Avaliação dos resultados nos ensaios clínicos na DPOC: Da função pulmonar aos marcadores biológicos

Cazzola, M.; MacNee, W.; Martinez, F.J.; Rabe, K.F.

doi:10.1016/S0873-2159(15)30266-X

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Pulmonology

ISSN: 2531-0437

Pulmonology (previously Revista Portuguesa de Pneumologia) is the official journal of the Portuguese Society of Pulmonology (Sociedade Portuguesa de Pneumologia/SPP). The journal publishes 6 issues per year, mainly about respiratory system diseases in adults and clinical research. This work can range from peer-reviewed original articles to review articles, editorials, and opinion articles. The journal is printed in English, and is freely available in its web page as well as in Medline and other databases.

Special Issue 2023. Volume 29, Issue S4.

Indexed in:

Science Citation Index Expanded, Journal of Citation Reports; Index Medicus/MEDLINE; Scopus; EMBASE/Excerpta Medica

As sociedades científicas respiratórias europeia e americana (ERS e ATS) constituíram um grupo de trabalho sobre a “Avaliação dos resultados nos ensaios clínicos na DPOC: da função pulmonar aos marcadores biológicos” para informar a comunidade de investigadores em DPOC sobre o possível uso e limitações dos resultados obtidos e marcadores usados actualmente na avaliação do impacto da terapêutica farmacológica. Com base na revisão da literatura, este documento aborda diferentes secções que avaliam marcadores e resultados específicos: função pulmonar; resultados centrados no doente; exacerbações; nortalidade; impacto social e económico; exames de imagem; marcadores não pulmonares; mínima diferença clinicamente significativa; marcadores biológicos.

Full text is only aviable in PDF

Bibliografia

[1.]

Global Initiative for Chronic Obstructive Lung Disease.

Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease.

(2008)www.goldcopd.org

[2.]

M. Bergner.

The sickness impact profile.

Quality of Life: Assessment and Application, pp. 79-94

[3.]

G.H. Guyatt, L.B. Berman, M. Townsend, S.O. Pugsley, L.W. Chambers.

A measure of quality of life for clinical trials in chronic lung disease.

Thorax, 42 (1987), pp. 773-778

Medline

[4.]

P.W. Jones, F.H. Quirk, C.M. Baveystock, P. Littlejohns.

A self-complete measure of health status for chronic airflow limitation. The St. George’s Respiratory Questionnaire.

Am Rev Respir Dis, 145 (1992), pp. 1321-1327

http://dx.doi.org/10.1164/ajrccm/145.6.1321 | Medline

[5.]

R. Garrod, J.C. Bestall, E.A. Paul, J.A. Wedzicha, P.W. Jones.

Development and validation of a standardized measure of activity of daily living in patients with severe COPD: the London Chest Activity of Daily Living scale (LCADL).

Respir Med, 94 (2000), pp. 589-596

http://dx.doi.org/10.1053/rmed.2000.0786 | Medline

[6.]

J.C. Bestall, E.A. Paul, R. Garrod, R. Garnham, P.W. Jones, J.A. Wedzicha.

Usefulness of the Medical Research Council (MRC) dyspnoea scale as a measure of disability in patients with chronic obstructive pulmonary disease.

Thorax, 54 (1999), pp. 581-586

Medline

[7.]

D.A. Mahler, D.H. Weinberg, C.K. Wells, A.R. Feinstein.

The measurement of dyspnea. Contents, interobserver agreement, and physiologic correlates of two new clinical indexes.

Chest, 85 (1984), pp. 751-758

Medline