array:24 [
  "pii" => "S2531043720301227"
  "issn" => "25310437"
  "doi" => "10.1016/j.pulmoe.2020.05.006"
  "estado" => "S300"
  "fechaPublicacion" => "2021-05-01"
  "aid" => "1493"
  "copyright" => "Sociedade Portuguesa de Pneumologia"
  "copyrightAnyo" => "2020"
  "documento" => "article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "fla"
  "cita" => "Pulmonol. 2021;27:208-14"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S2531043720301409"
    "issn" => "25310437"
    "doi" => "10.1016/j.pulmoe.2020.06.006"
    "estado" => "S300"
    "fechaPublicacion" => "2021-05-01"
    "aid" => "1511"
    "copyright" => "Sociedade Portuguesa de Pneumologia"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "sco"
    "cita" => "Pulmonol. 2021;27:215-8"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Brief Communication</span>"
      "titulo" => "Alterations in central hemodynamic in patients with COPD after acute high intensity exercise"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "215"
          "paginaFinal" => "218"
        ]
      ]
      "contieneResumen" => array:1 [
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 3952
              "Ancho" => 1642
              "Tamanyo" => 308378
            ]
          ]
          "detalles" => array:1 [
            0 => array:3 [
              "identificador" => "at0005"
              "detalle" => "Figure "
              "rol" => "short"
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The relationships between central diastolic blood pressure and parameters of pulmonary function&#46; Central diastolic blood pressure &#40;cDBP&#41;&#44; forced expiratory volume-one second &#40;FEV<span class="elsevierStyleInf">1</span>&#41;&#44; forced expiratory flow between 25&#37; and 75&#37; of FVC &#40;FEF<span class="elsevierStyleInf">25&#8211;75</span>&#41;&#44; maximum voluntary ventilation &#40;MVV&#41;&#46; a&#41; The relationships between pre-exercise cDBP and pre-exercise FEV<span class="elsevierStyleInf">1</span> &#40;r&#8239;&#61;&#8239;&#8722;0&#46;499&#44; p&#8239;&#61;&#8239;0&#46;01&#41; and post-exercise cDBP and pre-exercise FEV<span class="elsevierStyleInf">1</span> &#40;r&#8239;&#61;&#8239;&#8722;0&#46;484&#44; p&#8239;&#61;&#8239;0&#46;02&#41;&#46; b&#41; The relationships between pre-exercise cDBP and pre-exercise FEF<span class="elsevierStyleInf">25&#8211;75</span> &#40;r&#8239;&#61;&#8239;&#8722;0&#46;530&#44; p&#8239;&#61;&#8239;0&#46;01&#41; and post-exercise cDBP and pre-exercise FEF<span class="elsevierStyleInf">25&#8211;75</span> &#40;r&#8239;&#61;&#8239;&#8722;0&#46;414&#44; p&#8239;&#61;&#8239;0&#46;04&#41;&#46; c&#41; The relationships between pre-exercise cDBP and pre-exercise MVV &#40;r&#8239;&#61;&#8239;&#8722;0&#46;349&#44; p&#8239;&#61;&#8239;0&#46;09&#41; and post-exercise cDBP and pre-exercise MVV &#40;r&#8239;&#61;&#8239;&#8722;0&#46;493&#44; p&#8239;&#61;&#8239;0&#46;01&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "M&#46; Behnia, C&#46;M&#46; Wheatley-Guy, B&#46;D&#46; Johnson, A&#46; Avolio, C&#46;-H&#46; Kim"
          "autores" => array:5 [
            0 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Behnia"
            ]
            1 => array:2 [
              "nombre" => "C&#46;M&#46;"
              "apellidos" => "Wheatley-Guy"
            ]
            2 => array:2 [
              "nombre" => "B&#46;D&#46;"
              "apellidos" => "Johnson"
            ]
            3 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Avolio"
            ]
            4 => array:2 [
              "nombre" => "C&#46;-H&#46;"
              "apellidos" => "Kim"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2531043720301409?idApp=UINPBA00004E"
    "url" => "/25310437/0000002700000003/v1_202105020809/S2531043720301409/v1_202105020809/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2531043720301392"
    "issn" => "25310437"
    "doi" => "10.1016/j.pulmoe.2020.06.005"
    "estado" => "S300"
    "fechaPublicacion" => "2021-05-01"
    "aid" => "1510"
    "copyright" => "Sociedade Portuguesa de Pneumologia"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Pulmonol. 2021;27:194-207"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
      "titulo" => "Cardio-pulmonary-exercise testing&#44; stress-induced right ventricular diastolic dysfunction and exercise capacity in non-severe chronic obstructive pulmonary disease"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "194"
          "paginaFinal" => "207"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:6 [
          "identificador" => "fig0025"
          "etiqueta" => "Fig&#46; 4"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr4.jpeg"
              "Alto" => 1640
              "Ancho" => 1515
              "Tamanyo" => 88837
            ]
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Radostina Vlaeva Cherneva, Stefan Veselinov Denchev, Zheina Vlaeva Cherneva"
          "autores" => array:3 [
            0 => array:3 [
              "preGrado" => "MD&#44; PhD"
              "nombre" => "Radostina Vlaeva"
              "apellidos" => "Cherneva"
            ]
            1 => array:3 [
              "preGrado" => "MD&#44; PhD"
              "nombre" => "Stefan Veselinov"
              "apellidos" => "Denchev"
            ]
            2 => array:3 [
              "preGrado" => "MD&#44; PhD"
              "nombre" => "Zheina Vlaeva"
              "apellidos" => "Cherneva"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2531043720301392?idApp=UINPBA00004E"
    "url" => "/25310437/0000002700000003/v1_202105020809/S2531043720301392/v1_202105020809/en/main.assets"
  ]
  "en" => array:19 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
    "titulo" => "Small airways&#8217; function in Obstructive Sleep Apnea-Hypopnea Syndrome"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "208"
        "paginaFinal" => "214"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "K&#46; Giannadaki, S&#46; Schiza, G&#46; Vavougios, V&#46; Ladopoulos, N&#46; Tzanakis, N&#46; Siafakas"
        "autores" => array:6 [
          0 => array:3 [
            "nombre" => "K&#46;"
            "apellidos" => "Giannadaki"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "S&#46;"
            "apellidos" => "Schiza"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "G&#46;"
            "apellidos" => "Vavougios"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "V&#46;"
            "apellidos" => "Ladopoulos"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "N&#46;"
            "apellidos" => "Tzanakis"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          5 => array:4 [
            "nombre" => "N&#46;"
            "apellidos" => "Siafakas"
            "email" => array:2 [
              0 => "siafak@med.uoc.gr"
              1 => "siafakan@uoc.gr"
            ]
            "referencia" => array:3 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              2 => array:2 [
                "etiqueta" => "&#42;"
                "identificador" => "cor0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:4 [
          0 => array:3 [
            "entidad" => "Department of Thoracic Medicine&#44; University Hospital of Heraklion&#44; Heraklion&#44; Crete&#44; Greece"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Sleep Disorders Center&#44; Medical School&#44; University of Crete&#44; Heraklion&#44; Crete&#44; Greece"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Department of Neurology&#44; Athens Naval Hospital and Scientific Research Associate&#44; University of Thessaly&#44; Larisa&#44; Greece"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "Foundation for Research and Technology Hellas&#44; Institute of Electronic Structure and Laser&#44; Heraklion&#44; Crete&#44; Greece"
            "etiqueta" => "d"
            "identificador" => "aff0020"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:8 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 2219
            "Ancho" => 3175
            "Tamanyo" => 131423
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0045"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Mean values &#40;&#177;SD&#41; of VisoV&#729;&#37; and &#916;V&#729;max50&#37; in control subjects and in patients with OSAHS&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Sleep is a complex&#44; active and in many ways a different condition from alertness&#46; During sleep&#44; the control of breathing is subject to an altered regulation&#46; In addition&#44; the mechanics of breathing change&#44; the resistance of the upper airways increases and the functional residual capacity decreases&#46; This reduction in lung volumes leads to an increased tendency towards upper airway obstruction and contributes to the reduction of flow during inhalation&#44; although the exact mechanisms of these findings have not been described in detail&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The most common sleep disorder-OSAHS-has been studied and reviewed extensively&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a> Among the important physiological traits causing OSAHS are&#58; &#40;1&#41; pharyngeal anatomy&#47;collapsibility&#44; &#40;2&#41; ventilatory control system gain &#40;loop gain&#41;&#44; &#40;3&#41; the ability of the upper airway to dilate&#47;stiffen in response to an increase in ventilator drive&#44; and &#40;4&#41; arousal threshold&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Although&#44; large and small airways are part of the same anatomical compartment of the lungs&#44; the studies of the pathophysiology of OSAHS have focused primarily on the function of the upper airways&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The aim of our study is to investigate the function of small airways in patients with OSAHS&#44; and to compare it with healthy controls&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">To the best of our knowledge&#44; this is the first investigation of the small airways in OSAHS showing that their function is affected&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Materials and methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Subjects</span><p id="par0025" class="elsevierStylePara elsevierViewall">23 subjects &#40;13 males&#44; 10 females&#59; mean age&#44; 51&#46;6 years&#41; with a diagnosis of mild to severe OSAHS&#44; without comorbidities and 8 controls &#40;3 males&#44; 5 females&#59; mean age&#44; 45&#46;9 years&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41; were included in the study&#46; Patients and controls were recruited at the Sleep Disorders Center of the Medical School of University of Crete from June 2013 to July 2014&#44; complaining of sleep-related symptoms&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">Subjects having any of the following were excluded from the study&#58;</p><p id="par0035" class="elsevierStylePara elsevierViewall">&#40;1&#41; Severe obesity &#40;Body Mass Index &#40;BMI&#41; &#62;40<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&#44; &#40;2&#41; Current smokers or ex-smokers &#62;30<span class="elsevierStyleHsp" style=""></span>pys&#44; &#40;3&#41; Patients with concomitant pulmonary disease &#40;e&#46;g&#46; Chronic Obstructive Pulmonary Disease &#40;COPD&#41;&#44; asthma&#44; interstitial lung disease&#44; active pulmonary tuberculosis&#44; &#40;4&#41; Patients previously diagnosed with sleep-related disorder&#44; &#40;5&#41; Patients who have clinically significant renal&#44; cardiovascular&#44; neurological&#44; endocrine&#44; immunological&#44; psychiatric&#44; gastrointestinal&#44; hepatic&#44; or hematological abnormalities&#44; &#40;6&#41; Pregnancy&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Protocol</span><p id="par0305" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">1&#46;</span><p id="par0040" class="elsevierStylePara elsevierViewall">Physical examination was performed and medical history was taken&#44; including sleep disorders symptoms&#46; The daytime somnolence was evaluated with the Epworth scale and measurements of&#58; Weight &#40;kg&#41; and Height &#40;m&#41; were performed&#46; The BMI &#40;kg&#47;m<span class="elsevierStyleSup">2</span>&#41; was calculated&#44; and the neck circumference &#40;cm&#41; was measured at the height of the cricothyroid cartilage&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">2&#46;</span><p id="par0045" class="elsevierStylePara elsevierViewall">Patients and control subjects underwent polysomnographic sleep study where the following parameters were recorded&#58; Electroencephalography&#44; Electrooculogram&#44; Electromyography in submental muscle and anterior tibia muscles bilaterally&#44; Electrocardiogram&#44; microphone should be placed over the trachea or on the side of the neck &#40;from AAST&#41;&#44; the detection of air flow with oral-nasal thermistor and pressure transducer&#44; oxyhemoglobin saturation by finger pulse oximeter&#44; the movement of thoracic and abdominal wall with special elastic belts of thorax and abdomen for the recording of the respiratory effort and body position&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">The diagnosis of OSAHS was established when the Apnea-Hypopnea Index &#40;AHI&#41; &#8805;5 and its severity was distinguished as&#58;<ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">&#8226;</span><p id="par0055" class="elsevierStylePara elsevierViewall">Mild&#58; 5<span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>AHI<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>15</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">&#8226;</span><p id="par0060" class="elsevierStylePara elsevierViewall">Moderate&#58; 15<span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>AHI<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>30</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">&#8226;</span><p id="par0065" class="elsevierStylePara elsevierViewall">Severe&#58; AHI<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>30</p></li></ul></p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">3&#46;</span><p id="par0070" class="elsevierStylePara elsevierViewall">Patients and controls underwent spirometry&#44; according to the ERS&#47;ATS guidelines&#44; in sitting and supine position&#46;</p></li></ul></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Assessment of small airways</span><p id="par0075" class="elsevierStylePara elsevierViewall">The small airways&#8217; function was assessed using the Helium-Oxygen flow&#8211;volume method&#46; The subject was seated and instructed to perform maximal expiratory flow-volume curves while breathing room air or a mixture of 80&#37; He and 20&#37; O2&#46; Flow-volume curves while breathing He-O2 were measured after the subject had breathed in at least three Vital Capacity &#40;VC&#41; inspirations of the He-O2 mixture &#40;heliox&#41;&#46; The two curves obtained from breathing room air and the He-O2 mixture&#44; were superimposed visually from Total Lung Capacity &#40;TLC&#41;&#46; A difference of less than 5&#37; in FVC between breathing room and the He-O2 mixture was considered acceptable &#40;the mean of our data was &#60;3&#37;&#41;&#46; When the V&#729;&#8722;V curves did not have identical FVC&#44; they were superimposed from Residual Volume &#40;RV&#41;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a> &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The volume at which the flow became identical was defined as VisoV&#8901;&#46; The VisoV&#8901; was expressed as a percentage of the Forced Vital Capacity &#40;FVC&#41;&#44; according to the method of Dosman and colleagues<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The value of &#916;V&#729;max50 was calculated from the equation &#916;V&#729;max50&#61;&#40;V&#8901;Emax50He&#8722;V&#8901;Emax50air&#47;V&#8901;Emax50air&#41;&#215;100&#44; and expressed as a percentage of V&#729;Emax50 while breathing room air&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Statistical analysis</span><p id="par0080" class="elsevierStylePara elsevierViewall">Descriptive analysis of the participants&#8217; characteristics was conducted&#46; The normality assumption of the continuous variables was assessed via the One Sample Kolmogorov &#8211; Smirnov Test and through graphical inspection&#46; Continuous variables are presented as mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>standard deviation &#40;SD&#41; or as median and 25th&#8211;75th percentiles&#46; Differences between continuous variables were assessed via the independent samples <span class="elsevierStyleItalic">T</span>-test and the independent Mann&#8211;Whitney <span class="elsevierStyleItalic">U</span> Test where appropriate&#46; Differences between categorical variables were assessed via the Fisher&#39;s exact test&#46; Linear regression analysis was used on the association of OSAHS with V&#729;isoV&#44; adjusted for BMI&#46; Wilcoxon matched-pairs signed-ranked test was used for comparison between sitting and supine posture&#46; For all tests&#44; a <span class="elsevierStyleItalic">p</span>-value<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05 was considered statistically significant&#46; All statistical tests were performed using the SPSS 22&#46;0 &#40;IBM Corporation&#44; Illinois&#44; US&#41; and Stata 13&#46;0 &#40;StataCorp&#44; College Station&#44; TX&#44; US&#41;&#46;</p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Results</span><p id="par0085" class="elsevierStylePara elsevierViewall">Demographic data&#44; smoking habits&#44; pulmonary function tests &#40;PFTs&#41;&#44; and sleep related parameters of the patients and control subjects&#44; are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Statistically significant differences between patient and controls&#44; were found regarding BMI&#44; Epworth Sleepiness Scale &#40;ESS&#41; and neck circumference &#40;<span class="elsevierStyleItalic">p</span>-value<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">The parameters of small airways&#8217; function are shown on <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0100" class="elsevierStylePara elsevierViewall">The mean values of the basic parameters of small airways&#8217; function &#40;VisoV&#729;&#37; and DV&#729;max50&#37; in patients and controls are shown in <a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#46; VisoV&#729; was statistically significantly increased in patients with OSAHS compared to controls &#40;18&#46;79<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9&#46;39 vs&#46; 4&#46;72<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;68&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;004&#41;&#46; OSAHS was significantly associated with higher VisoV&#729; &#91;beta &#40;95&#37; CI&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>12&#46;118 &#40;1&#46;51&#44; 22&#46;73&#41;&#93;&#44; independently of BMI&#46; No statistically significantly relationship was found between VisoV&#729; and ESS or neck circumference in OSAHS patients&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0105" class="elsevierStylePara elsevierViewall">&#916;V&#729;max50&#37; was not statistically significantly different &#123;26&#46;2 &#40;9&#46;1&#44; 55&#46;6&#41; vs&#46; 37&#46;2 &#40;29&#46;5&#44; 41&#46;8&#41;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;551&#125;&#44; although a trend to decrease was seen in patients&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Non-significant differences in the mean values of FVC&#44; Forced Expiratory Volume in 1<span class="elsevierStyleHsp" style=""></span>s &#40;FEV<span class="elsevierStyleInf">1</span>&#41;&#44; FEV<span class="elsevierStyleInf">1</span>&#47;FVC&#44; Maximal &#40;mid-&#41; Expiratory Flow at 25&#8211;75&#37; of FVC &#40;MMEF<span class="elsevierStyleInf">25&#8211;75</span>&#41; and Maximal &#40;mid-&#41; Expiratory Flow at 50&#37; of FVC &#40;MMEF<span class="elsevierStyleInf">50</span>&#41; were found between patients with OSAHS and the controls in sitting position &#40;<a class="elsevierStyleCrossRefs" href="#tbl0005">Tables 1 and 2</a>&#41;&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">In patients with OSAHS&#44; the mean values of pulmonary function tests in supine position had significantly decreased statistically from their values in sitting position &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Discussion</span><p id="par0120" class="elsevierStylePara elsevierViewall">Small airways are the peripheral membranous bronchioles&#44; 2<span class="elsevierStyleHsp" style=""></span>mm less in diameter&#46; They make up a very large area which is difficult to approach functionally&#44; clinically and therapeutically&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;8</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">The main finding of the present study is that small airways&#8217; function is affected in OSAHS&#44; as the VisoV&#729; increases&#44; despite normal baseline spirometric values&#46; These findings&#44; to the best of our knowledge&#44; are reported for the first time&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">The pathogenesis of OSAHS is multifactorial&#59; anatomical and functional changes of the upper airway and its musculature result in partial or complete and recurrent obstructions of the upper airway during sleep&#46; Anatomical changes contribute to the reduction of the diameter of the upper airway while the functional changes to the increased collapsibility and susceptibility to obstruction and these changes may interact&#44; i&#46;e&#46;&#44; the structural changes affect the functional ones and vice versa&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">It is well known&#44; that during sleep the pattern of breathing is variable and that sleep stages significantly affect this pattern&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> In addition&#44; in OSAHS it is reported that lung volumes may continuously vary during NREM sleep and this may contribute to passive collapse of the upper airways&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> However&#44; during sleep&#44; the common finding is the reduction of FRC or the End Expiratory Lung Volume &#40;EELV&#41;&#44; even if it fluctuates&#46; Breathing at low lung volumes results in reduction of the elastic restoring force of the lungs &#40;elastic recoil&#41; and reduces radial traction exerted by the lung parenchyma on the airways to keep them open with reduced flow resistances&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> This occurs even in normal sleeping subjects and may be enhanced abnormally in sleeping disorders&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0140" class="elsevierStylePara elsevierViewall">Additionally&#44; in obese subjects with OSAHS&#44; it has been shown that reduced pulmonary volumes&#44; secondarily lead to narrowing and obstruction of the upper airways&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> Jordan et al showed that when genioglossus muscle fails to stabilize breathing in OSAHS&#44; this may be related to reduced lung volume&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a></p><p id="par0145" class="elsevierStylePara elsevierViewall">Therefore&#44; the majority of the pathophysiological studies have focused on the collapsibility of the upper airways&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">In contrast&#44; our study found an affected function at the site of the small airways&#46; We speculate that this could be due to opening and closure of the small airways caused by the abrupt changes in the airway pressure at low lung volumes&#46; It is well known&#44; that during the obstruction of the upper airways the airway pressure increases in order to reopen the collapsed site and to initiate inspiratory flow&#46; When this has been achieved&#44; a significant and abrupt drop in the airway pressure is seen&#46; These changes in airway pressure are transmitted into the whole respiratory system and may cause collapsibility and flapping at the site of the membranous small airways&#46; In support of this argument there are studies in animals showing that ventilation at low lung volumes leads to an abnormal successive opening and closure of small airways&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> Such periodic continuous occlusion and opening&#44; creates conditions for inflammation and oxidative stress in the regions of the final bronchioles and alveolar sacks&#44; which means destruction of lung parenchyma&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a></p><p id="par0155" class="elsevierStylePara elsevierViewall">In 2002&#44; D&#8217;Angelo E&#44; Milic-Emili J et al&#44; reported that small-volume ventilation causes peripheral airway injury and increases airway resistance in normal rabbits and this is probably due to cyclic opening and closing of the peripheral airways&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a></p><p id="par0160" class="elsevierStylePara elsevierViewall">In addition&#44; Yalcin HC et al&#44; in an in vitro model of airway reopening showed significant epithelial cell injury&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> Moreover&#44; Zerah-Lancner et al&#44; found a significant decrease in the FEV<span class="elsevierStyleInf">1</span>&#47;FVC ratio&#44; in the V<span class="elsevierStyleInf">50</span> and V<span class="elsevierStyleInf">25</span>&#44; as the severity of OSAHS increases&#44; in 170 patients undergoing a sleep study&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a></p><p id="par0165" class="elsevierStylePara elsevierViewall">Baydur et al&#44; showed expiratory flow limitation in COPD and OSAHS patients&#44; but their results could not distinguish the two cohorts&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a></p><p id="par0170" class="elsevierStylePara elsevierViewall">Finally&#44; in agreement with our results are those of Abdeyrim et al and Cai et al who used the impulse oscillation technique to show that the peripheral airway resistance increased in obese OSAS patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">20&#44;21</span></a> Moreover&#44; Abdeyrim et al showed that Reactance at 5<span class="elsevierStyleHsp" style=""></span>Hz correlated with peripheral airway resistance and with the decreased FRC&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a></p><p id="par0175" class="elsevierStylePara elsevierViewall">In addition&#44; Avraam et al reported that reductions in FVC while supine and with increased body weight may contribute to worsening of OSAHS&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a></p><p id="par0180" class="elsevierStylePara elsevierViewall">In accordance with these studies&#44; our results show a significant decrease in patient pulmonary function values in supine position from the sitting&#44; &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41; which strengthens our argument that breathing at low lung volumes may affect negatively small airways function&#46;</p><p id="par0185" class="elsevierStylePara elsevierViewall">Moreover&#44; Heinzer et al showed that the increase in pulmonary volumes reduces sleep disturbances and improves sleep architecture in patients with OSAHS during non-REM sleep&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a></p><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Review and critique of the method</span><p id="par0190" class="elsevierStylePara elsevierViewall">In 1974&#44; Hutheon et al introduced the volume of isoflow as a new test for the detection of small-airway dysfunction&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> During the terminal 10&#37; to 15&#37; of VC&#44; the flow rates during helium-oxygen and air breathing are identical&#59; this is the volume of isoflow point&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> The isoflow phenomenon is seen because flow in the small airways is laminar and so independent of gas density&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a>VisoV&#729; is expressed as a percent of VC and occurs in normal nonsmoking subjects at 10&#37; to 15&#37; of VC from RV&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a> The reduction in radius is making the phenomenon of laminar flow to accurate at higher lung volumes &#40;increase in VisoV&#729;&#41; and this is considered as a malfunction of small airways&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a></p><p id="par0195" class="elsevierStylePara elsevierViewall">Despas et al reported that early manifestation of peripheral airway obstruction can be detected in patients with mild asthma using the He-O<span class="elsevierStyleInf">2</span> mixture&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Moreover&#44; Dosman et al showed that the use of Heliox during a maximal expiratory flow-volume maneuver was capable of detecting functional abnormalities in smokers at a stage when spirometric indices were within the normal range&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0200" class="elsevierStylePara elsevierViewall">This technique has been used by Siafakas et al to investigate small airways&#8217; function in acromegaly&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a> It has been also used by our department&#44; for the investigation of small airways&#8217; function in non-respiratory diseases such as inflammatory bowel diseases&#44; with interesting results&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">29</span></a> In agreement with the present study they found alterations only in the VisoV&#729; index and not in the &#916;V&#729;max50 and considered that &#916;V&#729;max50 could not be a sensitive index for the early detection of small airway dysfunction&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">30</span></a></p><p id="par0205" class="elsevierStylePara elsevierViewall">It is well known that&#44; the small airways of the lung&#44; the so-called &#8220;quiet zone&#8221;&#44;<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">30&#44;31</span></a> is a difficult anatomical area to approach and therefore for studying its function&#46; Multiple methods have been proposed to study this area of the lung&#44; including complicated and invasive techniques&#46; Nevertheless&#44; there is a lack of a globally acceptable methodology to investigate small airways&#46;<a class="elsevierStyleCrossRefs" href="#bib0160"><span class="elsevierStyleSup">32&#44;33</span></a></p><p id="par0210" class="elsevierStylePara elsevierViewall">There are some studies that criticize density-dependence tests for their variability and their validity for detecting narrowing of the small airways&#44;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">34</span></a> however the majority agree that those tests correlate well with the small airways function&#46;<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">35&#44;36</span></a></p><p id="par0215" class="elsevierStylePara elsevierViewall">Although&#44; BMI was statistically different between the two groups&#44; regression analysis showed that VisoV&#729; was statistically higher in OSAHS patients&#44; independently of BMI&#46; Similarly&#44; Abdeyrim et al reported that FRC and Expiratory Reserve Volume reductions were independent from BMI in OSAHS patients&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a></p><p id="par0220" class="elsevierStylePara elsevierViewall">Limitation of our study is the quite small sample size&#46; Only 23 patients with OSAHS were studied and 8 controls&#46; However&#44; the results of VisoV&#729; clearly separated patients from controls &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><p id="par0225" class="elsevierStylePara elsevierViewall">Finally&#44; preliminary results have shown a trend towards improvement in small airways parameters in OSAHS patients after therapy with CPAP&#46; Thus&#44; it would be worth investigating the effects of treatment of OSAHS on the function of small airways in the future&#46;</p></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Conclusions</span><p id="par0230" class="elsevierStylePara elsevierViewall">The main finding of the present study is that patients with OSAHS showed a dysfunction of the small airways&#44; since the VisoV&#729; index was increased&#44; despite their normal baseline spirometric values&#46;</p><p id="par0235" class="elsevierStylePara elsevierViewall">This is probably due to the reduction of the lung volumes&#44; the cycle opening and closure of the small airways and subsequent inflammation and oxidant stress&#46;</p><p id="par0240" class="elsevierStylePara elsevierViewall">The function of the small airways may affect the natural history of OSAHS and these findings could lead to new therapeutic implications&#46; However&#44; larger studies are needed to verify our results&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Compliance with ethical standards</span><p id="par0245" class="elsevierStylePara elsevierViewall">This study was supported by an unrestricted grant to University of Crete by Elpen Hellas&#44; with no other involvement in the study&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Ethical approval</span><p id="par0250" class="elsevierStylePara elsevierViewall">All procedures performed in the study were in accordance with the ethical standards of the Research Ethics and Deontology Committee of the University of Crete&#44; and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards&#46;</p><p id="par0255" class="elsevierStylePara elsevierViewall">All subjects have signed an Informed Consent Form prior to any investigation&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Authors contributions</span><p id="par0260" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">KG&#58;</span> She was involved in all parts of this work&#44; the design of the study&#44; the experiments&#44; the analysis of the data&#44; and the interpretation of the results&#44; the drafting and writing of the manuscript&#46;</p><p id="par0265" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">SS&#58;</span> Contributed in the design of the study&#44; in the analysis of the data and supervised the polysomnographic sleep studies&#46;</p><p id="par0270" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">GV&#58;</span> Contributed in the acquisition and the analysis of the data and in their statistical interpretation&#46;</p><p id="par0275" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">VL&#58;</span> He was involved in the design of the study&#44; in the analysis of the data and supervised the Heliox experiments&#46;</p><p id="par0280" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">NT&#58;</span> contributed in the design of the study&#44; organized the Heliox experiments and was involved in the analysis of the data&#46;</p><p id="par0285" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">NS&#58;</span> He is the senior investigator of the study involved in all aspects&#58; design&#44; analysis&#44; interpretation of the results and supervised the writing of the manuscript&#46;</p><p id="par0290" class="elsevierStylePara elsevierViewall">All authors have read and approved the final manuscript&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Conflicts of interest</span><p id="par0295" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflict of interest&#46;</p><p id="par0300" class="elsevierStylePara elsevierViewall">The authors have no relationship with the tobacco industry or its affiliates and subsidiaries that benefited any of the manuscript authors or the tobacco industry in its promotion of tobacco products&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:12 [
        0 => array:3 [
          "identificador" => "xres1505799"
          "titulo" => "Abstract"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0005"
              "titulo" => "Introduction and objectives"
            ]
            1 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Materials and methods"
            ]
            2 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "Results"
            ]
            3 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Conclusions"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec1366511"
          "titulo" => "Keywords"
        ]
        2 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        3 => array:3 [
          "identificador" => "sec0010"
          "titulo" => "Materials and methods"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "sec0015"
              "titulo" => "Subjects"
            ]
            1 => array:2 [
              "identificador" => "sec0020"
              "titulo" => "Protocol"
            ]
            2 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Assessment of small airways"
            ]
            3 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "Statistical analysis"
            ]
          ]
        ]
        4 => array:2 [
          "identificador" => "sec0035"
          "titulo" => "Results"
        ]
        5 => array:3 [
          "identificador" => "sec0040"
          "titulo" => "Discussion"
          "secciones" => array:1 [
            0 => array:2 [
              "identificador" => "sec0045"
              "titulo" => "Review and critique of the method"
            ]
          ]
        ]
        6 => array:2 [
          "identificador" => "sec0050"
          "titulo" => "Conclusions"
        ]
        7 => array:2 [
          "identificador" => "sec0055"
          "titulo" => "Compliance with ethical standards"
        ]
        8 => array:2 [
          "identificador" => "sec0060"
          "titulo" => "Ethical approval"
        ]
        9 => array:2 [
          "identificador" => "sec0065"
          "titulo" => "Authors contributions"
        ]
        10 => array:2 [
          "identificador" => "sec0070"
          "titulo" => "Conflicts of interest"
        ]
        11 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2020-03-17"
    "fechaAceptado" => "2020-05-17"
    "PalabrasClave" => array:1 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1366511"
          "palabras" => array:5 [
            0 => "Sleep disorders"
            1 => "Lung mechanics"
            2 => "Physiology"
            3 => "Isoflow"
            4 => "Heliox"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:1 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction and objectives</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Most of the studies of the pathophysiology of Obstructive Sleep Apnea-Hypopnea Syndrome &#40;OSAHS&#41; focus on the collapsibility and obstruction of the upper airways&#46; The aim of our study was the investigation of small airways&#8217; function in patients with OSAHS&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Materials and methods</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">We studied 23 patients &#40;mean age&#44; 51&#46;6 years&#41; diagnosed with mild to severe OSAHS&#44; without comorbidities and 8 controls &#40;mean age&#44; 45&#46;9 years&#41;&#46; All subjects underwent full polysomnography sleep study&#59; spirometry and maximum flow&#47;volume curves while breathing room air and a mixture of 80&#37;He-20&#37;O<span class="elsevierStyleInf">2</span>&#46; The volume of equal flows &#40;VisoV&#8901;&#41; of the two curves and the difference of flows at 50&#37; of FVC &#40;&#916;V&#729;max50&#41; were calculated&#44; as indicates of small airways&#8217; function&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">The results showed that VisoV&#8901; was significantly increased in patients with OSAHS compared with controls &#40;18&#46;79<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9&#46;39 vs&#46; 4&#46;72<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;68&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;004&#41;&#46; No statistically significantly difference was found in &#916;V&#729;max50&#37; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;551&#41;&#59; or the maximum Expiratory flow at 25&#8211;75&#37; of FVC &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;067&#41; and the maximum expiratory flow at 50&#37; of FVC &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;174&#41; breathing air&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">We conclude that at the time of the diagnosis of OSAHS&#44; the function of the small airways is affected&#46; This could be due to breathing at low lung volumes and the cyclic closure&#47;opening of the small airways and may affect the natural history of OSAHS&#46; The findings could lead to new therapeutic implications&#44; targeting directly the small airways&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Introduction and objectives"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Materials and methods"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusions"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#8902;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Preliminary results of this study have been previously reported&#44; as an abstract&#44; at the ERS International Congress 2017 Eur Resp J 2017 50&#58; PA2309&#46;</p>"
      ]
    ]
    "multimedia" => array:5 [
      0 => array:8 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1223
            "Ancho" => 3167
            "Tamanyo" => 395992
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0040"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A&#46; Forced expiratory flow-volume curves on breathing air &#40;blue curve&#41; and the mixture 80&#37; He and 20&#37; O2 &#40;red curve&#41; in a control subject&#46; B&#46; Same as A of a typical OSAHS patient&#46;</p> <p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Green lines show the point at where the two curves coincide &#40;VisoV&#729;&#41;&#46;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 2219
            "Ancho" => 3175
            "Tamanyo" => 131423
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0045"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Mean values &#40;&#177;SD&#41; of VisoV&#729;&#37; and &#916;V&#729;max50&#37; in control subjects and in patients with OSAHS&#46;</p>"
        ]
      ]
      2 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0050"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">AHI&#58; Apnea-Hypopnea Index&#44; ESS&#58; Epworth Sleepiness Scale&#44; BMI&#58; Body Mass Index&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Patients &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>23&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Controls &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>-Value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sex&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;433&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13 &#40;56&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;37&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 &#40;43&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;62&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Age&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">51&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">45&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>15&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;310&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Smoking&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;676&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ex<span class="elsevierStyleBold">-</span>smokers&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;39&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;25&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nonsmokers&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14 &#40;60&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;75&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ESS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;020&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">BMI <span class="elsevierStyleBold">&#40;</span>kg<span class="elsevierStyleBold">&#47;</span>m<span class="elsevierStyleSup"><span class="elsevierStyleBold">2</span></span><span class="elsevierStyleBold">&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">31&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;003&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Neck circumference<span class="elsevierStyleBold">&#40;</span>cm<span class="elsevierStyleBold">&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40&#46;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;036&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mild OSAHS &#40;5&#8804;AHI<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;21&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Moderate OSHAS &#40;15&#8804;AHI<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>30&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 &#40;43&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Severe OSHAS &#40;AHI&#8805;30&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;34&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">FEV<span class="elsevierStyleInf"><span class="elsevierStyleBold">1</span></span><span class="elsevierStyleBold">&#40;</span>L<span class="elsevierStyleBold">&#47;</span>min<span class="elsevierStyleBold">&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">93&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">104&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>11&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;070&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">FVC <span class="elsevierStyleBold">&#40;</span>L<span class="elsevierStyleBold">&#47;</span>min<span class="elsevierStyleBold">&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">97&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>15&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">106&#46;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>14&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;262&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">FEV<span class="elsevierStyleInf"><span class="elsevierStyleBold">1</span></span><span class="elsevierStyleBold">&#47;</span>FVC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">79&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">84&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;062&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2586797.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Characteristics of patients and controls subjects&#46;</p>"
        ]
      ]
      3 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0055"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Patients &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>23&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Controls &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>-Value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">MMEF<span class="elsevierStyleInf"><span class="elsevierStyleBold">25&#8211;75</span></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">77&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>25&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>16&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;067&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">MEF<span class="elsevierStyleInf"><span class="elsevierStyleBold">50</span></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">86&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>28&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">103&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>21&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;174&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">VisoV&#729;&#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&#916;V&#729;max50&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&#46;2 &#40;9&#46;1&#44; 55&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">37&#46;2 &#40;29&#46;5&#44; 41&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;551&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2586798.png"
              ]
            ]
          ]
          "notaPie" => array:1 [
            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Values are presented as Median &#40;25th&#44; 75th percentile&#41;&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Parameters of small airways&#8217; function in patients and control subjects in sitting position&#46;</p>"
        ]
      ]
      4 => array:8 [
        "identificador" => "tbl0015"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0060"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Wilcoxon matched-pairs signed-ranked test&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Sitting position&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Supine position&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>-Value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">FEV<span class="elsevierStyleInf">1</span> &#40;L&#47;min&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">92&#46;5 &#40;87&#46;0&#44; 101&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">85&#46;5 &#40;74&#46;0&#44; 98&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;0021&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">FVC &#40;L&#47;min&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">95&#46;0 &#40;91&#46;0&#44; 109&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">91&#46;0 &#40;79&#46;0&#44; 99&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">FEV<span class="elsevierStyleInf">1</span>&#47;FVC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">80&#46;0 &#40;78&#46;5&#44; 81&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">78&#46;6 &#40;71&#46;7&#44; 83&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">MMEF<span class="elsevierStyleInf">25-75</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">74&#46;0 &#40;58&#46;0&#44; 98&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">63&#46;5 &#40;50&#46;0&#44; 82&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;0039&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">MEF<span class="elsevierStyleInf">50</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">86&#46;0 &#40;64&#46;0&#44; 108&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">86&#46;5 &#40;58&#46;0&#44; 91&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;0157&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2586796.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Pulmonary function tests in sitting and supine position&#44; in patients&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:36 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Progressive changes in airway resistance during sleep"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46; Kay"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1152/jappl.1996.81.1.282"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Appl Physiol"
                        "fecha" => "1996"
                        "volumen" => "81"
                        "paginaInicial" => "282"
                        "paginaFinal" => "292"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8828676"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Decrease in functional residual capacity during sleep in normal humans"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46;W&#46; Hudgel"
                            1 => "P&#46; devadatta"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1152/jappl.1984.57.5.1319"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Appl Physiol"
                        "fecha" => "1984"
                        "volumen" => "57"
                        "paginaInicial" => "1319"
                        "paginaFinal" => "1322"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6520027"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Obstuctive sleep apnea"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46;B&#46; Fogel"
                            1 => "D&#46;P&#46; White"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Adv Intern Med"
                        "fecha" => "2000"
                        "volumen" => "45"
                        "paginaInicial" => "351"
                        "paginaFinal" => "389"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10635055"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A method for measuring and modeling the physiological traits causing obstructive sleep apnea"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;S&#46; Jordan"
                            1 => "D&#46;P&#46; White"
                            2 => "Y&#46;L&#46; Lo"
                            3 => "A&#46; Wellman"
                            4 => "D&#46;J&#46; Eckert"
                            5 => "S&#46; Yim-Yeh"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1152/japplphysiol.00972.2010"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Appl Physiol"
                        "fecha" => "2011"
                        "volumen" => "110"
                        "paginaInicial" => "1627"
                        "paginaFinal" => "1637"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21436459"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Site of airway obstruction in asthma as determined by measuring maximal expiratory flow breathing air and a helium-oxygen mixture"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46;J&#46; Despas"
                            1 => "M&#46; Lenoux"
                            2 => "P&#46;T&#46; Macklem"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1172/JCI107150"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Invest"
                        "fecha" => "1972"
                        "volumen" => "51"
                        "paginaInicial" => "3235"
                        "paginaFinal" => "3243"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4640957"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The use of a helium-oxygen mixture during maximum expiratory flow to demonstrate obstruction in small airways in smokers"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46; Dosman"
                            1 => "F&#46;R&#46; Bode"
                            2 => "J&#46; Urbanetti"
                            3 => "R&#46;R&#46; Martin"
                            4 => "P&#46;T&#46; Macklem"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1172/JCI108010"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin invest"
                        "fecha" => "1975"
                        "volumen" => "55"
                        "paginaInicial" => "1090"
                        "paginaFinal" => "1099"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16695964"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pathophysiology of the small airways"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46; Baraldo"
                            1 => "M&#46; Saetta"
                            2 => "M&#46;G&#46; Cosio"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Semin Respir Crit Care Med"
                        "fecha" => "2003"
                        "volumen" => "24"
                        "paginaInicial" => "465"
                        "paginaFinal" => "472"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Treating the small airways"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "O&#46;S&#46; Usmani"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000343629"
                      "Revista" => array:6 [
                        "tituloSerie" => "Respiration"
                        "fecha" => "2012"
                        "volumen" => "84"
                        "paginaInicial" => "441"
                        "paginaFinal" => "453"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23154684"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Partitioning of pulmonary resistance in the dog"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "P&#46;T&#46; Macklem"
                            1 => "A&#46;J&#46; Woolcock"
                            2 => "C&#46; Hogg"
                            3 => "J&#46;A&#46; Nadel"
                            4 => "N&#46;J&#46; Wilson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1152/jappl.1969.26.6.798"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Appl Physiol"
                        "fecha" => "1969"
                        "volumen" => "26"
                        "paginaInicial" => "798"
                        "paginaFinal" => "805"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5786411"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Respiration during sleep in normal man"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "N&#46;J&#46; Douglas"
                            1 => "D&#46;P&#46; White"
                            2 => "C&#46;K&#46; Pickett"
                            3 => "J&#46;V&#46; Weil"
                            4 => "C&#46;W&#46; Zwillich"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/thx.37.11.840"
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "1982"
                        "volumen" => "37"
                        "paginaInicial" => "840"
                        "paginaFinal" => "844"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7164002"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Changes in end-expiratory lung volume during sleep in patients with occlusive apnea"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46;M&#46; Aronson"
                            1 => "C&#46;G&#46; Alex"
                            2 => "E&#46; Onal"
                            3 => "M&#46; Lopata"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1152/jappl.1987.63.4.1642"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Appl Physiol"
                        "fecha" => "1985"
                        "volumen" => "63"
                        "paginaInicial" => "1642"
                        "paginaFinal" => "1647"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3693200"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pulmonary function and sleep apnea"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "V&#46; Hoffstein"
                            1 => "Z&#46; Oliver"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s11325-003-0159-8"
                      "Revista" => array:6 [
                        "tituloSerie" => "Sleep Breath"
                        "fecha" => "2003"
                        "volumen" => "7"
                        "paginaInicial" => "159"
                        "paginaFinal" => "165"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14710335"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lung volume dependence of pharyngeal cross-sectional area in patients with obstructive sleep apnea"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "V&#46; Hoffstein"
                            1 => "N&#46; Zamel"
                            2 => "A&#46;E&#46; Phillipson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/arrd.1984.130.2.175"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1984"
                        "volumen" => "130"
                        "paginaInicial" => "175"
                        "paginaFinal" => "178"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6465671"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Airway dilator muscle activity and lung volume during stable breathing in obstructive sleep apnea"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;S&#46; Jordan"
                            1 => "D&#46;P&#46; White"
                            2 => "Y&#46;L&#46; Lo"
                            3 => "A&#46; Wellman"
                            4 => "D&#46;J&#46; Eckert"
                            5 => "S&#46; Yim-Yeh"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/sleep/32.3.361"
                      "Revista" => array:6 [
                        "tituloSerie" => "Sleep"
                        "fecha" => "2009"
                        "volumen" => "32"
                        "paginaInicial" => "361"
                        "paginaFinal" => "368"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19294956"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tidal ventilation at low airway pressure can augment lung injury"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46;G&#46; Muscedere"
                            1 => "J&#46;B&#46; Mullen"
                            2 => "K&#46; Gan"
                            3 => "A&#46;S&#46; Slutsky"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.149.5.8173774"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "1994"
                        "volumen" => "149"
                        "paginaInicial" => "1327"
                        "paginaFinal" => "1334"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8173774"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Low-volume ventilation causes peripheral airway injury and increased airway resistance in normal rabbits"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "E&#46; D&#8217;Angelo"
                            1 => "M&#46; Pecchiari"
                            2 => "P&#46; Baraggia"
                            3 => "M&#46; Saetta"
                            4 => "E&#46; Balestro"
                            5 => "J&#46; Milic-Emili"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1152/japplphysiol.00776.2001"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Appl Physiol"
                        "fecha" => "2002"
                        "volumen" => "92"
                        "paginaInicial" => "949"
                        "paginaFinal" => "956"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11842025"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Influence of airway diameter and cell confluence on epithelial cell injury in an in vitro model of airway reopening"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "H&#46;C&#46; Yalcin"
                            1 => "S&#46;F&#46; Perry"
                            2 => "S&#46;N&#46; Ghadiali"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1152/japplphysiol.00164.2007"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Appl Physiol"
                        "fecha" => "1985"
                        "volumen" => "103"
                        "paginaInicial" => "1796"
                        "paginaFinal" => "1805"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17673567"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pulmonary function in obese snorers with or without sleep apnea syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "F&#46; Zerah-Lancner"
                            1 => "F&#46; Lofaso"
                            2 => "A&#46; Coste"
                            3 => "F&#46; Ricolfi"
                            4 => "F&#46; Goldenberg"
                            5 => "A&#46; Harf"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.156.2.9609015"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "1997"
                        "volumen" => "156"
                        "paginaInicial" => "522"
                        "paginaFinal" => "527"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9279234"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Expiratory flow limitation in obstructive sleep apnea and COPD&#58; a quantitative method to detect pattern differences using the negative expiratory pressure technique"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; Baydur"
                            1 => "C&#46; Vigen"
                            2 => "Z&#46; Chen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2174/1874306401206010111"
                      "Revista" => array:6 [
                        "tituloSerie" => "Open Respir Med J"
                        "fecha" => "2012"
                        "volumen" => "6"
                        "paginaInicial" => "111"
                        "paginaFinal" => "120"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23166569"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Receiver operating characteristics of impulse oscillometry parameters for predicting obstructive sleep apnea in preobese and obese snorers"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Abdeyrim"
                            1 => "L&#46; Tang"
                            2 => "A&#46; Muhamat"
                            3 => "K&#46; Abudeyrim"
                            4 => "Y&#46; Zhang"
                            5 => "N&#46; Li"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/s12890-016-0284-3"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMC Pulm Med"
                        "fecha" => "2016"
                        "volumen" => "16"
                        "paginaInicial" => "125"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27549623"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alteration of respiratory resistance in patients with obstructive sleep apnea hypopnea syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "Z&#46;C&#46; Cai"
                            1 => "T&#46;F&#46; Li"
                            2 => "X&#46;X&#46; LU"
                            3 => "Y&#46;F&#46; Wang"
                            4 => "X&#46; Wang"
                            5 => "T&#46; Xu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Nan Fang Yi Ke Da Xue Xue Bao"
                        "fecha" => "2018"
                        "volumen" => "38"
                        "paginaInicial" => "765"
                        "paginaFinal" => "768"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29997103"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The effect of sex and body weight on lung volumes during sleep"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Avraam"
                            1 => "A&#46; Dawson"
                            2 => "P&#46;D&#46; Rochford"
                            3 => "D&#46;J&#46; Brazzale"
                            4 => "F&#46;J&#46; O&#39;donoghue"
                            5 => "J&#46; Trinder"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "Sleep"
                        "fecha" => "2019"
                        "volumen" => "42"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of increased lung volume on sleep disordered breathing in patients with sleep apnoea"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;C&#46; Heinzer"
                            1 => "M&#46;L&#46; Stanchina"
                            2 => "A&#46; Malhotra"
                            3 => "A&#46;S&#46; Jordan"
                            4 => "S&#46;R&#46; Patel"
                            5 => "Y&#46;L&#46; Lo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/thx.2005.052084"
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "2006"
                        "volumen" => "61"
                        "paginaInicial" => "435"
                        "paginaFinal" => "439"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16490766"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Volume of isoflow&#58; a new test in detection of mild abnormalities of lung mechanics"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Hutcheon"
                            1 => "P&#46; Griffin"
                            2 => "H&#46; Levison"
                            3 => "N&#46; Zamel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/arrd.1974.110.4.458"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1974"
                        "volumen" => "110"
                        "paginaInicial" => "458"
                        "paginaFinal" => "465"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4416882"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Structure and function of small airways in health and disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "V&#46; Ranga"
                            1 => "J&#46; Kleinerman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Pathol Lab Med"
                        "fecha" => "1978"
                        "volumen" => "102"
                        "paginaInicial" => "609"
                        "paginaFinal" => "617"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/363090"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The volume of isoflow and increase in maximal flow at 50 percent of forced vital capacity during helium-oxygen breathing as tests of small airway dysfunction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46;F&#46; Gelb"
                            1 => "E&#46; Klein"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.71.3.396"
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1977"
                        "volumen" => "71"
                        "paginaInicial" => "396"
                        "paginaFinal" => "399"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/837755"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bronchial pressure measurements in emphysema and bronchitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46;T&#46; Macklem"
                            1 => "R&#46;G&#46; Fraser"
                            2 => "W&#46;G&#46; Brown"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Clin Invest"
                        "fecha" => "1965"
                        "volumen" => "44"
                        "paginaInicial" => "897"
                        "paginaFinal" => "905"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Small airway function in acromegaly"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "N&#46;M&#46; Siafakas"
                            1 => "J&#46; Sigalas"
                            2 => "B&#46; Filaditaki"
                            3 => "K&#46; Tsirogiannis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Bull Eur Physiopathol Respir"
                        "fecha" => "1987"
                        "volumen" => "23"
                        "paginaInicial" => "329"
                        "paginaFinal" => "334"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3690020"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Small airways function in patients with inflammatory bowel disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "N&#46; Tzanakis"
                            1 => "M&#46; Samiou"
                            2 => "D&#46; Bouros"
                            3 => "J&#46; Mouzas"
                            4 => "E&#46; Kouroumalis"
                            5 => "M&#46;N&#46; Siafakas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.157.2.97-04075"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "1998"
                        "volumen" => "157"
                        "paginaInicial" => "382"
                        "paginaFinal" => "386"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9476847"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Small airways disease&#58; time for a revisit&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46;A&#46; Stockley"
                            1 => "B&#46;G&#46; Cooper"
                            2 => "R&#46;A&#46; Stockley"
                            3 => "E&#46; Sapey"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Int J Chron Obstruct Pulmon Dis"
                        "fecha" => "2017"
                        "volumen" => "12"
                        "paginaInicial" => "2343"
                        "paginaFinal" => "2353"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The lung&#39;s &#8220;Quiet Zone&#8221;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46; Mead"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM197006042822311"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1970"
                        "volumen" => "282"
                        "paginaInicial" => "1318"
                        "paginaFinal" => "1319"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5442364"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The small airways and distal lung compartment in asthma and COPD&#58; a time for reappraisal"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Contoli"
                            1 => "J&#46; Bousquet"
                            2 => "L&#46;M&#46; Fabbri"
                            3 => "H&#46; Magnussen"
                            4 => "K&#46;F&#46; Rabe"
                            5 => "N&#46;M&#46; Siafakas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1398-9995.2009.02242.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Allergy"
                        "fecha" => "2010"
                        "volumen" => "65"
                        "paginaInicial" => "141"
                        "paginaFinal" => "151"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19909298"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Techniques for assessing small airways function&#58; possible application in asthma and COPD"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "K&#46; Katsoulis"
                            1 => "K&#46; kostikas"
                            2 => "T&#46; Kontakiotis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.rmed.2013.05.003"
                      "Revista" => array:6 [
                        "tituloSerie" => "Respir Med"
                        "fecha" => "2016"
                        "volumen" => "119"
                        "paginaInicial" => "e2"
                        "paginaFinal" => "e9"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23764129"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Density dependence of forced expiratory flows&#58; methodological aspects"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "D&#46;B&#46; Teculescu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Bull Eur Physiopathol Respir"
                        "fecha" => "1985"
                        "volumen" => "21"
                        "paginaInicial" => "193"
                        "paginaFinal" => "204"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3888319"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The relations between structural changes in small airways and pulmonary-function tests"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Cosio"
                            1 => "H&#46; Ghezzo"
                            2 => "J&#46;C&#46; Hogg"
                            3 => "R&#46; Corbin"
                            4 => "M&#46; Loveland"
                            5 => "J&#46; Dosman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM197806082982303"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1978"
                        "volumen" => "298"
                        "paginaInicial" => "1277"
                        "paginaFinal" => "1281"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/651978"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The detection of small airway disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;L&#46; Wright"
                            1 => "L&#46;M&#46; Lawson"
                            2 => "P&#46;D&#46; Par&#233;"
                            3 => "S&#46; Kennedy"
                            4 => "B&#46; Wiggs"
                            5 => "J&#46;C&#46; Hogg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/arrd.1984.129.6.989"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1984"
                        "volumen" => "129"
                        "paginaInicial" => "989"
                        "paginaFinal" => "994"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6732056"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/25310437/0000002700000003/v1_202105020809/S2531043720301227/v1_202105020809/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "72878"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Original articles"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/25310437/0000002700000003/v1_202105020809/S2531043720301227/v1_202105020809/en/main.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2531043720301227?idApp=UINPBA00004E"
]
Share
Journal Information
Vol. 27. Issue 3.
Pages 208-214 (May - June 2021)
Share
Share
Download PDF
More article options
Visits
4267
Vol. 27. Issue 3.
Pages 208-214 (May - June 2021)
Original article
Open Access
Small airways’ function in Obstructive Sleep Apnea-Hypopnea Syndrome
Visits
4267
K. Giannadakia,b, S. Schizaa,b, G. Vavougiosc, V. Ladopoulosd, N. Tzanakisa,b, N. Siafakasa,b,
Corresponding author
a Department of Thoracic Medicine, University Hospital of Heraklion, Heraklion, Crete, Greece
b Sleep Disorders Center, Medical School, University of Crete, Heraklion, Crete, Greece
c Department of Neurology, Athens Naval Hospital and Scientific Research Associate, University of Thessaly, Larisa, Greece
d Foundation for Research and Technology Hellas, Institute of Electronic Structure and Laser, Heraklion, Crete, Greece
This item has received

Under a Creative Commons license
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Figures (2)
Tables (3)
Table 1. Characteristics of patients and controls subjects.
Table 2. Parameters of small airways’ function in patients and control subjects in sitting position.
Table 3. Pulmonary function tests in sitting and supine position, in patients.
Show moreShow less
Abstract
Introduction and objectives

Most of the studies of the pathophysiology of Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS) focus on the collapsibility and obstruction of the upper airways. The aim of our study was the investigation of small airways’ function in patients with OSAHS.

Materials and methods

We studied 23 patients (mean age, 51.6 years) diagnosed with mild to severe OSAHS, without comorbidities and 8 controls (mean age, 45.9 years). All subjects underwent full polysomnography sleep study; spirometry and maximum flow/volume curves while breathing room air and a mixture of 80%He-20%O2. The volume of equal flows (VisoV⋅) of the two curves and the difference of flows at 50% of FVC (ΔV˙max50) were calculated, as indicates of small airways’ function.

Results

The results showed that VisoV⋅ was significantly increased in patients with OSAHS compared with controls (18.79±9.39 vs. 4.72±4.68, p=0.004). No statistically significantly difference was found in ΔV˙max50% (p=0.551); or the maximum Expiratory flow at 25–75% of FVC (p=0.067) and the maximum expiratory flow at 50% of FVC (p=0.174) breathing air.

Conclusions

We conclude that at the time of the diagnosis of OSAHS, the function of the small airways is affected. This could be due to breathing at low lung volumes and the cyclic closure/opening of the small airways and may affect the natural history of OSAHS. The findings could lead to new therapeutic implications, targeting directly the small airways.

Keywords:
Sleep disorders
Lung mechanics
Physiology
Isoflow
Heliox
Full Text
Introduction

Sleep is a complex, active and in many ways a different condition from alertness. During sleep, the control of breathing is subject to an altered regulation. In addition, the mechanics of breathing change, the resistance of the upper airways increases and the functional residual capacity decreases. This reduction in lung volumes leads to an increased tendency towards upper airway obstruction and contributes to the reduction of flow during inhalation, although the exact mechanisms of these findings have not been described in detail.1,2

The most common sleep disorder-OSAHS-has been studied and reviewed extensively.3,4 Among the important physiological traits causing OSAHS are: (1) pharyngeal anatomy/collapsibility, (2) ventilatory control system gain (loop gain), (3) the ability of the upper airway to dilate/stiffen in response to an increase in ventilator drive, and (4) arousal threshold.4 Although, large and small airways are part of the same anatomical compartment of the lungs, the studies of the pathophysiology of OSAHS have focused primarily on the function of the upper airways.

The aim of our study is to investigate the function of small airways in patients with OSAHS, and to compare it with healthy controls.

To the best of our knowledge, this is the first investigation of the small airways in OSAHS showing that their function is affected.

Materials and methodsSubjects

23 subjects (13 males, 10 females; mean age, 51.6 years) with a diagnosis of mild to severe OSAHS, without comorbidities and 8 controls (3 males, 5 females; mean age, 45.9 years) (Table 1) were included in the study. Patients and controls were recruited at the Sleep Disorders Center of the Medical School of University of Crete from June 2013 to July 2014, complaining of sleep-related symptoms.

Table 1.

Characteristics of patients and controls subjects.

  Patients (n=23)  Controls (n=8)  p-Value 
Sex      0.433 
Male  13 (56.5)  3 (37.5)   
Female  10 (43.5)  5 (62.5)   
Age  51.6±12.7  45.9±15.5  0.310 
Smoking      0.676 
Ex-smokers  9 (39.1)  2 (25.0)   
Nonsmokers  14 (60.9)  6 (75.0)   
ESS  10.8±5.5  5.6±3.4  0.020 
BMI (kg/m2)  31.6±5.7  24.6±3.4  0.003 
Neck circumference(cm)  40.0±3.4  36.5±5.0  0.036 
Mild OSAHS (5≤AHI<15)  5 (21.7)     
Moderate OSHAS (15≤AHI<30)  10 (43.5)     
Severe OSHAS (AHI≥30)  8 (34.8)     
FEV1(L/min)  93.2±13.7  104.8±11.3  0.070 
FVC (L/min)  97.9±15.6  106.0±14.1  0.262 
FEV1/FVC  79.7±5.2  84.2±3.9  0.062 

AHI: Apnea-Hypopnea Index, ESS: Epworth Sleepiness Scale, BMI: Body Mass Index.

Subjects having any of the following were excluded from the study:

(1) Severe obesity (Body Mass Index (BMI) >40kg/m2), (2) Current smokers or ex-smokers >30pys, (3) Patients with concomitant pulmonary disease (e.g. Chronic Obstructive Pulmonary Disease (COPD), asthma, interstitial lung disease, active pulmonary tuberculosis, (4) Patients previously diagnosed with sleep-related disorder, (5) Patients who have clinically significant renal, cardiovascular, neurological, endocrine, immunological, psychiatric, gastrointestinal, hepatic, or hematological abnormalities, (6) Pregnancy.

Protocol

  • 1.

    Physical examination was performed and medical history was taken, including sleep disorders symptoms. The daytime somnolence was evaluated with the Epworth scale and measurements of: Weight (kg) and Height (m) were performed. The BMI (kg/m2) was calculated, and the neck circumference (cm) was measured at the height of the cricothyroid cartilage.

  • 2.

    Patients and control subjects underwent polysomnographic sleep study where the following parameters were recorded: Electroencephalography, Electrooculogram, Electromyography in submental muscle and anterior tibia muscles bilaterally, Electrocardiogram, microphone should be placed over the trachea or on the side of the neck (from AAST), the detection of air flow with oral-nasal thermistor and pressure transducer, oxyhemoglobin saturation by finger pulse oximeter, the movement of thoracic and abdominal wall with special elastic belts of thorax and abdomen for the recording of the respiratory effort and body position.

    The diagnosis of OSAHS was established when the Apnea-Hypopnea Index (AHI) ≥5 and its severity was distinguished as:

    • Mild: 5AHI<15

    • Moderate: 15AHI<30

    • Severe: AHI30

  • 3.

    Patients and controls underwent spirometry, according to the ERS/ATS guidelines, in sitting and supine position.

Assessment of small airways

The small airways’ function was assessed using the Helium-Oxygen flow–volume method. The subject was seated and instructed to perform maximal expiratory flow-volume curves while breathing room air or a mixture of 80% He and 20% O2. Flow-volume curves while breathing He-O2 were measured after the subject had breathed in at least three Vital Capacity (VC) inspirations of the He-O2 mixture (heliox). The two curves obtained from breathing room air and the He-O2 mixture, were superimposed visually from Total Lung Capacity (TLC). A difference of less than 5% in FVC between breathing room and the He-O2 mixture was considered acceptable (the mean of our data was <3%). When the V˙−V curves did not have identical FVC, they were superimposed from Residual Volume (RV)5,6 (Fig. 1). The volume at which the flow became identical was defined as VisoV⋅. The VisoV⋅ was expressed as a percentage of the Forced Vital Capacity (FVC), according to the method of Dosman and colleagues6 (Fig. 1). The value of ΔV˙max50 was calculated from the equation ΔV˙max50=(V⋅Emax50He−V⋅Emax50air/V⋅Emax50air)×100, and expressed as a percentage of V˙Emax50 while breathing room air.6

Figure 1.

A. Forced expiratory flow-volume curves on breathing air (blue curve) and the mixture 80% He and 20% O2 (red curve) in a control subject. B. Same as A of a typical OSAHS patient.

Green lines show the point at where the two curves coincide (VisoV˙).

(0.38MB).
Statistical analysis

Descriptive analysis of the participants’ characteristics was conducted. The normality assumption of the continuous variables was assessed via the One Sample Kolmogorov – Smirnov Test and through graphical inspection. Continuous variables are presented as mean±standard deviation (SD) or as median and 25th–75th percentiles. Differences between continuous variables were assessed via the independent samples T-test and the independent Mann–Whitney U Test where appropriate. Differences between categorical variables were assessed via the Fisher's exact test. Linear regression analysis was used on the association of OSAHS with V˙isoV, adjusted for BMI. Wilcoxon matched-pairs signed-ranked test was used for comparison between sitting and supine posture. For all tests, a p-value<0.05 was considered statistically significant. All statistical tests were performed using the SPSS 22.0 (IBM Corporation, Illinois, US) and Stata 13.0 (StataCorp, College Station, TX, US).

Results

Demographic data, smoking habits, pulmonary function tests (PFTs), and sleep related parameters of the patients and control subjects, are shown in Table 1.

Statistically significant differences between patient and controls, were found regarding BMI, Epworth Sleepiness Scale (ESS) and neck circumference (p-value<0.05).

The parameters of small airways’ function are shown on Table 2.

Table 2.

Parameters of small airways’ function in patients and control subjects in sitting position.

  Patients (n=23)  Controls (n=8)  p-Value 
MMEF25–75  77.5±25.5  100.8±16.3  0.067 
MEF50  86.3±28.1  103.8±21.0  0.174 
VisoV˙(%)  18.8±9.4  4.7±4.7  0.004 
aΔV˙max50%  26.2 (9.1, 55.6)  37.2 (29.5, 41.8)  0.551 
a

Values are presented as Median (25th, 75th percentile).

The mean values of the basic parameters of small airways’ function (VisoV˙% and DV˙max50% in patients and controls are shown in Fig. 2. VisoV˙ was statistically significantly increased in patients with OSAHS compared to controls (18.79±9.39 vs. 4.72±4.68, p=0.004). OSAHS was significantly associated with higher VisoV˙ [beta (95% CI)=12.118 (1.51, 22.73)], independently of BMI. No statistically significantly relationship was found between VisoV˙ and ESS or neck circumference in OSAHS patients.

Figure 2.

Mean values (±SD) of VisoV˙% and ΔV˙max50% in control subjects and in patients with OSAHS.

(0.13MB).

ΔV˙max50% was not statistically significantly different {26.2 (9.1, 55.6) vs. 37.2 (29.5, 41.8), p=0.551}, although a trend to decrease was seen in patients.

Non-significant differences in the mean values of FVC, Forced Expiratory Volume in 1s (FEV1), FEV1/FVC, Maximal (mid-) Expiratory Flow at 25–75% of FVC (MMEF25–75) and Maximal (mid-) Expiratory Flow at 50% of FVC (MMEF50) were found between patients with OSAHS and the controls in sitting position (Tables 1 and 2).

In patients with OSAHS, the mean values of pulmonary function tests in supine position had significantly decreased statistically from their values in sitting position (Table 3).

Table 3.

Pulmonary function tests in sitting and supine position, in patients.

  Sitting position  Supine position  p-Value 
FEV1 (L/min)  92.5 (87.0, 101.0)  85.5 (74.0, 98.0)  0.0021 
FVC (L/min)  95.0 (91.0, 109.0)  91.0 (79.0, 99.0)  0.004 
FEV1/FVC  80.0 (78.5, 81.7)  78.6 (71.7, 83.3)  0.004 
MMEF25-75  74.0 (58.0, 98.7)  63.5 (50.0, 82.0)  0.0039 
MEF50  86.0 (64.0, 108.0)  86.5 (58.0, 91.0)  0.0157 

Wilcoxon matched-pairs signed-ranked test.

Discussion

Small airways are the peripheral membranous bronchioles, 2mm less in diameter. They make up a very large area which is difficult to approach functionally, clinically and therapeutically.7,8

The main finding of the present study is that small airways’ function is affected in OSAHS, as the VisoV˙ increases, despite normal baseline spirometric values. These findings, to the best of our knowledge, are reported for the first time.

The pathogenesis of OSAHS is multifactorial; anatomical and functional changes of the upper airway and its musculature result in partial or complete and recurrent obstructions of the upper airway during sleep. Anatomical changes contribute to the reduction of the diameter of the upper airway while the functional changes to the increased collapsibility and susceptibility to obstruction and these changes may interact, i.e., the structural changes affect the functional ones and vice versa.9

It is well known, that during sleep the pattern of breathing is variable and that sleep stages significantly affect this pattern.10 In addition, in OSAHS it is reported that lung volumes may continuously vary during NREM sleep and this may contribute to passive collapse of the upper airways.11 However, during sleep, the common finding is the reduction of FRC or the End Expiratory Lung Volume (EELV), even if it fluctuates. Breathing at low lung volumes results in reduction of the elastic restoring force of the lungs (elastic recoil) and reduces radial traction exerted by the lung parenchyma on the airways to keep them open with reduced flow resistances.12 This occurs even in normal sleeping subjects and may be enhanced abnormally in sleeping disorders.1

Additionally, in obese subjects with OSAHS, it has been shown that reduced pulmonary volumes, secondarily lead to narrowing and obstruction of the upper airways.13 Jordan et al showed that when genioglossus muscle fails to stabilize breathing in OSAHS, this may be related to reduced lung volume.14

Therefore, the majority of the pathophysiological studies have focused on the collapsibility of the upper airways.

In contrast, our study found an affected function at the site of the small airways. We speculate that this could be due to opening and closure of the small airways caused by the abrupt changes in the airway pressure at low lung volumes. It is well known, that during the obstruction of the upper airways the airway pressure increases in order to reopen the collapsed site and to initiate inspiratory flow. When this has been achieved, a significant and abrupt drop in the airway pressure is seen. These changes in airway pressure are transmitted into the whole respiratory system and may cause collapsibility and flapping at the site of the membranous small airways. In support of this argument there are studies in animals showing that ventilation at low lung volumes leads to an abnormal successive opening and closure of small airways.15 Such periodic continuous occlusion and opening, creates conditions for inflammation and oxidative stress in the regions of the final bronchioles and alveolar sacks, which means destruction of lung parenchyma.15

In 2002, D’Angelo E, Milic-Emili J et al, reported that small-volume ventilation causes peripheral airway injury and increases airway resistance in normal rabbits and this is probably due to cyclic opening and closing of the peripheral airways.16

In addition, Yalcin HC et al, in an in vitro model of airway reopening showed significant epithelial cell injury.17 Moreover, Zerah-Lancner et al, found a significant decrease in the FEV1/FVC ratio, in the V50 and V25, as the severity of OSAHS increases, in 170 patients undergoing a sleep study.18

Baydur et al, showed expiratory flow limitation in COPD and OSAHS patients, but their results could not distinguish the two cohorts.19

Finally, in agreement with our results are those of Abdeyrim et al and Cai et al who used the impulse oscillation technique to show that the peripheral airway resistance increased in obese OSAS patients.20,21 Moreover, Abdeyrim et al showed that Reactance at 5Hz correlated with peripheral airway resistance and with the decreased FRC.20

In addition, Avraam et al reported that reductions in FVC while supine and with increased body weight may contribute to worsening of OSAHS.22

In accordance with these studies, our results show a significant decrease in patient pulmonary function values in supine position from the sitting, (Table 3) which strengthens our argument that breathing at low lung volumes may affect negatively small airways function.

Moreover, Heinzer et al showed that the increase in pulmonary volumes reduces sleep disturbances and improves sleep architecture in patients with OSAHS during non-REM sleep.23

Review and critique of the method

In 1974, Hutheon et al introduced the volume of isoflow as a new test for the detection of small-airway dysfunction.24 During the terminal 10% to 15% of VC, the flow rates during helium-oxygen and air breathing are identical; this is the volume of isoflow point.25 The isoflow phenomenon is seen because flow in the small airways is laminar and so independent of gas density.26VisoV˙ is expressed as a percent of VC and occurs in normal nonsmoking subjects at 10% to 15% of VC from RV.26 The reduction in radius is making the phenomenon of laminar flow to accurate at higher lung volumes (increase in VisoV˙) and this is considered as a malfunction of small airways.27

Despas et al reported that early manifestation of peripheral airway obstruction can be detected in patients with mild asthma using the He-O2 mixture.5 Moreover, Dosman et al showed that the use of Heliox during a maximal expiratory flow-volume maneuver was capable of detecting functional abnormalities in smokers at a stage when spirometric indices were within the normal range.6

This technique has been used by Siafakas et al to investigate small airways’ function in acromegaly.28 It has been also used by our department, for the investigation of small airways’ function in non-respiratory diseases such as inflammatory bowel diseases, with interesting results.29 In agreement with the present study they found alterations only in the VisoV˙ index and not in the ΔV˙max50 and considered that ΔV˙max50 could not be a sensitive index for the early detection of small airway dysfunction.30

It is well known that, the small airways of the lung, the so-called “quiet zone”,30,31 is a difficult anatomical area to approach and therefore for studying its function. Multiple methods have been proposed to study this area of the lung, including complicated and invasive techniques. Nevertheless, there is a lack of a globally acceptable methodology to investigate small airways.32,33

There are some studies that criticize density-dependence tests for their variability and their validity for detecting narrowing of the small airways,34 however the majority agree that those tests correlate well with the small airways function.35,36

Although, BMI was statistically different between the two groups, regression analysis showed that VisoV˙ was statistically higher in OSAHS patients, independently of BMI. Similarly, Abdeyrim et al reported that FRC and Expiratory Reserve Volume reductions were independent from BMI in OSAHS patients.20

Limitation of our study is the quite small sample size. Only 23 patients with OSAHS were studied and 8 controls. However, the results of VisoV˙ clearly separated patients from controls (Fig. 2).

Finally, preliminary results have shown a trend towards improvement in small airways parameters in OSAHS patients after therapy with CPAP. Thus, it would be worth investigating the effects of treatment of OSAHS on the function of small airways in the future.

Conclusions

The main finding of the present study is that patients with OSAHS showed a dysfunction of the small airways, since the VisoV˙ index was increased, despite their normal baseline spirometric values.

This is probably due to the reduction of the lung volumes, the cycle opening and closure of the small airways and subsequent inflammation and oxidant stress.

The function of the small airways may affect the natural history of OSAHS and these findings could lead to new therapeutic implications. However, larger studies are needed to verify our results.

Compliance with ethical standards

This study was supported by an unrestricted grant to University of Crete by Elpen Hellas, with no other involvement in the study.

Ethical approval

All procedures performed in the study were in accordance with the ethical standards of the Research Ethics and Deontology Committee of the University of Crete, and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

All subjects have signed an Informed Consent Form prior to any investigation.

Authors contributions

KG: She was involved in all parts of this work, the design of the study, the experiments, the analysis of the data, and the interpretation of the results, the drafting and writing of the manuscript.

SS: Contributed in the design of the study, in the analysis of the data and supervised the polysomnographic sleep studies.

GV: Contributed in the acquisition and the analysis of the data and in their statistical interpretation.

VL: He was involved in the design of the study, in the analysis of the data and supervised the Heliox experiments.

NT: contributed in the design of the study, organized the Heliox experiments and was involved in the analysis of the data.

NS: He is the senior investigator of the study involved in all aspects: design, analysis, interpretation of the results and supervised the writing of the manuscript.

All authors have read and approved the final manuscript.

Conflicts of interest

The authors declare that they have no conflict of interest.

The authors have no relationship with the tobacco industry or its affiliates and subsidiaries that benefited any of the manuscript authors or the tobacco industry in its promotion of tobacco products.

References
[1]
A. Kay.
Progressive changes in airway resistance during sleep.
J Appl Physiol, 81 (1996), pp. 282-292
[2]
D.W. Hudgel, P. devadatta.
Decrease in functional residual capacity during sleep in normal humans.
J Appl Physiol, 57 (1984), pp. 1319-1322
[3]
R.B. Fogel, D.P. White.
Obstuctive sleep apnea.
Adv Intern Med, 45 (2000), pp. 351-389
[4]
A.S. Jordan, D.P. White, Y.L. Lo, A. Wellman, D.J. Eckert, S. Yim-Yeh, et al.
A method for measuring and modeling the physiological traits causing obstructive sleep apnea.
J Appl Physiol, 110 (2011), pp. 1627-1637
[5]
P.J. Despas, M. Lenoux, P.T. Macklem.
Site of airway obstruction in asthma as determined by measuring maximal expiratory flow breathing air and a helium-oxygen mixture.
J Clin Invest, 51 (1972), pp. 3235-3243
[6]
J. Dosman, F.R. Bode, J. Urbanetti, R.R. Martin, P.T. Macklem.
The use of a helium-oxygen mixture during maximum expiratory flow to demonstrate obstruction in small airways in smokers.
J Clin invest, 55 (1975), pp. 1090-1099
[7]
S. Baraldo, M. Saetta, M.G. Cosio.
Pathophysiology of the small airways.
Semin Respir Crit Care Med, 24 (2003), pp. 465-472
[8]
O.S. Usmani.
Treating the small airways.
Respiration, 84 (2012), pp. 441-453
[9]
P.T. Macklem, A.J. Woolcock, C. Hogg, J.A. Nadel, N.J. Wilson.
Partitioning of pulmonary resistance in the dog.
J Appl Physiol, 26 (1969), pp. 798-805
[10]
N.J. Douglas, D.P. White, C.K. Pickett, J.V. Weil, C.W. Zwillich.
Respiration during sleep in normal man.
Thorax, 37 (1982), pp. 840-844
[11]
R.M. Aronson, C.G. Alex, E. Onal, M. Lopata.
Changes in end-expiratory lung volume during sleep in patients with occlusive apnea.
J Appl Physiol, 63 (1985), pp. 1642-1647
[12]
V. Hoffstein, Z. Oliver.
Pulmonary function and sleep apnea.
Sleep Breath, 7 (2003), pp. 159-165
[13]
V. Hoffstein, N. Zamel, A.E. Phillipson.
Lung volume dependence of pharyngeal cross-sectional area in patients with obstructive sleep apnea.
Am Rev Respir Dis, 130 (1984), pp. 175-178
[14]
A.S. Jordan, D.P. White, Y.L. Lo, A. Wellman, D.J. Eckert, S. Yim-Yeh, et al.
Airway dilator muscle activity and lung volume during stable breathing in obstructive sleep apnea.
Sleep, 32 (2009), pp. 361-368
[15]
J.G. Muscedere, J.B. Mullen, K. Gan, A.S. Slutsky.
Tidal ventilation at low airway pressure can augment lung injury.
Am J Respir Crit Care Med, 149 (1994), pp. 1327-1334
[16]
E. D’Angelo, M. Pecchiari, P. Baraggia, M. Saetta, E. Balestro, J. Milic-Emili.
Low-volume ventilation causes peripheral airway injury and increased airway resistance in normal rabbits.
J Appl Physiol, 92 (2002), pp. 949-956
[17]
H.C. Yalcin, S.F. Perry, S.N. Ghadiali.
Influence of airway diameter and cell confluence on epithelial cell injury in an in vitro model of airway reopening.
J Appl Physiol, 103 (1985), pp. 1796-1805
[18]
F. Zerah-Lancner, F. Lofaso, A. Coste, F. Ricolfi, F. Goldenberg, A. Harf.
Pulmonary function in obese snorers with or without sleep apnea syndrome.
Am J Respir Crit Care Med, 156 (1997), pp. 522-527
[19]
A. Baydur, C. Vigen, Z. Chen.
Expiratory flow limitation in obstructive sleep apnea and COPD: a quantitative method to detect pattern differences using the negative expiratory pressure technique.
Open Respir Med J, 6 (2012), pp. 111-120
[20]
A. Abdeyrim, L. Tang, A. Muhamat, K. Abudeyrim, Y. Zhang, N. Li, et al.
Receiver operating characteristics of impulse oscillometry parameters for predicting obstructive sleep apnea in preobese and obese snorers.
BMC Pulm Med, 16 (2016), pp. 125
[21]
Z.C. Cai, T.F. Li, X.X. LU, Y.F. Wang, X. Wang, T. Xu.
Alteration of respiratory resistance in patients with obstructive sleep apnea hypopnea syndrome.
Nan Fang Yi Ke Da Xue Xue Bao, 38 (2018), pp. 765-768
[22]
J. Avraam, A. Dawson, P.D. Rochford, D.J. Brazzale, F.J. O'donoghue, J. Trinder, et al.
The effect of sex and body weight on lung volumes during sleep.
Sleep, 42 (2019),
[23]
R.C. Heinzer, M.L. Stanchina, A. Malhotra, A.S. Jordan, S.R. Patel, Y.L. Lo, et al.
Effect of increased lung volume on sleep disordered breathing in patients with sleep apnoea.
Thorax, 61 (2006), pp. 435-439
[24]
M. Hutcheon, P. Griffin, H. Levison, N. Zamel.
Volume of isoflow: a new test in detection of mild abnormalities of lung mechanics.
Am Rev Respir Dis, 110 (1974), pp. 458-465
[25]
V. Ranga, J. Kleinerman.
Structure and function of small airways in health and disease.
Arch Pathol Lab Med, 102 (1978), pp. 609-617
[26]
A.F. Gelb, E. Klein.
The volume of isoflow and increase in maximal flow at 50 percent of forced vital capacity during helium-oxygen breathing as tests of small airway dysfunction.
Chest, 71 (1977), pp. 396-399
[27]
P.T. Macklem, R.G. Fraser, W.G. Brown.
Bronchial pressure measurements in emphysema and bronchitis.
J Clin Invest, 44 (1965), pp. 897-905
[28]
N.M. Siafakas, J. Sigalas, B. Filaditaki, K. Tsirogiannis.
Small airway function in acromegaly.
Bull Eur Physiopathol Respir, 23 (1987), pp. 329-334
[29]
N. Tzanakis, M. Samiou, D. Bouros, J. Mouzas, E. Kouroumalis, M.N. Siafakas.
Small airways function in patients with inflammatory bowel disease.
Am J Respir Crit Care Med, 157 (1998), pp. 382-386
[30]
J.A. Stockley, B.G. Cooper, R.A. Stockley, E. Sapey.
Small airways disease: time for a revisit?.
Int J Chron Obstruct Pulmon Dis, 12 (2017), pp. 2343-2353
[31]
J. Mead.
The lung's “Quiet Zone”.
N Engl J Med, 282 (1970), pp. 1318-1319
[32]
M. Contoli, J. Bousquet, L.M. Fabbri, H. Magnussen, K.F. Rabe, N.M. Siafakas, et al.
The small airways and distal lung compartment in asthma and COPD: a time for reappraisal.
[33]
K. Katsoulis, K. kostikas, T. Kontakiotis.
Techniques for assessing small airways function: possible application in asthma and COPD.
Respir Med, 119 (2016), pp. e2-e9
[34]
D.B. Teculescu.
Density dependence of forced expiratory flows: methodological aspects.
Bull Eur Physiopathol Respir, 21 (1985), pp. 193-204
[35]
M. Cosio, H. Ghezzo, J.C. Hogg, R. Corbin, M. Loveland, J. Dosman, et al.
The relations between structural changes in small airways and pulmonary-function tests.
N Engl J Med, 298 (1978), pp. 1277-1281
[36]
J.L. Wright, L.M. Lawson, P.D. Paré, S. Kennedy, B. Wiggs, J.C. Hogg.
The detection of small airway disease.
Am Rev Respir Dis, 129 (1984), pp. 989-994

Preliminary results of this study have been previously reported, as an abstract, at the ERS International Congress 2017 Eur Resp J 2017 50: PA2309.

Copyright © 2020. Sociedade Portuguesa de Pneumologia
Download PDF
Pulmonology
Article options
Tools

Are you a health professional able to prescribe or dispense drugs?