxoids is safe and immunogenic in adolescents and adults"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => true
                            "autores" => array:6 [
                              0 => "S&#46;A&#46; Halperin"
                              1 => "B&#46; Smith"
                              2 => "M&#46; Russell"
                              3 => "P&#46; Hasselback"
                              4 => "R&#46; Guasparini"
                              5 => "D&#46; Skowronski"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:7 [
                          "tituloSerie" => "Vaccine"
                          "fecha" => "2000"
                          "volumen" => "18"
                          "numero" => "14"
                          "paginaInicial" => "1312"
                          "paginaFinal" => "1319"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10618527"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              22 => array:3 [
                "identificador" => "bb0115"
                "etiqueta" => "23&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Acellular vaccines containing reduced quantities of pertussis antigens as a booster in adolescents"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => true
                            "autores" => array:6 [
                              0 => "N&#46;N&#46; Tran Minh"
                              1 => "Q&#46; He"
                              2 => "A&#46; Ramalho"
                              3 => "A&#46; Kaufhold"
                              4 => "M&#46;K&#46; Viljanen"
                              5 => "H&#46; Arvilommi"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:7 [
                          "tituloSerie" => "Pediatrics"
                          "fecha" => "1999"
                          "volumen" => "104"
                          "numero" => "6"
                          "paginaInicial" => "e70"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10586004"
                              "web" => "Medline"
                            ]
                          ]
                          "itemHostRev" => array:3 [
                            "pii" => "S001650851400242X"
                            "estado" => "S300"
                            "issn" => "00165085"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              23 => array:3 [
                "identificador" => "bb0120"
                "etiqueta" => "24&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "A randomized trial of two acellular pertussis vaccines &#40;dTpa and pa&#41; and a licensed diphtheria-tetanus vaccine &#40;Td&#41; in adults"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:5 [
                              0 => "F&#46;M&#46; Turnbull"
                              1 => "T&#46;C&#46; Heath"
                              2 => "B&#46;B&#46; Jalaludin"
                              3 => "M&#46;A&#46; Burgess"
                              4 => "A&#46;C&#46; Ramalho"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:7 [
                          "tituloSerie" => "Vaccine"
                          "fecha" => "2000"
                          "volumen" => "19"
                          "numero" => "6"
                          "paginaInicial" => "628"
                          "paginaFinal" => "636"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11090714"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              24 => array:3 [
                "identificador" => "bb0125"
                "etiqueta" => "25&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Is pertussis a frequent cause of cough in adolescents and adults&#63; Should routine pertussis immunization be recommended&#63;"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:1 [
                              0 => "K&#46;M&#46; Edwards"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1086/320762"
                        "Revista" => array:7 [
                          "tituloSerie" => "Clin Infect Dis"
                          "fecha" => "2001"
                          "volumen" => "32"
                          "numero" => "12"
                          "paginaInicial" => "1698"
                          "paginaFinal" => "1699"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11360209"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              25 => array:3 [
                "identificador" => "bb0130"
                "etiqueta" => "26&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Adolescent and adult pertussis vaccination&#58; computer simulations of five new strategies"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:2 [
                              0 => "A&#46; Van Rie"
                              1 => "H&#46;W&#46; Hethcote"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1016/j.vaccine.2004.01.067"
                        "Revista" => array:7 [
                          "tituloSerie" => "Vaccine"
                          "fecha" => "2004"
                          "volumen" => "22"
                          "numero" => "23&#8211;24"
                          "paginaInicial" => "3154"
                          "paginaFinal" => "3165"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15297068"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              26 => array:3 [
                "identificador" => "bb0135"
                "etiqueta" => "27&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Two primary doses of diphthe-ria&#8211;tetanus&#8211;acellular pertussis vaccine induce immunological responses to <span class="elsevierStyleItalic">Bordetella pertussis</span> as strong as those induced by three primary doses"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:2 [
                              0 => "T&#46; Tomoda"
                              1 => "T&#46;K&#46; Hoa"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Vaccine"
                          "fecha" => "1997"
                          "volumen" => "15"
                          "paginaInicial" => "1955"
                          "paginaFinal" => "-1958"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9413107"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              27 => array:3 [
                "identificador" => "bb0140"
                "etiqueta" => "28&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Using computer simulations to compare pertussis vaccination strategies in Australia"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:3 [
                              0 => "H&#46;W&#46; Hethcote"
                              1 => "P&#46; Horby"
                              2 => "P&#46; McIntyre"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1016/j.vaccine.2003.11.053"
                        "Revista" => array:7 [
                          "tituloSerie" => "Vaccine"
                          "fecha" => "2004"
                          "volumen" => "22"
                          "numero" => "17&#8211;18"
                          "paginaInicial" => "2181"
                          "paginaFinal" => "2191"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15149775"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              28 => array:3 [
                "identificador" => "bb0145"
                "etiqueta" => "29&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Sustained efficacy during the first 6 years of life of 3-component acellular pertussis vaccines administered in infancy&#58; the Italian experience"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => true
                            "autores" => array:6 [
                              0 => "S&#46; Salmaso"
                              1 => "P&#46; Mastrantonio"
                              2 => "A&#46;E&#46; Tozzi"
                              3 => "P&#46; Stefanelli"
                              4 => "A&#46; Anemona"
                              5 => "M&#46;L&#46; Ciofi degli Atti"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Pediatrics"
                          "fecha" => "2001"
                          "volumen" => "108"
                          "numero" => "5"
                          "paginaInicial" => "E81"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11694665"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              29 => array:3 [
                "identificador" => "bb0150"
                "etiqueta" => "30&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "A modelling analysis of pertussis transmission and vaccination in Rio de Janeiro&#44; Brazil"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:4 [
                              0 => "P&#46;M&#46; Luz"
                              1 => "C&#46;T&#46; Codeco"
                              2 => "G&#46;L&#46; Werneck"
                              3 => "C&#46;J&#46; Struchiner"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1017/S095026880500539X"
                        "Revista" => array:7 [
                          "tituloSerie" => "Epidemiol Infect"
                          "fecha" => "2006"
                          "volumen" => "134"
                          "numero" => "4"
                          "paginaInicial" => "850"
                          "paginaFinal" => "862"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16316489"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              30 => array:3 [
                "identificador" => "bb0155"
                "etiqueta" => "31&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "New pertussis vaccination strategies beyond infancy&#58; recommendations by the global pertussis initiative"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => true
                            "autores" => array:6 [
                              0 => "K&#46;D&#46; Forsyth"
                              1 => "M&#46; Campins-Marti"
                              2 => "J&#46; Caro"
                              3 => "J&#46;D&#46; Cherry"
                              4 => "D&#46; Greenberg"
                              5 => "N&#46; Guiso"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1086/426020"
                        "Revista" => array:7 [
                          "tituloSerie" => "Clin Infect Dis"
                          "fecha" => "2004"
                          "volumen" => "39"
                          "numero" => "12"
                          "paginaInicial" => "1802"
                          "paginaFinal" => "1809"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15578403"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              31 => array:3 [
                "identificador" => "bb0160"
                "etiqueta" => "32&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Prevention of pertussis&#58; recommendations derived from the second Global Pertussis Initiative roundtable meeting"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:5 [
                              0 => "K&#46;D&#46; Forsyth"
                              1 => "Wirsing von Konig CH"
                              2 => "T&#46; Tan"
                              3 => "J&#46; Caro"
                              4 => "S&#46; Plotkin"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1016/j.vaccine.2006.12.017"
                        "Revista" => array:7 [
                          "tituloSerie" => "Vaccine"
                          "fecha" => "2007"
                          "volumen" => "25"
                          "numero" => "14"
                          "paginaInicial" => "2634"
                          "paginaFinal" => "2642"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17280745"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              32 => array:3 [
                "identificador" => "bb0165"
                "etiqueta" => "33&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:1 [
                        "titulo" => "Plano Nacional de Vacina&#231;&#227;o 2006"
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "WWW" => array:2 [
                          "link" => "www&#46;dgs&#46;pt&#47;"
                          "fecha" => "2009"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              33 => array:3 [
                "identificador" => "bb0170"
                "etiqueta" => "34&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Adult formulation of a five component acellular pertussis vaccine combined with diphtheria and tetanus toxoids and inactivated poliovirus vaccine is safe and immunogenic in adolescents and adults"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => true
                            "autores" => array:6 [
                              0 => "S&#46;A&#46; Halperin"
                              1 => "B&#46; Smith"
                              2 => "M&#46; Russell"
                              3 => "D&#46; Scheifele"
                              4 => "E&#46; Mills"
                              5 => "P&#46; Hasselback"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:7 [
                          "tituloSerie" => "Pediatr Infect Dis J"
                          "fecha" => "2000"
                          "volumen" => "19"
                          "numero" => "4"
                          "paginaInicial" => "276"
                          "paginaFinal" => "283"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10783014"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              34 => array:3 [
                "identificador" => "bb0175"
                "etiqueta" => "35&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "The EUVAC-NET survey&#58; national pertussis surveillance systems in the European Union&#44; Switzerland&#44; Norway&#44; and Iceland"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:4 [
                              0 => "J&#46;E&#46; Schmidt"
                              1 => "A&#46;E&#46; Tozzi"
                              2 => "L&#46; Rava"
                              3 => "S&#46; Glismann"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:7 [
                          "tituloSerie" => "Euro Surveill"
                          "fecha" => "2001"
                          "volumen" => "6"
                          "numero" => "6"
                          "paginaInicial" => "98"
                          "paginaFinal" => "104"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11675537"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              35 => array:3 [
                "identificador" => "bb0180"
                "etiqueta" => "36&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Diphtheria&#44; pertussis&#44; and measles in Portugal before and after mass vaccination&#58; a time series analysis"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:3 [
                              0 => "M&#46;C&#46; Gomes"
                              1 => "J&#46;J&#46; Gomes"
                              2 => "A&#46;C&#46; Paulo"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:7 [
                          "tituloSerie" => "Eur J Epidemiol"
                          "fecha" => "1999"
                          "volumen" => "15"
                          "numero" => "9"
                          "paginaInicial" => "791"
                          "paginaFinal" => "798"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10608357"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              36 => array:3 [
                "identificador" => "bb0185"
                "etiqueta" => "37&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Immunisation coverage in the European Union"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:2 [
                              0 => "N&#46; Guerin"
                              1 => "C&#46; Roure"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:7 [
                          "tituloSerie" => "Euro Surveill"
                          "fecha" => "1997"
                          "volumen" => "2"
                          "numero" => "1"
                          "paginaInicial" => "2"
                          "paginaFinal" => "4"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12631831"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              37 => array:3 [
                "identificador" => "bb0190"
                "etiqueta" => "38&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Resurgence of pertussis in northern Portugal&#58; two severe cases in very young children"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => true
                            "autores" => array:6 [
                              0 => "G&#46; Goncalves"
                              1 => "E&#46; Machado"
                              2 => "E&#46; Gouveia"
                              3 => "M&#46;A&#46; Santos"
                              4 => "L&#46; Castro"
                              5 => "R&#46; Aguas"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:5 [
                          "tituloSerie" => "Euro Surveill"
                          "fecha" => "2005"
                          "volumen" => "10"
                          "numero" => "6"
                          "paginaInicial" => "E0506233"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              38 => array:3 [
                "identificador" => "bb0195"
                "etiqueta" => "39&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:1 [
                        "titulo" => "Doen&#231;as de Declara&#231;&#227;o Obrigat&#243;ria"
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "WWW" => array:2 [
                          "link" => "www&#46;dgs&#46;pt&#47;"
                          "fecha" => "2008"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              39 => array:3 [
                "identificador" => "bb0200"
                "etiqueta" => "40&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Evaluation of strategies for use of acellular pertussis vaccine in adolescents and adults&#58; a cost-benefit analysis"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:4 [
                              0 => "K&#46;W&#46; Purdy"
                              1 => "J&#46;W&#46; Hay"
                              2 => "M&#46;F&#46; Botteman"
                              3 => "J&#46;I&#46; Ward"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1086/421091"
                        "Revista" => array:7 [
                          "tituloSerie" => "Clin Infect Dis"
                          "fecha" => "2004"
                          "volumen" => "39"
                          "numero" => "1"
                          "paginaInicial" => "20"
                          "paginaFinal" => "28"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15206048"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "pt"
  "url" => "/08732159/0000001600000004/v1_201509151519/S0873215915300532/v1_201509151519/pt/main.assets"
  "Apartado" => array:4 [
    "identificador" => "9575"
    "tipo" => "SECCION"
    "pt" => array:2 [
      "titulo" => "Artigos originais"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "pt"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/08732159/0000001600000004/v1_201509151519/S0873215915300532/v1_201509151519/pt/main.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215915300532?idApp=UINPBA00004E"
]
Share
Journal Information
Vol. 16. Issue 4.
Pages 573-588 (July - August 2010)
Share
Share
Download PDF
More article options
Vol. 16. Issue 4.
Pages 573-588 (July - August 2010)
Artigo de Revisão/Review Article
Open Access
Pertussis em Portugal – A importância de uma nova estratégia vacinal
Pertussis in Portugal – Time for a new strategy
Visits
7105
Susana Gama de Sousa1,
Corresponding author
susana.gama@chma.min_saude.pt
susanagamasousa@gmail.com

Correspondência/Correspondence to: Serviço de Pediatria, Centro Hospitalar Médio Ave – Unidade de Famalicão, Rua Cupertino de Miranda, s/n Apartado 31, 4764-958 Vila Nova de Famalicão, Telef: (+351) 252300800
, Henrique Barros2
1 Pediatra, Serviço de Higiene e Epidemiologia, Instituto Superior de Saúde Pública – Faculdade de Medicina da Universidade do Porto, Porto e Serviço de Pediatria, Centro Hospitalar Médio Ave, Famalicão, Portugal/Pediatrician, Department of Hygiene and Epidemiology, Institute of Public Health and University of Porto Medical School, Porto and Pediatric Department of Centro Hospitalar Médio Ave, Famalicão, Portugal
2 Prof. Catedrático e Director do Serviço de Higiene e Epidemiologia, Instituto de Saúde Pública – Faculdade de Medicina da Universidade do Porto, Porto, Portugal/Department of Hygiene and Epidemiology, Institute of Public Health – University of Porto Medical School, Porto, Portugal
This item has received

Under a Creative Commons license
Article information
Resumo

A introdução da vacina antipertussis nos programas de vacinação originou uma diminuição drástica da incidência de tosse convulsa no mundo. No entanto, nos últimos anos tem-se observado um aumento gradual do número de notificações, facto que já levou vários países a reformularem estratégias vacinais para esta doença. Foi efectuada uma revisão epidemiológica da tosse convulsa, realçando estudos baseados em modelos matemáticos que tentam prever o impacto de novas estratégias vacinais e novas recomendações internacionais. Tendo em conta a realidade portuguesa, alerta-se para a necessidade de um reforço vacinal na idade da adolescência e sugerem-se outras recomendações para um melhor controlo da tosse convulsa no nosso país.

Rev Port Pneumol 2010; XVI (4): 573-588

Palavras-chave:
Tosse convulsa
coqueluche
Bordetella pertussis
vacinação
modelos matemáticos
Abstract

The introduction of routine vaccination against Bordetella pertussis led to a drastic decline in the number of reported cases of pertussis. Nevertheless, a gradual increase in pertussis notifications has been observed in the last years, and political vaccination changes have been conducted in some countries. Pertussis epidemiology is reviewed, taking into account mathematical models studies concerning new vaccinal strategies for pertussis prevention and new international recommendations. Regarding Portugal, the need for a “booster” in adolescence is emphasized, and other recommendations for pertussis control are suggested.

Rev Port Pneumol 2010; XVI (4): 573-588

Key-words:
Bordetella pertussis
pertussis
vaccination
Portugal
mathematical models
Full text is only aviable in PDF
Bibliografia/Bibliography
[1.]
Centers for Disease Control, Prevention.
Pertussis – United States, January 1992–June 1995.
MMWR, 44 (1995), pp. 525-529
[2.]
C.R. Vitek, F.B. Pascual, A.L. Baughman, T.V. Murphy.
Increase in deaths from pertussis among young infants in the United States in the 1990s.
Pediatr Infect Dis J, 22 (2003), pp. 628-634
[3.]
World Health Organization.
WHO position paper on pertussis.
(January 2005)www.who.int/
[4.]
Q. He, M.K. Viljanen, S. Nikkari, R. Lyytikainen, J. Mertsola.
Outcomes of Bordetella pertussis infection in different age groups of an immunized population.
J Infect Dis, 170 (1994), pp. 873-877
[5.]
D. Jenkinson.
Duration of effectiveness of pertussis vaccine: evidence from a 10 year community study.
Br Med J (Clin Res Ed), 296 (1988), pp. 612-614
[6.]
N. Khetsuriani, K. Bisgard, D.R. Prevots, M. Brennan, M. Wharton, S. Pandya, et al.
Pertussis outbreak in an elementary school with high vaccination coverage.
Pediatr Infect Dis J, 20 (2001), pp. 1108-1112
[7.]
A.M. Kapaskelis, E.K. Vouloumanou, E.K. Rafailidis, P. Hatzoupoulou, D. Nikita, M.E. Falagas.
High prevalence of antibody titers against Bordetella pertussis in an adult population with prolonged cough.
Resp Med, 102 (2008), pp. 1586-1591
[8.]
P. Strebel, J. Nordin, K. Edwards.
Population based incidence of pertussis among adolescents and adults, Minnesota 1995-1996.
J Infect Dis, 183 (2001), pp. 1353-1359
[9.]
M. Knuf, H.J. Schmitt, J. Wolter, L. Schuerman, J.M. Jacquet, D. Kieninger, C.A. Siegrist, F. Zepp.
Neonatal vaccination with acellular pertussis vaccine accelerates the acquisition of pertussis antibodies in infants.
J Pediatr, 152 (2008), pp. 655-660
[10.]
R.M.M.R. Anderson.
Infectious diseases of humans: dynamics and control.
Oxford Science Publications, (1991),
[11.]
J.D. Cherry.
The science and fiction of the “resurgence” of pertussis.
Pediatrics, 112 (2003), pp. 405-406
[12.]
K.M. Edwards MD., Mortimer EA Jr..
Pertussis vaccine, 3rd ed, W.B. Saunders, (1999),
[13.]
P. Das.
Whooping cough makes global comeback.
Lancet Infect Dis, 2 (2002), pp. 322
[14.]
B. Ntezayabo, G. De Serres, B. Duval.
Pertussis resurgence in Canada largely caused by a cohort effect.
Pediatr Infect Dis J, 22 (2003), pp. 22-27
[15.]
F.R. Mooi, I.H. van Loo, A.J. King.
Adaptation of Bordetella pertussis to vaccination: a cause for its reemergence?.
Emerg Infect Dis, 7 (2001), pp. 526-528
[16.]
E. Njamkepo, F. Rimlinger, S. Thiberge, N. Guiso.
Thirty-five years’ experience with the whole-cell pertussis vaccine in France: vaccine strains analysis and immunogenicity.
Vaccine, 31 (2002), pp. 1290-1294
[17.]
H.O. Hallander, A. Advani, D. Donnelly, L. Gustafsson, R.M. Carlsson.
Shifts of Bordetella pertussis variants in Sweden from 1970 to 2003, during three periods marked by different vaccination programs.
J Clin Microbiol, 43 (2005), pp. 2856-2865
[18.]
H. Broutin, J.F. Guegan, E. Elguero, F. Simondon, B. Cazelles.
Large-scale comparative analysis of pertussis population dynamics: periodicity, synchrony, and impact of vaccination.
Am J Epidemiol, 161 (2005), pp. 1159-1167
[19.]
M. Tanaka, C.R. Vitek, F.B. Pascual, K.M. Bisgard, J.E. Tate, T.V. Murphy.
Trends in pertussis among infants in the United States, 1980-1999.
Jama, 290 (2003), pp. 2968-2975
[20.]
Konig C.H. Wirsing von, S. Postels-Multani, H.L. Bock, H.J. Schmitt.
Pertussis in adults: frequency of transmission after household exposure.
Lancet, 346 (1995), pp. 1326-1329
[21.]
J.W. Bass, R.R. Wittler.
Return of epidemic pertussis in the United States.
Pediatr Infect Dis J, 13 (1994), pp. 343-345
[22.]
S.A. Halperin, B. Smith, M. Russell, P. Hasselback, R. Guasparini, D. Skowronski, et al.
An adult formulation of a five-component acellular pertussis vaccine combined with diphtheria and tetanus toxoids is safe and immunogenic in adolescents and adults.
Vaccine, 18 (2000), pp. 1312-1319
[23.]
N.N. Tran Minh, Q. He, A. Ramalho, A. Kaufhold, M.K. Viljanen, H. Arvilommi, et al.
Acellular vaccines containing reduced quantities of pertussis antigens as a booster in adolescents.
Pediatrics, 104 (1999), pp. e70
[24.]
F.M. Turnbull, T.C. Heath, B.B. Jalaludin, M.A. Burgess, A.C. Ramalho.
A randomized trial of two acellular pertussis vaccines (dTpa and pa) and a licensed diphtheria-tetanus vaccine (Td) in adults.
Vaccine, 19 (2000), pp. 628-636
[25.]
K.M. Edwards.
Is pertussis a frequent cause of cough in adolescents and adults? Should routine pertussis immunization be recommended?.
Clin Infect Dis, 32 (2001), pp. 1698-1699
[26.]
A. Van Rie, H.W. Hethcote.
Adolescent and adult pertussis vaccination: computer simulations of five new strategies.
Vaccine, 22 (2004), pp. 3154-3165
[27.]
T. Tomoda, T.K. Hoa.
Two primary doses of diphthe-ria–tetanus–acellular pertussis vaccine induce immunological responses to Bordetella pertussis as strong as those induced by three primary doses.
Vaccine, 15 (1997), pp. 1955--1958
[28.]
H.W. Hethcote, P. Horby, P. McIntyre.
Using computer simulations to compare pertussis vaccination strategies in Australia.
Vaccine, 22 (2004), pp. 2181-2191
[29.]
S. Salmaso, P. Mastrantonio, A.E. Tozzi, P. Stefanelli, A. Anemona, M.L. Ciofi degli Atti, et al.
Sustained efficacy during the first 6 years of life of 3-component acellular pertussis vaccines administered in infancy: the Italian experience.
Pediatrics, 108 (2001), pp. E81
[30.]
P.M. Luz, C.T. Codeco, G.L. Werneck, C.J. Struchiner.
A modelling analysis of pertussis transmission and vaccination in Rio de Janeiro, Brazil.
Epidemiol Infect, 134 (2006), pp. 850-862
[31.]
K.D. Forsyth, M. Campins-Marti, J. Caro, J.D. Cherry, D. Greenberg, N. Guiso, et al.
New pertussis vaccination strategies beyond infancy: recommendations by the global pertussis initiative.
Clin Infect Dis, 39 (2004), pp. 1802-1809
[32.]
K.D. Forsyth, Wirsing von Konig CH, T. Tan, J. Caro, S. Plotkin.
Prevention of pertussis: recommendations derived from the second Global Pertussis Initiative roundtable meeting.
Vaccine, 25 (2007), pp. 2634-2642
[33.]
Plano Nacional de Vacinação 2006.
[34.]
S.A. Halperin, B. Smith, M. Russell, D. Scheifele, E. Mills, P. Hasselback, et al.
Adult formulation of a five component acellular pertussis vaccine combined with diphtheria and tetanus toxoids and inactivated poliovirus vaccine is safe and immunogenic in adolescents and adults.
Pediatr Infect Dis J, 19 (2000), pp. 276-283
[35.]
J.E. Schmidt, A.E. Tozzi, L. Rava, S. Glismann.
The EUVAC-NET survey: national pertussis surveillance systems in the European Union, Switzerland, Norway, and Iceland.
Euro Surveill, 6 (2001), pp. 98-104
[36.]
M.C. Gomes, J.J. Gomes, A.C. Paulo.
Diphtheria, pertussis, and measles in Portugal before and after mass vaccination: a time series analysis.
Eur J Epidemiol, 15 (1999), pp. 791-798
[37.]
N. Guerin, C. Roure.
Immunisation coverage in the European Union.
Euro Surveill, 2 (1997), pp. 2-4
[38.]
G. Goncalves, E. Machado, E. Gouveia, M.A. Santos, L. Castro, R. Aguas, et al.
Resurgence of pertussis in northern Portugal: two severe cases in very young children.
Euro Surveill, 10 (2005), pp. E0506233
[39.]
Doenças de Declaração Obrigatória.
[40.]
K.W. Purdy, J.W. Hay, M.F. Botteman, J.I. Ward.
Evaluation of strategies for use of acellular pertussis vaccine in adolescents and adults: a cost-benefit analysis.
Clin Infect Dis, 39 (2004), pp. 20-28
Copyright © 2010. Sociedade Portuguesa de Pneumologia/SPP
Download PDF
Pulmonology
Article options
Tools

Are you a health professional able to prescribe or dispense drugs?