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Resumo
O papel das células T reguladoras na indução e manu-tenção da tolerância periférica tem recebido uma aten-ção crescente nos últimos anos. Foram descritos vários subgrupos de células T reguladoras, com base em marcadores de superfície e na produção de citocinas, não havendo no entanto marcadores específicos para nenhum destes subgrupos, pelo que a sua classifica-ção se baseia no seu mecanismo de supressão.
Desconhece-se qual dos subgrupos de células T reguladoras terá papel preponderante na prevenção e con-trolo das doenças alérgicas, sendo no entanto consensual a sua importância para a homeostasia.
Rev Port Pneumol 2007; XIII (3): 365-376
Palavras-chave:
Doenças alérgicas
células T reguladoras
tolerância periférica
Abstract
The role of regulatory T cells in the induction and maintenance of peripheral tolerance has received growing attention during the last years. Several subsets of regulatory T cells were described based on their surface markers and citokine production, but nevertheless, there are no specific markers for any subsets and their classification relies on their suppression mechanism.
It is unknown which of the subgroups of regulatory T cells is more important in the prevention and control of allergic diseases, being commonly accepted its importance in homeostasis.
Rev Port Pneumol 2007; XIII (3): 365-376
Key-words:
Allergic diseases
peripheral tolerance
regulatory T cells
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