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Resumo
O stress oxidativo é um dos factores de risco para o desenvolvimento de displasia broncopulmonar no recém-nascido de pré-termo. Este apresenta deficiente defesa antioxidante. Por outro lado, o stress oxidativo também tem papel no crescimento e desenvolvimento celular. A relação entre stress oxidativo e crescimento celular necessita de ser melhor conhecida antes da introdução de terapêuticas antioxidantes. Várias terapêuticas antioxidantes têm sido tentadas, até ao momento sem êxito. Neste artigo é feita uma revisão da evidência do papel dos radicais livres de oxigénio na displasia broncopulmonar.
Rev Port Pneumol 2008; XIV (1): 113-126
Palavras-chave:
Displasia broncopulmonar
defesa antioxidante
recém-nascido de pré-termo
stress oxidativo
Abstract
Oxidative stress is a risk factor for bronchopulmonary dysplasia in the preterm newborn. Antioxidant defense is impaired in the preterm newborn. Oxidative stress is also involved in cell growth and development. The relationship between oxidative stress and cell growth needs to be understood before antioxidant therapy can be routinely introduced. Several antioxidant therapies have been unsuccessfully tried until now. This review highlights the importance of oxygen free radicals in the pathogenesis of bronchopulmonary dysplasia.
Rev Port Pneumol 2008; XIV (1): 113-126
Key-words:
Bronchopulmonary dysplasia
antioxidant defense
preterm infant
oxidative stress
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