array:24 [
  "pii" => "S2173511508702896"
  "issn" => "21735115"
  "doi" => "10.1016/S2173-5115(08)70289-6"
  "estado" => "S300"
  "fechaPublicacion" => "2008-07-01"
  "aid" => "70289"
  "copyright" => "Sociedade Portuguesa de Pneumologia"
  "copyrightAnyo" => "2008"
  "documento" => "article"
  "crossmark" => 0
  "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
  "subdocumento" => "sco"
  "cita" => "Rev Port Pneumol. 2008;14:579-83"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 3549
    "formatos" => array:3 [
      "EPUB" => 214
      "HTML" => 1584
      "PDF" => 1751
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S2173511508702902"
    "issn" => "21735115"
    "doi" => "10.1016/S2173-5115(08)70290-2"
    "estado" => "S300"
    "fechaPublicacion" => "2008-07-01"
    "aid" => "70290"
    "copyright" => "Sociedade Portuguesa de Pneumologia"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "sco"
    "cita" => "Rev Port Pneumol. 2008;14:584-7"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3525
      "formatos" => array:3 [
        "EPUB" => 224
        "HTML" => 1302
        "PDF" => 1999
      ]
    ]
    "pt" => array:9 [
      "idiomaDefecto" => true
      "titulo" => "A resposta broncodilatadora em doentes com DPOC (dados do estudo UPLIFT)"
      "tienePdf" => "pt"
      "tieneTextoCompleto" => 0
      "tieneResumen" => "pt"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "584"
          "paginaFinal" => "587"
        ]
      ]
      "contieneResumen" => array:1 [
        "pt" => true
      ]
      "contienePdf" => array:1 [
        "pt" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "D. Tashkin, B. Celli, M. Decramer, D. Liu, D. Burkhart, C. Cassino, S. Kesten"
          "autores" => array:7 [
            0 => array:2 [
              "nombre" => "D."
              "apellidos" => "Tashkin"
            ]
            1 => array:2 [
              "nombre" => "B."
              "apellidos" => "Celli"
            ]
            2 => array:2 [
              "nombre" => "M."
              "apellidos" => "Decramer"
            ]
            3 => array:2 [
              "nombre" => "D."
              "apellidos" => "Liu"
            ]
            4 => array:2 [
              "nombre" => "D."
              "apellidos" => "Burkhart"
            ]
            5 => array:2 [
              "nombre" => "C."
              "apellidos" => "Cassino"
            ]
            6 => array:2 [
              "nombre" => "S."
              "apellidos" => "Kesten"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "pt"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511508702902?idApp=UINPBA00004E"
    "url" => "/21735115/0000001400000004/v1_201305151456/S2173511508702902/v1_201305151456/pt/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2173511508702884"
    "issn" => "21735115"
    "doi" => "10.1016/S2173-5115(08)70288-4"
    "estado" => "S300"
    "fechaPublicacion" => "2008-07-01"
    "aid" => "70288"
    "copyright" => "Sociedade Portuguesa de Pneumologia"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "sco"
    "cita" => "Rev Port Pneumol. 2008;14:577-8"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 3164
      "formatos" => array:3 [
        "EPUB" => 211
        "HTML" => 1471
        "PDF" => 1482
      ]
    ]
    "pt" => array:9 [
      "idiomaDefecto" => true
      "titulo" => "Achados macroscópicos e histológicos no processo de cicatrização de lesões por inalação"
      "tienePdf" => "pt"
      "tieneTextoCompleto" => 0
      "tieneResumen" => "pt"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "577"
          "paginaFinal" => "578"
        ]
      ]
      "contieneResumen" => array:1 [
        "pt" => true
      ]
      "contienePdf" => array:1 [
        "pt" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "A. Anakawa"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "A."
              "apellidos" => "Anakawa"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "pt"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511508702884?idApp=UINPBA00004E"
    "url" => "/21735115/0000001400000004/v1_201305151456/S2173511508702884/v1_201305151456/pt/main.assets"
  ]
  "pt" => array:10 [
    "idiomaDefecto" => true
    "titulo" => "Avaliação dos resultados nos ensaios clínicos na DPOC: Da função pulmonar aos marcadores biológicos"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "579"
        "paginaFinal" => "583"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "M. Cazzola, W. MacNee, F.J. Martinez, K.F. Rabe"
        "autores" => array:4 [
          0 => array:2 [
            "nombre" => "M."
            "apellidos" => "Cazzola"
          ]
          1 => array:2 [
            "nombre" => "W."
            "apellidos" => "MacNee"
          ]
          2 => array:2 [
            "nombre" => "F.J."
            "apellidos" => "Martinez"
          ]
          3 => array:2 [
            "nombre" => "K.F."
            "apellidos" => "Rabe"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:1 [
            "entidad" => "On behalf of the ATS/ERS TASK Force on outcomes of COPD. Eur Respir J 2008&#59; 31:416-468"
          ]
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "tieneResumen" => true
    "resumen" => array:1 [
      "pt" => array:2 [
        "titulo" => "Resumo"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">As sociedades cient&#237;ficas respirat&#243;rias europeia e americana &#40;ERS e ATS&#41; constitu&#237;ram um grupo de trabalho sobre a &#8220;Avalia&#231;&#227;o dos resultados nos ensaios cl&#237;nicos na DPOC&#58; da fun&#231;&#227;o pulmonar aos marcadores biol&#243;gicos&#8221; para informar a comunidade de investigadores em DPOC sobre o poss&#237;vel uso e limita&#231;&#245;es dos resultados obtidos e marcadores usados actualmente na avalia&#231;&#227;o do impacto da terap&#234;utica farmacol&#243;gica&#46; Com base na revis&#227;o da literatura&#44; este documento aborda diferentes sec&#231;&#245;es que avaliam marcadores e resultados espec&#237;ficos&#58; fun&#231;&#227;o pulmonar&#59; resultados centrados no doente&#59; exacerba&#231;&#245;es&#59; nortalidade&#59; impacto social e econ&#243;mico&#59; exames de imagem&#59; marcadores n&#227;o pulmonares&#59; m&#237;nima diferen&#231;a clinicamente significativa&#59; marcadores biol&#243;gicos&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliografia"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Global Initiative for Chronic Obstructive Lung Disease&#46; Global strategy for the diagnosis&#44; management and prevention of chronic obstructive pulmonary disease&#46; NHLBI&#47;WHO Workshop Report &#40;Updated 2007&#41;&#46; <a class="elsevierStyleInterRef" href="http://www.goldcopd.org/">www&#46;goldcopd&#46;org</a>&#46; &#218;ltimo acessoem 21-05-2008&#46;"
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Bergner M&#46; The sickness impact profile&#46; In Walker SR&#44; ed&#46;&#44; Quality of Life&#58; Assessment and Application&#46; Boston&#44; MTP&#44; 1987&#58; 79&#8211;94&#46;"
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A measure of quality of life for clinical trials in chronic lung disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "G&#46;H&#46; Guyatt"
                            1 => "L&#46;B&#46; Berman"
                            2 => "M&#46; Townsend"
                            3 => "S&#46;O&#46; Pugsley"
                            4 => "L&#46;W&#46; Chambers"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "1987"
                        "volumen" => "42"
                        "paginaInicial" => "773"
                        "paginaFinal" => "778"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3321537"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A self-complete measure of health status for chronic airflow limitation&#46; The St&#46; George&#39;s Respiratory Questionnaire"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "P&#46;W&#46; Jones"
                            1 => "F&#46;H&#46; Quirk"
                            2 => "C&#46;M&#46; Baveystock"
                            3 => "P&#46; Littlejohns"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm/145.6.1321"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1992"
                        "volumen" => "145"
                        "paginaInicial" => "1321"
                        "paginaFinal" => "1327"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1595997"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Development and validation of a standardized measure of activity of daily living in patients with severe COPD&#58; the London Chest Activity of Daily Living scale &#40;LCADL&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46; Garrod"
                            1 => "J&#46;C&#46; Bestall"
                            2 => "E&#46;A&#46; Paul"
                            3 => "J&#46;A&#46; Wedzicha"
                            4 => "P&#46;W&#46; Jones"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/rmed.2000.0786"
                      "Revista" => array:6 [
                        "tituloSerie" => "Respir Med"
                        "fecha" => "2000"
                        "volumen" => "94"
                        "paginaInicial" => "589"
                        "paginaFinal" => "596"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10921765"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Usefulness of the Medical Research Council &#40;MRC&#41; dyspnoea scale as a measure of disability in patients with chronic obstructive pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;C&#46; Bestall"
                            1 => "E&#46;A&#46; Paul"
                            2 => "R&#46; Garrod"
                            3 => "R&#46; Garnham"
                            4 => "P&#46;W&#46; Jones"
                            5 => "J&#46;A&#46; Wedzicha"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "1999"
                        "volumen" => "54"
                        "paginaInicial" => "581"
                        "paginaFinal" => "586"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10377201"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The measurement of dyspnea&#46; Contents&#44; interobserver agreement&#44; and physiologic correlates of two new clinical indexes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46;A&#46; Mahler"
                            1 => "D&#46;H&#46; Weinberg"
                            2 => "C&#46;K&#46; Wells"
                            3 => "A&#46;R&#46; Feinstein"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1984"
                        "volumen" => "85"
                        "paginaInicial" => "751"
                        "paginaFinal" => "758"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6723384"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Psychophysical bases of perceived exertion"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "G&#46;A&#46; Borg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Sci Sports Exerc"
                        "fecha" => "1982"
                        "volumen" => "14"
                        "paginaInicial" => "377"
                        "paginaFinal" => "381"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7154893"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pulmonary rehabilitation and the BODE index in COPD"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46;G&#46; Cote"
                            1 => "B&#46;R&#46; Celli"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1183/09031936.05.00045505"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2005"
                        "volumen" => "26"
                        "paginaInicial" => "630"
                        "paginaFinal" => "636"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16204593"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Weight loss is a reversible factor in the prognosis of chronic obstructive pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46;M&#46; Schols"
                            1 => "J&#46; Slangen"
                            2 => "L&#46; Volovics"
                            3 => "E&#46;F&#46; Wouters"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.157.6.9705017"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "1998"
                        "volumen" => "157"
                        "paginaInicial" => "1791"
                        "paginaFinal" => "1797"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9620907"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "pt"
  "url" => "/21735115/0000001400000004/v1_201305151456/S2173511508702896/v1_201305151456/pt/main.assets"
  "Apartado" => array:4 [
    "identificador" => "9598"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "As Nossas Leituras"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735115/0000001400000004/v1_201305151456/S2173511508702896/v1_201305151456/pt/main.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511508702896?idApp=UINPBA00004E"
]
Share
Journal Information
Vol. 14. Issue 4.
Pages 579-583 (July - August 2008)
Share
Share
Download PDF
More article options
Vol. 14. Issue 4.
Pages 579-583 (July - August 2008)
Full text access
Avaliação dos resultados nos ensaios clínicos na DPOC: Da função pulmonar aos marcadores biológicos
Visits
883
M. Cazzola, W. MacNee, F.J. Martinez, K.F. Rabe
On behalf of the ATS/ERS TASK Force on outcomes of COPD. Eur Respir J 2008; 31:416-468
This item has received
Article information
Abstract
Bibliography
Download PDF
Statistics
Resumo

As sociedades científicas respiratórias europeia e americana (ERS e ATS) constituíram um grupo de trabalho sobre a “Avaliação dos resultados nos ensaios clínicos na DPOC: da função pulmonar aos marcadores biológicos” para informar a comunidade de investigadores em DPOC sobre o possível uso e limitações dos resultados obtidos e marcadores usados actualmente na avaliação do impacto da terapêutica farmacológica. Com base na revisão da literatura, este documento aborda diferentes secções que avaliam marcadores e resultados específicos: função pulmonar; resultados centrados no doente; exacerbações; nortalidade; impacto social e económico; exames de imagem; marcadores não pulmonares; mínima diferença clinicamente significativa; marcadores biológicos.

Full text is only aviable in PDF
Bibliografia
[1.]
Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Workshop Report (Updated 2007). www.goldcopd.org. Último acessoem 21-05-2008.
[2.]
Bergner M. The sickness impact profile. In Walker SR, ed., Quality of Life: Assessment and Application. Boston, MTP, 1987: 79–94.
[3.]
G.H. Guyatt, L.B. Berman, M. Townsend, S.O. Pugsley, L.W. Chambers.
A measure of quality of life for clinical trials in chronic lung disease.
Thorax, 42 (1987), pp. 773-778
[4.]
P.W. Jones, F.H. Quirk, C.M. Baveystock, P. Littlejohns.
A self-complete measure of health status for chronic airflow limitation. The St. George's Respiratory Questionnaire.
Am Rev Respir Dis, 145 (1992), pp. 1321-1327
[5.]
R. Garrod, J.C. Bestall, E.A. Paul, J.A. Wedzicha, P.W. Jones.
Development and validation of a standardized measure of activity of daily living in patients with severe COPD: the London Chest Activity of Daily Living scale (LCADL).
Respir Med, 94 (2000), pp. 589-596
[6.]
J.C. Bestall, E.A. Paul, R. Garrod, R. Garnham, P.W. Jones, J.A. Wedzicha.
Usefulness of the Medical Research Council (MRC) dyspnoea scale as a measure of disability in patients with chronic obstructive pulmonary disease.
Thorax, 54 (1999), pp. 581-586
[7.]
D.A. Mahler, D.H. Weinberg, C.K. Wells, A.R. Feinstein.
The measurement of dyspnea. Contents, interobserver agreement, and physiologic correlates of two new clinical indexes.
Chest, 85 (1984), pp. 751-758
[8.]
G.A. Borg.
Psychophysical bases of perceived exertion.
Med Sci Sports Exerc, 14 (1982), pp. 377-381
[9.]
C.G. Cote, B.R. Celli.
Pulmonary rehabilitation and the BODE index in COPD.
Eur Respir J, 26 (2005), pp. 630-636
[10.]
A.M. Schols, J. Slangen, L. Volovics, E.F. Wouters.
Weight loss is a reversible factor in the prognosis of chronic obstructive pulmonary disease.
Am J Respir Crit Care Med, 157 (1998), pp. 1791-1797
Copyright © 2008. Sociedade Portuguesa de Pneumologia
Download PDF
Pulmonology
Article options
Tools

Are you a health professional able to prescribe or dispense drugs?