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                  "referenciaCompleta" => "Global Initiative for Chronic Obstructive Lung Disease&#46; Global strategy for the diagnosis&#44; management and prevention of chronic obstructive pulmonary disease&#46; NHLBI&#47;WHO Workshop Report &#40;Updated 2007&#41;&#46; <a class="elsevierStyleInterRef" href="http://www.goldcopd.org/">www&#46;goldcopd&#46;org</a>&#46; &#218;ltimo acessoem 21-05-2008&#46;"
                ]
              ]
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              "identificador" => "bib2"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Bergner M&#46; The sickness impact profile&#46; In Walker SR&#44; ed&#46;&#44; Quality of Life&#58; Assessment and Application&#46; Boston&#44; MTP&#44; 1987&#58; 79&#8211;94&#46;"
                ]
              ]
            ]
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A measure of quality of life for clinical trials in chronic lung disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "G&#46;H&#46; Guyatt"
                            1 => "L&#46;B&#46; Berman"
                            2 => "M&#46; Townsend"
                            3 => "S&#46;O&#46; Pugsley"
                            4 => "L&#46;W&#46; Chambers"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "1987"
                        "volumen" => "42"
                        "paginaInicial" => "773"
                        "paginaFinal" => "778"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3321537"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib4"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A self-complete measure of health status for chronic airflow limitation&#46; The St&#46; George&#39;s Respiratory Questionnaire"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
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                            1 => "F&#46;H&#46; Quirk"
                            2 => "C&#46;M&#46; Baveystock"
                            3 => "P&#46; Littlejohns"
                          ]
                        ]
                      ]
                    ]
                  ]
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                      "doi" => "10.1164/ajrccm/145.6.1321"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1992"
                        "volumen" => "145"
                        "paginaInicial" => "1321"
                        "paginaFinal" => "1327"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1595997"
                            "web" => "Medline"
                          ]
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                    ]
                  ]
                ]
              ]
            ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Development and validation of a standardized measure of activity of daily living in patients with severe COPD&#58; the London Chest Activity of Daily Living scale &#40;LCADL&#41;"
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                        0 => array:2 [
                          "etal" => false
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                            1 => "J&#46;C&#46; Bestall"
                            2 => "E&#46;A&#46; Paul"
                            3 => "J&#46;A&#46; Wedzicha"
                            4 => "P&#46;W&#46; Jones"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/rmed.2000.0786"
                      "Revista" => array:6 [
                        "tituloSerie" => "Respir Med"
                        "fecha" => "2000"
                        "volumen" => "94"
                        "paginaInicial" => "589"
                        "paginaFinal" => "596"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10921765"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Usefulness of the Medical Research Council &#40;MRC&#41; dyspnoea scale as a measure of disability in patients with chronic obstructive pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
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                            1 => "E&#46;A&#46; Paul"
                            2 => "R&#46; Garrod"
                            3 => "R&#46; Garnham"
                            4 => "P&#46;W&#46; Jones"
                            5 => "J&#46;A&#46; Wedzicha"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
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                        "fecha" => "1999"
                        "volumen" => "54"
                        "paginaInicial" => "581"
                        "paginaFinal" => "586"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10377201"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib7"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The measurement of dyspnea&#46; Contents&#44; interobserver agreement&#44; and physiologic correlates of two new clinical indexes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46;A&#46; Mahler"
                            1 => "D&#46;H&#46; Weinberg"
                            2 => "C&#46;K&#46; Wells"
                            3 => "A&#46;R&#46; Feinstein"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1984"
                        "volumen" => "85"
                        "paginaInicial" => "751"
                        "paginaFinal" => "758"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6723384"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Psychophysical bases of perceived exertion"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "G&#46;A&#46; Borg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Sci Sports Exerc"
                        "fecha" => "1982"
                        "volumen" => "14"
                        "paginaInicial" => "377"
                        "paginaFinal" => "381"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7154893"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pulmonary rehabilitation and the BODE index in COPD"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46;G&#46; Cote"
                            1 => "B&#46;R&#46; Celli"
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                        ]
                      ]
                    ]
                  ]
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                    0 => array:2 [
                      "doi" => "10.1183/09031936.05.00045505"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2005"
                        "volumen" => "26"
                        "paginaInicial" => "630"
                        "paginaFinal" => "636"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16204593"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Weight loss is a reversible factor in the prognosis of chronic obstructive pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46;M&#46; Schols"
                            1 => "J&#46; Slangen"
                            2 => "L&#46; Volovics"
                            3 => "E&#46;F&#46; Wouters"
                          ]
                        ]
                      ]
                    ]
                  ]
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                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "1998"
                        "volumen" => "157"
                        "paginaInicial" => "1791"
                        "paginaFinal" => "1797"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9620907"
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Journal Information
Vol. 14. Issue 4.
Pages 579-583 (July - August 2008)
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Vol. 14. Issue 4.
Pages 579-583 (July - August 2008)
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Avaliação dos resultados nos ensaios clínicos na DPOC: Da função pulmonar aos marcadores biológicos
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M. Cazzola, W. MacNee, F.J. Martinez, K.F. Rabe
On behalf of the ATS/ERS TASK Force on outcomes of COPD. Eur Respir J 2008; 31:416-468
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Resumo

As sociedades científicas respiratórias europeia e americana (ERS e ATS) constituíram um grupo de trabalho sobre a “Avaliação dos resultados nos ensaios clínicos na DPOC: da função pulmonar aos marcadores biológicos” para informar a comunidade de investigadores em DPOC sobre o possível uso e limitações dos resultados obtidos e marcadores usados actualmente na avaliação do impacto da terapêutica farmacológica. Com base na revisão da literatura, este documento aborda diferentes secções que avaliam marcadores e resultados específicos: função pulmonar; resultados centrados no doente; exacerbações; nortalidade; impacto social e económico; exames de imagem; marcadores não pulmonares; mínima diferença clinicamente significativa; marcadores biológicos.

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Bibliografia
[1.]
Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Workshop Report (Updated 2007). www.goldcopd.org. Último acessoem 21-05-2008.
[2.]
Bergner M. The sickness impact profile. In Walker SR, ed., Quality of Life: Assessment and Application. Boston, MTP, 1987: 79–94.
[3.]
G.H. Guyatt, L.B. Berman, M. Townsend, S.O. Pugsley, L.W. Chambers.
A measure of quality of life for clinical trials in chronic lung disease.
Thorax, 42 (1987), pp. 773-778
[4.]
P.W. Jones, F.H. Quirk, C.M. Baveystock, P. Littlejohns.
A self-complete measure of health status for chronic airflow limitation. The St. George's Respiratory Questionnaire.
Am Rev Respir Dis, 145 (1992), pp. 1321-1327
[5.]
R. Garrod, J.C. Bestall, E.A. Paul, J.A. Wedzicha, P.W. Jones.
Development and validation of a standardized measure of activity of daily living in patients with severe COPD: the London Chest Activity of Daily Living scale (LCADL).
Respir Med, 94 (2000), pp. 589-596
[6.]
J.C. Bestall, E.A. Paul, R. Garrod, R. Garnham, P.W. Jones, J.A. Wedzicha.
Usefulness of the Medical Research Council (MRC) dyspnoea scale as a measure of disability in patients with chronic obstructive pulmonary disease.
Thorax, 54 (1999), pp. 581-586
[7.]
D.A. Mahler, D.H. Weinberg, C.K. Wells, A.R. Feinstein.
The measurement of dyspnea. Contents, interobserver agreement, and physiologic correlates of two new clinical indexes.
Chest, 85 (1984), pp. 751-758
[8.]
G.A. Borg.
Psychophysical bases of perceived exertion.
Med Sci Sports Exerc, 14 (1982), pp. 377-381
[9.]
C.G. Cote, B.R. Celli.
Pulmonary rehabilitation and the BODE index in COPD.
Eur Respir J, 26 (2005), pp. 630-636
[10.]
A.M. Schols, J. Slangen, L. Volovics, E.F. Wouters.
Weight loss is a reversible factor in the prognosis of chronic obstructive pulmonary disease.
Am J Respir Crit Care Med, 157 (1998), pp. 1791-1797
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