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Vol. 14. Issue 5.
Pages 687-692 (September - October 2008)
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Vol. 14. Issue 5.
Pages 687-692 (September - October 2008)
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Pertussis with severe pulmonary hypertension in a newborn with good outcome – case report
Infecção por Bordetella pertussis com hipertensão pulmonar grave num recém-nascido com boa evolução clínica – Caso clínico
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Sérgia Soares1, Gustavo Rocha1,
,
Corresponding author
gusrocha@oninet.pt

Correspondence: Serviço de Neonatologia / Departamento de Pediatria, Hospital de São João – Piso 2, Alameda Prof. Hernâni Monteiro, 4202 – 451 Porto, Portugal. Tel.: +351 225095816, Fax: +351225512273.
, Susana Pissarra1,*, Ana Carriço2, Inês Azevedo3,*, Joana Sobrinho Simões4, Hercília Guimarães1,5,*
1 Division of Neonatology, Department of Pediatrics
2 Division of Pediatric Cardiology, Department of Pediatrics
3 Unit of Pediatric Pulmonology, Department of Pediatrics
4 Molecular Biopathology Laboratory, Department of Clinical Pathology
5 Division of Neonatology – Hospital São João
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Abstract

In spite of the availability and widespread use of vaccines, pertussis is far from controlled. Newborns and infants too young to be fully vaccinated, born from mothers with low antibody titers to Bordetella pertussis, are highly susceptible to infection and at risk of severe disease and death. Pertussis associated with pulmonary hypertension in the newborn is often fatal. The authors report a clinical case of severe pertussis-induced respiratory failure associated to severe pulmonary hypertension in a neonate successfully treated with sildenafil and inhaled nitric oxide.

Key-words:
Neonate
nitric oxide
pertussis
pulmonary hypertension
sildenafil
Resumo

Apesar da ampla cobertura vacinal, a infecção por Bordetella pertussis está longe de estar controlada. Os recém-nascidos e lactentes ainda sem imunização completa e filhos de mães com baixos títulos de anticorpos para a Bordetella pertussis são altamente susceptíveis à infecção e têm maior risco de doença grave e morte. A infecção por Bordetella pertussis associada a hipertensão pulmonar no recém-nascido é frequentemente fatal. Os autores descrevem um caso clínico de doença grave num recém-nascido com insuficiência respiratória aguda e hipertensão pulmonar grave, tratado com sucesso com sildenafil e óxido nítrico inalado.

Palavras-chave:
Recém-nascido
oxido nítrico
pertussis
hipertensão pulmonar
sildenafil
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Faculty of Medicine of Porto University, Porto, Portugal

Copyright © 2008. Sociedade Portuguesa de Pneumologia
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