array:24 [
  "pii" => "S0873215915301859"
  "issn" => "08732159"
  "doi" => "10.1016/S0873-2159(15)30185-9"
  "estado" => "S350"
  "fechaPublicacion" => "2009-09-01"
  "aid" => "10"
  "copyright" => "Sociedade Portuguesa de Pneumologia/SPP"
  "copyrightAnyo" => "2009"
  "documento" => "simple-article"
  "crossmark" => 0
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "rev"
  "cita" => "Rev Port Pneumol. 2009;15:899-921"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 2486
    "formatos" => array:3 [
      "EPUB" => 210
      "HTML" => 1500
      "PDF" => 776
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S0873215915301896"
    "issn" => "08732159"
    "doi" => "10.1016/S0873-2159(15)30189-6"
    "estado" => "S350"
    "fechaPublicacion" => "2009-09-01"
    "aid" => "14"
    "copyright" => "Sociedade Portuguesa de Pneumologia/SPP"
    "documento" => "simple-article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "pub"
    "cita" => "Rev Port Pneumol. 2009;15:943-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1959
      "formatos" => array:3 [
        "EPUB" => 190
        "HTML" => 1033
        "PDF" => 736
      ]
    ]
    "pt" => array:8 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Normas de Publica&#231;&#227;o&#47;Instructions for Authors</span>"
      "titulo" => "Normas de publica&#231;&#227;o na Revista Portuguesa de Pneumologia"
      "tienePdf" => "pt"
      "tieneTextoCompleto" => 0
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "943"
          "paginaFinal" => "946"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Portuguese Journal of Pulmonology Instructions for authors"
        ]
      ]
      "contienePdf" => array:1 [
        "pt" => true
      ]
    ]
    "idiomaDefecto" => "pt"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215915301896?idApp=UINPBA00004E"
    "url" => "/08732159/0000001500000005/v1_201509151448/S0873215915301896/v1_201509151448/pt/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S0873215915301847"
    "issn" => "08732159"
    "doi" => "10.1016/S0873-2159(15)30184-7"
    "estado" => "S350"
    "fechaPublicacion" => "2009-09-01"
    "aid" => "9"
    "copyright" => "Sociedade Portuguesa de Pneumologia&#47;SPP"
    "documento" => "simple-article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "rev"
    "cita" => "Rev Port Pneumol. 2009;15:891-8"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2738
      "formatos" => array:3 [
        "EPUB" => 228
        "HTML" => 1790
        "PDF" => 720
      ]
    ]
    "pt" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Artigo de Revis&#227;o&#47;Review Article</span>"
      "titulo" => "Rinite al&#233;rgica e doen&#231;as associadas"
      "tienePdf" => "pt"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "pt"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "891"
          "paginaFinal" => "898"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Allergic rhinitis and related diseases"
        ]
      ]
      "contieneResumen" => array:2 [
        "pt" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "pt" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Cid&#225;lia Rodrigues, Michele de Santis, Ana Maria Arrobas"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Cid&#225;lia"
              "apellidos" => "Rodrigues"
            ]
            1 => array:2 [
              "nombre" => "Michele"
              "apellidos" => "de Santis"
            ]
            2 => array:2 [
              "nombre" => "Ana Maria"
              "apellidos" => "Arrobas"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "pt"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215915301847?idApp=UINPBA00004E"
    "url" => "/08732159/0000001500000005/v1_201509151448/S0873215915301847/v1_201509151448/pt/main.assets"
  ]
  "pt" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Artigo de Revis&#227;o&#47;Review Article</span>"
    "titulo" => "Pneumopatias e doen&#231;a de refluxo gastroesof&#225;gico"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "899"
        "paginaFinal" => "921"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "Jo&#227;o Cl&#225;udio Barroso Pereira"
        "autores" => array:1 [
          0 => array:4 [
            "nombre" => "Jo&#227;o Cl&#225;udio Barroso"
            "apellidos" => "Pereira"
            "email" => array:1 [
              0 => "jclaudiobarroso&#64;oi&#46;com&#46;br"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">1</span>"
                "identificador" => "af0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:3 [
            "entidad" => "M&#233;dico Tisiologista do Servi&#231;o de Atendimento Especializado da SMS-Belford Roxo&#44; M&#233;dico do CRA-DIP do Hospital Municipal Nelson de S&#225; Earp e do Programa de Controle da Tuberculose da SMS &#8211; Petr&#243;polis &#8211; Rio de Janeiro &#8211; Brasil&#46;"
            "etiqueta" => "1"
            "identificador" => "af0005"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "en" => array:1 [
        "titulo" => "Lung diseases and gastro-oesophageal reflux disease"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2009-01-20"
    "fechaAceptado" => "2009-03-20"
    "PalabrasClave" => array:2 [
      "pt" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palavras-chaves"
          "identificador" => "xpalclavsec570196"
          "palabras" => array:4 [
            0 => "Doen&#231;a de refluxo gastroesof&#225;gico"
            1 => "doen&#231;as pulmonares"
            2 => "preval&#234;ncia"
            3 => "mecanismos"
          ]
        ]
      ]
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key-words"
          "identificador" => "xpalclavsec570197"
          "palabras" => array:3 [
            0 => "Gastro-oesophageal reflux disease"
            1 => "lung disorders"
            2 => "prevalence and mechanisms"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "pt" => array:2 [
        "titulo" => "Resumo"
        "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">A doen&#231;a do refluxo gastroesof&#225;gico decorre do refluxo patol&#243;gico do est&#244;mago para o es&#243;fago&#46; Quando esse refluxo ocorre fora do es&#243;fago denomina-se doen&#231;a de refluxo extraesof&#225;gico&#46;</p><p id="sp1005" class="elsevierStyleSimplePara elsevierViewall">O autor prop&#245;e uma revis&#227;o sobre as doen&#231;as pulmonares associadas ao refluxo&#46; &#201; avaliado&#44; previamente&#44; de forma resumida o conceito de cada doen&#231;a e&#44; em seguida&#44; de modo sistem&#225;tico&#44; s&#227;o discutidos a preval&#234;ncia do refluxo sobre as pneumopatias&#44; os mecanis-mo que explicam essas intera&#231;&#245;es e o impacto do tratamento do refluxo gastroesofagiano sobre as doen&#231;as pulmonares&#46;</p><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall">O autor conclui que &#233; ineg&#225;vel a exist&#234;ncia de uma conex&#227;o entre doen&#231;a de refluxo gastroesof&#225;gico e v&#225;rias doen&#231;as pulmonares&#44; sendo mister estudos complementares para corroborar essa associa&#231;&#227;o&#46;</p><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2009&#59; XV &#40;5&#41;&#58; 899-921</span></p></span>"
      ]
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span id="as0010" class="elsevierStyleSection elsevierViewall"><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall">Gastro-oesophageal Reflux Disease is a consequence of pathological reflux from stomach to oesophagus&#46; Whenever the refluxed contents extended beyond the oesophagus itself&#44; is called Extraoesophageal Reflux Disease&#46;</p><p id="sp1020" class="elsevierStyleSimplePara elsevierViewall">The author proposes a review about pulmonary disorders and gastroesophageal reflux&#46; Previously&#44; it is evaluated in an abridged way&#44; the concepts of each diseases and after that&#44; in a systematic form&#44; it is discussed the prevalence of gastro-oesophageal reflux in lung diseases&#44; all the mechanisms studies and the impact of gastro-oesophageal treatment on lung disorders&#46;</p><p id="sp0025" class="elsevierStyleSimplePara elsevierViewall">The author concludes that is undeniable the link between Gastro-oesophageal reflux and lung diseases and further reaserch is mandatory in order to corroborate this association&#46;</p><p id="sp0030" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2009&#59; XV &#40;5&#41;&#58; 899-921</span></p></span>"
      ]
    ]
    "lecturaRecomendada" => array:1 [
      0 => array:3 [
        "vista" => "all"
        "titulo" => "<span class="elsevierStyleSectionTitle" id="st0025">Bibliografia</span>"
        "seccion" => array:1 [
          0 => array:2 [
            "vista" => "all"
            "bibliografiaReferencia" => array:151 [
              0 => array:3 [
                "identificador" => "bb0005"
                "etiqueta" => "1&#46;"
                "referencia" => array:1 [
                  0 => array:1 [
                    "referenciaCompleta" => "Moayyedi P&#44; Talley NJ&#46; Gastro-oesophageal reflux disease&#46; A comprehensive review&#46; Lancet 206&#59; 367&#58;2086-2100&#46;"
                  ]
                ]
              ]
              1 => array:3 [
                "identificador" => "bb0010"
                "etiqueta" => "2&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Gastroeosophageal reflux and respiratory disease in children"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "J Pediatr"
                          "fecha" => "1988"
                          "volumen" => "112"
                          "paginaInicial" => "847"
                          "paginaFinal" => "858"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              2 => array:3 [
                "identificador" => "bb0015"
                "etiqueta" => "3&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Extraoesophageal manifestations of gastro-oesophageal reflux&#46; Recent advances in clinical practice"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1136/gut.2004.053025"
                        "Revista" => array:6 [
                          "tituloSerie" => "Gut"
                          "fecha" => "2005"
                          "volumen" => "54"
                          "paginaInicial" => "1492"
                          "paginaFinal" => "1499"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              3 => array:3 [
                "identificador" => "bb0020"
                "etiqueta" => "4&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Respiratory complications of gastro-oesophageal reflux"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Scan J Gastroenterology"
                          "fecha" => "1989"
                          "volumen" => "168"
                          "numero" => "suppl"
                          "paginaInicial" => "67"
                          "paginaFinal" => "72"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              4 => array:3 [
                "identificador" => "bb0025"
                "etiqueta" => "5&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Pulmonary aspiration shown by scintigraphy in gastroesophageal reflux-related respiratory disease"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1378/chest.130.5.1520"
                        "Revista" => array:7 [
                          "tituloSerie" => "Chest"
                          "fecha" => "2006"
                          "volumen" => "130"
                          "numero" => "5"
                          "paginaInicial" => "1520"
                          "paginaFinal" => "1526"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              5 => array:3 [
                "identificador" => "bb0030"
                "etiqueta" => "6&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Laparoscopic fundoplication to enhance pulmonary function in children with severe reactive airway disease and gastroesophageal reflux disease"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:7 [
                          "tituloSerie" => "Surgical Endoscopy"
                          "fecha" => "1997"
                          "volumen" => "11"
                          "numero" => "11"
                          "paginaInicial" => "1088"
                          "paginaFinal" => "1090"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              6 => array:3 [
                "identificador" => "bb0035"
                "etiqueta" => "7&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Gastroesophageal reflux and respiratory symptoms&#58; is there an association&#63; Proposed mechanisms and treatment"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:7 [
                          "tituloSerie" => "DICP&#8211; the Annals of Pharmacotherapy"
                          "fecha" => "1990"
                          "volumen" => "24"
                          "numero" => "11"
                          "paginaInicial" => "1064"
                          "paginaFinal" => "1069"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              7 => array:3 [
                "identificador" => "bb0040"
                "etiqueta" => "8&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Otolaryngologic manifestations of gastroesopahgeal reflux"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Am J Gastroenterology"
                          "fecha" => "1991"
                          "volumen" => "86"
                          "numero" => "7"
                          "paginaInicial" => "801"
                          "paginaFinal" => "808"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              8 => array:3 [
                "identificador" => "bb0045"
                "etiqueta" => "9&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Diseases of the esophagus"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "LibroEditado" => array:5 [
                          "titulo" => "Cecil Medicine"
                          "paginaInicial" => "1001"
                          "paginaFinal" => "1004"
                          "edicion" => "23"
                          "serieFecha" => "2008"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              9 => array:3 [
                "identificador" => "bb0050"
                "etiqueta" => "10&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Extraesophageal gastroesophageal re-flux disease"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Presentation and approach to treatment&#46; Gastroenterology Clinic North Am"
                          "fecha" => "1999"
                          "volumen" => "28"
                          "numero" => "4"
                          "paginaInicial" => "861"
                          "paginaFinal" => "873"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              10 => array:3 [
                "identificador" => "bb0055"
                "etiqueta" => "11&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Medical treatment of supraesophageal complications of gastroesophageal reflux disease"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:7 [
                          "tituloSerie" => "Am J Med"
                          "fecha" => "2001"
                          "volumen" => "111"
                          "numero" => "Supl&#46; 8A"
                          "paginaInicial" => "197s"
                          "paginaFinal" => "201s"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              11 => array:3 [
                "identificador" => "bb0060"
                "etiqueta" => "12&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Extraoesophageal manifestations of gastro-oesophageal reflux"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1136/gut.2004.053025"
                        "Revista" => array:7 [
                          "tituloSerie" => "Gut"
                          "fecha" => "2005"
                          "volumen" => "54"
                          "numero" => "10"
                          "paginaInicial" => "1492"
                          "paginaFinal" => "1499"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              12 => array:3 [
                "identificador" => "bb0065"
                "etiqueta" => "13&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Fundoplication for laryngopharyngeal reflux disease"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1016/j.jamcollsurg.2004.03.022"
                        "Revista" => array:7 [
                          "tituloSerie" => "Journal of the American College of Surgeons"
                          "fecha" => "2004"
                          "volumen" => "199"
                          "numero" => "1"
                          "paginaInicial" => "23"
                          "paginaFinal" => "30"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              13 => array:3 [
                "identificador" => "bb0070"
                "etiqueta" => "14&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Pulmonary consequences of aspiration"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:7 [
                          "tituloSerie" => "Dysphagia"
                          "fecha" => "1989"
                          "volumen" => "3"
                          "numero" => "4"
                          "paginaInicial" => "179"
                          "paginaFinal" => "183"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              14 => array:3 [
                "identificador" => "bb0075"
                "etiqueta" => "15&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Gastroesophageal reflux disease and extraesophageal disease"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:7 [
                          "tituloSerie" => "Review in Gastroenterological Disorders"
                          "fecha" => "2005"
                          "volumen" => "5"
                          "numero" => "suppl 2"
                          "paginaInicial" => "s31"
                          "paginaFinal" => "s38"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              15 => array:3 [
                "identificador" => "bb0080"
                "etiqueta" => "16&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:1 [
                        "titulo" => "III Consenso brasileiro no manejo da asma"
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "J Bras Pneumol"
                          "fecha" => "2002"
                          "volumen" => "28"
                          "numero" => "Supl&#46; 1"
                          "paginaInicial" => "8"
                          "paginaFinal" => "17"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              16 => array:3 [
                "identificador" => "bb0085"
                "etiqueta" => "17&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "The association of gastroesophageal reflux with bronchial asthma&#46; Can asthma also trigger reflux&#63;"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:7 [
                          "tituloSerie" => "Hepato-gastroenterology"
                          "fecha" => "2006"
                          "volumen" => "53"
                          "numero" => "67"
                          "paginaInicial" => "64"
                          "paginaFinal" => "72"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              17 => array:3 [
                "identificador" => "bb0090"
                "etiqueta" => "18&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Gastro-oesophageal reflux disease in &#8220;difficult-to-control&#8221; asthma&#58; prevalence and response to treatment with acid suppressive therapy"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1111/j.1365-2036.2006.02888.x"
                        "Revista" => array:8 [
                          "tituloSerie" => "Alimentary Pharmacology Therapeutics"
                          "fecha" => "2006"
                          "volumen" => "23"
                          "numero" => "9"
                          "paginaInicial" => "1321"
                          "paginaFinal" => "1327"
                          "link" => array:1 [ …1]
                          "itemHostRev" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              18 => array:3 [
                "identificador" => "bb0095"
                "etiqueta" => "19&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Associations between respiratory symptons&#44; lung function and oesophageal reflux symptons in a population based birth cohort"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1186/1465-9921-7-142"
                        "Revista" => array:6 [
                          "tituloSerie" => "Respiratory Research"
                          "fecha" => "2006"
                          "volumen" => "7"
                          "paginaInicial" => "142"
                          "paginaFinal" => "145"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              19 => array:3 [
                "identificador" => "bb0100"
                "etiqueta" => "20&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Effects of esomeprazole 40<span class="elsevierStyleHsp" style=""></span>mg twice a day on asthma&#58; a randomized placebo controlled trial"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1164/rccm.200507-1167OC"
                        "Revista" => array:7 [
                          "tituloSerie" => "Am J Respir Crit Care Med"
                          "fecha" => "2006"
                          "volumen" => "173"
                          "numero" => "10"
                          "paginaInicial" => "1091"
                          "paginaFinal" => "1097"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              20 => array:3 [
                "identificador" => "bb0105"
                "etiqueta" => "21&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Airway inflammation in subjects with gastro-oesophageal reflux and gastro-oesophageal reflux related asthma"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "J Interne Med"
                          "fecha" => "2006"
                          "volumen" => "259"
                          "numero" => "3"
                          "paginaInicial" => "323"
                          "paginaFinal" => "331"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              21 => array:3 [
                "identificador" => "bb0110"
                "etiqueta" => "22&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Acid suppression does not change respiratory symptons in children with asthma and gastro-oesophageal reflux disease"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Archives Diseases Childhood"
                          "fecha" => "2005"
                          "volumen" => "90"
                          "numero" => "9"
                          "paginaInicial" => "956"
                          "paginaFinal" => "960"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              22 => array:3 [
                "identificador" => "bb0115"
                "etiqueta" => "23&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "The spectrum of pulmonary symptons due to gastroesophageal reflux"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1016/j.thorsurg.2005.04.002"
                        "Revista" => array:7 [
                          "tituloSerie" => "Thoracic Surgery Clinics"
                          "fecha" => "2005"
                          "volumen" => "15"
                          "numero" => "3"
                          "paginaInicial" => "353"
                          "paginaFinal" => "368"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              23 => array:3 [
                "identificador" => "bb0120"
                "etiqueta" => "24&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Nocturnal asthma and gastro-esophageal reflux"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:7 [
                          "tituloSerie" => "Am J Med"
                          "fecha" => "2001"
                          "volumen" => "111"
                          "numero" => "Sup&#46; 8A"
                          "paginaInicial" => "31S"
                          "paginaFinal" => "36S"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              24 => array:3 [
                "identificador" => "bb0125"
                "etiqueta" => "25&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Reflex mechanisms in gastroesophageal reflux disease and asthma"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:7 [
                          "tituloSerie" => "Am J Med"
                          "fecha" => "2003"
                          "volumen" => "115"
                          "numero" => "Supl&#46; 3A"
                          "paginaInicial" => "45S"
                          "paginaFinal" => "48S"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              25 => array:3 [
                "identificador" => "bb0130"
                "etiqueta" => "26&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Gastroesophageal reflux&#44; asthma and mechanics of interation"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:7 [
                          "tituloSerie" => "Am J Med"
                          "fecha" => "2001"
                          "volumen" => "111"
                          "numero" => "Supl&#46; 8A"
                          "paginaInicial" => "8S"
                          "paginaFinal" => "12S"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              26 => array:3 [
                "identificador" => "bb0135"
                "etiqueta" => "27&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Acid reflux and asthma"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Current Opinion in Pulmonary Medicine"
                          "fecha" => "2003"
                          "volumen" => "9"
                          "paginaInicial" => "42"
                          "paginaFinal" => "45"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              27 => array:3 [
                "identificador" => "bb0140"
                "etiqueta" => "28&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Role of gastroesophageal reflux disease in asthmatic patients"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:7 [
                          "tituloSerie" => "European Review for Medical and Pharmacological Sciences"
                          "fecha" => "2005"
                          "volumen" => "9"
                          "numero" => "3"
                          "paginaInicial" => "151"
                          "paginaFinal" => "160"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              28 => array:3 [
                "identificador" => "bb0145"
                "etiqueta" => "29&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Gastroesophageal reflux&#58; a potential asthma trigger"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1016/j.iac.2004.09.006"
                        "Revista" => array:8 [
                          "tituloSerie" => "Immunology and Allergy Clinics of North America"
                          "fecha" => "2005"
                          "volumen" => "25"
                          "numero" => "1"
                          "paginaInicial" => "131"
                          "paginaFinal" => "148"
                          "link" => array:1 [ …1]
                          "itemHostRev" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              29 => array:3 [
                "identificador" => "bb0150"
                "etiqueta" => "30&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Recent clinical investigations examin-ing the association of asthma and gastroesophageal re-flux"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:7 [
                          "tituloSerie" => "Am J Med"
                          "fecha" => "2003"
                          "volumen" => "115"
                          "numero" => "Suppl 3A"
                          "paginaInicial" => "39S"
                          "paginaFinal" => "44S"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              30 => array:3 [
                "identificador" => "bb0155"
                "etiqueta" => "31&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Asthmatics with gastroesophageal reflux&#58; long term results of randomized trial of medical and surgical antireflux therapies"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:5 [
                          "tituloSerie" => "Am J Gastrenterol"
                          "fecha" => "2003"
                          "volumen" => "98"
                          "paginaInicial" => "987"
                          "paginaFinal" => "999"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              31 => array:3 [
                "identificador" => "bb0160"
                "etiqueta" => "32&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Gastroesophageal reflux disease and asthma&#46; A longitudinal study in UK general practice"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1378/chest.128.1.85"
                        "Revista" => array:7 [
                          "tituloSerie" => "Chest"
                          "fecha" => "2005"
                          "volumen" => "128"
                          "numero" => "1"
                          "paginaInicial" => "85"
                          "paginaFinal" => "93"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              32 => array:3 [
                "identificador" => "bb0165"
                "etiqueta" => "33&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Gastroesophageal reflux treatment for asthma in adults and children"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:3 [
                          "tituloSerie" => "Cochrane Data-base Syst Rev"
                          "fecha" => "2003"
                          "numero" => "Issue 2"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              33 => array:3 [
                "identificador" => "bb0170"
                "etiqueta" => "34&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Prevalence of gastroesophageal reflux in difficult asthma"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1378/chest.127.4.1227"
                        "Revista" => array:7 [
                          "tituloSerie" => "Chest"
                          "fecha" => "2005"
                          "volumen" => "127"
                          "numero" => "4"
                          "paginaInicial" => "1227"
                          "paginaFinal" => "1231"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              34 => array:3 [
                "identificador" => "bb0175"
                "etiqueta" => "35&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Effects of 24 weeks of lansopra-zole therapy on asthma symptons&#44; exacerbations&#44; quality of life&#44; and pulmonary function in adult asthmatic patients with acid reflux symptons"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1378/chest.128.3.1128"
                        "Revista" => array:6 [
                          "tituloSerie" => "Chest"
                          "fecha" => "2005"
                          "volumen" => "128"
                          "paginaInicial" => "1128"
                          "paginaFinal" => "1135"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              35 => array:3 [
                "identificador" => "bb0180"
                "etiqueta" => "36&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Pulmonary complications of gastroesophageal reflux"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "LibroEditado" => array:5 [
                          "titulo" => "The esophagus"
                          "paginaInicial" => "530"
                          "paginaFinal" => "545"
                          "edicion" => "4"
                          "serieFecha" => "2004"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              36 => array:3 [
                "identificador" => "bb0185"
                "etiqueta" => "37&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Chronic persistent cough and gastro-oesophageal reflux"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Thorax"
                          "fecha" => "1991"
                          "volumen" => "46"
                          "paginaInicial" => "479"
                          "paginaFinal" => "483"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              37 => array:3 [
                "identificador" => "bb0190"
                "etiqueta" => "38&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Chronic cough and gastro-esophageal reflux"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:5 [
                          "tituloSerie" => "Can Med Assoc J"
                          "fecha" => "1989"
                          "volumen" => "140"
                          "paginaInicial" => "520"
                          "paginaFinal" => "524"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              38 => array:3 [
                "identificador" => "bb0195"
                "etiqueta" => "39&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Anatomic diagnostic protocol in evaluating chronic cough with specific reference to gastroesophageal reflux disease"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Am J Med"
                          "fecha" => "2000"
                          "volumen" => "108"
                          "numero" => "Suppl 4A"
                          "paginaInicial" => "1265"
                          "paginaFinal" => "1305"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              39 => array:3 [
                "identificador" => "bb0200"
                "etiqueta" => "40&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Chronic cough&#46; The most common causes"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:5 [
                          "tituloSerie" => "Can Farm Physician"
                          "fecha" => "2002"
                          "volumen" => "48"
                          "paginaInicial" => "1311"
                          "paginaFinal" => "1316"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              40 => array:3 [
                "identificador" => "bb0205"
                "etiqueta" => "41&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Acid reflux in patients with chronic unexplained cough during 24 hours ambulatory pressure&#44; pH and impedance monitoring"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1136/gut.2004.055418"
                        "Revista" => array:6 [
                          "tituloSerie" => "Gut"
                          "fecha" => "2005"
                          "volumen" => "54"
                          "paginaInicial" => "449"
                          "paginaFinal" => "454"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              41 => array:3 [
                "identificador" => "bb0210"
                "etiqueta" => "42&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Effects of esophageal acid perfusion on cough responsiveness in patients with bronchial asthma"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:7 [
                          "tituloSerie" => "Chest"
                          "fecha" => "2002"
                          "volumen" => "122"
                          "numero" => "2"
                          "paginaInicial" => "505"
                          "paginaFinal" => "509"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              42 => array:3 [
                "identificador" => "bb0215"
                "etiqueta" => "43&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Pathogenesis of chronic persistent cough associated with gastroesophageal reflux"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1164/ajrccm.149.1.8111576"
                        "Revista" => array:6 [
                          "tituloSerie" => "Am J Respir Crit Care Med"
                          "fecha" => "1999"
                          "volumen" => "149"
                          "paginaInicial" => "160"
                          "paginaFinal" => "167"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              43 => array:3 [
                "identificador" => "bb0220"
                "etiqueta" => "44&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "A prospective evaluation of esophageal testing and double blind&#44; randomized study of omeprazole in a diagnostic and therapeutic al- gorithm for chronic cough"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1111/j.1572-0241.1999.01504.x"
                        "Revista" => array:6 [
                          "tituloSerie" => "Am J Gastroenterol"
                          "fecha" => "1999"
                          "volumen" => "94"
                          "paginaInicial" => "3131"
                          "paginaFinal" => "3138"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              44 => array:3 [
                "identificador" => "bb0225"
                "etiqueta" => "45&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Accurately diagnosing and successfully treating chronic cough due to gastroesopha-geal reflux disease can be difficult"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1111/j.1572-0241.1999.03095.x"
                        "Revista" => array:6 [
                          "tituloSerie" => "Am J Gastroenterol"
                          "fecha" => "1999"
                          "volumen" => "94"
                          "paginaInicial" => "3095"
                          "paginaFinal" => "3098"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              45 => array:3 [
                "identificador" => "bb0230"
                "etiqueta" => "46&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Chronic cough due to gastroesophageal reflux disease&#46; ACCP evidence-based clinical practice guidelines"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1378/chest.129.1_suppl.80S"
                        "Revista" => array:6 [
                          "tituloSerie" => "Chest"
                          "fecha" => "2006"
                          "volumen" => "129"
                          "paginaInicial" => "80S"
                          "paginaFinal" => "94S"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              46 => array:3 [
                "identificador" => "bb0235"
                "etiqueta" => "47&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Chronic cough and gastro-esophageal reflux disease&#58; Experience with specific therapy for diagnosis and treatment"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Chest"
                          "fecha" => "2003"
                          "volumen" => "123"
                          "paginaInicial" => "679"
                          "paginaFinal" => "684"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              47 => array:3 [
                "identificador" => "bb0240"
                "etiqueta" => "48&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:1 [
                        "titulo" => "II Consenso brasileiro sobre doen&#231;a pulmonar obstrutiva cr&#244;nica"
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "J Bras Pneumol"
                          "fecha" => "2004"
                          "volumen" => "30"
                          "numero" => "supl 5"
                          "paginaInicial" => "1"
                          "paginaFinal" => "42"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              48 => array:3 [
                "identificador" => "bb0245"
                "etiqueta" => "49&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Increased prevalence of gastro esophageal reflux symptons in patients with COPD"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Chest"
                          "fecha" => "2001"
                          "volumen" => "119"
                          "paginaInicial" => "1043"
                          "paginaFinal" => "1048"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              49 => array:3 [
                "identificador" => "bb0250"
                "etiqueta" => "50&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Increased gastro-esophageal reflux disease in patients with severe COPD"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Eur Respir J"
                          "fecha" => "2004"
                          "volumen" => "23"
                          "paginaInicial" => "841"
                          "paginaFinal" => "845"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              50 => array:3 [
                "identificador" => "bb0255"
                "etiqueta" => "51&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Esophageal function and gastro-esophageal reflux during sleep and waking in patients with chronic obstructive pulmonary disease"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Chest"
                          "fecha" => "1992"
                          "volumen" => "101"
                          "paginaInicial" => "1521"
                          "paginaFinal" => "1525"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              51 => array:3 [
                "identificador" => "bb0260"
                "etiqueta" => "52&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Commorbid occurrence of laryngeal or pulmonary disease with esophagitis in United States military veterans"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Gastroenterology"
                          "fecha" => "1997"
                          "volumen" => "113"
                          "paginaInicial" => "755"
                          "paginaFinal" => "760"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              52 => array:3 [
                "identificador" => "bb0265"
                "etiqueta" => "53&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Prevalence of benign esophageal disease in Danish population with special reference to pulmonary disease"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "J Intern Med"
                          "fecha" => "1989"
                          "volumen" => "225"
                          "paginaInicial" => "393"
                          "paginaFinal" => "401"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              53 => array:3 [
                "identificador" => "bb0270"
                "etiqueta" => "54&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Oropharingeal deglutition in stable COPD"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:7 [
                          "tituloSerie" => "Chest"
                          "fecha" => "2002"
                          "volumen" => "121"
                          "numero" => "2"
                          "paginaInicial" => "361"
                          "paginaFinal" => "369"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              54 => array:3 [
                "identificador" => "bb0275"
                "etiqueta" => "55&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Epidemiology of gastro-oesophageal reflux disease&#58; a systematic review"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1136/gut.2004.051821"
                        "Revista" => array:6 [
                          "tituloSerie" => "Gut"
                          "fecha" => "2005"
                          "volumen" => "54"
                          "paginaInicial" => "710"
                          "paginaFinal" => "717"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              55 => array:3 [
                "identificador" => "bb0280"
                "etiqueta" => "56&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Cricopharyngeal dysfunction in chronic obstructive pulmonary disease"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Chest"
                          "fecha" => "1990"
                          "volumen" => "97"
                          "paginaInicial" => "347"
                          "paginaFinal" => "352"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              56 => array:3 [
                "identificador" => "bb0285"
                "etiqueta" => "57&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Coordination of deglutition and phases of respiration&#58; effect on aging&#44; tachypnea&#44; bolus volume&#44; and chronic obstructive pulmonary disease"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:5 [
                          "tituloSerie" => "Am J Physiol"
                          "fecha" => "1992"
                          "volumen" => "263"
                          "paginaInicial" => "G 750"
                          "paginaFinal" => "G 755"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              57 => array:3 [
                "identificador" => "bb0290"
                "etiqueta" => "58&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Relationship between gastroesophageal reflux disease and COPD in UK primare care"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1378/chest.08-0902"
                        "Revista" => array:6 [
                          "tituloSerie" => "Chest"
                          "fecha" => "2008"
                          "volumen" => "134"
                          "paginaInicial" => "1223"
                          "paginaFinal" => "1230"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              58 => array:3 [
                "identificador" => "bb0295"
                "etiqueta" => "59&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Increased prevalence of gastro-esophageal reflux in symptons with COPD"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Chest"
                          "fecha" => "2001"
                          "volumen" => "119"
                          "paginaInicial" => "1043"
                          "paginaFinal" => "1048"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              59 => array:3 [
                "identificador" => "bb0300"
                "etiqueta" => "60&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Increased gastroesophageal reflux disease in patients with severe COPD"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Eur Respir J"
                          "fecha" => "2004"
                          "volumen" => "23"
                          "paginaInicial" => "841"
                          "paginaFinal" => "845"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              60 => array:3 [
                "identificador" => "bb0305"
                "etiqueta" => "61&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Role of gastroesophageal reflux symptons in exacerbations of COPD"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1378/chest.130.4.1096"
                        "Revista" => array:6 [
                          "tituloSerie" => "Chest"
                          "fecha" => "2006"
                          "volumen" => "130"
                          "paginaInicial" => "1096"
                          "paginaFinal" => "1101"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              61 => array:3 [
                "identificador" => "bb0310"
                "etiqueta" => "62&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Are upper gastrointestinal symptons associated with exacerbations of COPD&#63;"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1111/j.1742-1241.2008.01772.x"
                        "Revista" => array:6 [
                          "tituloSerie" => "Int J Clin Pract"
                          "fecha" => "2008"
                          "volumen" => "62"
                          "paginaInicial" => "967"
                          "paginaFinal" => "969"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              62 => array:3 [
                "identificador" => "bb0315"
                "etiqueta" => "63&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Beyond heartburn&#58; a review of the spectrum of reflux-induced disease"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:5 [
                          "tituloSerie" => "Farm Pracrt"
                          "fecha" => "2005"
                          "volumen" => "22"
                          "paginaInicial" => "591"
                          "paginaFinal" => "603"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              63 => array:3 [
                "identificador" => "bb0320"
                "etiqueta" => "64&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Classification of the idiopathic intersticial pneumonias"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1164/ajrccm.165.2.ats01"
                        "Revista" => array:6 [
                          "tituloSerie" => "Am J Respir Crit Care Med"
                          "fecha" => "2002"
                          "volumen" => "165"
                          "paginaInicial" => "277"
                          "paginaFinal" => "304"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              64 => array:3 [
                "identificador" => "bb0325"
                "etiqueta" => "65&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Idiophatic pulmonary fibrosis&#58; how often is it really idiophatic&#63;"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "J Gastrointestinal Surg"
                          "fecha" => "2005"
                          "volumen" => "9"
                          "numero" => "8"
                          "paginaInicial" => "1053"
                          "paginaFinal" => "1056"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              65 => array:3 [
                "identificador" => "bb0330"
                "etiqueta" => "66&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "High prevalence of abnormal and gastro-oesophageal reflux in idiopathic pulmonary fibrosis"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1183/09031936.06.00037005"
                        "Revista" => array:7 [
                          "tituloSerie" => "Eur Respir J"
                          "fecha" => "2006"
                          "volumen" => "27"
                          "numero" => "1"
                          "paginaInicial" => "136"
                          "paginaFinal" => "142"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              66 => array:3 [
                "identificador" => "bb0335"
                "etiqueta" => "67&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Increased prevalence of gastroesophageal reflux in patients with idiopathic pulmonary fibrosis"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1164/ajrccm.160.6.9808134"
                        "Revista" => array:5 [
                          "tituloSerie" => "Am J Respir Crit Care Med"
                          "fecha" => "1998"
                          "paginaInicial" => "1804"
                          "paginaFinal" => "1808"
                          "link" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              67 => array:3 [
                "identificador" => "bb0340"
                "etiqueta" => "68&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Idiopathic pulmonary fibrosis diagnosis and treatment&#58; international consensus statement"
                        "autores" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1164/ajrccm.161.2.ats3-00"
                        "Revista" => array:6 [
                          "tituloSerie" => "Am J Respir Crit Care Med"
                           …5
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              68 => array:3 [
                "identificador" => "bb0345"
                "etiqueta" => "69&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Gastroesophageal reflux in patients with idiopathic pulmonary fibrosis referred for lung transplantation"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1016/j.jtcvs.2006.09.085"
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              69 => array:3 [
                "identificador" => "bb0350"
                "etiqueta" => "70&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Pulmonary effects of experimental graded aspiration of hydrochloric acid"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              70 => array:3 [
                "identificador" => "bb0355"
                "etiqueta" => "71&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Increased alveolar epithelial permeability with acid aspiration&#58; the effects of high-dose steroids"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1164/arrd.1979.120.5.1119"
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              71 => array:3 [
                "identificador" => "bb0360"
                "etiqueta" => "72&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Immediate histopathology of hydro-choloric acid aspiration"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              72 => array:3 [
                "identificador" => "bb0365"
                "etiqueta" => "73&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Aspiration of gastric contents&#58; an experimental study"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              73 => array:3 [
                "identificador" => "bb0370"
                "etiqueta" => "74&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "The pulmonary consequences of aspiration of gastric contents at pH values greater than 2&#46;5"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1164/arrd.1980.121.1.119"
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              74 => array:3 [
                "identificador" => "bb0375"
                "etiqueta" => "75&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Lung albumin content after acid aspiration pulmonary injury"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:5 [ …5]
                      ]
                    ]
                  ]
                ]
              ]
              75 => array:3 [
                "identificador" => "bb0380"
                "etiqueta" => "76&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Experimental pulmonary fibrosis induced by trisodium citrate and acid citrate&#8211; dextrose"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              76 => array:3 [
                "identificador" => "bb0385"
                "etiqueta" => "77&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Sole treatment of acid gastro-esophageal reflux in idiopathic pulmonary fibrosis"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1378/chest.129.3.794"
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              77 => array:3 [
                "identificador" => "bb0390"
                "etiqueta" => "78&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Microchimerism and systemic sclerosis"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              78 => array:3 [
                "identificador" => "bb0395"
                "etiqueta" => "79&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Unique characteristics of systemic sclerosis sine scleroderma-associated intersticial lung disease"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1378/chest.130.4.976"
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              79 => array:3 [
                "identificador" => "bb0400"
                "etiqueta" => "80&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Esophageal involvement in scleroderma&#58; gastroesophageal reflux&#44; the common problem"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1016/j.semarthrit.2006.08.002"
                        "Revista" => array:7 [ …7]
                      ]
                    ]
                  ]
                ]
              ]
              80 => array:3 [
                "identificador" => "bb0405"
                "etiqueta" => "81&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Scleroderma"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "LibroEditado" => array:5 [ …5]
                      ]
                    ]
                  ]
                ]
              ]
              81 => array:3 [
                "identificador" => "bb0410"
                "etiqueta" => "82&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Intersticial lung diseases in collagen vascular diseases"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              82 => array:3 [
                "identificador" => "bb0415"
                "etiqueta" => "83&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Association of esophageal dysfunction and pulmonary function impairment in systemic sclerosis"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1111/j.1572-0241.1998.00341.x"
                        "Revista" => array:7 [ …7]
                      ]
                    ]
                  ]
                ]
              ]
              83 => array:3 [
                "identificador" => "bb0420"
                "etiqueta" => "84&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Pulmonary disease in progressive systemic sclerosis&#46; A complication of gas-troesophageal reflux and occult aspiration&#63;"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:7 [ …7]
                      ]
                    ]
                  ]
                ]
              ]
              84 => array:3 [
                "identificador" => "bb0425"
                "etiqueta" => "85&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Pulmonary function and gastroesophageal reflux in systemic sclerosis"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:7 [ …7]
                      ]
                    ]
                  ]
                ]
              ]
              85 => array:3 [
                "identificador" => "bb0430"
                "etiqueta" => "86&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Classification and approach to bronchiolar diseases"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1097/01.mcp.0000208455.80725.2a"
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              86 => array:3 [
                "identificador" => "bb0435"
                "etiqueta" => "87&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Prevalence of gastroesophageal reflux in end stage lung disease candidates for lung transplan"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1016/j.athoracsur.2005.03.106"
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              87 => array:3 [
                "identificador" => "bb0440"
                "etiqueta" => "88&#46;"
                "referencia" => array:1 [
                  0 => array:1 [
                    "referenciaCompleta" => "Young LR&#44; Hajiliadis D&#44; <span class="elsevierStyleItalic">et</span> cols&#46; Lung transplantation exacerbates gastroesophageal reflux disease&#46;"
                  ]
                ]
              ]
              88 => array:3 [
                "identificador" => "bb0445"
                "etiqueta" => "89&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Early reflux monitoring following lung transplantation underestimates the incidence of GERD"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:7 [ …7]
                      ]
                    ]
                  ]
                ]
              ]
              89 => array:3 [
                "identificador" => "bb0450"
                "etiqueta" => "90&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Improved lung allograft function after fundoplication in patients with gastro-esophageal reflux disease undergoing lung transplantation"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              90 => array:3 [
                "identificador" => "bb0455"
                "etiqueta" => "91&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Lung transplantation"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1056/NEJM199904083401406"
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              91 => array:3 [
                "identificador" => "bb0460"
                "etiqueta" => "92&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Bronchiolitis obliterans syndrome&#58; an update of the diagnosis of diagnostic criteria"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              92 => array:3 [
                "identificador" => "bb0465"
                "etiqueta" => "92&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Bronchiolar disorders&#46; State of art"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1164/rccm.200301-053SO"
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              93 => array:3 [
                "identificador" => "bb0470"
                "etiqueta" => "93&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Preval&#234;ncia de refluxo gastroesof&#225;gico em doentes com doen&#231;a pulmonar avan&#231;ada em candidatos a transplante pulmonar"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:7 [ …7]
                      ]
                    ]
                  ]
                ]
              ]
              94 => array:3 [
                "identificador" => "bb0475"
                "etiqueta" => "94&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "25 perguntas frequentes em pneumologia"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:4 [ …4]
                      ]
                    ]
                  ]
                ]
              ]
              95 => array:3 [
                "identificador" => "bb0480"
                "etiqueta" => "95&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "&#8220;Why am I sleepy&#63;&#34; Sorting the somnolent"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1164/ajrccm.163.6.2007021"
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              96 => array:3 [
                "identificador" => "bb0485"
                "etiqueta" => "96&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Nocturnal gastroesophageal reflux&#58; Symptom of obstructive sleep apnea syndrome in association with impaired swallowing"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              97 => array:3 [
                "identificador" => "bb0490"
                "etiqueta" => "97&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Arousal in patients with gastro-oesophageal reflux and sleep apnea"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              98 => array:3 [
                "identificador" => "bb0495"
                "etiqueta" => "98&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Arousal in patients with gastro-oesophageal reflux and sleep apnea"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              99 => array:3 [
                "identificador" => "bb0500"
                "etiqueta" => "99&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Gastroesophageal reflux in patients with sleep apnea syndrome"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              100 => array:3 [
                "identificador" => "bb0505"
                "etiqueta" => "100&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Nasal CPAP reduces gastroesophageal reflux in obstructive sleep apnea syndrome"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              101 => array:3 [
                "identificador" => "bb0510"
                "etiqueta" => "101&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Obstructive sleep apnea and gastroesophageal reflux"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              102 => array:3 [
                "identificador" => "bb0515"
                "etiqueta" => "102&#46;"
                "referencia" => array:1 [
                  0 => array:1 [
                    "referenciaCompleta" => "Fass R&#46; Gastroesophageal reflux disease and sleep&#46; J Clin Gastroenterol 41&#40;Supl&#46; 2&#40;&#58;5154-5159&#46;"
                  ]
                ]
              ]
              103 => array:3 [
                "identificador" => "bb0520"
                "etiqueta" => "103&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Effects of hypoxia on respiratory neural output and lower esophageal sphincter pressure in piglets"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1203/00006450-200207000-00011"
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              104 => array:3 [
                "identificador" => "bb0525"
                "etiqueta" => "104&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Impaired swallowing reflex in patients with obstructive sleep apnea syndrome"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              105 => array:3 [
                "identificador" => "bb0530"
                "etiqueta" => "105&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Is the relationship between obstructive sleep apnea and gastroesophageal reflux clinically important&#63;"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              106 => array:3 [
                "identificador" => "bb0535"
                "etiqueta" => "106&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "&#8220;Silent&#8221; gastroesophageal reflux in patients with unexplained sleep complaints"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:5 [ …5]
                      ]
                    ]
                  ]
                ]
              ]
              107 => array:3 [
                "identificador" => "bb0540"
                "etiqueta" => "107&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Effects of esomeprazole on nighttime heartburn and sleep quality in patients with GERD&#58; a randomized placebo controlled trial"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1111/j.1572-0241.2005.00285.x"
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              108 => array:3 [
                "identificador" => "bb0545"
                "etiqueta" => "108&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "The Effect of gastro-esophageal reflux and omeprazole on key sleep parameters"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1111/j.1365-2036.2005.02573.x"
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              109 => array:3 [
                "identificador" => "bb0550"
                "etiqueta" => "109&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Nasal continuous positive airway pressure and weight loss improve swallowing reflex in patients with obstructive sleep apnea syndrome"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "29551"
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              110 => array:3 [
                "identificador" => "bb0555"
                "etiqueta" => "110&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Gastroesophageal reflux and obstructive sleep apnea"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1097/00005537-200112000-00012"
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              111 => array:3 [
                "identificador" => "bb0560"
                "etiqueta" => "111&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Nocturnal gastroesophageal reflux&#58; Symptons of obstructive sleep apnea syndrome in association with impaired swallowing"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              112 => array:3 [
                "identificador" => "bb0565"
                "etiqueta" => "112&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Nasal CPAP reduces gastroesophageal reflux in obstructive sleep apnea syndrome"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              113 => array:3 [
                "identificador" => "bb0570"
                "etiqueta" => "113&#41;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:1 [
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:4 [ …4]
                      ]
                    ]
                  ]
                ]
              ]
              114 => array:3 [
                "identificador" => "bb0575"
                "etiqueta" => "114&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Cystic fibrosis"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1164/ajrccm.154.5.8912731"
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              115 => array:3 [
                "identificador" => "bb0580"
                "etiqueta" => "115&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Frequency&#44; consequences and pharmacological treatment of gastroesophageal reflux in children with cystic fibrosis&#46; Medical science monitor&#46; International Medical Journal of Experimental and"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              116 => array:3 [
                "identificador" => "bb0585"
                "etiqueta" => "116&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Prevalence and mechanisms of gastro-oesophageal reflux in adult cystic fibrosis patients"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              117 => array:3 [
                "identificador" => "bb0590"
                "etiqueta" => "117&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Gastrointestinal Ph&#44; motility&#47; transit and permeability in cystic fibrosis"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              118 => array:3 [
                "identificador" => "bb0595"
                "etiqueta" => "118&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Pancreazymin secretion tests of exocrine pancreatic function in cystic fibrosis and the significance of the results for the pathogenesis of the disease"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              119 => array:3 [
                "identificador" => "bb0600"
                "etiqueta" => "119&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Factors that influence induction of gastroesophageal reflux in normal human subjects"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:5 [ …5]
                      ]
                    ]
                  ]
                ]
              ]
              120 => array:3 [
                "identificador" => "bb0605"
                "etiqueta" => "120&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Factors affecting clinical out-come in gastrostomy fed children with cystic fibrosis"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1002/ppul.10321"
                        "Revista" => array:7 [ …7]
                      ]
                    ]
                  ]
                ]
              ]
              121 => array:3 [
                "identificador" => "bb0610"
                "etiqueta" => "121&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:1 [
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1016/j.healun.2004.11.312"
                        "Revista" => array:7 [ …7]
                      ]
                    ]
                  ]
                ]
              ]
              122 => array:3 [
                "identificador" => "bb0615"
                "etiqueta" => "122&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Tracheobronchial aspiration of gastric contents in critically ill tube-fed patients&#58; Frequency&#44; outcomes&#44; and risk factors"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              123 => array:3 [
                "identificador" => "bb0620"
                "etiqueta" => "123&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Aspiration pneumonias&#58; under-diagnosed and under treated"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1097/MCP.0b013e3280f629f0"
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              124 => array:3 [
                "identificador" => "bb0625"
                "etiqueta" => "124&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Prevalence of silent gastro-esophageal reflux in association with recurrent lower respiratory tract infections"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              125 => array:3 [
                "identificador" => "bb0630"
                "etiqueta" => "125&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "99mm TC sulfur colloid gastroesophageal scintigraphy with late imaging to evaluate patients with posterior laryngitis"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              126 => array:3 [
                "identificador" => "bb0635"
                "etiqueta" => "126&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Duodenal gastroesophageal reflux and esophageal mucosal injury in mechanically ventilated patients"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              127 => array:3 [
                "identificador" => "bb0640"
                "etiqueta" => "127&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "An analysis of upper GI endoscopy done for patients in surgical intensive care&#58; high incidence of&#44; and morbidity from reflux oesophagitis"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              128 => array:3 [
                "identificador" => "bb0645"
                "etiqueta" => "128&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Effect of nasogastric tube size on gastroesophageal reflux and microaspiration in intubated patients"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              129 => array:3 [
                "identificador" => "bb0650"
                "etiqueta" => "129&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Gastro-oesophageal reflux in mechanically ventilated patients&#58; effects of an oesophageal ballon"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              130 => array:3 [
                "identificador" => "bb0655"
                "etiqueta" => "130&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Tracheobronchial aspiration of gastric contents in critically ill tube-fed patients&#58; frequency&#44; outcomes and risk factors"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1097/01.CCM.0000206106.65220.59"
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              131 => array:3 [
                "identificador" => "bb0660"
                "etiqueta" => "131&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Gastroesophageal reflux and aspiration of gastric contents in anesthetic practice"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              132 => array:3 [
                "identificador" => "bb0665"
                "etiqueta" => "132&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Penafiel A&#44; <span class="elsevierStyleItalic">et al</span>"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:5 [ …5]
                      ]
                    ]
                  ]
                ]
              ]
              133 => array:3 [
                "identificador" => "bb0670"
                "etiqueta" => "133&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Pulmonary aspiration of gastric contents in patients receiving mechanical ventilation&#58; the effect of body position"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              134 => array:3 [
                "identificador" => "bb0675"
                "etiqueta" => "134&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Factors influencing intra-operative gastric regurgitation&#46; A prospective random study of nasogastric tube drainage"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:5 [ …5]
                      ]
                    ]
                  ]
                ]
              ]
              135 => array:3 [
                "identificador" => "bb0680"
                "etiqueta" => "135&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Esophageal pharmacology"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "LibroEditado" => array:4 [ …4]
                      ]
                    ]
                  ]
                ]
              ]
              136 => array:3 [
                "identificador" => "bb0685"
                "etiqueta" => "136&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Bronchiectasis"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1378/chest.08-0776"
                        "Revista" => array:7 [ …7]
                      ]
                    ]
                  ]
                ]
              ]
              137 => array:3 [
                "identificador" => "bb0690"
                "etiqueta" => "137&#46;"
                "referencia" => array:1 [
                  0 => array:1 [
                    "referenciaCompleta" => "Tsang KW&#44; Tipoe GL&#46; Bronchiectasis&#58; not an orphan disease in the East&#46; Int J Tuberc Lung Dis 8&#40;6&#41;&#58; 691-702&#46;"
                  ]
                ]
              ]
              138 => array:3 [
                "identificador" => "bb0695"
                "etiqueta" => "138&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Bronchiectasis"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              139 => array:3 [
                "identificador" => "bb0700"
                "etiqueta" => "139&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "An investigation into causative factors in patients with bronchiectasis"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1164/ajrccm.162.4.9906120"
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              140 => array:3 [
                "identificador" => "bb0705"
                "etiqueta" => "140&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "<span class="elsevierStyleItalic">Helicobacter pylori</span> and upper gastro-intestinal symptons in bronchiectasis"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              141 => array:3 [
                "identificador" => "bb0710"
                "etiqueta" => "141&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "<span class="elsevierStyleItalic">Helicobacter pylori</span> seropre-valence in patients with bronchiectasis"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              142 => array:3 [
                "identificador" => "bb0715"
                "etiqueta" => "142&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Pulmonary disease due to non tuberculous mycobacteria"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1378/chest.07-0358"
                        "Revista" => array:7 [ …7]
                      ]
                    ]
                  ]
                ]
              ]
              143 => array:3 [
                "identificador" => "bb0720"
                "etiqueta" => "143&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Prevalence of gastroesophageal reflux disease in patients with non tuberculous myco-bacterial lung disease"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1378/chest.06-2280"
                        "Revista" => array:7 [ …7]
                      ]
                    ]
                  ]
                ]
              ]
              144 => array:3 [
                "identificador" => "bb0725"
                "etiqueta" => "144&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Rapidly growing mycobacterial lung infection in association with esophageal disorders"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              145 => array:3 [
                "identificador" => "bb0730"
                "etiqueta" => "145&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Pulmonary disease caused by rapidly growing mycobacteria"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              146 => array:3 [
                "identificador" => "bb0735"
                "etiqueta" => "146&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Infections due to rapidly growing mycobacteria"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1086/504381"
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              147 => array:3 [
                "identificador" => "bb0740"
                "etiqueta" => "147&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Lung disease due to more common non tuberculous mycobacteria"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1378/chest.129.6.1653"
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              148 => array:3 [
                "identificador" => "bb0745"
                "etiqueta" => "148&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Clinical features of pulmonary disease caused by rapidly growing mycobacteria&#58; an analysis of 154 patients"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1164/ajrccm/147.5.1271"
                        "Revista" => array:6 [ …6]
                      ]
                    ]
                  ]
                ]
              ]
              149 => array:3 [
                "identificador" => "bb0750"
                "etiqueta" => "149&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Gastroesophageal reflux disease&#44; acid suppression&#44; and <span class="elsevierStyleItalic">Mycobacterium avium complex</span> pulmonary disease"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1378/chest.06-1906"
                        "Revista" => array:7 [ …7]
                      ]
                    ]
                  ]
                ]
              ]
              150 => array:3 [
                "identificador" => "bb0755"
                "etiqueta" => "150&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Exogenous lipoid pneumonia superinfected with acid fast bacilli in infants&#58; a report of nine cases"
                        "autores" => array:1 [ …1]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1080/15513810600788798"
                        "Revista" => array:7 [ …7]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "pt"
  "url" => "/08732159/0000001500000005/v1_201509151448/S0873215915301859/v1_201509151448/pt/main.assets"
  "Apartado" => array:4 [
    "identificador" => "43356"
    "tipo" => "SECCION"
    "pt" => array:2 [
      "titulo" => "Artigos de revis&#227;o"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "pt"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/08732159/0000001500000005/v1_201509151448/S0873215915301859/v1_201509151448/pt/main.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215915301859?idApp=UINPBA00004E"
]
Share
Journal Information
Vol. 15. Issue 5.
Pages 899-921 (September - October 2009)
Share
Share
Download PDF
More article options
Vol. 15. Issue 5.
Pages 899-921 (September - October 2009)
Artigo de Revisão/Review Article
Open Access
Pneumopatias e doença de refluxo gastroesofágico
Lung diseases and gastro-oesophageal reflux disease
Visits
6063
João Cláudio Barroso Pereira1
1 Médico Tisiologista do Serviço de Atendimento Especializado da SMS-Belford Roxo, Médico do CRA-DIP do Hospital Municipal Nelson de Sá Earp e do Programa de Controle da Tuberculose da SMS – Petrópolis – Rio de Janeiro – Brasil.
This item has received

Under a Creative Commons license
Article information
Resumo

A doença do refluxo gastroesofágico decorre do refluxo patológico do estômago para o esófago. Quando esse refluxo ocorre fora do esófago denomina-se doença de refluxo extraesofágico.

O autor propõe uma revisão sobre as doenças pulmonares associadas ao refluxo. É avaliado, previamente, de forma resumida o conceito de cada doença e, em seguida, de modo sistemático, são discutidos a prevalência do refluxo sobre as pneumopatias, os mecanis-mo que explicam essas interações e o impacto do tratamento do refluxo gastroesofagiano sobre as doenças pulmonares.

O autor conclui que é inegável a existência de uma conexão entre doença de refluxo gastroesofágico e várias doenças pulmonares, sendo mister estudos complementares para corroborar essa associação.

Rev Port Pneumol 2009; XV (5): 899-921

Palavras-chaves:
Doença de refluxo gastroesofágico
doenças pulmonares
prevalência
mecanismos
Abstract

Gastro-oesophageal Reflux Disease is a consequence of pathological reflux from stomach to oesophagus. Whenever the refluxed contents extended beyond the oesophagus itself, is called Extraoesophageal Reflux Disease.

The author proposes a review about pulmonary disorders and gastroesophageal reflux. Previously, it is evaluated in an abridged way, the concepts of each diseases and after that, in a systematic form, it is discussed the prevalence of gastro-oesophageal reflux in lung diseases, all the mechanisms studies and the impact of gastro-oesophageal treatment on lung disorders.

The author concludes that is undeniable the link between Gastro-oesophageal reflux and lung diseases and further reaserch is mandatory in order to corroborate this association.

Rev Port Pneumol 2009; XV (5): 899-921

Key-words:
Gastro-oesophageal reflux disease
lung disorders
prevalence and mechanisms
Full text is only aviable in PDF
Bibliografia
[1.]
Moayyedi P, Talley NJ. Gastro-oesophageal reflux disease. A comprehensive review. Lancet 206; 367:2086-2100.
[2.]
S.R. Orenstein, D.M. Orenstein.
Gastroeosophageal reflux and respiratory disease in children.
J Pediatr, 112 (1988), pp. 847-858
[3.]
J. Poelmans, J. Tack.
Extraoesophageal manifestations of gastro-oesophageal reflux. Recent advances in clinical practice.
Gut, 54 (2005), pp. 1492-1499
[4.]
C.E. Pope.
Respiratory complications of gastro-oesophageal reflux.
Scan J Gastroenterology, 168 (1989), pp. 67-72
[5.]
A.M. Ravelli, M.B. Panarotto.
Pulmonary aspiration shown by scintigraphy in gastroesophageal reflux-related respiratory disease.
Chest, 130 (2006), pp. 1520-1526
[6.]
S.S. Rothenberg, D. Bratton, et al.
Laparoscopic fundoplication to enhance pulmonary function in children with severe reactive airway disease and gastroesophageal reflux disease.
Surgical Endoscopy, 11 (1997), pp. 1088-1090
[7.]
E.R. Gonzales.
Gastroesophageal reflux and respiratory symptoms: is there an association? Proposed mechanisms and treatment.
DICP– the Annals of Pharmacotherapy, 24 (1990), pp. 1064-1069
[8.]
E.B. Gaynor.
Otolaryngologic manifestations of gastroesopahgeal reflux.
Am J Gastroenterology, 86 (1991), pp. 801-808
[9.]
R.C. Orlando.
Diseases of the esophagus.
Cecil Medicine, 23, pp. 1001-1004
[10.]
M.B. Fennerty.
Extraesophageal gastroesophageal re-flux disease.
Presentation and approach to treatment. Gastroenterology Clinic North Am, 28 (1999), pp. 861-873
[11.]
W.J. Hogan, R. Shaker.
Medical treatment of supraesophageal complications of gastroesophageal reflux disease.
Am J Med, 111 (2001), pp. 197s-201s
[12.]
J. Poelmans, J. Tack.
Extraoesophageal manifestations of gastro-oesophageal reflux.
Gut, 54 (2005), pp. 1492-1499
[13.]
C.J. Westcott, M.B. Hopkins, et al.
Fundoplication for laryngopharyngeal reflux disease.
Journal of the American College of Surgeons, 199 (2004), pp. 23-30
[14.]
P.B. Terry, S.D. Fuller.
Pulmonary consequences of aspiration.
Dysphagia, 3 (1989), pp. 179-183
[15.]
P.O. Katz.
Gastroesophageal reflux disease and extraesophageal disease.
Review in Gastroenterological Disorders, 5 (2005), pp. s31-s38
[16.]
III Consenso brasileiro no manejo da asma.
J Bras Pneumol, 28 (2002), pp. 8-17
[17.]
L.I. Al-Asoom, A. Al-Rubaish.
The association of gastroesophageal reflux with bronchial asthma. Can asthma also trigger reflux?.
Hepato-gastroenterology, 53 (2006), pp. 64-72
[18.]
C.H. Wong, et al.
Gastro-oesophageal reflux disease in “difficult-to-control” asthma: prevalence and response to treatment with acid suppressive therapy.
Alimentary Pharmacology Therapeutics, 23 (2006), pp. 1321-1327
[19.]
R.J. Hancox.
Associations between respiratory symptons, lung function and oesophageal reflux symptons in a population based birth cohort.
Respiratory Research, 7 (2006), pp. 142-145
[20.]
T.O. Kijander, S.M. Harding.
Effects of esomeprazole 40mg twice a day on asthma: a randomized placebo controlled trial.
Am J Respir Crit Care Med, 173 (2006), pp. 1091-1097
[21.]
G.E. Carpagnano, O. Resta.
Airway inflammation in subjects with gastro-oesophageal reflux and gastro-oesophageal reflux related asthma.
J Interne Med, 259 (2006), pp. 323-331
[22.]
K. Stordal, et al.
Acid suppression does not change respiratory symptons in children with asthma and gastro-oesophageal reflux disease.
Archives Diseases Childhood, 90 (2005), pp. 956-960
[23.]
S.J. Sontag.
The spectrum of pulmonary symptons due to gastroesophageal reflux.
Thoracic Surgery Clinics, 15 (2005), pp. 353-368
[24.]
F. Cibella, G. Cuttitta.
Nocturnal asthma and gastro-esophageal reflux.
Am J Med, 111 (2001), pp. 31S-36S
[25.]
B.J. Canning, S.B. Mazzone.
Reflex mechanisms in gastroesophageal reflux disease and asthma.
Am J Med, 115 (2003), pp. 45S-48S
[26.]
S.M. Harding.
Gastroesophageal reflux, asthma and mechanics of interation.
Am J Med, 111 (2001), pp. 8S-12S
[27.]
S.M. Harding.
Acid reflux and asthma.
Current Opinion in Pulmonary Medicine, 9 (2003), pp. 42-45
[28.]
S.P. Jiang, L.W. Huang.
Role of gastroesophageal reflux disease in asthmatic patients.
European Review for Medical and Pharmacological Sciences, 9 (2005), pp. 151-160
[29.]
S.M. Harding.
Gastroesophageal reflux: a potential asthma trigger.
Immunology and Allergy Clinics of North America, 25 (2005), pp. 131-148
[30.]
S.M. Harding.
Recent clinical investigations examin-ing the association of asthma and gastroesophageal re-flux.
Am J Med, 115 (2003), pp. 39S-44S
[31.]
S.J. Sontag.
Asthmatics with gastroesophageal reflux: long term results of randomized trial of medical and surgical antireflux therapies.
Am J Gastrenterol, 98 (2003), pp. 987-999
[32.]
Ruigómez, et al.
Gastroesophageal reflux disease and asthma. A longitudinal study in UK general practice.
Chest, 128 (2005), pp. 85-93
[33.]
P.G. Gibson.
Gastroesophageal reflux treatment for asthma in adults and children.
Cochrane Data-base Syst Rev, (2003),
[34.]
J.J. Leggett.
Prevalence of gastroesophageal reflux in difficult asthma.
Chest, 127 (2005), pp. 1227-1231
[35.]
M.R. Littner.
Effects of 24 weeks of lansopra-zole therapy on asthma symptons, exacerbations, quality of life, and pulmonary function in adult asthmatic patients with acid reflux symptons.
Chest, 128 (2005), pp. 1128-1135
[36.]
S.M. Harding.
Pulmonary complications of gastroesophageal reflux.
The esophagus, 4, pp. 530-545
[37.]
A.J. Ing.
Chronic persistent cough and gastro-oesophageal reflux.
Thorax, 46 (1991), pp. 479-483
[38.]
J.M. Fitzgerald, et al.
Chronic cough and gastro-esophageal reflux.
Can Med Assoc J, 140 (1989), pp. 520-524
[39.]
R.S. Irwin, J.M. Madison.
Anatomic diagnostic protocol in evaluating chronic cough with specific reference to gastroesophageal reflux disease.
Am J Med, 108 (2000), pp. 1265-1305
[40.]
A. D`Urzo, P. Jugovic.
Chronic cough. The most common causes.
Can Farm Physician, 48 (2002), pp. 1311-1316
[41.]
D. Sifrim, L. Dupont.
Acid reflux in patients with chronic unexplained cough during 24 hours ambulatory pressure, pH and impedance monitoring.
[42.]
D.N. Wu, K. Yamanchi.
Effects of esophageal acid perfusion on cough responsiveness in patients with bronchial asthma.
Chest, 122 (2002), pp. 505-509
[43.]
A.J. Ing, et al.
Pathogenesis of chronic persistent cough associated with gastroesophageal reflux.
Am J Respir Crit Care Med, 149 (1999), pp. 160-167
[44.]
T. Ours, M.S. Kavuru, et al.
A prospective evaluation of esophageal testing and double blind, randomized study of omeprazole in a diagnostic and therapeutic al- gorithm for chronic cough.
Am J Gastroenterol, 94 (1999), pp. 3131-3138
[45.]
R.S. Irwin, J.K. Zawacki.
Accurately diagnosing and successfully treating chronic cough due to gastroesopha-geal reflux disease can be difficult.
Am J Gastroenterol, 94 (1999), pp. 3095-3098
[46.]
R.S. Irwin.
Chronic cough due to gastroesophageal reflux disease. ACCP evidence-based clinical practice guidelines.
[47.]
R.H. Poe, M.C. Kallay.
Chronic cough and gastro-esophageal reflux disease: Experience with specific therapy for diagnosis and treatment.
Chest, 123 (2003), pp. 679-684
[48.]
II Consenso brasileiro sobre doença pulmonar obstrutiva crônica.
J Bras Pneumol, 30 (2004), pp. 1-42
[49.]
B. Mokhlesi, et al.
Increased prevalence of gastro esophageal reflux symptons in patients with COPD.
Chest, 119 (2001), pp. 1043-1048
[50.]
C. Casanova, et al.
Increased gastro-esophageal reflux disease in patients with severe COPD.
Eur Respir J, 23 (2004), pp. 841-845
[51.]
W.C. Orr, et al.
Esophageal function and gastro-esophageal reflux during sleep and waking in patients with chronic obstructive pulmonary disease.
Chest, 101 (1992), pp. 1521-1525
[52.]
H.B. El Serag, A. Sonnenberg.
Commorbid occurrence of laryngeal or pulmonary disease with esophagitis in United States military veterans.
Gastroenterology, 113 (1997), pp. 755-760
[53.]
L.I. Anderson, G. Jensen.
Prevalence of benign esophageal disease in Danish population with special reference to pulmonary disease.
J Intern Med, 225 (1989), pp. 393-401
[54.]
B. Mokhlesi, et al.
Oropharingeal deglutition in stable COPD.
Chest, 121 (2002), pp. 361-369
[55.]
J. Dent, et al.
Epidemiology of gastro-oesophageal reflux disease: a systematic review.
[56.]
M. Stein.
Cricopharyngeal dysfunction in chronic obstructive pulmonary disease.
Chest, 97 (1990), pp. 347-352
[57.]
R. Shaker.
Coordination of deglutition and phases of respiration: effect on aging, tachypnea, bolus volume, and chronic obstructive pulmonary disease.
Am J Physiol, 263 (1992), pp. G 750-G 755
[58.]
L.A. García Rodrigues, A. Ruigómez.
Relationship between gastroesophageal reflux disease and COPD in UK primare care.
Chest, 134 (2008), pp. 1223-1230
[59.]
B. Mokhlesi, et al.
Increased prevalence of gastro-esophageal reflux in symptons with COPD.
Chest, 119 (2001), pp. 1043-1048
[60.]
C. Casanova, et al.
Increased gastroesophageal reflux disease in patients with severe COPD.
Eur Respir J, 23 (2004), pp. 841-845
[61.]
I.E. Rascon Aguilar, et al.
Role of gastroesophageal reflux symptons in exacerbations of COPD.
Chest, 130 (2006), pp. 1096-1101
[62.]
E. Cholongitas, et al.
Are upper gastrointestinal symptons associated with exacerbations of COPD?.
Int J Clin Pract, 62 (2008), pp. 967-969
[63.]
A.P. Hungin.
Beyond heartburn: a review of the spectrum of reflux-induced disease.
Farm Pracrt, 22 (2005), pp. 591-603
[64.]
American Thoracic Society &, European Respiratory Society – International Multidisciplinary Consensus.
Classification of the idiopathic intersticial pneumonias.
Am J Respir Crit Care Med, 165 (2002), pp. 277-304
[65.]
G. Patti Marco, Tedesco Pietro.
Idiophatic pulmonary fibrosis: how often is it really idiophatic?.
J Gastrointestinal Surg, 9 (2005), pp. 1053-1056
[66.]
G. Raghu, G. Raghu.
High prevalence of abnormal and gastro-oesophageal reflux in idiopathic pulmonary fibrosis.
Eur Respir J, 27 (2006), pp. 136-142
[67.]
R.W. Tobin, C.E. Pope, et al.
Increased prevalence of gastroesophageal reflux in patients with idiopathic pulmonary fibrosis.
Am J Respir Crit Care Med, (1998), pp. 1804-1808
[68.]
American Thoracic Society.
Idiopathic pulmonary fibrosis diagnosis and treatment: international consensus statement.
Am J Respir Crit Care Med, 161 (2000), pp. 646-664
[69.]
M.P. Sweet.
Gastroesophageal reflux in patients with idiopathic pulmonary fibrosis referred for lung transplantation.
J Thorac Cardiovasc Surg, 133 (2007), pp. 1078-1084
[70.]
L.J. Greenfield, R.P. Singleton.
Pulmonary effects of experimental graded aspiration of hydrochloric acid.
Ann Surg, 170 (1969), pp. 74-86
[71.]
F.L. Glauser, J.E. Millen.
Increased alveolar epithelial permeability with acid aspiration: the effects of high-dose steroids.
Am Rev Respir Dis, 120 (1970), pp. 1119-1123
[72.]
S. Salley.
Immediate histopathology of hydro-choloric acid aspiration.
Scan Electron Microsc, 3 (1970), pp. 911-920
[73.]
J.R. Teabeaut.
Aspiration of gastric contents: an experimental study.
Am J Pathol, 28 (1952), pp. 51-62
[74.]
D.J. Schwartz, et al.
The pulmonary consequences of aspiration of gastric contents at pH values greater than 2.5.
Am Rev Respir Dis, 121 (1980), pp. 119-126
[75.]
J.C. Stohert.
Lung albumin content after acid aspiration pulmonary injury.
J Sing Res, 30 (1981), pp. 256-261
[76.]
T. Mitsuhashi, et al.
Experimental pulmonary fibrosis induced by trisodium citrate and acid citrate– dextrose.
Exp Mol Pathol, 42 (1985), pp. 261-270
[77.]
G. Raghu.
Sole treatment of acid gastro-esophageal reflux in idiopathic pulmonary fibrosis.
Chest, 129 (2006), pp. 794-800
[78.]
S.A. Jimenez, et al.
Microchimerism and systemic sclerosis.
Curr Opin Rheumatol, 17 (2005), pp. 86-89
[79.]
A. Fisher, R.T. Meehan.
Unique characteristics of systemic sclerosis sine scleroderma-associated intersticial lung disease.
Chest, 130 (2006), pp. 976-981
[80.]
K. Ntoumazios Stavros.
Esophageal involvement in scleroderma: gastroesophageal reflux, the common problem.
Seminars in Arthritis and Rheumatism, 36 (2006), pp. 173-181
[81.]
F.M. Wigley.
Scleroderma.
Cecil Medicine, 23, pp. 2032-2041
[82.]
C. Lamblin, C. Bergoin.
Intersticial lung diseases in collagen vascular diseases.
Eur Respir J, 18 (2001), pp. 69s-80s
[83.]
G. Lock.
Association of esophageal dysfunction and pulmonary function impairment in systemic sclerosis.
Am J Gastroenterol, 93 (2004), pp. 341-345
[84.]
D.A. Johnson, W.E. Drane.
Pulmonary disease in progressive systemic sclerosis. A complication of gas-troesophageal reflux and occult aspiration?.
Arch Intern Med, 149 (1989), pp. 589-593
[85.]
M.B. Troshinsky, G.C. Kane.
Pulmonary function and gastroesophageal reflux in systemic sclerosis.
Ann Intern Med, 121 (1994), pp. 6-10
[86.]
J.H. Ryu.
Classification and approach to bronchiolar diseases.
Current Opinion in Pulmonary Medicine, 12 (2006), pp. 145-151
[87.]
F. D `Ovídio.
Prevalence of gastroesophageal reflux in end stage lung disease candidates for lung transplan.
Ann Thorac Surg, 80 (2005), pp. 1254-1260
[88.]
Young LR, Hajiliadis D, et cols. Lung transplantation exacerbates gastroesophageal reflux disease.
[89.]
M.G. Hartwig, et al.
Early reflux monitoring following lung transplantation underestimates the incidence of GERD.
Am J Transplant, 4 (2004), pp. 231-288
[90.]
R.D. Davis, C.L. Lau, et al.
Improved lung allograft function after fundoplication in patients with gastro-esophageal reflux disease undergoing lung transplantation.
J Thorac Cardiovascular Surg, 125 (2002), pp. 533-542
[91.]
S. Arcasoy, R.M. Kotloff.
Lung transplantation.
N Engl J Med, 340 (1999), pp. 1081-1091
[92.]
M. Estenne, et al.
Bronchiolitis obliterans syndrome: an update of the diagnosis of diagnostic criteria.
J Heart Lung Transplant, 21 (2002), pp. 297-310
[92.]
J.H. Ryu.
Bronchiolar disorders. State of art.
Am J Respir Crit Care Med, 168 (2003), pp. 1277-1292
[93.]
G.A. Fortunato, M.M. Machado.
Prevalência de refluxo gastroesofágico em doentes com doença pulmonar avançada em candidatos a transplante pulmonar.
J Bras Pneumol, 34 (2008), pp. 772-778
[94.]
J.C. Winck, J.R. Dias, J.M. dos Santos.
25 perguntas frequentes em pneumologia.
Sono, (2001), pp. 47-56
[95.]
N.J. Douglas.
“Why am I sleepy?" Sorting the somnolent.
Am J Respir Crit Care Med, 163 (2001), pp. 1310-1313
[96.]
S. Teramoto.
Nocturnal gastroesophageal reflux: Symptom of obstructive sleep apnea syndrome in association with impaired swallowing.
Chest, 122 (2002), pp. 2266-2267
[97.]
T. Penzel, H.F. Becker.
Arousal in patients with gastro-oesophageal reflux and sleep apnea.
Eur Respir J, 14 (1999), pp. 1266-1270
[98.]
T. Penzel, H.F. Becker, et al.
Arousal in patients with gastro-oesophageal reflux and sleep apnea.
Eur Respir J, 14 (1999), pp. 1266-1270
[99.]
K.I. Graft, M. Karans.
Gastroesophageal reflux in patients with sleep apnea syndrome.
Z Gastroenterol, 33 (1995), pp. 689-693
[100.]
P. Kerr.
Nasal CPAP reduces gastroesophageal reflux in obstructive sleep apnea syndrome.
Chest, 101 (1992), pp. 1539-1544
[101.]
A.J. Ing, M.C. Ngu, et al.
Obstructive sleep apnea and gastroesophageal reflux.
Am J Med, 108 (2000), pp. 120s-125s
[102.]
Fass R. Gastroesophageal reflux disease and sleep. J Clin Gastroenterol 41(Supl. 2(:5154-5159.
[103.]
P. Kiatchoosakun, et al.
Effects of hypoxia on respiratory neural output and lower esophageal sphincter pressure in piglets.
[104.]
S. Teramoto, E. Sudo.
Impaired swallowing reflex in patients with obstructive sleep apnea syndrome.
Chest, 116 (1999), pp. 17-21
[105.]
S.K. Field.
Is the relationship between obstructive sleep apnea and gastroesophageal reflux clinically important?.
Chest, 121 (2002), pp. 1730-1733
[106.]
W.C. Orr, S. Goodrich, et al.
“Silent” gastroesophageal reflux in patients with unexplained sleep complaints.
Am J Gastroenterol, 100 (2005), pp. S50-S51
[107.]
D. Johnson.
Effects of esomeprazole on nighttime heartburn and sleep quality in patients with GERD: a randomized placebo controlled trial.
Am J Gastroenterol, 100 (2005), pp. 1914-1922
[108.]
A.J. Dimarino, K. Banwait.
The Effect of gastro-esophageal reflux and omeprazole on key sleep parameters.
Aliment Pharmacol Ther, 22 (2005), pp. 325-329
[109.]
S. Kada.
Nasal continuous positive airway pressure and weight loss improve swallowing reflex in patients with obstructive sleep apnea syndrome.
Respiration, 67 (2000), pp. 464-466
[110.]
B.A. Senior, M. Khan.
Gastroesophageal reflux and obstructive sleep apnea.
Laryngoscope, 111 (2001), pp. 2144-2146
[111.]
S. Teramoto.
Nocturnal gastroesophageal reflux: Symptons of obstructive sleep apnea syndrome in association with impaired swallowing.
Chest, 122 (2002), pp. 2266-2267
[112.]
P. Kerr, et al.
Nasal CPAP reduces gastroesophageal reflux in obstructive sleep apnea syndrome.
Chest, 101 (1992), pp. 1539-1544
[113)]
M. Zamboni, C.A.C. Pereira.
Sociedade Brasileira de Pneumologia e Tisiologia. Ed Atheneu, (2007), pp. 193-206
[114.]
P.B. Davis.
Cystic fibrosis.
Am J Respir Crit Care Med, 154 (1996), pp. 1229-1256
[115.]
J. Brodizicki.
Frequency, consequences and pharmacological treatment of gastroesophageal reflux in children with cystic fibrosis. Medical science monitor. International Medical Journal of Experimental and.
Clinical Research, 8 (2002), pp. 529-537
[116.]
M.J. Ledson.
Prevalence and mechanisms of gastro-oesophageal reflux in adult cystic fibrosis patients.
J R Soc Med, 91 (1998), pp. 7-9
[117.]
P.C. Gregory.
Gastrointestinal Ph, motility/ transit and permeability in cystic fibrosis.
Journal of Pediatric Gastroenterol and Nutrition, 23 (1996), pp. 513-523
[118.]
B. Hardoru, et al.
Pancreazymin secretion tests of exocrine pancreatic function in cystic fibrosis and the significance of the results for the pathogenesis of the disease.
Can Med Ass J, 98 (1968), pp. 377-388
[119.]
J. Dent.
Factors that influence induction of gastroesophageal reflux in normal human subjects.
Digest Disease Science, 33 (1988), pp. 270-275
[120.]
R. Olivier Mark, et al.
Factors affecting clinical out-come in gastrostomy fed children with cystic fibrosis.
Pediatric Pulmonology, 37 (2004), pp. 324-329
[121.]
B.M. Button, R. Stuart.
Journal of Heart and Lung Transplantation, 24 (2005), pp. 1522-1529
[122.]
N.A. Metheny, R.E. Clouse.
Tracheobronchial aspiration of gastric contents in critically ill tube-fed patients: Frequency, outcomes, and risk factors.
Crit Care Med, 36 (2006), pp. 1007-1014
[123.]
H. Shigemitsu, K. Afshar.
Aspiration pneumonias: under-diagnosed and under treated.
Current Opinion in Pulmonary Medicine, 13 (2007), pp. 192-198
[124.]
J.T. Eluvathingal, et al.
Prevalence of silent gastro-esophageal reflux in association with recurrent lower respiratory tract infections.
Clinical Nuclear Medicine, 48 (2003), pp. 476-479
[125.]
A. Bestetti, F. Carola, et al.
99mm TC sulfur colloid gastroesophageal scintigraphy with late imaging to evaluate patients with posterior laryngitis.
J Nucl Med, 41 (2000), pp. 1597-1602
[126.]
A. Wilmer, J. Tack, et al.
Duodenal gastroesophageal reflux and esophageal mucosal injury in mechanically ventilated patients.
Gastroenterology, 116 (1999), pp. 1293-1299
[127.]
P.W. Plaisier, et al.
An analysis of upper GI endoscopy done for patients in surgical intensive care: high incidence of, and morbidity from reflux oesophagitis.
Eur J Surg, 163 (1997), pp. 903-907
[128.]
M. Ferrer.
Effect of nasogastric tube size on gastroesophageal reflux and microaspiration in intubated patients.
Ann Intern Med, 130 (1999), pp. 991-994
[129.]
M. Orozco Levi.
Gastro-oesophageal reflux in mechanically ventilated patients: effects of an oesophageal ballon.
Eur Respir J, 22 (2003), pp. 348-353
[130.]
N.A. Metheny, et al.
Tracheobronchial aspiration of gastric contents in critically ill tube-fed patients: frequency, outcomes and risk factors.
Crit Care Med, 34 (2006), pp. 1007-1015
[131.]
A. Ng, G. Smith.
Gastroesophageal reflux and aspiration of gastric contents in anesthetic practice.
Anesth Analg, 93 (2001), pp. 494-513
[132.]
J. Ibanez.
Penafiel A, et al.
Gastroesophageal reflux in intubated patients receiving enteral nutrition: effects of supine and semirecumbent positions Journal Parenteral Enteral Nutrition, 16 (1992), pp. 419-422
[133.]
A. Torres, J. Serra Batlles, et al.
Pulmonary aspiration of gastric contents in patients receiving mechanical ventilation: the effect of body position.
Ann Intern Med, 116 (1992), pp. 540-543
[134.]
B. Satiani.
Factors influencing intra-operative gastric regurgitation. A prospective random study of nasogastric tube drainage.
Arch Surg, 13 (1978), pp. 712-723
[135.]
K. Schulze–Delrien.
Esophageal pharmacology.
Diseases of the esophagus, pp. 35-39
[136.]
A.E. O`Donnell.
Bronchiectasis.
Chest, 134 (2008), pp. 815-823
[137.]
Tsang KW, Tipoe GL. Bronchiectasis: not an orphan disease in the East. Int J Tuberc Lung Dis 8(6): 691-702.
[138.]
R.J. Boyton.
Bronchiectasis.
Medicine, 36 (2008), pp. 315-320
[139.]
M.C. Pasteur, S.M. Helliwell.
An investigation into causative factors in patients with bronchiectasis.
Am J Respir Crit Care Med, 162 (2000), pp. 1277-1284
[140.]
K.W. Tsang, et al.
Helicobacter pylori and upper gastro-intestinal symptons in bronchiectasis.
Eur Respir J, 14 (1999), pp. 1345-1350
[141.]
K. Najafizadeh.
Helicobacter pylori seropre-valence in patients with bronchiectasis.
Tanaffos, 5 (2006), pp. 25-29
[142.]
J. Glassroth.
Pulmonary disease due to non tuberculous mycobacteria.
Chest, 133 (2008), pp. 243-251
[143.]
W.J. Koh.
Prevalence of gastroesophageal reflux disease in patients with non tuberculous myco-bacterial lung disease.
Chest, 131 (2007), pp. 1825-1830
[144.]
D. Hadjiliadis.
Rapidly growing mycobacterial lung infection in association with esophageal disorders.
Mayo Clin Proc, 74 (1999), pp. 45-51
[145.]
C.L. Daley, D.E. Griffith.
Pulmonary disease caused by rapidly growing mycobacteria.
Clin Chest Med, 23 (2002), pp. 623-632
[146.]
M.A. Groote, G. Huit.
Infections due to rapidly growing mycobacteria.
Clin Infect Dis, 42 (2006), pp. 1756-1763
[147.]
S.K. Field, R.L. Cowie.
Lung disease due to more common non tuberculous mycobacteria.
Chest, 129 (2006), pp. 1653-1672
[148.]
D.E. Griffith, et al.
Clinical features of pulmonary disease caused by rapidly growing mycobacteria: an analysis of 154 patients.
Am Rev Respir Dis, 147 (1993), pp. 1271-1278
[149.]
R.M. Thomson.
Gastroesophageal reflux disease, acid suppression, and Mycobacterium avium complex pulmonary disease.
Chest, 131 (2007), pp. 1166-1171
[150.]
R.S. Cecilia.
Exogenous lipoid pneumonia superinfected with acid fast bacilli in infants: a report of nine cases.
Fetal and Pediatric Pathology, 25 (2006), pp. 107-117
Copyright © 2009. Sociedade Portuguesa de Pneumologia/SPP
Download PDF
Pulmonology
Article options
Tools

Are you a health professional able to prescribe or dispense drugs?