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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Asthma is one of the most common chronic diseases&#44; affecting an estimated 300 million people worldwide&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> In a study by Sousa et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> the prevalence of asthma in a Portuguese urban population was 10&#46;2&#37;&#44; the mean age of asthmatics was 27&#46;0 years and no significant difference in prevalence was found between males and females&#46; This inflammatory disorder of the airways has an adverse impact on various dimensions of health and quality of life&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Moreover&#44; the socio-economic impact of asthma is substantial&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Patient-based instruments are increasingly used to measure the outcomes of health care interventions since they provide evidence of the impact of a specific health condition from the viewpoint of the patient&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The Living with Asthma Questionnaire &#40;LWAQ&#41;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#8211;8</span></a> is a reliable and valid disease-specific health-related quality of life measure which was designed to assess patients with asthma&#46; This questionnaire was developed in the United Kingdom through focus groups discussions and standard psychometric techniques&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#8211;8</span></a> In a structured review of the literature on asthma-specific quality of life measures by Apfelbacher et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> the LWAQ was considered the most comprehensive questionnaire&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Validated versions of the LWAQ for the Japanese and<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> Norwegian<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> languages are already available&#46; However&#44; there was no Portuguese version available before the current study and&#44; in order to apply this questionnaire in Portugal&#44; a process of cross-cultural adaptation and validation was needed&#46; The aim of the present paper is to present the process followed by the authors to translate and culturally adapt the LWAQ to the Portuguese language and to test its reliability and validity in patients with asthma&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Cross-cultural adaptation</span><p id="par0020" class="elsevierStylePara elsevierViewall">The cross-cultural adaptation process of the LWAQ was conducted according to the sequential methodology&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">12&#44;13</span></a> The English LWAQ was translated into Portuguese independently by two Portuguese native translators&#46; The obtained translations were discussed in a first consensus panel to achieve the first preliminary version&#46; This consensus version was translated back to English independently by two English native translators without prior knowledge of the original version&#46; The translations and back translations were discussed in a second consensus panel and reviewed by four physicians &#40;specialists in pneumology and allergology&#41; to achieve a second preliminary version&#46; This consensus version was completed by a panel of 7 patients with asthma &#40;4 females&#44; 3 males&#59; age&#58; 44&#46;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>19&#46;9 years&#59; 3 only can read and write&#47;complete basic education level&#44; 4 complete secondary&#47;superior education level&#41; to verify if all items of the questionnaire were acceptable&#44; understandable&#44; and included all the expected concepts without any redundancy&#46; Patients were selected according to the criteria used in the validation study &#40;as specified in the next section&#41;&#46; This panel of patients was held to achieve the final version of Portuguese LWAQ questionnaire&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Validation study</span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Subjects</span><p id="par0025" class="elsevierStylePara elsevierViewall">The sample comprised consecutive patients with asthma referred for outpatient physical therapy from health care institutions across Castelo Branco during a 5-month period&#46; No attempt was made to standardize the physical therapy treatments&#46; Subjects were selected after obtaining informed consent and checking the inclusion and exclusion criteria&#46; To be included&#44; subjects had to have a diagnosis of asthma validated by a physician&#44; to be aged 18 years or older&#44; and to be referred for physical therapy intervention due to asthma&#46; Subjects were excluded if they had other respiratory disorders or any other disabling problem&#44; or if they were illiterate&#44; not knowing how to read and&#47;or write&#46; All outpatient health care institutions obtained approval from their respective review boards&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Measurements</span><p id="par0030" class="elsevierStylePara elsevierViewall">Measurements were performed at the above mentioned outpatient health care institutions&#46; For reproducibility purposes&#44; the subjects who agreed were assessed twice&#44; separated by a 72<span class="elsevierStyleHsp" style=""></span>h interval&#46; This time interval was chosen to minimize the probability of occurrence of relevant changes in patient&#39;s clinical condition&#46; Data was collected using the under mentioned patient self-reported measures&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The LWAQ<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#8211;8</span></a> includes 68 item that produce a total score but can also be combined to cover four constructs &#40;avoidance&#59; distress&#59; preoccupation&#59; activities&#41; and eleven domains &#40;social&#47;leisure&#59; sport&#59; holidays&#59; sleep&#59; work and other activities&#59; colds&#59; mobility&#59; effects on others&#59; medication&#59; sex&#59; dysphoric states&#41;&#46; A score&#44; from 0 &#40;very good health-related quality of life&#41; to 2 &#40;very poor health-related quality of life&#41;&#44; is separately produced for LWAQ total&#44; constructs and domains&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The SF-36<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">14&#8211;16</span></a> includes 36 items that are combined in eight subscales&#58; physical functioning&#44; role-physical&#44; bodily pain&#44; general health&#44; vitality&#44; social functioning&#44; role-emotional and mental health&#46; A score&#44; from 0 &#40;worst possible health status&#41; to 100 &#40;best possible health status&#41;&#44; is independently produced for each subscale&#46; The SF-36 was cross-culturally adapted and validated to the Portuguese language&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">17&#44;18</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">A form was used to acquire subject information on gender&#44; age and educational level&#46;</p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Statistical analyses</span><p id="par0050" class="elsevierStylePara elsevierViewall">Quantitative variables are described using mean and standard deviation values whereas categorical variables are described using frequency and percentage values&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Reliability&#46;</span> Internal consistency was measured using Cronbach&#39;s alpha coefficients&#46; A Cronbach&#39;s alpha coefficient between 0&#46;70 and 0&#46;95 received a positive rating&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> Reproducibility of the LWAQ total&#44; constructs and domains was assessed using intraclass correlation coefficients &#40;ICC&#41; for agreement&#44; formula 2&#46;1&#46; An ICC greater than or equal to 0&#46;70 received a positive rating&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Validity&#46;</span> Construct validity was investigated testing three predefined hypotheses involving expected significant correlations between LWAQ total&#44; constructs and domains&#44; and SF-36 dimensions with similar content&#58; &#40;1&#41; LWAQ total&#44; constructs and domains should present higher number of good to fair &#40;negative&#41; correlations with SF-36 physical functioning&#44; role-physical&#44; general health and vitality than for the other SF-36 dimensions&#59; &#40;2&#41; globally&#44; LWAQ total&#44; constructs and domains should present higher &#40;negative&#41; correlations with SF-36 general health than for the other SF-36 dimensions&#59; &#40;3&#41; LWAQ total&#44; constructs and domains should present higher number of little &#40;negative&#41; or none correlations with SF-36 bodily pain than for the other SF-36 dimensions&#46; Construct validity was analyzed using Spearman&#39;s correlation coefficients&#46; Spearman&#39;s correlation coefficients were interpreted as follows&#58; excellent relationship if higher than 0&#46;90&#59; good if between 0&#46;90 and 0&#46;71&#59; fair if between 0&#46;70 and 0&#46;51&#59; weak if between 0&#46;50 and 0&#46;31&#44; little or none if lower than or equal to 0&#46;30&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> A <span class="elsevierStyleItalic">p</span> value of 0&#46;05 was taken as the reference level of significance&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Statistical analyses were performed using SPSS 15&#46;0 for Windows&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Results</span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Cross-cultural adaptation</span><p id="par0070" class="elsevierStylePara elsevierViewall">The second preliminary version of the Portuguese LWAQ questionnaire was well accepted in the pre-test&#46; All the questions and response options were considered satisfactorily understandable by the subjects&#46; Even so&#44; in order to improve clarity&#44; minor rewording was made on three items&#44; based on patient&#39;s suggestions&#46; On the item 9 the sentence &#8220;o meu corpo irrita-me&#8221; &#40;Pt&#41;&#44; previously chosen as translation of &#8220;I feel angry with my body&#8221;&#44; was reworded to &#8220;o meu corpo incomoda-me&#8221; &#40;Pt&#41;&#46; On the items 28 and 37 the term &#8220;um monte&#8221; &#40;Pt&#41;&#44; previously chosen as translation of &#8220;a hill&#8221;&#44; was reworded to &#8220;uma ladeira&#47;subida&#8221; &#40;Pt&#41;&#46; The revised version was used in the validation study&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Validation study</span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Subjects</span><p id="par0075" class="elsevierStylePara elsevierViewall">The descriptive statistics are presented in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; A total of 61 patients were included in the internal consistency and construct validity assessment&#44; of which 31 &#40;50&#46;8&#37;&#41; were also included in the reproducibility assessment&#46; All patients had the disease controlled&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Reliability</span><p id="par0080" class="elsevierStylePara elsevierViewall">All of the reliability results are summarized in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Validity</span><p id="par0085" class="elsevierStylePara elsevierViewall">The three predefined hypotheses concerning construct validity were confirmed &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span></span></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Discussion</span><p id="par0090" class="elsevierStylePara elsevierViewall">The cross-cultural adaptation process was conducted successfully and resulted in a reasonably acceptable and understandable Portuguese version of the LWAQ&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">High Cronbach&#39;s alpha coefficients for most of the scores of the measure confirmed that the Portuguese LWAQ total&#44; constructs &#40;except preoccupation&#41; and domains &#40;except sleep and effects on others&#41; are internally consistent&#46; Even the LWAQ total&#44; which was above the acceptable value of 0&#46;95&#44; yielded a Cronbach&#39;s alpha coefficient of 0&#46;97&#46; Similar internal consistency findings were obtained by the Norwegian version of the LWAQ &#40;Cronbach&#39;s alpha coefficient of 0&#46;97&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">High ICC for all the scores of the measure revealed that the stability of the Portuguese LWAQ total&#44; constructs and domains over time was good&#46; Similar reproducibility findings were obtained by the original version of the LWAQ &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;95<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> and <span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;9<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a>&#41;&#44; by the Japanese version &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;81&#41;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> and by the Norwegian version &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;95&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">All predefined hypotheses involving expected significant correlations between LWAQ total&#44; constructs and domains&#44; and SF-36 dimensions &#40;with similar content&#41; were confirmed&#46; In fact&#44; LWAQ scores presented better correlations with the SF-36 dimensions that contribute to the physical component&#44; in particular the general health dimension&#44; than for the mental component&#46; The exception was the bodily pain dimension&#44; which is justified by the fact that pain is not the main symptom in asthma&#46; Other studies also provided evidence for construct validity of the LWAQ as indicated by factor analysis<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;10</span></a>&#44; known-groups comparisons<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;11</span></a>&#44; and associations with other existing measures<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;11</span></a>&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Some limitations of this study should be acknowledged&#46; The sample used is not representative of the entire population of Portuguese patients with asthma&#46; In fact&#44; only patients with asthma referred for physical therapy were recruited&#46; Further validation in other asthma populations is therefore advised&#46; Owing to practical reasons&#44; asthma severity and duration were not record&#46; Further validation studies should consider these variables&#46; The responsiveness of the Portuguese LWAQ was not tested&#46; More testing is needed in order to test this psychometric property&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Nevertheless&#44; we may conclude that the Portuguese LWAQ evidenced good reliability and validity for patients with asthma&#46;</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Ethical disclosures</span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Protection of human and animal subjects</span><p id="par0120" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study&#46;</p></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0145">Confidentiality of data</span><p id="par0125" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work center on the publication of patient data and that all the patients included in the study received sufficient information and gave their written informed consent to participate in the study&#46;</p></span><span id="sec0090" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0150">Right to privacy and informed consent</span><p id="par0130" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span></span><span id="sec0095" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0155">Conflicts of interest</span><p id="par0135" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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    "fechaAceptado" => "2013-02-08"
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            1 => "Health-related quality of life"
            2 => "Living with Asthma Questionnaire"
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        0 => array:4 [
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            1 => "Qualidade de vida relacionada com a sa&#250;de"
            2 => "Living with Asthma Questionnaire"
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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To translate and culturally adapt the Living with Asthma Questionnaire &#40;LWAQ&#41; to the Portuguese language and to test its reliability and validity&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The Portuguese version of this disease-specific health-related quality of life measure was obtained with forward&#47;backward translations&#44; consensus panels and a pre-test&#46; The Portuguese LWAQ and Medical Outcomes Study &#8211; 36 item Short Form &#40;SF-36&#41; questionnaires&#44; and a form for the characteristics of the patients were administered to 61 subjects with asthma&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Reliability of LWAQ scores was good with Cronbach&#39;s alpha coefficients ranging from 0&#46;70 to 0&#46;97 &#91;with the exception of &#8220;preoccupation&#8221; &#40;0&#46;62&#41; construct&#44; and &#8220;sleep&#8221; &#40;0&#46;67&#41; and &#8220;effects on others&#8221; &#40;0&#46;47&#41; domains&#93; and intraclass correlation coefficients between 0&#46;86 and 0&#46;99&#46; Construct validity was supported by the confirmation of predefined hypotheses involving expected significant correlations between LWAQ total&#44; constructs and domains&#44; and SF-36 dimensions with similar content&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The Portuguese LWAQ exhibited suitable psychometric properties&#44; in terms of internal consistency&#44; reproducibility and construct validity&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0035">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Traduzir e adaptar culturalmente o Living with Asthma Questionnaire &#40;LWAQ&#41; para a l&#237;ngua portuguesa e testar a sua fiabilidade e validade&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A vers&#227;o portuguesa desta medida de qualidade de vida relacionada com a sa&#250;de&#44; espec&#237;fica de doen&#231;a&#44; foi obtida atrav&#233;s de tradu&#231;&#245;es e retrovers&#245;es&#44; pain&#233;is de consenso e pr&#233;-teste&#46; A vers&#227;o portuguesa dos question&#225;rios LWAQ e Medical Outcomes Study - 36 item Short Form &#40;SF-36&#41;&#44; e um formul&#225;rio das caracter&#237;sticas dos doentes foram administrados a 61 asm&#225;ticos&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">A fiabilidade das pontua&#231;&#245;es do LWAQ foi considerada boa com coeficientes alfa de Cronbach a variarem entre 0&#44;70 e 0&#44;97 &#91;com exce&#231;&#227;o do constructo &#171;preocupa&#231;&#245;es&#187; &#40;0&#44;62&#41;&#44; e dos dom&#237;nios &#171;sono&#187; &#40;0&#44;67&#41; e &#171;efeitos nos outros&#187; &#40;0&#44;47&#41;&#93; e coeficientes de correla&#231;&#227;o intraclasse entre 0&#44;86 e 0&#44;99&#46; A validade de constru&#231;&#227;o foi suportada pela confirma&#231;&#227;o de hip&#243;teses predefinidas envolvendo as correla&#231;&#245;es esperadas entre os constructos&#44; dom&#237;nio e pontua&#231;&#227;o total do LWAQ&#44; e as dimens&#245;es do SF-36 com conceitos semelhantes&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0050">Conclus&#227;o</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">A vers&#227;o portuguesa do LWAQ apresentou caracter&#237;sticas psicom&#233;tricas adequadas em termos de coer&#234;ncia interna&#44; reprodutibilidade e validade de constru&#231;&#227;o&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0035">Please cite this article as&#58; Soles Gon&#231;alves R&#44; et al&#46; Adapta&#231;&#227;o cultural e valida&#231;&#227;o da vers&#227;o portuguesa do Living with Asthma Questionnaire&#46; Rev Port Pneumol&#46; 2013&#46; <span class="elsevierStyleInterRef" id="intr0005" href="doi:10.1016/j.rppneu.2013.02.002">http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1016&#47;j&#46;rppneu&#46;2013&#46;02&#46;002</span></p>"
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Age &#40;years&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35&#46;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>15&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">43&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>16&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Educational level</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Complete secondary&#47;superior education level</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36 &#40;59&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14 &#40;45&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">LWAQ scores &#40;points&#41;</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Total</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Constructs</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Avoidance&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Distress&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Preoccupation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Activities&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Domains</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Social&#47;leisure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Sport&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Holidays&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Sleep&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Work and other activities&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Colds&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Mobility&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Effects on others&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Medication&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Sex&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t">80&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>19&#46;0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Vitality&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">57&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>18&#46;8&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t">83&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>17&#46;3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">81&#46;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>18&#46;5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">80&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>19&#46;2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">75&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>18&#46;5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Mental health&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">71&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>18&#46;2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">70&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>17&#46;6&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;97<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">&#8225;</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;62<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">&#8224;</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;82&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#46;81&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;96 &#40;0&#46;91&#8211;0&#46;98&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Holidays &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;95 &#40;0&#46;90&#8211;0&#46;98&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sleep &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;67<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">&#8224;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;95 &#40;0&#46;90&#8211;0&#46;98&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Work and other activities &#40;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;83&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;97 &#40;0&#46;94&#8211;0&#46;99&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;95 &#40;0&#46;89&#8211;0&#46;97&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mobility &#40;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;83&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;99 &#40;0&#46;98&#8211;0&#46;99&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Effects on others &#40;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;47<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">&#8224;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;89 &#40;0&#46;79&#8211;0&#46;95&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Medication &#40;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;86 &#40;0&#46;74&#8211;0&#46;93&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sex &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;94 &#40;0&#46;87&#8211;0&#46;97&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Dysphoric states &#40;23&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;88&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;94 &#40;0&#46;87&#8211;0&#46;97&#41;&nbsp;\t\t\t\t\t\t\n
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          "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Spearman&#39;s correlation coefficients &#40;LWAQ is 0&#8211;2 points&#44; best to worst&#59; SF-36 is 0&#8211;100 points&#44; worst to best&#41;&#46;</p><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Good correlations in bold&#47;underline&#59; fair correlations in bold&#59; weak correlations in italic&#59; little or none correlations in regular&#46;</p>"
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Avoidance&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Distress&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Holidays&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Work and other activities&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Colds&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Mobility&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Effects on others&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Sex&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Dysphoric states&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="17" align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Physical functioning&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">&#8722;<span class="elsevierStyleUnderline">0&#46;77</span></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">&#8722;<span class="elsevierStyleUnderline">0&#46;74</span></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">&#8722;0&#46;62</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;<span class="elsevierStyleItalic">0&#46;43</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">&#8722;<span class="elsevierStyleUnderline">0&#46;78</span></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">&#8722;0&#46;69</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">&#8722;0&#46;59</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Vitality&nbsp;\t\t\t\t\t\t\n
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Journal Information
Vol. 19. Issue 4.
Pages 157-162 (July - August 2013)
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1080
Vol. 19. Issue 4.
Pages 157-162 (July - August 2013)
Original article
Full text access
Cross-cultural adaptation and validation of the Portuguese version of the Living with Asthma Questionnaire
Visits
1080
R. Soles Gonçalvesa,b,c,
Corresponding author
ruigoncalves@estescoimbra.pt

Corresponding author.
, L.M. Cavalheiroa,c, J. Neves Gila,c, A. Lima Rodriguesb, A. Pereira Coutinhob, G. Alves Henriquesb, P. Lopes Ferreirac,d
a Escola Superior de Tecnologia da Saúde de Coimbra, Instituto Politécnico de Coimbra, Coimbra, Portugal
b Escola Superior de Saúde Dr. Lopes Dias, Instituto Politécnico de Castelo Branco, Castelo Branco, Portugal
c Centro de Estudos e Investigação em Saúde, Universidade de Coimbra, Coimbra, Portugal
d Faculdade de Economia, Universidade de Coimbra, Coimbra, Portugal
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Tables (3)
Table 1. Characteristics of the subjects.
Table 2. Reliability of the LWAQ total, constructs and domains.
Table 3. Construct validity of the LWAQ total, constructs and domains (N=61).
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Abstract
Objective

To translate and culturally adapt the Living with Asthma Questionnaire (LWAQ) to the Portuguese language and to test its reliability and validity.

Methods

The Portuguese version of this disease-specific health-related quality of life measure was obtained with forward/backward translations, consensus panels and a pre-test. The Portuguese LWAQ and Medical Outcomes Study – 36 item Short Form (SF-36) questionnaires, and a form for the characteristics of the patients were administered to 61 subjects with asthma.

Results

Reliability of LWAQ scores was good with Cronbach's alpha coefficients ranging from 0.70 to 0.97 [with the exception of “preoccupation” (0.62) construct, and “sleep” (0.67) and “effects on others” (0.47) domains] and intraclass correlation coefficients between 0.86 and 0.99. Construct validity was supported by the confirmation of predefined hypotheses involving expected significant correlations between LWAQ total, constructs and domains, and SF-36 dimensions with similar content.

Conclusion

The Portuguese LWAQ exhibited suitable psychometric properties, in terms of internal consistency, reproducibility and construct validity.

Keywords:
Asthma
Health-related quality of life
Living with Asthma Questionnaire
Resumo
Objetivo

Traduzir e adaptar culturalmente o Living with Asthma Questionnaire (LWAQ) para a língua portuguesa e testar a sua fiabilidade e validade.

Métodos

A versão portuguesa desta medida de qualidade de vida relacionada com a saúde, específica de doença, foi obtida através de traduções e retroversões, painéis de consenso e pré-teste. A versão portuguesa dos questionários LWAQ e Medical Outcomes Study - 36 item Short Form (SF-36), e um formulário das características dos doentes foram administrados a 61 asmáticos.

Resultados

A fiabilidade das pontuações do LWAQ foi considerada boa com coeficientes alfa de Cronbach a variarem entre 0,70 e 0,97 [com exceção do constructo «preocupações» (0,62), e dos domínios «sono» (0,67) e «efeitos nos outros» (0,47)] e coeficientes de correlação intraclasse entre 0,86 e 0,99. A validade de construção foi suportada pela confirmação de hipóteses predefinidas envolvendo as correlações esperadas entre os constructos, domínio e pontuação total do LWAQ, e as dimensões do SF-36 com conceitos semelhantes.

Conclusão

A versão portuguesa do LWAQ apresentou características psicométricas adequadas em termos de coerência interna, reprodutibilidade e validade de construção.

Palavras-chave:
Asma
Qualidade de vida relacionada com a saúde
Living with Asthma Questionnaire
Full Text
Introduction

Asthma is one of the most common chronic diseases, affecting an estimated 300 million people worldwide.1 In a study by Sousa et al.,2 the prevalence of asthma in a Portuguese urban population was 10.2%, the mean age of asthmatics was 27.0 years and no significant difference in prevalence was found between males and females. This inflammatory disorder of the airways has an adverse impact on various dimensions of health and quality of life.3 Moreover, the socio-economic impact of asthma is substantial.4 Patient-based instruments are increasingly used to measure the outcomes of health care interventions since they provide evidence of the impact of a specific health condition from the viewpoint of the patient.5

The Living with Asthma Questionnaire (LWAQ)6–8 is a reliable and valid disease-specific health-related quality of life measure which was designed to assess patients with asthma. This questionnaire was developed in the United Kingdom through focus groups discussions and standard psychometric techniques.6–8 In a structured review of the literature on asthma-specific quality of life measures by Apfelbacher et al.,9 the LWAQ was considered the most comprehensive questionnaire.

Validated versions of the LWAQ for the Japanese and10 Norwegian11 languages are already available. However, there was no Portuguese version available before the current study and, in order to apply this questionnaire in Portugal, a process of cross-cultural adaptation and validation was needed. The aim of the present paper is to present the process followed by the authors to translate and culturally adapt the LWAQ to the Portuguese language and to test its reliability and validity in patients with asthma.

MethodsCross-cultural adaptation

The cross-cultural adaptation process of the LWAQ was conducted according to the sequential methodology.12,13 The English LWAQ was translated into Portuguese independently by two Portuguese native translators. The obtained translations were discussed in a first consensus panel to achieve the first preliminary version. This consensus version was translated back to English independently by two English native translators without prior knowledge of the original version. The translations and back translations were discussed in a second consensus panel and reviewed by four physicians (specialists in pneumology and allergology) to achieve a second preliminary version. This consensus version was completed by a panel of 7 patients with asthma (4 females, 3 males; age: 44.0±19.9 years; 3 only can read and write/complete basic education level, 4 complete secondary/superior education level) to verify if all items of the questionnaire were acceptable, understandable, and included all the expected concepts without any redundancy. Patients were selected according to the criteria used in the validation study (as specified in the next section). This panel of patients was held to achieve the final version of Portuguese LWAQ questionnaire.

Validation studySubjects

The sample comprised consecutive patients with asthma referred for outpatient physical therapy from health care institutions across Castelo Branco during a 5-month period. No attempt was made to standardize the physical therapy treatments. Subjects were selected after obtaining informed consent and checking the inclusion and exclusion criteria. To be included, subjects had to have a diagnosis of asthma validated by a physician, to be aged 18 years or older, and to be referred for physical therapy intervention due to asthma. Subjects were excluded if they had other respiratory disorders or any other disabling problem, or if they were illiterate, not knowing how to read and/or write. All outpatient health care institutions obtained approval from their respective review boards.

Measurements

Measurements were performed at the above mentioned outpatient health care institutions. For reproducibility purposes, the subjects who agreed were assessed twice, separated by a 72h interval. This time interval was chosen to minimize the probability of occurrence of relevant changes in patient's clinical condition. Data was collected using the under mentioned patient self-reported measures.

The LWAQ6–8 includes 68 item that produce a total score but can also be combined to cover four constructs (avoidance; distress; preoccupation; activities) and eleven domains (social/leisure; sport; holidays; sleep; work and other activities; colds; mobility; effects on others; medication; sex; dysphoric states). A score, from 0 (very good health-related quality of life) to 2 (very poor health-related quality of life), is separately produced for LWAQ total, constructs and domains.

The SF-3614–16 includes 36 items that are combined in eight subscales: physical functioning, role-physical, bodily pain, general health, vitality, social functioning, role-emotional and mental health. A score, from 0 (worst possible health status) to 100 (best possible health status), is independently produced for each subscale. The SF-36 was cross-culturally adapted and validated to the Portuguese language.17,18

A form was used to acquire subject information on gender, age and educational level.

Statistical analyses

Quantitative variables are described using mean and standard deviation values whereas categorical variables are described using frequency and percentage values.

Reliability. Internal consistency was measured using Cronbach's alpha coefficients. A Cronbach's alpha coefficient between 0.70 and 0.95 received a positive rating.19 Reproducibility of the LWAQ total, constructs and domains was assessed using intraclass correlation coefficients (ICC) for agreement, formula 2.1. An ICC greater than or equal to 0.70 received a positive rating.19

Validity. Construct validity was investigated testing three predefined hypotheses involving expected significant correlations between LWAQ total, constructs and domains, and SF-36 dimensions with similar content: (1) LWAQ total, constructs and domains should present higher number of good to fair (negative) correlations with SF-36 physical functioning, role-physical, general health and vitality than for the other SF-36 dimensions; (2) globally, LWAQ total, constructs and domains should present higher (negative) correlations with SF-36 general health than for the other SF-36 dimensions; (3) LWAQ total, constructs and domains should present higher number of little (negative) or none correlations with SF-36 bodily pain than for the other SF-36 dimensions. Construct validity was analyzed using Spearman's correlation coefficients. Spearman's correlation coefficients were interpreted as follows: excellent relationship if higher than 0.90; good if between 0.90 and 0.71; fair if between 0.70 and 0.51; weak if between 0.50 and 0.31, little or none if lower than or equal to 0.30.20 A p value of 0.05 was taken as the reference level of significance.

Statistical analyses were performed using SPSS 15.0 for Windows.

ResultsCross-cultural adaptation

The second preliminary version of the Portuguese LWAQ questionnaire was well accepted in the pre-test. All the questions and response options were considered satisfactorily understandable by the subjects. Even so, in order to improve clarity, minor rewording was made on three items, based on patient's suggestions. On the item 9 the sentence “o meu corpo irrita-me” (Pt), previously chosen as translation of “I feel angry with my body”, was reworded to “o meu corpo incomoda-me” (Pt). On the items 28 and 37 the term “um monte” (Pt), previously chosen as translation of “a hill”, was reworded to “uma ladeira/subida” (Pt). The revised version was used in the validation study.

Validation studySubjects

The descriptive statistics are presented in Table 1. A total of 61 patients were included in the internal consistency and construct validity assessment, of which 31 (50.8%) were also included in the reproducibility assessment. All patients had the disease controlled.

Table 1.

Characteristics of the subjects.

Characteristics  Total sample (N=61)  Reproducibility group (N=31)a 
Gender
Female  31 (50.8)  17 (54.8) 
Age (years)  35.0±15.8  43.1±16.5 
Educational level
Complete secondary/superior education level  36 (59.0)  14 (45.2) 
LWAQ scores (points)
Total  0.8±0.4  1.0±0.3 
Constructs
Avoidance  0.8±0.4  1.0±0.4 
Distress  0.6±0.4  0.8±0.4 
Preoccupation  1.1±0.3  1.2±0.3 
Activities  0.9±0.5  1.2±0.3 
Domains
Social/leisure  0.8±0.5  1.1±0.5 
Sport  0.8±0.6  1.1±0.6 
Holidays  0.8±0.6  1.0±0.6 
Sleep  0.8±0.4  1.0±0.4 
Work and other activities  1.0±0.5  1.2±0.5 
Colds  1.0±0.5  1.2±0.6 
Mobility  1.0±0.5  1.2±0.4 
Effects on others  0.5±0.4  0.7±0.4 
Medication  0.9±0.4  1.0±0.4 
Sex  0.3±0.5  0.3±0.5 
Dysphoric states  0.7±0.3  0.9±0.3 
SF-36 scores (points)
Dimensions
Physical functioning  71.1±20.4  63.4±19.9 
Role-physical  80.7±19.0  75.6±19.2 
Bodily pain  83.2±21.5  77.6±24.6 
General health  46.8±21.8  35.5±20.3 
Vitality  57.4±18.8  51.5±20.3 
Social functioning  83.8±17.3  81.0±18.5 
Role-emotional  80.5±19.2  75.5±18.5 
Mental health  71.9±18.2  70.2±17.6 

Quantitative variables: mean±standard deviation; Categorical variables: frequency (percentage).

a

Group where all subjects were assessed again 72h later.

Reliability

All of the reliability results are summarized in Table 2.

Table 2.

Reliability of the LWAQ total, constructs and domains.

LWAQ (number of items)  Cronbach's alpha coefficients [N=61]  Intraclass correlation coefficients (95% confidence intervals) [N=31]a 
Total (68)  0.97  0.97 (0.95–0.99) 
Constructs
Avoidance (18)  0.91  0.95 (0.91–0.98) 
Distress (19)  0.92  0.97 (0.93–0.98) 
Preoccupation (10)  0.62  0.90 (0.79–0.95) 
Activities (15)  0.92  0.99 (0.98–0.99) 
Domains
Social/leisure (6)  0.82  0.91 (0.82–0.96) 
Sport (3)  0.81  0.96 (0.91–0.98) 
Holidays (3)  0.70  0.95 (0.90–0.98) 
Sleep (4)  0.67  0.95 (0.90–0.98) 
Work and other activities (6)  0.83  0.97 (0.94–0.99) 
Colds (5)  0.74  0.95 (0.89–0.97) 
Mobility (6)  0.83  0.99 (0.98–0.99) 
Effects on others (5)  0.47  0.89 (0.79–0.95) 
Medication (6)  0.70  0.86 (0.74–0.93) 
Sex (1)  NA  0.94 (0.87–0.97) 
Dysphoric states (23)  0.88  0.94 (0.87–0.97) 
a

The questionnaire was completed twice, separated by 72h.

Cronbach's alpha coefficient lower than 0.70.

Cronbach's alpha coefficient higher than 0.95.

NA=not applicable.

Validity

The three predefined hypotheses concerning construct validity were confirmed (Table 3).

Table 3.

Construct validity of the LWAQ total, constructs and domains (N=61).

SF-36 scores (points)  LWAQ scores (points)
  Total  ConstructsDomains
    Avoidance  Distress  Preoccupation  Activities  Social/leisure  Sport  Holidays  Sleep  Work and other activities  Colds  Mobility  Effects on others  Medication  Sex  Dysphoric states 
Dimensions
Physical functioning  0.77  0.74  −0.62  0.43  0.78  −0.69  −0.59  −0.56  0.36  0.71  −0.63  0.78  0.40  0.50  0.33  −0.61 
Role-physical  0.71  0.73  −0.57  −0.56  −0.65  −0.69  0.42  −0.52  0.42  −0.66  −0.68  −0.64  0.32  −0.58  −0.18*  −0.60 
Bodily pain  −0.29  −0.29  0.34  −0.12*  −0.23*  0.32  −0.09*  −0.05*  −0.19*  −0.21*  −0.26  −0.25*  −0.22*  −0.30  −0.01*  0.32 
General heath  0.83  0.78  −0.67  −0.59  0.78  −0.68  −0.64  −0.58  −0.53  0.72  −0.66  0.74  0.45  −0.57  0.32  0.71 
Vitality  0.73  0.71  −0.68  0.48  −0.63  −0.60  0.46  −0.51  0.47  −0.60  −0.52  −0.61  −0.58  0.48  0.32  −0.69 
Social functioning  0.48  −0.51  0.48  0.35  0.41  0.47  −0.27  0.45  0.34  0.40  0.47  0.40  −0.25*  −0.27  −0.22*  −0.51 
Role-emotional  −0.53  −0.51  0.46  0.42  0.50  0.50  0.31  0.42  0.34  0.50  0.36  0.47  0.48  −0.25*  −0.18*  −0.55 
Mental health  −0.54  −0.51  −0.63  0.33  0.43  0.40  0.39  0.37  0.42  0.42  0.31  0.45  0.40  0.43  0.34  −0.61 

Spearman's correlation coefficients (LWAQ is 0–2 points, best to worst; SF-36 is 0–100 points, worst to best).

Good correlations in bold/underline; fair correlations in bold; weak correlations in italic; little or none correlations in regular.

*

Correlations not significant (p>0.05).

Discussion

The cross-cultural adaptation process was conducted successfully and resulted in a reasonably acceptable and understandable Portuguese version of the LWAQ.

High Cronbach's alpha coefficients for most of the scores of the measure confirmed that the Portuguese LWAQ total, constructs (except preoccupation) and domains (except sleep and effects on others) are internally consistent. Even the LWAQ total, which was above the acceptable value of 0.95, yielded a Cronbach's alpha coefficient of 0.97. Similar internal consistency findings were obtained by the Norwegian version of the LWAQ (Cronbach's alpha coefficient of 0.97).11

High ICC for all the scores of the measure revealed that the stability of the Portuguese LWAQ total, constructs and domains over time was good. Similar reproducibility findings were obtained by the original version of the LWAQ (r=0.956 and r=0.97), by the Japanese version (r=0.81)10 and by the Norwegian version (r=0.95).11

All predefined hypotheses involving expected significant correlations between LWAQ total, constructs and domains, and SF-36 dimensions (with similar content) were confirmed. In fact, LWAQ scores presented better correlations with the SF-36 dimensions that contribute to the physical component, in particular the general health dimension, than for the mental component. The exception was the bodily pain dimension, which is justified by the fact that pain is not the main symptom in asthma. Other studies also provided evidence for construct validity of the LWAQ as indicated by factor analysis8,10, known-groups comparisons6,11, and associations with other existing measures7,11.

Some limitations of this study should be acknowledged. The sample used is not representative of the entire population of Portuguese patients with asthma. In fact, only patients with asthma referred for physical therapy were recruited. Further validation in other asthma populations is therefore advised. Owing to practical reasons, asthma severity and duration were not record. Further validation studies should consider these variables. The responsiveness of the Portuguese LWAQ was not tested. More testing is needed in order to test this psychometric property.

Nevertheless, we may conclude that the Portuguese LWAQ evidenced good reliability and validity for patients with asthma.

Ethical disclosuresProtection of human and animal subjects

The authors declare that no experiments were performed on humans or animals for this study.

Confidentiality of data

The authors declare that they have followed the protocols of their work center on the publication of patient data and that all the patients included in the study received sufficient information and gave their written informed consent to participate in the study.

Right to privacy and informed consent

The authors declare that no patient data appear in this article.

Conflicts of interest

The authors have no conflicts of interest to declare.

Acknowledgements

The authors would like to thank the physical therapy staff from the outpatient health care institutions. In addition, the patients who participated in this study also deserve our deep gratitude.

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Please cite this article as: Soles Gonçalves R, et al. Adaptação cultural e validação da versão portuguesa do Living with Asthma Questionnaire. Rev Port Pneumol. 2013. http://dx.doi.org/10.1016/j.rppneu.2013.02.002

Copyright © 2012. Sociedade Portuguesa de Pneumologia
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