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        "titulo" => "Efeitos do salbutamol e do formoterol sobre press&#227;o arterial&#44; frequ&#234;ncia card&#237;aca e satura&#231;&#227;o de oxig&#233;nio em asm&#225;ticos&#44; durante uma hora"
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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Aim</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To analyse systolic &#40;SBP&#41; and diastolic blood pressure &#40;DBP&#41;&#44; partial oxygen saturation &#40;SpO<span class="elsevierStyleInf">2</span>&#41; and heart rate &#40;HR&#41; disorders for an hour after short and long acting &#223;<span class="elsevierStyleInf">2</span>-agonists&#46;</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Twenty-four severe persistent asthma Pulmonology outpatients at Hospital Universitario Gaffree e Guinle were selected&#46; SBP&#44; DBP&#44; SpO<span class="elsevierStyleInf">2</span> and HR values were determined before and after 400<span class="elsevierStyleHsp" style=""></span>&#956;g of salbutamol and 12<span class="elsevierStyleHsp" style=""></span>&#956;g of formoterol&#44; on different days&#44; with a minimum interval of 24 hours&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">All patients showed ventilatory obstruction&#44; as seen by a reduced FEV1&#47;FVC ratio&#46; There was no statistical SBP&#47;DBP&#47;HR difference after bronchodilator agents&#44; but SpO<span class="elsevierStyleInf">2</span> increased with salbutamol&#46;</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">A standard dose of salbutamol and formoterol does not cause haemodynamic disorder&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objectivo</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Analisar os poss&#237;veis efeitos do uso de &#946;-2-agonistas&#44; de curta e longa dura&#231;&#227;o&#44; nas press&#245;es arteriais sist&#243;lica &#40;PAS&#41; e diast&#243;lica &#40;PAD&#41;&#44; na satura&#231;&#227;o parcial de oxig&#233;nio &#40;SpO<span class="elsevierStyleInf">2</span>&#41; e na frequ&#234;ncia card&#237;aca &#40;FC&#41;&#44; durante o per&#237;odo de uma hora&#46;</p> <span class="elsevierStyleSectionTitle">Material e m&#233;todos</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Vinte e quatro doentes com asma persistente grave&#44; em tratamento no ambulat&#243;rio de Pneumologia do Hospital Universit&#225;rio Gaffr&#233;e e Guinle&#44; foram seleccionados para um ensaio cl&#237;nico sequencial e cruzado&#46; Os valores da PAS&#44; PAD&#44; SpO<span class="elsevierStyleInf">2</span> e FC foram registados antes e ap&#243;s o uso de broncodilatadores&#44; salbutamol 400<span class="elsevierStyleHsp" style=""></span>&#956;g e formoterol 12<span class="elsevierStyleHsp" style=""></span>&#956;g&#44; em dias diferentes&#44; com intervalo m&#237;nimo de 24 horas&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Todos os doentes apresentaram dist&#250;rbio ventilat&#243;rio obstrutivo&#44; identificado pela redu&#231;&#227;o da rela&#231;&#227;o entre o volume expirat&#243;rio for&#231;ado no primeiro segundo &#40;VEMS&#41; e a capacidade vital for&#231;ada &#40;CVF&#41;&#46; Ap&#243;s o uso de subst&#226;ncia broncodilatadora&#44; n&#227;o houve varia&#231;&#227;o significativa nas PAS e PAD&#44; nem na FC&#59; por&#233;m&#44; a SpO<span class="elsevierStyleInf">2</span> aumentou com o uso de salbutamol&#46;</p> <span class="elsevierStyleSectionTitle">Conclus&#227;o</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">N&#227;o foram observadas altera&#231;&#245;es hemodin&#226;micas significativas ap&#243;s o uso de salbutamol e formoterol nas doses preconizadas&#46;</p>"
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Vol. 14. Issue 3.
Pages 353-361 (May - June 2008)
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Vol. 14. Issue 3.
Pages 353-361 (May - June 2008)
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One hour effects of salbutamol and formoterol on blood pressure, heart rate and oxygen saturation in asthmatics
Efeitos do salbutamol e do formoterol sobre pressão arterial, frequência cardíaca e saturação de oxigénio em asmáticos, durante uma hora
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Geraldo Andrade Capuchinho-Júnior1, Ricardo Marques Dias2,4,
Corresponding author
dias.ricardomarques@gmail.com

Corresponding author/Correspondência: Rua Barão da Torre 388/104 – CEP 22411-000, Ipanema – Rio de Janeiro – RJ - Brasil.
, Sônia Regina da Silva de Carvalho3
1 Académico da Escola de Medicina e Cirurgia da Universidade Federal do Estado do Rio de Janeiro (UniRio), bolseiro do Programa de Iniciação Científica da UNIRIO (IC/ UniRio) / Scholarship holder, UNIRIO Scientific Initiation Programme (IC/UniRio)
2 Professor Titular de Pneumologia da UniRio, Doutor em Medicina (Pneumologia). Líder do Grupo de Pesquisa “Pneumologia-UNIRIO” / Titular Professor, Pulmonology UniRio, MD (Pulmonology). UniRio-Pulmonology research team leader
3 Professora Adjunta da UniRio, Mestre em Medicina (Pneumologia) / Assistant Professor, UniRio, MSc Medicine (Pulmonology)
4 Hospital Universitário Gaffrée e Guinle (HUGG) – Unidade Cardiopulmonar Chefe do Serviço
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Abstract
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Abstract
Aim

To analyse systolic (SBP) and diastolic blood pressure (DBP), partial oxygen saturation (SpO2) and heart rate (HR) disorders for an hour after short and long acting ß2-agonists.

Material and methods

Twenty-four severe persistent asthma Pulmonology outpatients at Hospital Universitario Gaffree e Guinle were selected. SBP, DBP, SpO2 and HR values were determined before and after 400μg of salbutamol and 12μg of formoterol, on different days, with a minimum interval of 24 hours.

Results

All patients showed ventilatory obstruction, as seen by a reduced FEV1/FVC ratio. There was no statistical SBP/DBP/HR difference after bronchodilator agents, but SpO2 increased with salbutamol.

Conclusion

A standard dose of salbutamol and formoterol does not cause haemodynamic disorder.

Key-words:
Asthma
bronchodilator agents/adverse effects
heart rate
blood pressure
oxygen saturation
Resumo
Objectivo

Analisar os possíveis efeitos do uso de β-2-agonistas, de curta e longa duração, nas pressões arteriais sistólica (PAS) e diastólica (PAD), na saturação parcial de oxigénio (SpO2) e na frequência cardíaca (FC), durante o período de uma hora.

Material e métodos

Vinte e quatro doentes com asma persistente grave, em tratamento no ambulatório de Pneumologia do Hospital Universitário Gaffrée e Guinle, foram seleccionados para um ensaio clínico sequencial e cruzado. Os valores da PAS, PAD, SpO2 e FC foram registados antes e após o uso de broncodilatadores, salbutamol 400μg e formoterol 12μg, em dias diferentes, com intervalo mínimo de 24 horas.

Resultados

Todos os doentes apresentaram distúrbio ventilatório obstrutivo, identificado pela redução da relação entre o volume expiratório forçado no primeiro segundo (VEMS) e a capacidade vital forçada (CVF). Após o uso de substância broncodilatadora, não houve variação significativa nas PAS e PAD, nem na FC; porém, a SpO2 aumentou com o uso de salbutamol.

Conclusão

Não foram observadas alterações hemodinâmicas significativas após o uso de salbutamol e formoterol nas doses preconizadas.

Palavras-chave:
Asma
broncodilatadores/efeitos adversos
frequência cardíaca
pressão arterial sistémica
saturação de oxigénio
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Bibliography/Bibliografia
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Copyright © 2008. Sociedade Portuguesa de Pneumologia
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