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Vol. 21. Issue 3.
Pages 166-168 (May - June 2015)
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Vol. 21. Issue 3.
Pages 166-168 (May - June 2015)
Letter to the Editor
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Tuberculosis retreatment in Northern Portugal
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C. Pacheco
Corresponding author
ceciliafpacheco@gmail.com

Corresponding author.
Pneumology Department, Hospital de Braga, Portugal
E. Silva
Pneumology Department, Hospital de Viseu, Portugal
O. Oliveira
Institute of Public Health, University of Porto, Porto, Portugal
A. Carvalhoa,b
a Pulmonology Department, Centro Hospitalar de Vila Nova de Gaia/Espinho, EPE, Vila Nova de Gaia, Portugal
b Chest Disease Centre of Vila Nova de Gaia, Vila Nova de Gaia, Portugal
A.M. Correia
Public Health Department, Regional North Health Administration, Portugal
R. Duartea,b,c,d
a Pulmonology Department, Centro Hospitalar de Vila Nova de Gaia/Espinho, EPE, Vila Nova de Gaia, Portugal
b Chest Disease Centre of Vila Nova de Gaia, Vila Nova de Gaia, Portugal
c Epi Unit, Institute of Public Health, University of Porto, Porto, Portugal
d Epidemiology Department, Medical School, University of Porto, Porto, Portugal
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Tables (2)
Table 1. Risk factors for retreatment.
Table 2. Patients outcome.
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Dear Editor,

Tuberculosis (TB) continues to be a global public health problem.

In Portugal, the incidence is higher in several urban centers, some of which are in northern Portugal, like Porto and Viana do Castelo (20–50 cases per 100,000 people). The retreatment takes place annually in these centers and the rate is also higher (2.97/100,000 people and 2.45/100,000 people, respectively) than in others in Portugal.1

The persistence of tuberculous bacilli in patients who are cured or in those whose treatment was not correctly completed is an important issue.2 Published risk factors for treatment failure or relapse include medical factors like HIV infection, diabetes mellitus, low body weight, cavitation on chest X-ray, high bacterial burden, short duration of treatment, drug resistance, positive culture after two months of treatment and socio-demographic factors like male gender, unemployment, drug abuse, alcoholism, smoking and poor treatment adherence.2–5

Retreatment cases are the leading risk factor for drug resistance if not appropriately and effectively managed, especially in HIV-seronegative patients.4,6

We carried out a study to assess risk factors and outcome for retreatment in TB patients in northern Portugal.

The World Health Organization (WHO) standard definition was used for treatment outcome (treatment success, death, failure, default and transferred out).3,5,7

The cases included were all retreatment TB cases (having received previous treatments) reported in 2012 in Northern Portugal and controls were the new cases (having received no previous treatment for TB) that were registered during the same period. Cases and controls were selected from the national database, which integrates the data from the mandatory registration of TB. For each case we randomly selected 2 controls. Risk factors (male sex, age over 40, HIV infection, diabetes mellitus, drug resistance, cavitation on chest X-ray, pulmonary vs. extra-pulmonary TB, unemployment, intravenous drug abuse and alcohol abuse) and outcomes for retreatment cases were compared against those for new cases.

We analyzed 57 cases and 118 controls (Table 1). In the cases, the median age was 48.0 years (range: 27.0–83.0) and 47 patients (82.5%) were male. In controls, the median age was 45.0 years (range: 14.0–85.0) and 67 patients (56.8%) were male.

Table 1.

Risk factors for retreatment.

Risk factors  New cases (n=118)  Retreatment (n=57)  Univariate analysisMultivariate analysis
      OR* (95% CI)  p-value  aOR* (95% CI)  p-value 
Age
≤40 years  47 (39.8)  12 (21.1)  1.0    1.0   
>40 years  71 (60.2)  45 (78.9)  2.48 (1.19–5.18)  0.015  3.12 (1.38–7.06)  0.006 
Sex
Female  51 (43.2)  10 (17.5)  1.0    1.0   
Male  67 (56.8)  47 (82.5)  3.58 (1.65–7.76)  0.001  2.87 (1.25–6.57)  0.013 
Risk factors
None  95 (80.6)  44 (77.2)  1.0       
Alcohol abuse only  22 (18.6)  9 (15.8)  0.88 (0.38–2.08)  0.776     
Injection drug use only  1 (0.8)  4 (7.0)  8.64 (0.94–79.54)  0.057     
HIV status
Negative  110 (93.2)  45 (78.9)  1.0    1.0   
Positive  8 (6.8)  12(21.1)  3.67 (1.41–9.57)  0.008  5.31 (1.80–15.66)  0.002 
Site of disease
Extra-pulmonary  18 (15.3)  2 (3.5)  1.0    1.0   
Pulmonary  100 (84.7)  55 (95.6)  4.95 (1.11–22.13)  0.036  6.56 (1.26–34.22)  0.026 
Chest radiography
No cavitation  65 (55.1)  29 (50.9)  1.0       
Cavitation  53 (44.9)  28 (49.1)  1.18 (0.63–2.23)  0.601     
Diabetes Mellitus
No  6 (5.1)  3 (5.3)  1.0       
Yes  112 (94.9)  54 (94.7)  1.04 (0.25–4.31)  0.96     
Unemployed
No  98 (83.1)  41 (71.9)  1.0       
Yes  20 (16.9)  16 (28.1)  1.91 (0.90–4.06)  0.091     
MDR TB
No  110 (93.2)  55 (96.5)  1.0       
Yes  8 (6.8)  2 (3.5)  0.50 (0.11–2.44)  0.391     

The number of cases of pulmonary TB was higher in retreatment group (96.5% vs. 84.7%, p=0.04). There were no differences when factors such as diabetes mellitus, immunosuppression, drug resistance, unemployment, intravenous drug abuse and alcohol abuse were compared.

Male sex (adjusted OR: 2.87, 95% CI: 1.25–6.57, p=0.013), HIV-positive status (adjusted OR: 5.31, 95% CI: 1.80–15.66, p=0.002) and age over 40 (adjusted OR: 3.12, 95% CI: 1.38–7.06, p=0.006) were independent risk factors identified for retreatment (Table 1). Of the 57 retreatment cases identified, 46 (81%) had been successfully treated in the past.

The treatment success rate was lower among patients who had received prior TB treatment than in patients who had never been treated for TB (80.7% vs. 92.5%, p=0.04). In retreatment group 6 patients (10.5%) died while 7 patients (5.9%) died among the new cases, although this was not a statistically significant difference (p=0.36) (Table 2).

Table 2.

Patients outcome.

Categories  Treatment success  Poor outcomep-Value 
  Treatment completed  Died  Failed  Defaulted   
Treatment history
Never treated for TB  109 (92.5)  7 (5.9)  1 (0.8)  1 (0.8)  0.04 
Previously treated for TB  46 (80.7)  6 (10.5)  3 (5.2)  2 (3.6)   
Total  155 (88.5)  13 (7.4)  4 (2.3)  3 (1.8)   

Male sex appears as a risk factor for retreatment, in ours and in other studies.2–4,8 Although it is not fully understood why this is a risk factor for retreatment of tuberculosis, it is thought that this may be due to habits associated more to men than women as smoking, intravenous drug abuse and alcohol abuse.

Dooley et al.3 commented that although retreatment guidelines are often the same for patients with failure of, default from, or relapse after initial treatment, these groups may benefit from different management strategies.

The number of cases of pulmonary TB was also higher in the retreatment group, although there are no studies in the literature that can explain this result.

In our population there were no differences when comparing factors such as diabetes mellitus, drug resistance, unemployment, intravenous drug abuse and alcoholism.

The low rate of multi drug resistance (MDR) TB in the retreatment group and the fact that there were no statistically significant differences when compared with the control group suggests that these patients may not have been exposed to many drugs in the past or that they had had a complete treatment, which was also noted by Kritski et al. in their population.6

Despite this result, the treatment success rate was lower among patients who had received prior TB treatment than in patients who had never been treated for TB.

Identifying local patient characteristics that confer higher risk of relapse, failure or default from primary TB treatment may help inform country-specific prevention strategies aiming to reduce the need for retreatment, resulting in cost savings and diminished morbidity and transmission.

Conflict of interest

The authors have no conflicts of interest to declare.

References
[1]
Programa Nacional de Luta Contra a Tuberculose – Ponto da situação epidemiológica e de desempenho.
Direcção Geral da Saúde. Divisão de Doenças Transmissíveis, (2013),
[2]
H. Oliveira, D. Filho.
Recidivas em tuberculose e seus fatores de risco.
Pan Am J Public Health, 7 (2000), pp. 232-241
[3]
K. Dooley, O. Lahlou, I. Ghali, J. Knudsen, M.D. Elmessaooudis, I. Cherkaoui, et al.
Risk factors for tuberculosis treatment failure, default, or relapse and outcomes of retreatment in Morocco.
BMC Public Health, 11 (2011), pp. 140
[4]
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Evaluation of tuberculosis patients’management when re-treated in Cotonou, Benin.
Rev Mal Respir, 30 (2013), pp. 774-779
[5]
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Contributions of culture and antimicrobial susceptibility tests to the retreatment of patients with pulmonary tuberculosis.
Rev Soc Bras Med Trop, 46 (2013), pp. 441-446
[6]
A. Kritski, L. Jesus, M. Andrade, E. Werneck-Barroso, M. Vieira, A. Hoffner, et al.
Retreatment tuberculosis cases. Factors associated with drug resistance and adverse outcomes.
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[7]
World Health Organization.
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World Health Organization, (2011),
[8]
K. Dolma, L. Adhikari, P. Dadul, L. Laden Singhi, J. Mahanta.
A study on the assessment of retreatment tuberculosis patients attending the DOTS centre in Sikkim, India from 2002 to 2010.
Res J Infect Dis, 1 (2013), pp. 3
Copyright © 2014. Sociedade Portuguesa de Pneumologia
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