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        "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">A cirurgia de revasculariza&#231;&#227;o do mioc&#225;rdio envolve o acometimento&#44; tanto do peric&#225;rdio como da pleura&#44; conduzindo ao favorecimento de processos inflamat&#243;rios respons&#225;veis pelo desenvolvimento de derrames nestes compartimentos&#46;</p><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Objectivo&#58;</span> Estudar o comportamento das citocinas proliferativas TGF-&#946; &#40;factor beta de transforma&#231;&#227;o do crescimento&#41; e VEGF &#40;factor de crescimento do endot&#233;lio vascular&#41; nos l&#237;quidos de 16 transudatos e de 43 derrames pleurais de doentes submetidos a cirurgias de revasculariza&#231;&#227;o do mioc&#225;rdio provenientes do Instituto de Cora&#231;&#227;o e do Servi&#231;o de Pneumologia da Universidade do S&#227;o Paulo nos intervalos de 2&#44; 24 e 48 horas de p&#243;s-operat&#243;rio&#46;</p><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Resultados&#58;</span> O derrame pleural p&#243;s-revasculariza&#231;&#227;o do mioc&#225;rdio &#233; um exsudato mobilizador de TGF-&#946; e VEGF no p&#243;s-operat&#243;rio imediato&#46; Os n&#237;veis de TGF-&#946; apresentam-se elevados nas primeiras 2 horas para ca&#237;rem progressivamente at&#233; se aproximarem dos valores dos transudatos ao fim de 48 horas&#44; enquanto o VEGF se inicia com n&#237;veis elevados j&#225; nas primeiras 2 horas com tend&#234;ncia a aumento pelo menos at&#233; 48 horas de p&#243;s-operat&#243;rio&#46;</p><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Conclus&#245;es&#58;</span> O TGF-&#946; parece comportar-se como elemento gatilho sobre a c&#233;lula mesotelial pleural para a libera&#231;&#227;o de VEGF no desenvolvimento de derrame pleural nas cirurgias de revasculariza&#231;&#227;o do mioc&#225;rdio&#46;</p><p id="sp0025" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2006&#59; XII &#40;4&#41;&#58; 359-367</span></p></span>"
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        "titulo" => "Abstract"
        "resumen" => "<span id="as0010" class="elsevierStyleSection elsevierViewall"><p id="sp0030" class="elsevierStyleSimplePara elsevierViewall">Coronary artery bypass graft &#40;CABG&#41; surgeries can impact on the pericardium and pleural space&#44; leading to inflammation which can cause effusion&#46;</p><p id="sp0035" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Aim&#58;</span> To study the role of the proliferative cytokines TGF-&#946; and VEGF in the fluids of 16 transudates and 43 pleural effusions of patients who underwent CABG at the Heart Unit and Pulmonology Unit of the University Hospital of S&#227;o Paulo&#46; Levels of cytokines were assessed 2&#44; 24 and 48 hours post-surgery&#46;</p><p id="sp0040" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Results&#58;</span> The pleural effusion after CABG is an exsudative mobilizer of TGF-&#946; and VEGF cytokines immediately after surgery&#46; The TGF-&#946; concentrations were elevated 2 hours after surgery but started to fall soon after&#44; reaching transudate levels after 48 hours&#46; VEGF levels were high in the first 2 hours post surgery and tended to maintain the same concentrations for at least 48 hours after surgery&#46;</p><p id="sp0045" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Conclusions&#58;</span> Based on the results obtained&#44; TGF-&#946; is a cytokine that seems to work as a trigger&#44; leading the pleural mesothelial cell to express VEGF a cause of pleural effusion in CABG surgeries&#46;</p><p id="sp0050" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2006&#59; XII &#40;4&#41;&#58; 359-367</span></p></span>"
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Vol. 12. Issue 4.
Pages 359-367 (July - August 2006)
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Vol. 12. Issue 4.
Pages 359-367 (July - August 2006)
Artigo Original\Original Article
Open Access
Papel das citocinas proliferativas TGF-β e VEGF no derrame pleural pós-revascularização do miocárdio
The proliferative cytokines TGF-β and VEGF in pleural effusions post-coronary artery bypass graft
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4669
António M.S. Chibante1,
Corresponding author
chibante@domain.com.br

Correspondência/Correspondence to: António M S Chibante, Centro de Investigações Pneumológicas RJ, Rua Sorocaba, 477 sala 601 Rio de Janeiro, Brasil, Cep: 22.271-110 E
, Marcelo Alexandre C. Vaz2, Francisco Vargas Suso2
1 Serviço de Cardiopneumologia, Hospital Gaffrée-Guinle. Univesidade do Rio de Janeiro/Cardiopulmonology Unit, Hospital Gaffrée-Guinle. Universidade do Rio de Janeiro
2 Serviço de Pneumologia, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo/Pulmonolgy Unit, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
This item has received

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Article information
Resumo

A cirurgia de revascularização do miocárdio envolve o acometimento, tanto do pericárdio como da pleura, conduzindo ao favorecimento de processos inflamatórios responsáveis pelo desenvolvimento de derrames nestes compartimentos.

Objectivo: Estudar o comportamento das citocinas proliferativas TGF-β (factor beta de transformação do crescimento) e VEGF (factor de crescimento do endotélio vascular) nos líquidos de 16 transudatos e de 43 derrames pleurais de doentes submetidos a cirurgias de revascularização do miocárdio provenientes do Instituto de Coração e do Serviço de Pneumologia da Universidade do São Paulo nos intervalos de 2, 24 e 48 horas de pós-operatório.

Resultados: O derrame pleural pós-revascularização do miocárdio é um exsudato mobilizador de TGF-β e VEGF no pós-operatório imediato. Os níveis de TGF-β apresentam-se elevados nas primeiras 2 horas para caírem progressivamente até se aproximarem dos valores dos transudatos ao fim de 48 horas, enquanto o VEGF se inicia com níveis elevados já nas primeiras 2 horas com tendência a aumento pelo menos até 48 horas de pós-operatório.

Conclusões: O TGF-β parece comportar-se como elemento gatilho sobre a célula mesotelial pleural para a liberação de VEGF no desenvolvimento de derrame pleural nas cirurgias de revascularização do miocárdio.

Rev Port Pneumol 2006; XII (4): 359-367

Palavras-chave:
Inflamação
citocinas
derrame pleural
revascularização do miocárdio
Abstract

Coronary artery bypass graft (CABG) surgeries can impact on the pericardium and pleural space, leading to inflammation which can cause effusion.

Aim: To study the role of the proliferative cytokines TGF-β and VEGF in the fluids of 16 transudates and 43 pleural effusions of patients who underwent CABG at the Heart Unit and Pulmonology Unit of the University Hospital of São Paulo. Levels of cytokines were assessed 2, 24 and 48 hours post-surgery.

Results: The pleural effusion after CABG is an exsudative mobilizer of TGF-β and VEGF cytokines immediately after surgery. The TGF-β concentrations were elevated 2 hours after surgery but started to fall soon after, reaching transudate levels after 48 hours. VEGF levels were high in the first 2 hours post surgery and tended to maintain the same concentrations for at least 48 hours after surgery.

Conclusions: Based on the results obtained, TGF-β is a cytokine that seems to work as a trigger, leading the pleural mesothelial cell to express VEGF a cause of pleural effusion in CABG surgeries.

Rev Port Pneumol 2006; XII (4): 359-367

Key-words:
Inflammation
cytokines
pleural effusions
coronary artery bypass grafting
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